Abstract:
OBJECTIVES:To determine the effects of an intravenous bolus dose of a vasopressin analogue, terlipressin (1 mg), on systemic haemodynamic parameters and gastric mucosal perfusion (GMP) in patients with catecholamine-treated septic shock using a gastric tonometry and laser-Doppler flowmetry technique. DESIGN:Prospective open label study. SETTINGS:Two multidisciplinary intensive care units. PATIENTS:Fifteen patients with norepinephrine-treated septic shock. INTERVENTIONS:Every patient with mean arterial pressure between 50 and 55 mmHg treated with high dose norepinephrine received an intravenous bolus dose of terlipressin as last resort therapy. A laser-Doppler probe and tonometer were introduced into the gastric lumen. MEASUREMENTS AND MAIN RESULTS:Terlipressin produced a decrease in cardiac output ( p<0.05), a progressive increase in mean arterial pressure ( p<0.05) and in GMP, detected by laser-Doppler flowmetry ( p<0.05) over 30 min and sustained for at least 24 h. The ratio of GMP to systemic oxygen delivery increased after terlipressin bolus dose ( p<0.05). The gradient between gastric mucosal and arterial PCO(2) tended to be lower after terlipressin, and the difference was statistically significant ( p<0.05) after 8 h. Terlipressin administration significantly increased ( p<0.05) urine output compared to baseline and higher values were found at each set of measurement. The terlipressin-induced increase in urine output was associated with a significantly increased creatinine clearance ( p<0.05). Reduction of the high-dose norepinephrine was observed in all patients ( p<0.05). CONCLUSIONS:Our findings showed that, in patients with norepinephrine-treated septic shock, terlipressin increased GMP, urine output and creatinine clearance by an increase in mean arterial pressure.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Morelli A,Rocco M,Conti G,Orecchioni A,De Gaetano A,Cortese G,Coluzzi F,Vernaglione E,Pelaia P,Pietropaoli Pdoi
10.1007/s00134-003-2094-3keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
597-604issue
4eissn
0342-4642issn
1432-1238journal_volume
30pub_type
临床试验,杂志文章abstract:OBJECTIVE:To evaluate the effectiveness of screening strategy and contact precautions for patients with methicillin-resistant Staphylococcus aureus (MRSA). DESIGN AND SETTING:Prospective observational cohort from 1 February 1995 to 31 December 2001 in three intensive care units (45 beds) in a French teaching hospital....
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-005-2679-0
更新日期:2005-08-01 00:00:00
abstract:PURPOSE:To test the hypothesis that RNA editing is altered in pediatric patients with cyanotic congenital heart disease (CHD) and to determine whether A-to-I RNA editing is associated with the postoperative course following cardiac surgery. Cyanotic CHD is associated with a unique pathophysiology caused by chronic hypo...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-011-2296-z
更新日期:2011-10-01 00:00:00
abstract::Physicians are increasingly involved in how their critically ill patients die [72]. The more this happens, the more physicians will have to understand not only how their own backgrounds and biases influence their medical management, but also the cultural and religious backgrounds of the patient and surrogate [72, 73]....
journal_title:Intensive care medicine
pub_type: 杂志文章,评审
doi:10.1007/s001340000641
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:Lung injury is a severe complication of acute pancreatitis that increases the mortality rate of the disease. The pathophysiology of acute pancreatitis has been studied in several experimental models, but the kinetics of pulmonary complications in relation to the pancreatic disease is not completely understood...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-006-0264-9
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:The primary objective was to test the hypothesis that clinical re-expansion pulmonary edema is predominantly due to increased permeability of the alveolar-capillary barrier. A secondary objective was to determine if the alveolar epithelium was functionally intact in patients with re-expansion pulmonary edema ...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-004-2379-1
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Changes in body temperature have important impact on measurements of blood gases. In blood gas analyzers the samples are always kept constant at a temperature of exactly 37 degrees C during the measurements, and therefore results are not correct if body temperature differs from 37 degrees C. OBJECTIVE:Lack ...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-004-2369-3
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:The purpose of a scientific paper is to communicate results and within the paper this applies especially to the presentation of data. It is the universal practice in medical journals to present statistical results using tables. Good tables are an integral part of the manuscript. To help researchers communi...
journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-014-3248-1
更新日期:2014-05-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF01686054
更新日期:1979-05-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-002-1225-6
更新日期:2002-03-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 临床试验,杂志文章
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更新日期:1996-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-02-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-009-1623-0
更新日期:2009-12-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章,meta分析
doi:10.1007/s00134-017-5004-9
更新日期:2018-02-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
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更新日期:1998-06-01 00:00:00
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更新日期:2014-04-01 00:00:00
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journal_title:Intensive care medicine
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更新日期:2015-05-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF00295990
更新日期:1989-01-01 00:00:00
abstract:: ...
journal_title:Intensive care medicine
pub_type: 信件
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更新日期:2018-06-01 00:00:00
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journal_title:Intensive care medicine
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更新日期:1983-01-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
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更新日期:2002-09-01 00:00:00
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更新日期:2020-05-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 临床试验,杂志文章
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更新日期:1999-06-01 00:00:00
abstract:: ...
journal_title:Intensive care medicine
pub_type: 评论,社论
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更新日期:2019-01-01 00:00:00