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In vitro validation of a metabolic monitor for gas exchange measurements in ventilated neonates.

Abstract：

OBJECTIVE:To evaluate the Datex Deltatrac II for measurements in neonates requiring mechanical ventilation. DESIGN:Prospective laboratory evaluation, using a ventilated lung model and gas injection. During simulation of 79 neonatal respiratory settings, assessment of oxygen consumption (VO2), carbon dioxide production (VCO2) and respiratory quotient (RQ) was compared to a reference method (mass spectrometry, wet gas spirometry) using the statistical method of Bland and Altman. INTERVENTIONS:Respiratory variables, which may influence the accuracy and precision of gas exchange measurements, were varied within the following ranges: inspired oxygen fraction (FIO2): 0.21-0.8, expired carbon dioxide fraction (FECO2) and inspiratory-expiratory oxygen fraction (DFO2): 0.0032-0.0256, expiratory flow rate: 1.0-2.5 l/min, inspiratory pressure: 10-55 mbar, respiratory rate 25-60/min, constant RQ of 1. This resulted in 79 tests with VCO2 and VO2 ranging from 8-64 ml/min. MEASUREMENTS AND RESULTS:The coefficient of repeatability for ten single subsequent Deltatrac measurements was 8.09 ml/min for VO2 and 9.17 ml/min for VCO2 compared to 2.02 ml/min and 0.90 ml/min for VO2 and VCO2 with repeated reference measurements. The coefficient of repeatability of the Deltatrac measurements improved considerably when means of subsequent 5 min intervals were compared: 0.68 ml/min for VO2 and 0.28 ml/ min for VCO2. The difference between the two methods (Deltatrac-reference) was -3.8 % (2 s: 11.4%) for VO2, 13.2% (2s: 7.9%) for VCO2 and 17.6% (2s: 16.7%) for RQ. The agreement between methods deteriorated with smaller (FECO2) or DFO2 and increasing FIO2. CONCLUSIONS:Considering limits of agreement of less than +/- 20% as clinically acceptable, results for VO2 assessment indicate acceptable accuracy and precision whereas VCO2 and RQ assessments exceed this limit. Limited accuracy and precision result from detection of CO2 following dilution of expiratory gases and increased sensitivity to error propagation by Haldane equations due to the small differences between inspiratory and expiratory gas fractions.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Behrends M,Kernbach M,Bräuer A,Braun U,Peters J,Weyland W

doi

10.1007/s001340000708

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

228-35

issue

eissn

0342-4642

issn

1432-1238

journal_volume

pub_type

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In vitro validation of a metabolic monitor for gas exchange measurements in ventilated neonates.