Procalcitonin for discrimination between activity of systemic autoimmune disease and systemic bacterial infection.

Abstract:

OBJECTIVE:To investigate whether serum procalcitonin (PCT) levels could be useful to differentiate between systemic infection and the activity of the underlying disease in autoimmune disease. METHODS:In 18 patients with systemic lupus erythematodes (SLE) and 35 patients with systemic antineutrophil cytoplasmic antibody-associated vasculitis (AAV) clinical disease activity was assessed by score systems. Infection was defined by clinical and microbiological means. PCT was determined in parallel with concentrations of neopterin, interleukin-6 (IL-6), and C-reactive protein (CRP) in 397 serum samples. RESULTS:Only in 3 of the 324 samples taken from patients with autoimmune disease but without concomitant infection, serum PCT levels were above the normal range (>0.5 ng/ml), whereas neopterin, CRP and IL-6 were elevated in patients with active underlying disease. All systemic infections (N=16 in AAV-patients) were associated with markedly elevated PCT-levels (mean+/-SD:1.93+/-1.19 ng/ml). CONCLUSION:PCT may serve as a useful marker for the detection of systemic bacterial infection in patients with autoimmune disease.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Brunkhorst R,Eberhardt OK,Haubitz M,Brunkhorst FM

doi

10.1007/BF02900738

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

S199-201

eissn

0342-4642

issn

1432-1238

journal_volume

26 Suppl 2

pub_type

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