Automating the weaning process with advanced closed-loop systems.

abstract：:Pulmonary artery (PA) catheterization is now a routine procedure in the care of critically ill patients. We report a case in which a pulmonary artery catheter was a major factor in the demise of a patient who developed adult respiratory distress syndrome following a septic abortion. ...

journal_title：Intensive care medicine

authors： Melton JG,Kamal GD

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:After resuscitation, asphyxiated neonates often develop poor cardiac function with hypotension, pulmonary hypertension and multiorgan ischemia. In a swine model of neonatal hypoxia-reoxygenation, effects of epinephrine, dobutamine and milrinone on systemic, pulmonary and regional hemodynamics and oxygen tran...

journal_title：Intensive care medicine

authors： Joynt C,Bigam DL,Charrois G,Jewell LD,Korbutt G,Cheung PY

更新日期：2010-06-01 00:00:00

abstract：:We compare two patients admitted after near drowning. Both presented a severe metabolic acidosis, but only one of them developed an acute pulmonary edema with hypoxemia. An increase of lipid peroxides associated with a reduction of vitamin E concentration has been observed in this later patient. Lipid peroxidation, on...

journal_title：Intensive care medicine

authors： Bertrand Y,Artoisenet A,Allard B,Barbier B,de Meulder A,Raynaert M,Mathieu P,Dumont E

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between cytokines and the inflammatory responses in patients with out-of-hospital cardiac arrest, we examined the changes of cytokines as well as alterations in the markers of neutrophil activation, platelet and endothelial activation, and endothelial injury. DESIGN:Prospectiv...

journal_title：Intensive care medicine

authors： Gando S,Nanzaki S,Morimoto Y,Kobayashi S,Kemmotsu O

更新日期：1999-06-01 00:00:00

abstract：:Malaria remains today one of the major health problems in the tropics with increased morbidity and mortality. The most serious complications are caused by Plasmodium falciparum, which, in contrast to the benign malarias, may progress to a life-threatening multi-system disease. Our case concerns a young woman in the 14...

journal_title：Intensive care medicine

authors： Gregorakos L,Sakayianni K,Hroni D,Harizopoulou V,Georgiadou F,Adamidou M

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:This study was undertaken to determine the delay of extubation attributable to ventilator-associated pneumonia (VAP) in comparison to other complications and complexity of surgery after repair of congenital heart lesions in neonates and children. METHODS:Cohort study in a pediatric intensive care unit of a t...

journal_title：Intensive care medicine

authors： Fischer JE,Allen P,Fanconi S

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:The purpose of the study was do describe the architecture of accretions occurring on the tips of central venous catheters (CVC). DESIGN:A conservative procedure was used followed by two different techniques of electron microscopy. SETTING AND PATIENTS:the study included 19 catheters which have been used on ...

journal_title：Intensive care medicine

authors： Poisson DM,Touquet S,Bercault N,Arbeille B

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To examine the usefulness of preload indices obtained by transoesophageal echocardiography (TOE) for estimating stroke volume at various levels of cardiac index. DESIGN:Prospective clinical study. SETTING:Intensive care unit with surgical patients. PATIENTS:16 ventilated patients monitored via Swan-Ganz ca...

journal_title：Intensive care medicine

authors： Greim CA,Roewer N,Apfel C,Laux G,Schulte am Esch J

更新日期：1997-04-01 00:00:00

abstract：:A cardiorespiratory monitoring system allows the measurement of FAECO2 and FECO2 in the expired air of the patient at the mouth (endtidal CO2) and in a mixing box. From these parameters, combined with the measured PACO2, the alveolo-expired (DuA = PECO2/PAECO2) and alveolar-arterial (Dua = PAECO2/PACO2) ductances whic...

journal_title：Intensive care medicine

authors： Polu JM,Duvivier C,Sadoul P

更新日期：1980-08-01 00:00:00

abstract：PURPOSE:Ventricular-arterial (V-A) decoupling decreases myocardial efficiency and is exacerbated by tachycardia that increases static arterial elastance (Ea). We thus investigated the effects of heart rate (HR) reduction on Ea in septic shock patients using the beta-blocker esmolol. We hypothesized that esmolol improve...

journal_title：Intensive care medicine

authors： Morelli A,Singer M,Ranieri VM,D'Egidio A,Mascia L,Orecchioni A,Piscioneri F,Guarracino F,Greco E,Peruzzi M,Biondi-Zoccai G,Frati G,Romano SM

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:To assess the effects of the cyclooxygenase inhibitor diclofenac in a canine model of pulmonary occlusion and reperfusion of the left lower lobe (LLL). DESIGN:Twelve adult beagle dogs (13-17 kg) were randomly assigned to a control group (n = 6) and a diclofenac-treated group (n = 6). Animals in the treatment...

journal_title：Intensive care medicine

authors： Segiet W,Krieter H,Stieber C,Albrecht DM,van Ackern K

更新日期：1995-10-01 00:00:00

abstract：PURPOSE:To assess the generalisability of published clinical risk predictive models for invasive candidiasis in ICU patients. METHODS:The performance characteristics of published clinical risk factor-only and Candida colonisation-only predictive models for invasive candidiasis were assessed in a multicentre cohort of ...

journal_title：Intensive care medicine

authors： Playford EG,Lipman J,Kabir M,McBryde ES,Nimmo GR,Lau A,Sorrell TC

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:To determine the incidence, risk factors, and outcome of barotrauma in a cohort of mechanically ventilated patients where limited tidal volumes and airway pressures were used. DESIGN AND SETTING:Prospective cohort of 361 intensive care units from 20 countries. PATIENTS AND PARTICIPANTS:A total of 5183 patie...

journal_title：Intensive care medicine

authors： Anzueto A,Frutos-Vivar F,Esteban A,Alía I,Brochard L,Stewart T,Benito S,Tobin MJ,Elizalde J,Palizas F,David CM,Pimentel J,González M,Soto L,D'Empaire G,Pelosi P

更新日期：2004-04-01 00:00:00

abstract：:The case of an 11-year-old boy who suffered second and third degree burns to 78% of his body is reported. The large doses of morphine used as analgesia resulted in severe side effects: ventilatory dependence, impairment of gastrointestinal function and psychological disturbance. Intravenous lignocaine was added withou...

journal_title：Intensive care medicine

authors： Lyons B,Casey W,Doherty P,McHugh M,Moore KP

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVES:Critical illness increases the tendency to both coagulation and bleeding, complicating anticoagulation for continuous renal replacement therapy (CRRT). We analyzed strategies for anticoagulation in CRRT concerning implementation, efficacy and safety to provide evidence-based recommendations for clinical prac...

journal_title：Intensive care medicine

authors： Oudemans-van Straaten HM,Wester JPJ,de Pont ACJM,Schetz MRC

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:To compare haemodynamic and gas exchange effects after either atracurium or pancuronium given to ventilated neonates with respiratory failure. DESIGN:In this prospective study neonates were alternately assigned to receive either atracurium or pancuronium, intravenously. SETTING:Paediatric and neonatal ICU i...

journal_title：Intensive care medicine

authors： Piotrowski A

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:To identify objective trends of the course of illness that might be used as benchmarks in the auditing of the organization/performance of Intensive Care Units (ICU). DESIGN:Retrospective analysis. PATIENTS AND SETTING:A group of 12,615 patients and 55,464 patient-days prospectively collected in 89 ICUs of 1...

journal_title：Intensive care medicine

authors： Iapichino G,Radrizzani D,Ferla L,Pezzi A,Porta F,Zanforlin G,Miranda DR

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the use of antidotal therapy in patients with an elevated digitalis concentration following chronic or acute exposure. DESIGN AND SETTING:Retrospective review of patient records over 2 years in 20 city hospitals in France. PATIENTS:Overall 838 patients with an elevated serum digitalis concentrat...

journal_title：Intensive care medicine

authors： Lapostolle F,Borron SW,Verdier C,Arnaud F,Couvreur J,Mégarbane B,Baud F,Adnet F

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:To measure the effect of intense neuromuscular blockade (NMB) on oxygen consumption (VO(2)) in deeply sedated and mechanically ventilated children on the first day after complex congenital cardiac surgery. DESIGN:Prospective clinical interventional study. SETTING:Pediatric intensive care unit of an universi...

journal_title：Intensive care medicine

authors： Lemson J,Driessen JJ,van der Hoeven JG

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Evaluation of low-level PEEP (5 cm H2O) and the two different CPAP trigger modes in the Bennett 7200a ventilator (demand-valve and flow-by trigger modes) on inspiratory work of breathing (Wi) during the weaning phase. DESIGN:Prospective controlled study. SETTING:The intensive care unit of a university hospi...

journal_title：Intensive care medicine

authors： Sydow M,Golisch W,Buscher H,Zinserling J,Crozier TA,Burchardi H

更新日期：1995-11-01 00:00:00

abstract：RATIONALE:Acute respiratory distress syndrome (ARDS) is frequently associated with hemodynamic instability which appears as the main factor associated with mortality. Shock is driven by pulmonary hypertension, deleterious effects of mechanical ventilation (MV) on right ventricular (RV) function, and associated-sepsis. ...

journal_title：Intensive care medicine

authors： Vieillard-Baron A,Matthay M,Teboul JL,Bein T,Schultz M,Magder S,Marini JJ

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:Sepsis and its progression are known to have a major influence on the coagulation system. Current coagulation tests are of limited use when assessing coagulation in sepsis patients. This study aims to assess the potential for a new functional biomarker of clot microstructure, fractal dimension, to identify chan...

journal_title：Intensive care medicine

authors： Davies GR,Pillai S,Lawrence M,Mills GM,Aubrey R,D'Silva L,Battle C,Williams R,Brown R,Thomas D,Morris K,Evans PA

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To assess the impact of hemodynamic variables on the outcome of critically ill patients in septic shock and to identify the optimal threshold values related to outcome with special reference to continuously monitored mean arterial pressure (MAP) and mixed venous oxygen saturation (SvO2). DESIGN AND SETTING:R...

journal_title：Intensive care medicine

authors： Varpula M,Tallgren M,Saukkonen K,Voipio-Pulkki LM,Pettilä V

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:The Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy related to autoimmunity. However, no conclusive etiological concept has yet been found. We examined the variation in autoantibodies to lipids in serum of GBS patients in response to the course of the disease but investigated titer modif...

journal_title：Intensive care medicine

authors： Nakos G,Tziakou E,Maneta-Peyret L,Nassis C,Lekka ME

更新日期：2005-10-01 00:00:00

abstract：:Two hundred and seventy-three acute hemorrhagic shocks were treated in 1984 in a pre-hospital emergency care unit. Twenty patients (7%) had a paradoxical bradycardia: they were conscious, 9 of them had an undetectable systolic arterial pressure with the sphygmomanometric method but the femoral pulse was still present....

journal_title：Intensive care medicine

authors： Barriot P,Riou B

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:This study compared the recently introduced Microcuff endotracheal tube HVLP ICU featuring an ultrathin (7-microm) polyurethane cuff membrane with endotracheal tubes from different manufacturers regarding fluid leakage past the tube cuff. DESIGN:In vitro setup. MEASUREMENTS AND RESULTS:The following endotra...

journal_title：Intensive care medicine

authors： Dullenkopf A,Gerber A,Weiss M

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:To investigate the relationship between hemoglobin (Hgb) and brain tissue oxygen tension (PbtO(2)) after severe traumatic brain injury (TBI) and to examine its impact on outcome. METHODS:This was a retrospective analysis of a prospective cohort of severe TBI patients whose PbtO(2) was monitored. The relationsh...

journal_title：Intensive care medicine

authors： Oddo M,Levine JM,Kumar M,Iglesias K,Frangos S,Maloney-Wilensky E,Le Roux PD

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:To assess acute cardiorespiratory effects of recruitment manoeuvres in experimental acute lung injury. DESIGN:Experimental study in animal models of acute lung injury. SETTING:Experimental laboratory at a University Medical Centre. ANIMALS:Ten pigs with bronchoalveolar lavage and eight pigs with endotoxin-...

journal_title：Intensive care medicine

authors： Odenstedt H,Aneman A,Kárason S,Stenqvist O,Lundin S

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate the neuropathological outcome of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to i...

journal_title：Intensive care medicine

authors： Fathali N,Lekic T,Zhang JH,Tang J

更新日期：2010-09-01 00:00:00

abstract：:We analysed the case histories of 22 patients with life threatening asthma retrospectively. Fifteen patients needed mechanical ventilation. Three patients, all of them in cardiac arrest before or at the moment of admission, died. In five patients, halothane therapy was successfully used as a last resort. No major comp...

journal_title：Intensive care medicine

authors： Rosseel P,Lauwers LF,Baute L

更新日期：1985-01-01 00:00:00