Current practice regarding invasive monitoring in intensive care units in Finland. A nationwide study of the uses of arterial, pulmonary artery and central venous catheters and their effect on outcome. The Finnish Intensive Care Study Group.

abstract：PURPOSE:Meconium aspiration syndrome (MAS) is a life-threatening neonatal lung injury, whose pathophysiology has been mainly studied in animal models. In such models, pancreatic secretory phospholipase A2 (sPLA2-IB) and proinflammatory cytokines present in meconium challenge the lungs, catabolising surfactant and harmi...

journal_title：Intensive care medicine

authors： De Luca D,Minucci A,Tripodi D,Piastra M,Pietrini D,Zuppi C,Conti G,Carnielli VP,Capoluongo E

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:Blood O(2) saturation and lactate concentration gradients from superior vena cava (SVC) to pulmonary artery (PA) occur in critically ill patients. These gradients (DeltaSO(2) and Delta[Lac]) may be positive or negative. We tested the hypothesis that positive DeltaSO(2) and Delta[Lac] are associated with impro...

journal_title：Intensive care medicine

authors： Gutierrez G,Comignani P,Huespe L,Hurtado FJ,Dubin A,Jha V,Arzani Y,Lazzeri S,Sosa L,Riva J,Kohn W,Suarez D,Lacuesta G,Olmos D,Mizdraji C,Ojeda A

更新日期：2008-09-01 00:00:00

abstract：:In 16 patients with multiple injuries the effect of parenteral administration of a fat emulsion on the pulmonary vascular system has been studied. Using the Hewlett Packard 5600 A Intensive Care System, which allows vital parameters to be sampled at a rate of two values per min, pulmonary artery pressure (PAP) was mon...

journal_title：Intensive care medicine

authors： van Deyk K,Hempel V,Münch F,Kopp M,Graf H,Epple E

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Growth hormone (GH) given to reverse muscle catabolism in critical illness increased mortality, illustrating the need for better understanding of the pathophysiology of the GH axis. We describe the relationship between changes in plasma insulin-like growth factor-I (IGF-I) and growth hormone-binding protein (...

journal_title：Intensive care medicine

authors： O'Leary MJ,Quinton N,Ferguson CN,Preedy VR,Ross RJ,Hinds CJ

更新日期：2000-10-01 00:00:00

abstract：:The effects of continuous and supplementary bolus dose administration of etomidate have been investigated in ten artificially ventilated patients in traumatic coma. Continuous infusion of etomidate (5-25 micrograms/kg/min) proved to be a practical and safe means of sedating these patients and appeared to control moder...

journal_title：Intensive care medicine

authors： Prior JG,Hinds CJ,Williams J,Prior PF

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:Recalibration and determining discriminative power, internationally, of the existing delirium prediction model (PRE-DELIRIC) for intensive care patients. METHODS:A prospective multicenter cohort study was performed in eight intensive care units (ICUs) in six countries. The ten predictors (age, APACHE-II, urgen...

journal_title：Intensive care medicine

authors： van den Boogaard M,Schoonhoven L,Maseda E,Plowright C,Jones C,Luetz A,Sackey PV,Jorens PG,Aitken LM,van Haren FM,Donders R,van der Hoeven JG,Pickkers P

更新日期：2014-03-01 00:00:00

abstract：:Acetazolamide (Diamox) induced carbonic anhydrase inhibition is an efficient means of eliminating surplus water and bicarbonate in the overhydrated and alkalotic patient. Previous studies have demonstrated an unexpected and unexplained increase in arterial and venous oxygenation during acute carbonic anhydrase inhibit...

journal_title：Intensive care medicine

authors： Berthelsen PG,Dich-Nielsen JO

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Antipyrine metabolism is a "gold standard" measure of mixed cytochrome P450 (CYP) mediated drug metabolism in humans. Cytokines (e.g., interleukin-6) and nitric oxide reduce CYP 450 activity in vitro and in vivo. Because interleukin-6 and nitric oxide production increases in children with sepsis-induced multi...

journal_title：Intensive care medicine

authors： Carcillo JA,Doughty L,Kofos D,Frye RF,Kaplan SS,Sasser H,Burckart GJ

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:We perform an ethical analysis of European Union Directive 2001/20/EC on the simplification and harmonization of guidelines regarding good clinical practice in the conduct of clinical trials involving drugs. BACKGROUND:The Directive provides guidance on protecting incapacitated subjects who participate in dr...

journal_title：Intensive care medicine

authors： Silverman HJ,Druml C,Lemaire F,Nelson R,European Union Directive.

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:The aim of our study was to explore, using an innovative method, the effect of temporal changes in the mortality prediction performance of an existing model on the quality of care assessment. The prognostic model (rSAPS-II) was a recalibrated Simplified Acute Physiology Score-II model developed for very elderly...

journal_title：Intensive care medicine

authors： Minne L,Eslami S,de Keizer N,de Jonge E,de Rooij SE,Abu-Hanna A

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:To evaluate the development of demographics and outcome of very old (>80 years) critically ill patients admitted to intensive care units. SETTING:All consecutive patients admitted to 41 Austrian intensive care units (ICUs) over an 11-year period. METHODS:We performed a retrospective cohort study of prospectiv...

journal_title：Intensive care medicine

authors： Ihra GC,Lehberger J,Hochrieser H,Bauer P,Schmutz R,Metnitz B,Metnitz PG

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between cytokines and the inflammatory responses in patients with out-of-hospital cardiac arrest, we examined the changes of cytokines as well as alterations in the markers of neutrophil activation, platelet and endothelial activation, and endothelial injury. DESIGN:Prospectiv...

journal_title：Intensive care medicine

authors： Gando S,Nanzaki S,Morimoto Y,Kobayashi S,Kemmotsu O

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to explore trends and changes in sedation practices for mechanically ventilated patients in Danish intensive care units (ICUs) and to compare sedation practices in 1997 and 2003. DESIGN:The study was a follow-up survey with a descriptive and comparative cross-sectional multicenter de...

journal_title：Intensive care medicine

authors： Egerod I,Christensen BV,Johansen L

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:Assessing feasibility and physiological effects of sedation with sevoflurane, administered with the anesthetic conserving device (AnaConDa), in comparison with propofol and remifentanil. METHODS:Seventeen patients undergoing mechanical ventilation underwent sedation with sevoflurane delivered with AnaConDa (ph...

journal_title：Intensive care medicine

authors： Migliari M,Bellani G,Rona R,Isgrò S,Vergnano B,Mauri T,Patroniti N,Pesenti A,Foti G

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To assess the effects of the cyclooxygenase inhibitor diclofenac in a canine model of pulmonary occlusion and reperfusion of the left lower lobe (LLL). DESIGN:Twelve adult beagle dogs (13-17 kg) were randomly assigned to a control group (n = 6) and a diclofenac-treated group (n = 6). Animals in the treatment...

journal_title：Intensive care medicine

authors： Segiet W,Krieter H,Stieber C,Albrecht DM,van Ackern K

更新日期：1995-10-01 00:00:00

abstract：:Risk of critical illness is determined both by genetic and environmental influences, particularly those relating to infectious and cardiovascular diseases. Physiologically-based scoring systems cannot measure prior risk because they do not quantify physiological reserve independently of the acute illness. Genetic prof...

journal_title：Intensive care medicine

authors： Bion JF

更新日期：2000-01-01 00:00:00

abstract：:The effect of enteral feeding on O2-consumption (VO2) and CO2-production (VCO2) was studied in 9 ventilator-dependent patients, who were in a stable condition without signs of hypermetabolism. Resting energy expenditure (REE) in postabsorptive state was assessed and enteral feeding was started by continuous drip (480 ...

journal_title：Intensive care medicine

authors： van den Berg B,Stam H

更新日期：1988-01-01 00:00:00

abstract：:We describe a case of the dialysis disequilibrium syndrome (DDS) that was marked by the rapid onset of cerebral edema and the subsequent development of acute respiratory failure. The patient was treated successfully with a combination of mechanical hyperventilation and mannitol. The clinical presentation, pathogenesis...

journal_title：Intensive care medicine

authors： DiFresco V,Landman M,Jaber BL,White AC

更新日期：2000-05-01 00:00:00

abstract：:The effects of 142 intravenous boluses of althesin (0.05 ml/kg) on cerebral perfusion pressure (CPP) were studied in twelve head injured comatose patients. The data were divided into those where the mean pre-bolus intracranial pressure (ICP) was above or below 20 mmHg and then subdivided into those where the minimum p...

journal_title：Intensive care medicine

authors： Procaccio F,Bingham RM,Hinds CJ,Prior PF

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:We evaluated the impact of increasing tidal volume (V (t)), decreased chest wall compliance, and left ventricular (LV) contractility during intermittent positive-pressure ventilation (IPPV) on the relation between pulse pressure (PP) and LV stroke volume (SV(LV)) variation (PPV and SVV, respectively), and intra...

journal_title：Intensive care medicine

authors： Mesquida J,Kim HK,Pinsky MR

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:To examine whether an appropriately designed combination of an index of ventilatory endurance and the frequency divided by tidal volume ratio (f/VT) provides prognostic information for weaning outcome not offered by any index alone. DESIGN AND SETTING:Prospective study in a multidisciplinary intensive care u...

journal_title：Intensive care medicine

authors： Vassilakopoulos T,Routsi C,Sotiropoulou C,Bitsakou C,Stanopoulos I,Roussos C,Zakynthinos S

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:To establish the baseline prescribing error rate in a tertiary paediatric intensive care unit (PICU) and to determine the impact of a zero tolerance prescribing (ZTP) policy incorporating a dedicated prescribing area and daily feedback of prescribing errors. METHODS:A prospective, non-blinded, observational st...

journal_title：Intensive care medicine

authors： Booth R,Sturgess E,Taberner-Stokes A,Peters M

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:Previous studies on therapeutic interventions in sepsis have assumed stability of the measure of splanchnic blood flow throughout the study. We assessed the variability of splanchnic blood flow during stable global hemodynamics in eight patients with sepsis requiring treatment with dobutamine and/or norepine...

journal_title：Intensive care medicine

authors： Sakka SG,Reinhart K,Wegscheider K,Meier-Hellmann A

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:To assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers. DESIGN:Two groups of eight healthy subjects were randomized to receive either two pharmacological doses of intravenous FO fat emulsion or no treatment. ...

journal_title：Intensive care medicine

authors： Pluess TT,Hayoz D,Berger MM,Tappy L,Revelly JP,Michaeli B,Carpentier YA,Chioléro RL

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the incidence and the circumstances of a moderate increase in serum creatinine early after elective abdominal aortic surgery. DESIGN:Prospective clinical observational study. SETTING:Surgical intensive care unit in a university hospital. PATIENTS:Two hundred and fifteen consecutive adult patien...

journal_title：Intensive care medicine

authors： Ryckwaert F,Alric P,Picot MC,Djoufelkit K,Colson P

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To describe a real-time ultrasound sign, the visualization of the cavity and the walls of the maxillary sinus ("sinusogram"), and to assess its correlation with total opacity of the sinus. DESIGN:Prospective clinical study. SETTING:The medical ICU of a university-affiliated hospital. PATIENTS:The significa...

journal_title：Intensive care medicine

authors： Lichtenstein D,Biderman P,Mezière G,Gepner A

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:To demonstrate bleeding complications encountered in patients after cardiac surgery on continuous venovenous haemofiltration (CVVH) treated with continuous versus intermittent r-hirudin for heparin-induced thrombocytopenia (HIT) type II. DESIGN:Case description. SETTING:Cardiothoracic intensive care unit at...

journal_title：Intensive care medicine

authors： Kern H,Ziemer S,Kox WJ

更新日期：1999-11-01 00:00:00

abstract：:In 9 Goettingen minipigs we studied the effect of E. coli bacteremia on effective pulmonary capillary pressure and the longitudinal distribution of pulmonary vascular resistance. Precapillary pressure gradient (dPa) was calculated as the difference between mean pulmonary artery pressure (MPP) and effective pulmonary c...

journal_title：Intensive care medicine

authors： Fretschner R,Klöss T,Guggenberger H,Heuser D,Schmid HJ,Widmann M

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To determine the reliability of estimating arterial CO(2) pressure (PaCO(2)) using a recently introduced transcutaneous CO(2) pressure (PtcCO(2)) monitor in severe obese patients. DESIGN:Observational and interventional study. SETTING:District hospital with respiratory ward and bariatric surgery unit. PATI...

journal_title：Intensive care medicine

authors： Maniscalco M,Zedda A,Faraone S,Carratù P,Sofia M

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the Datex Deltatrac II for measurements in neonates requiring mechanical ventilation. DESIGN:Prospective laboratory evaluation, using a ventilated lung model and gas injection. During simulation of 79 neonatal respiratory settings, assessment of oxygen consumption (VO2), carbon dioxide production...

journal_title：Intensive care medicine

authors： Behrends M,Kernbach M,Bräuer A,Braun U,Peters J,Weyland W

更新日期：2001-01-01 00:00:00