Abstract:
OBJECTIVES:To measure the extent of dilution of helium-oxygen (heliox) by room air when given via high concentration reservoir mask to spontaneously breathing subjects. Substantial dilution of heliox by room air under these circumstances might alter its physical properties sufficiently to negate any potential clinical benefit in obstructive respiratory failure. DESIGN:Healthy volunteers breathing different concentrations of helium in oxygen via two different masks in a randomised crossover design. SETTING:Operating theatre in a university hospital. PATIENTS AND PARTICIPANTS:Six healthy volunteers. INTERVENTIONS:The concentrations of helium, nitrogen and oxygen were measured in the trachea of each volunteer using a mass spectrometer during normal breathing, hyperventilation and hypoventilation. MEASUREMENTS AND RESULTS:During normal breathing of Heliox21 (79% helium) via a standard non-rebreathe reservoir mask, within subject median percentage tracheal helium was 37.2% (range 29.3-52.2%) and nitrogen was 41.7% (27.4-49.4%). Air entrainment was affected by changes in breathing pattern: tracheal nitrogen concentration was greater during hyperventilation (55.4%; range 49.4-63.5%) and less during hypoventilation (33.1%; range 24.6-39.6%, p=0.043). Tracheal nitrogen could be almost completely abolished by administering heliox via a tightly fitting cushioned facemask, even during hyperventilation (2.2%; range 0.6-6.1%, p=0.028). CONCLUSIONS:Heliox administration via a standard high-concentration reservoir mask leads to significant dilution by room air. For the full potential benefits of heliox to be realised in spontaneously breathing patients, it should be administered via a system that achieves a gas tight seal, with no leaks between the delivery device and the surroundings.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Standley TD,Smith HL,Brennan LJ,Wilkins IA,Bradley PG,Barrera Groba C,Davey AJ,Menon DK,Wheeler DWdoi
10.1007/s00134-008-1064-1subject
Has Abstractpub_date
2008-08-01 00:00:00pages
1469-76issue
8eissn
0342-4642issn
1432-1238journal_volume
34pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:To determine if the plasma levels of three endothelial-specific proteins, von Willebrand factor (vWF), tissue factor pathway inhibitor (TFPI) and thrombomodulin (TM) may be useful in predicting the development of acute respiratory distress syndrome (ARDS). DESIGN:Blood samples were obtained from normal healt...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s001340051054
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journal_title:Intensive care medicine
pub_type: 杂志文章
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journal_title:Intensive care medicine
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更新日期:2011-09-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Intensive care medicine
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journal_title:Intensive care medicine
pub_type: 杂志文章,meta分析,评审
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更新日期:2006-02-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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更新日期:2010-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-04-01 00:00:00
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pub_type: 历史文章,杂志文章
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更新日期:2008-02-01 00:00:00
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更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s001340050534
更新日期:1998-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s00134-007-0730-z
更新日期:2007-09-01 00:00:00
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更新日期:2002-11-01 00:00:00
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更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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更新日期:2010-11-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章,已发布勘误
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更新日期:2020-05-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2008-07-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2003-01-01 00:00:00