Abstract:
OBJECTIVE:In contrast to indocyanine green (ICG) blood clearance, the plasma disappearance rate (PDR) of ICG does not require absolute ICG blood concentrations and today can be assessed transcutaneously. In this study, we analyzed the relation between ICG disappearance rate and ICG blood clearance as parameters of liver function in critically patients. DESIGN:Observational, clinical study. Retrospective analysis. SETTING:Operative intensive care unit of a university hospital. PATIENTS:209 patients (139 male, 70 female, age 10-88 years, 53+/-19 years) who underwent liver function monitoring for clinical indication. Patients suffered from sepsis (n=99), acute respiratory distress syndrome (n=31), severe head injury (n=38), hemorrhagic shock (n=19), intracranial hemorrhage (n=19), and cerebral infarction (n=3). All patients were sedated and mechanically ventilated via an endotracheal tube. MEASUREMENTS AND RESULTS:All patients were monitored by the transpulmonary double-indicator (thermo-dye dilution) technique using a thermistor and calibrated fiber-optic system (Pulsiocath 4F, PV 2024L, Pulsion Medical Systems, Munich, Germany). For each measurement, a dosage of 0.3 mg/kg ICG was injected central-venously. Transpulmonary ICG concentration curves were analyzed automatically using a computer system (COLD-Z021, Pulsion Medical Systems, Munich, Germany). By using the first ICG measurement in each patient after admission to the ICU, we analyzed 209 pairs of ICG disappearance rate and ICG blood clearance. Linear regression analysis revealed a correlation of r2=0.77 between ICG-PDR and ICG blood clearance. CONCLUSION:ICG-PDR does reflect ICG blood clearance with sufficient accuracy in critically ill patients and may be used as a surrogate.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Sakka SG,van Hout Ndoi
10.1007/s00134-006-0109-6keywords:
subject
Has Abstractpub_date
2006-05-01 00:00:00pages
766-9issue
5eissn
0342-4642issn
1432-1238journal_volume
32pub_type
杂志文章abstract:PURPOSE:To provide recommendations and standard operating procedures for intensive care units and hospital preparedness for an influenza pandemic. METHODS:Based on a literature review and expert opinion, a Delphi process was used to define the essential topics. RESULTS:Key recommendations include: Hospitals should in...
journal_title:Intensive care medicine
pub_type: 指南,杂志文章,评审
doi:10.1007/s00134-010-1759-y
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To determine the effects of increasing dosages of continuously infused arginine-vasopressin (AVP) on mucosal tissue oxygen tension and oxygen supply in an auto-perfused, innervated jejunal segment in an acute endotoxic porcine model. DESIGN:Prospective, randomized, experimental study. SETTING:University hos...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-005-2858-z
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To compare the effects of a cerebral perfusion pressure (CPP) intervention achieved with dopamine and norepinephrine after severe head injury. DESIGN:Prospective, controlled, trial. SETTING:Neurosciences critical care unit. PATIENTS:Eleven patients with a head injury, requiring dopamine or norepinephrine i...
journal_title:Intensive care medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00134-003-2155-7
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:Transcapillary heat transfer after injections of cold saline into the right atrium generates bronchial thermodilution curves resembling those observed in the aorta. Under the assumption that no indicator is lost or gained within the pulmonary capillary bed and changes in blood temperature are instantaneously ...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s001340050818
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:Erythrocytes influence the magnitude of hypoxia-induced pulmonary artery pressure increase. It is, however, unknown to what extent haemoconcentration and haemodilution affect this response and whether intrapulmonary blood volume (and thus vessel dimensions) alters the magnitude of pressure increase. Furthermo...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s001340051327
更新日期:2000-08-01 00:00:00
abstract::Surgical principles of early excision of devitalized tissue and prompt wound closure which govern the management of all traumatic injuries have been developed in the primary treatment of burns. Topical and systemic antibodies which delay wound infection and control invasive sepsis provide an initial period of two to t...
journal_title:Intensive care medicine
pub_type: 杂志文章,评审
doi:10.1007/BF01687263
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:Acute kidney injury (AKI) frequently occurs in critically ill patients and often precipitates use of renal replacement therapy (RRT). However, the ideal circumstances for whether and when to start RRT remain unclear. We performed evidence synthesis of the available literature to evaluate the value of biomarkers...
journal_title:Intensive care medicine
pub_type: 杂志文章,评审
doi:10.1007/s00134-018-5126-8
更新日期:2018-03-01 00:00:00
abstract::A randomized study of 30 patients undergoing uncomplicated surgery under spinal anesthesia was conducted to assess the influence of colloids on the kinetics of plasma fibronectin and complement. Both are opsonins of the reticuloendothelial system; moreover fibronectin is concerned with host resistance against septic c...
journal_title:Intensive care medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01691428
更新日期:1991-01-01 00:00:00
abstract::In hypoxia sensitive cells and tissues, the rates of glucose and O2 consumption are inversely related (Pasteur Effect). Under O2 limiting conditions the demands for glucose (glycogen) in such cells may drastically rise as a means for maintaining ATP turnover close to normoxic rates; nevertheless ion and electrical pot...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF00254926
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:To investigate at what time the peak level should be determined under conventional thrice daily (t.i.d.) administration of the aminoglycoside netilmicin and to study its serum concentrations under once daily (od) treatment to define the required daily dose and to gain information about convenient drug monito...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF01694773
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:This study assessed parameters of free radical damage to biomolecules, mitochondrial superoxide production, superoxide dismutase, and catalase activities and their relationship to sepsis mortality. DESIGN AND SETTING:Prospective animal study in a university laboratory for experimental. SUBJECTS:140 male Wis...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-003-1789-9
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:To evaluate whether helium-oxygen mixture reduces inspiratory work of breathing (WOB) in sedated, paralyzed, and mechanically ventilated patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). DESIGN AND SETTING:Open, prospective, randomized, crossover study in the medical intensive...
journal_title:Intensive care medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00134-003-1911-z
更新日期:2003-10-01 00:00:00
abstract:PURPOSE:To evaluate whether variability in milrinone blood levels (MBL) occurs during administration to critically ill children after surgical repair of congenital heart disease, and the clinical relevance of this variability. METHODS:Prospective cohort study conducted in the pediatric intensive care unit of a tertiar...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-013-2858-3
更新日期:2013-05-01 00:00:00
abstract::A rapid method for the bedside measurement of plasma, intracellular and whole blood lactates is described. The paper described a new method of measuring the L-lactate content of blood using an apparatus ("Lactate Analyzer 640", manufactured by Roche Bio-electronics, Basel) previously designed for this purpose but usin...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF01692921
更新日期:1980-11-01 00:00:00
abstract:INTRODUCTION:The concept of weaning-induced cardiac dysfunction emerged 26 years ago with the publication of a clinical study conducted by François Lemaire and collaborators. OBJECTIVES:One objective of this article is to remember the results and the historical context under which our pivotal study was conducted. Anot...
journal_title:Intensive care medicine
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s00134-014-3334-4
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To measure water balance and changes in distribution, and the effect of giving supplementary albumin, early after a burn injury. DESIGN:Consecutive patients (matched groups) and healthy controls. SETTING:National burn unit in a Swedish university hospital. PATIENTS AND SUBJECTS:Eighteen patients with 18%-9...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s001340100935
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:Hospital mortality of patients with septic multiorgan failure (MOF) is still around 95%. The present study investigates whether this high mortality could be significantly reduced by the addition of sequential hemofiltration (SH) with bicarbonate hemodialysis (HD) to the currently used life supportive measures...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF01726531
更新日期:1995-02-01 00:00:00
abstract::Since the introduction of synchronized intermittent mandatory ventilation (SIMV) several advantages have been attributed to this ventilatory mode, one of them being a more homogeneous distribution of ventilation and perfusion than during controlled mechanical ventilation (CMV). Up to now no data are available to confi...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF01704716
更新日期:1991-01-01 00:00:00
abstract::This article was originally published under a CC BY-NC 4.0 license, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...
journal_title:Intensive care medicine
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00134-018-5254-1
更新日期:2018-05-01 00:00:00
abstract::We report a case of hyperinflation induced isorythmic atrio-ventricular dissociation with circulatory failure in a patient with chronic obstructive pulmonary disease. The arrythmia was successfully treated by applying "pressure support ventilation" (PSV: 20 cmH2O) which, by decreasing the respiratory rate and increasi...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF00263868
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:To clarify the risk of secondary exposure of medical staff to sarin vapor in the emergency room, and to warn emergency room staffs of the hazard. DESIGN:Retrospective observational survey. SETTING:Emergency department of a university hospital in a metropolitan area of Japan. PARTICIPANTS:Fifteen doctors tr...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF01700667
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVE:To assess the role of antipseudomonal agents on Pseudomonas aeruginosa colonization and acquisition of resistance. DESIGN:Prospective cohort study. SETTING:Two medical intensive care units. PATIENTS AND PARTICIPANTS:346 patients admitted for >or= 48 h. INTERVENTION:Analysis of data from an 8-month study c...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-008-1326-y
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:Providing mechanical ventilation is challenging at supra-atmospheric pressure. The higher gas density increases resistance, reducing the flow delivered by the ventilator. A new hyperbaric ventilator (Siaretron IPER 1000) is said to compensate for these effects automatically. The aim of this bench test study was...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-012-2590-4
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Limiting the duration of invasive ventilation is an important goal in caring for critically ill patients. Several clinical trials have shown that compared to traditional care, protocols can reduce the total duration of mechanical ventilation. Computerized or automated weaning has the potential to improve wea...
journal_title:Intensive care medicine
pub_type: 杂志文章,评审
doi:10.1007/s00134-008-1154-0
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:To compare haemodynamic and gas exchange effects after either atracurium or pancuronium given to ventilated neonates with respiratory failure. DESIGN:In this prospective study neonates were alternately assigned to receive either atracurium or pancuronium, intravenously. SETTING:Paediatric and neonatal ICU i...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF01724880
更新日期:1993-01-01 00:00:00
abstract::A 46-year-old man was diagnosed clinically brain dead after sustaining head trauma. The patient was in deep coma, brain nerves were unresponsive and spontaneous breathing was absent. However, EEG showed well preserved activity, but no reactivity to external stimuli. EEG activity disappeared within 40 h. BAEP were high...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF02425159
更新日期:1995-01-01 00:00:00
abstract::The oxygen cost of breathing (which is the difference in oxygen consumption measured during controlled ventilation and again during spontaneous ventilation) was measured in 30 patients between the ages of 17 and 96 years at the time of commencement of weaning from mechanical ventilation. There was a significant expone...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF00254122
更新日期:1988-01-01 00:00:00
abstract::In the first study 6 patients with raised intracranial pressure due to brain oedema following head injury were given dihydroergotamine because of low perfusion pressure. The intracranial pressure fell simultaneously with the increase in arterial pressure. The intracranial pressure fell from 24 +/- 2 mmHg by a maximum ...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF00273564
更新日期:1989-01-01 00:00:00
abstract::The arterial oxygen and carbon dioxide tensions, pulmonary and systemic haemodynamics and pulmonary shunting and mechanics were measured during the first 30 min after intravenous labetalol administration. Thirty patients, recovering in the intensive care unit after neurosurgical interventions were randomly divided in ...
journal_title:Intensive care medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00255635
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To describe a real-time ultrasound sign, the visualization of the cavity and the walls of the maxillary sinus ("sinusogram"), and to assess its correlation with total opacity of the sinus. DESIGN:Prospective clinical study. SETTING:The medical ICU of a university-affiliated hospital. PATIENTS:The significa...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s001340050716
更新日期:1998-10-01 00:00:00