Abstract：
OBJECTIVE:This study assessed parameters of free radical damage to biomolecules, mitochondrial superoxide production, superoxide dismutase, and catalase activities and their relationship to sepsis mortality. DESIGN AND SETTING:Prospective animal study in a university laboratory for experimental. SUBJECTS:140 male Wistar rats. INTERVENTIONS:The animals were randomly divided into three groups: sham-operated (n=20), cecal ligation and perforation resuscitated with normal saline (n=40), and cecal ligation and perforation with normal saline plus antibiotics (n=40). MEASUREMENTS AND RESULTS:Blood samples were collected from all animals 3, 12, and 24 h after CLP through a jugular catheter inserted before CLP. Rats were evaluated during 5 days after the intervention. Nonsurvivor animals were grouped according to the duration between sepsis induction and death, and oxidative parameters were compared to survivors and sham-operated. Lipid peroxidation, protein carbonyls, and superoxide dismutase were significantly increased in nonsurvivor septic rats and were predictive of mortality. We demonstrated that there is a different modulation of superoxide dismutase and catalase in nonsurvivors during the course of septic response. There was a marked increase in superoxide dismutase activity without a proportional increase in catalase activity in nonsurvivors. CONCLUSIONS:This is the first report of plasma superoxide dismutase as an earlier marker of mortality. Ours results might help to clarify an important aspect of oxidative response to sepsis, i.e., an increase in superoxide dismutase activity without a proportional increase in catalase activity
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Ritter C,Andrades M,Frota Júnior ML,Bonatto F,Pinho RA,Polydoro M,Klamt F,Pinheiro CT,Menna-Barreto SS,Moreira JC,Dal-Pizzol Fdoi
10.1007/s00134-003-1789-9keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
1782-9issue
10eissn
0342-4642issn
1432-1238journal_volume
29pub_type
杂志文章abstract：PURPOSE:Caloric insufficiency during the first week of intensive care unit (ICU) stay was reported to be associated with increased infection rates, especially ICU-acquired bloodstream infection (ICU-BSI). However, the predisposition to ICU-BSI by a given pathogen remains not well known. We aimed to determine the impact...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-014-3502-6
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the origin of H+ ions participating in the generation of CO2 coming from sodium bicarbonate infusion during metabolic acidosis. We hypothesized that these H+ ions come from a back-titration of the main non-bicarbonate buffers present in the blood, i. e. the hemoglobin and the albumin, and thus pos...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051204
更新日期：2000-05-01 00:00:00
abstract：:Intravenous bolus endotoxin elicits a marked but transient increase in plasma TxB2 and 6-keto-PGF1 alpha in a large number of species. A smaller, delayed and more prolonged increase in TxB2 and 6-keto-PGF1 alpha are reported in animals with septic shock, i.e., those with fecal peritonitis or cecal ligation. Thromboxan...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/BF00254925
更新日期：1986-01-01 00:00:00
abstract：PURPOSE:Sepsis is a major health burden worldwide. Preclinical investigations in animals and retrospective studies in patients have suggested that inhibition of platelets may improve the outcome of sepsis. In this study we investigated whether chronic antiplatelet therapy impacts on the presentation and outcome of seps...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-015-4171-9
更新日期：2016-03-01 00:00:00
abstract：:Recombinant activated factor VII (rFVIIa, 'NovoSeven') is indicated for the treatment of spontaneous and surgical bleeding in patients with haemophilia A or B with antibodies to factors VIII or IX (FVIII or FIX) worldwide, and in patients with acquired haemophilia in Europe. In vitro cell models have demonstrated that...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-002-1469-1
更新日期：2002-10-01 00:00:00
abstract：:Acute renal failure in critically ill patients is seldom an isolated problem but is more usually associated with multiple organ failure. When choosing an extracorporeal kidney replacement therapy, these other failing organs must be taken into account. Therefore the choice of an artificial kidney in patients requiring ...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/BF00261492
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVES:Children with peripheral airways obstruction suffer the negative effects of intrinsic positive end-expiratory pressure: increased work of breathing and difficulty triggering assisted ventilatory support. We examined whether external positive end-expiratory pressure to offset intrinsic positive end-expiratory...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s00134-006-0445-6
更新日期：2007-01-01 00:00:00
abstract：:Surgical principles of early excision of devitalized tissue and prompt wound closure which govern the management of all traumatic injuries have been developed in the primary treatment of burns. Topical and systemic antibodies which delay wound infection and control invasive sepsis provide an initial period of two to t...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/BF01687263
更新日期：1981-01-01 00:00:00
abstract：:This article was originally published under a CC BY-NC 4.0 license, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...
journal_title：Intensive care medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00134-018-5254-1
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:To explore translation, conversion and definition ambiguities, when using severity scoring systems in patients admitted to intensive care units (ICUs). DESIGN:A prospective study of the prognosis of acute renal failure in ICUs. SETTING:The study was conducted in 20 French ICUs. PATIENTS:360 patients presen...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01705416
更新日期：1995-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the Datex Deltatrac II for measurements in neonates requiring mechanical ventilation. DESIGN:Prospective laboratory evaluation, using a ventilated lung model and gas injection. During simulation of 79 neonatal respiratory settings, assessment of oxygen consumption (VO2), carbon dioxide production...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000708
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:The role of haemofiltration as an adjunctive treatment of sepsis remains a contentious issue. To address the role of dose and to explore the biological effects of haemofiltration we compared the effects of standard and high-volume haemofiltration (HVHF) in a peritonitis-induced model of porcine septic shock. ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-008-1318-y
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:This study compared the recently introduced Microcuff endotracheal tube HVLP ICU featuring an ultrathin (7-microm) polyurethane cuff membrane with endotracheal tubes from different manufacturers regarding fluid leakage past the tube cuff. DESIGN:In vitro setup. MEASUREMENTS AND RESULTS:The following endotra...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-003-1933-6
更新日期：2003-10-01 00:00:00
abstract：:Results of the relationships between oxygen supply, demand, and uptake can be used to interpret cardiac output values, identify types of acute circulatory failure, guide attempts to improve cellular function, and thus prevent the development of multiple organ failure and death. Five steps in the interpretation of card...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/BF01785244
更新日期：1990-01-01 00:00:00
abstract：:Values obtained for cardiac output (CO) were compared using thermodilution (TD) with those obtained using bioimpedance (Bi) as measured using the Bomed NCCOM3 (Revision 6) in 28 consecutive patients in the first 24 h after coronary artery bypass surgery (CABS). In 46 paired measurements made in the first 12 h after CA...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01720674
更新日期：1991-01-01 00:00:00
abstract：:Peritonitis has been produced in rabbits by the spreading of 5 ml of caecal contents throughout the peritoneal cavity. After sacrifice at 5 h, electron microscopy revealed a increase of 600% in PMN and 1200% in lymphocytes in the pulmonary capillaries of the test animals when compared to the sham operated group. The p...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00265119
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVE:To investigate the hemodynamic and metabolic effects of the peroxisome proliferator-activated receptor (PPAR)-gamma ligand and nuclear-factor (NF)-kappa B inhibitor 15-deoxy-Delta12,14-prostaglandin-J2 (15d-PGJ2) during long-term, hyperdynamic porcine endotoxemia. DESIGN:Prospective, randomized, controlled e...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-006-0107-8
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:Dislocation of the heart is a rare complication of thoracic blunt trauma. A high index of suspicion of pericardium rupture is necessary to formulate an early diagnosis to reduce morbidity and mortality. PATIENTS:A 23-year-old man suffered a blunt thoracoabdominal trauma and was admitted 3 days later to a un...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1328-0
更新日期：2002-07-01 00:00:00
abstract：PURPOSE:To develop a liver function-related risk prediction tool to identify acute-on-chronic liver failure patients at greatest risk of in-hospital mortality. METHODS:The LiFe (liver, injury, failure, evaluation) score, was constructed based on the opinions of 157 intensivists within the European Society for Intensiv...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s00134-015-4203-5
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:Pressure-volume (PV) curves are recorded after induction of complete muscle paralysis, which may limit their clinical use. The feasibility of recording PV curves without paralysis has not been tested. In 19 patients with acute respiratory distress syndrome (ARDS) and no hemodynamic instability we prospectivel...
journal_title：Intensive care medicine
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00134-006-0265-8
更新日期：2006-09-01 00:00:00
abstract：: ...
journal_title：Intensive care medicine
pub_type： 评论,社论
doi：10.1007/s00134-018-5399-y
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:To examine the phenomenon of inappropriate triggering caused by an in-line suction catheter. DESIGN:We used a test lung to assess inappropriate triggering in four ventilators with both pressure and flow triggering. RESULTS:With pressure triggering, inappropriate triggering occurred only in the presence of P...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1239-0
更新日期：2002-04-01 00:00:00
abstract：:Arterial catheterization is the second most common invasive procedure performed in the intensive care unit. Despite the ubiquity of the procedure, complications including failure to place the catheter occur. While many clinicians are familiar with the use of ultrasound (US) guidance to decrease complication rates of c...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-009-1699-6
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:Pneumonia associated with invasive mechanical ventilation (IMV) is one of the indicator infections of the German Nosocomial Infection Surveillance System. In 2005 surveillance was extended to include pneumonia associated with noninvasive ventilation (NIV). The aim of this study was to determine the utilization ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-010-1863-z
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:To investigate the theoretical interactions between ventilator settings, tracheal gas insufflation (TGI), and alveolar ventilation. DESIGN:We derived differential equations governing compartmental volume changes in a one-compartment model of TGI-assisted ventilation and equations governing gas dilution in th...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01699238
更新日期：1996-10-01 00:00:00
abstract：OBJECTIVE:We perform an ethical analysis of European Union Directive 2001/20/EC on the simplification and harmonization of guidelines regarding good clinical practice in the conduct of clinical trials involving drugs. BACKGROUND:The Directive provides guidance on protecting incapacitated subjects who participate in dr...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2367-5
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVES:(a) To assess whether differences in lung morphology observed in patients with adult respiratory distress syndrome (ARDS) are associated with differences in cardiorespiratory parameters, lung mechanics, and outcome. (b) To propose a new ARDS Severity Score to identify patients with a high mortality risk. DE...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051317
更新日期：2000-08-01 00:00:00
abstract：OBJECTIVES:Critically ill patients often develop anaemia which can be related to a number of factors. However, the exact causes of anaemia in many patients remain unexplained. We hypothesized that the relationship between erythropoietin (EPO) and haematocrit may be altered in critically ill patients. DESIGN:Serum conc...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s001340050310
更新日期：1997-02-01 00:00:00
abstract：PURPOSE:To estimate the direct and indirect (contextual) effects of the factorized constituents of selective digestive decontamination and selective oropharyngeal decontamination (SDD/SOD), being topical antibiotic (TA) and protocolized antifungal prophylaxis (PAFP), on ICU-acquired candidemia. METHODS:A broad range o...
journal_title：Intensive care medicine
pub_type： 杂志文章,meta分析
doi：10.1007/s00134-015-4004-x
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVES:To assess the reproducibility of respiratory dead space measurements in ventilated children. DESIGN:Prospective study. SETTING:University pediatric intensive care unit. PATIENTS:Thirty-two mechanically ventilated children (0.13-15.4 years) who were clinically stable. METHODS:The single-breath CO(2) test ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2288-3
更新日期：2004-07-01 00:00:00
