当前位置： SCI文献检索 > INTENSIVE CARE MEDICINE期刊下所有文献 > Nasal, pulmonary and autoinhaled nitric oxide at rest and during moderate exercise.

Nasal, pulmonary and autoinhaled nitric oxide at rest and during moderate exercise.

Abstract：

OBJECTIVE:To investigate nasal nitric oxide (NO) excretion, pulmonary NO excretion, and autoinhalation of nasally released NO at rest compared with that during moderate exercise in smokers and non-smokers. DESIGN:Prospective observational study. SETTING:University laboratory. PARTICIPANTS:Fourteen healthy adult volunteers. INTERVENTIONS:Breathing of NO-purified air supplied via a tube system at rest and during a bicycle-ergometer workload of 60 Watt over a time of 10 min. MEASUREMENT AND RESULTS:We examined nasal and pulmonary NO excretion in smoking (n = 7) and non-smoking (n = 7) adult human volunteers. At rest, we measured constant nasal NO excretion rates of 311 +/- 89 nl/min for non-smokers and 261 +/- 142 nl/min for smokers (mean +/- SD, n.s.). During 60 W exercise, nasal NO release remained unchanged, while pulmonary NO excretion doubled compared with the rates at rest (non-smokers: 40 +/- 21 nl/min versus 23 +/- 14 nl/min, p < 0.05; smokers: 41 +/- 8 nl/min versus 22 +/- 8 nl/min, p < 0.05). The differences between smokers and non-smokers in nasal or pulmonary NO excretion were not significant. To determine the autoinhaled amount of nasally released NO, we also measured the NO concentration within the nasopharynx of five volunteers during nasal breathing. The average inhaled NO concentration was 17.8 +/- 3.1 ppb at rest and this decreased to 9.3 +/- 1.8 ppb during exercise of 60 W, while minute ventilation approximately doubled from 9 +/- 2 to 21 +/- 3 l/min. CONCLUSION:Our results demonstrate that moderate exercise increased exclusively pulmonary NO excretion. Nasal NO release, which is 10 times higher at rest, was not changed. The decrease in autoinhaled NO concentration during exercise results from dilution of the continuous nasal release by the increased respiratory gas flow. The individual NO release allows no conclusion about smoking habits.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Busch T,Kuhlen R,Knorr M,Kelly K,Lewandowski K,Rossaint R,Falke KJ,Gerlach H

doi

10.1007/s001340051172

keywords:

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

391-9

issue

eissn

0342-4642

issn

1432-1238

journal_volume

pub_type

杂志文章

在线工具

Nasal, pulmonary and autoinhaled nitric oxide at rest and during moderate exercise.