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Combined measurements of N-terminal pro-brain natriuretic peptide and cardiac troponins in potential organ donors.

Abstract：

OBJECTIVE:Brain death may induce cardiac dysfunction. In potential organ donors measurements of N-terminal pro-brain natriuretic peptide (NT-proBNP) and circulating cardiac troponins T and I (cTnT and cTnI), alone or in combination, are performed to investigate the accuracy of these biomarkers for early diagnosis of left ventricular systolic dysfunction. DESIGN AND SETTING:Prospective study in a multidisciplinary intensive care unit of an university hospital. PATIENTS:63 brain-dead patients scheduled for multiple organ harvesting. MEASUREMENTS AND RESULTS:We measured NT-proBNP, cTnT, and cTnI and determined fractional area change (FAC) using transesophageal echocardiography. Forty-five patients had normal FAC, 9 a moderate decrease in FAC (30-50), and 9 a severe decrease in FAC (

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Nicolas-Robin A,Salvi N,Medimagh S,Amour J,Le Manach Y,Coriat P,Riou B,Langeron O

doi

10.1007/s00134-007-0601-7

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

986-92

issue

6

eissn

0342-4642

issn

1432-1238

journal_volume

33

pub_type

杂志文章

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