Abstract：
OBJECTIVE:Biomarkers allowing accurate early staging of septic shock patients are lacking despite their obvious interest for patient management. Experimental models of septic shock in mouse previously noted a decrease in dendritic cell numbers. The aim of the study was to find a rapid reproducible biological test for an assessment of disease severity. DESIGN:Evaluation of peripheral blood dendritic cell counts by flow cytometry using three commercially available kits. PATIENTS AND PARTICIPANTS:Forty-two consecutive septic shock patients were studied prospectively. MEASUREMENTS AND RESULTS:Early low dendritic cell counts were correlated to disease severity as assessed by Simplified Acute Physiology Score or Sequential Organ Failure Assessment and predicted fatal outcome. The correlation was still present when the results were adjusted for age. CONCLUSION:The monitoring of blood dendritic cell count may provide an early and valuable assessment of the severity of the host response against infection and may influence the therapeutic management of septic shock patients.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Guisset O,Dilhuydy MS,Thiébaut R,Lefèvre J,Camou F,Sarrat A,Gabinski C,Moreau JF,Blanco Pdoi
10.1007/s00134-006-0436-7subject
Has Abstractpub_date
2007-01-01 00:00:00pages
148-52issue
1eissn
0342-4642issn
1432-1238journal_volume
33pub_type
杂志文章abstract：:The Editor-in-Chief has retracted this article [1] because a number of studies included in this review [2, 3, 4] (originally cited as references 98, 128, 129) have since been retracted. Consequently, this has rendered the content of the review unreliable. ...
journal_title：Intensive care medicine
pub_type： 杂志文章,撤回出版物
doi：10.1007/s00134-020-06068-5
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:To evaluate the Datex Deltatrac II for measurements in neonates requiring mechanical ventilation. DESIGN:Prospective laboratory evaluation, using a ventilated lung model and gas injection. During simulation of 79 neonatal respiratory settings, assessment of oxygen consumption (VO2), carbon dioxide production...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000708
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of terlipressin on oxygenation, PaO2/FIO2, heart rate, mean arterial pressure, and mortality in children with septic shock refractory to high doses of dopamine/dobutamine and adrenaline. DESIGN AND SETTING:A randomized, nonblind study in the pediatric intensive care unit of a universit...
journal_title：Intensive care medicine
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00134-007-0971-x
更新日期：2008-03-01 00:00:00
abstract：:The pharmacokinetics of theophylline and ethylenediamine were examined in 6 patients with septicaemia and multiorgan failure (MOF). The patients received a bolus injection of 4 mg/kg aminophylline. Aminophylline is the ethylenediamine salt of theophylline. The clearance of theophylline was reduced in all our patients ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01690768
更新日期：1991-01-01 00:00:00
abstract：:Pulmonary artery (PA) catheterization is now a routine procedure in the care of critically ill patients. We report a case in which a pulmonary artery catheter was a major factor in the demise of a patient who developed adult respiratory distress syndrome following a septic abortion. ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00295990
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the origin of H+ ions participating in the generation of CO2 coming from sodium bicarbonate infusion during metabolic acidosis. We hypothesized that these H+ ions come from a back-titration of the main non-bicarbonate buffers present in the blood, i. e. the hemoglobin and the albumin, and thus pos...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051204
更新日期：2000-05-01 00:00:00
abstract：:Malaria remains today one of the major health problems in the tropics with increased morbidity and mortality. The most serious complications are caused by Plasmodium falciparum, which, in contrast to the benign malarias, may progress to a life-threatening multi-system disease. Our case concerns a young woman in the 14...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050939
更新日期：1999-07-01 00:00:00
abstract：OBJECTIVE:Do-not-resuscitate orders (DNR orders) and advance directives (AD) have been developed and their use by patients is increasing. The objective of the study was to evaluate the compliance with patient's wishes and doctors' and nurses' agreement on decision-making in the treatment of elderly patients from a cros...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000602
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:In critical illness, serum total cortisol (TC) may not adequately reflect adrenal function because of reduced cortisol-binding globulin (CBG). AIM:To evaluate adrenal function of critically ill children, using free cortisol index (FCI), calculated free cortisol (cFC), and TC levels. METHODS:Thirty-two crit...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-009-1480-x
更新日期：2009-07-01 00:00:00
abstract：INTRODUCTION:Extracorporeal carbon dioxide removal (ECCO2R) has been proposed for hypercapnic respiratory failure in chronic obstructive pulmonary disease (COPD) exacerbations, to avoid intubation or reduce length of invasive ventilation. Balance of risks, efficacy, and benefits of ECCO2R in patients with COPD is uncle...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-015-3921-z
更新日期：2015-10-01 00:00:00
abstract：PURPOSE:Evidence of variation in mortality after surgery may indicate preventable postoperative death. We sought to determine if regional differences in outcome were present in surgical patients admitted to critical care in the UK. METHODS:We extracted data on admission characteristics, case mix and outcome of all pat...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-015-3980-1
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVES:Critical illness increases the tendency to both coagulation and bleeding, complicating anticoagulation for continuous renal replacement therapy (CRRT). We analyzed strategies for anticoagulation in CRRT concerning implementation, efficacy and safety to provide evidence-based recommendations for clinical prac...
journal_title：Intensive care medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00134-005-0044-y
更新日期：2006-02-01 00:00:00
abstract：OBJECTIVE:The purpose of the study was do describe the architecture of accretions occurring on the tips of central venous catheters (CVC). DESIGN:A conservative procedure was used followed by two different techniques of electron microscopy. SETTING AND PATIENTS:the study included 19 catheters which have been used on ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01708582
更新日期：1992-01-01 00:00:00
abstract：:Risk of critical illness is determined both by genetic and environmental influences, particularly those relating to infectious and cardiovascular diseases. Physiologically-based scoring systems cannot measure prior risk because they do not quantify physiological reserve independently of the acute illness. Genetic prof...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s001340051120
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:To estimate the direct and indirect (contextual) effects of the factorized constituents of selective digestive decontamination and selective oropharyngeal decontamination (SDD/SOD), being topical antibiotic (TA) and protocolized antifungal prophylaxis (PAFP), on ICU-acquired candidemia. METHODS:A broad range o...
journal_title：Intensive care medicine
pub_type： 杂志文章,meta分析
doi：10.1007/s00134-015-4004-x
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:To examine whether an appropriately designed combination of an index of ventilatory endurance and the frequency divided by tidal volume ratio (f/VT) provides prognostic information for weaning outcome not offered by any index alone. DESIGN AND SETTING:Prospective study in a multidisciplinary intensive care u...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-006-0104-y
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVE:To describe the incidence, risk factors, and impact on mortality of acute kidney injury (AKI) in patients with 2009 influenza A (H1N1) viral pneumonia requiring mechanical ventilation. DESIGN:Observational cohort study. PATIENTS AND METHODS:AKI was defined as risk, injury or failure, according to the RIFLE ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-011-2167-7
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:To determine the incidence of Clostridium difficile (CD) diarrhoea in feed-intolerant, critically ill patients who received erythromycin-based prokinetic therapy. DESIGN AND SETTING:Prospective observational study in a mixed intensive care unit. METHODS:The development of diarrhoea (> 3 loose, liquid stool ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-007-0834-5
更新日期：2008-01-01 00:00:00
abstract：:Activation of the complement system within the lung can lead to acute pulmonary damage and dysfunction. Based on a variety of experimental models it is now apparent that lung injury is related to complement-induced generation of oxygen derived free radicals from neutrophils and from macrophages. In addition to the oxy...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00315362
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVE:To compare the effects of patient-initiated, pressure-regulated, volume-controlled ventilation (PRVC) with pressure-preset intermittent mandatory ventilation (IMV) in neonates with respiratory failure. DESIGN:Randomised, prospective study. SETTING:Intensive care unit (14 beds) in a 300-bed paediatric teachi...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s001340050441
更新日期：1997-09-01 00:00:00
abstract：:We present a patient with evidence of severe intravascular hemolysis after mitral valve repair, an established method for the surgical treatment of mitral valve disease to avoid prosthesis related complications. The coincidence of this uncommon complication with hemodynamic instability due to pre-existing myocardial d...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01694714
更新日期：1993-01-01 00:00:00
abstract：OBJECTIVE:To determine the impact of missing Acute Physiology Score (APS) values on risk-adjusted mortality. DESIGN:Retrospective review of prospectively collected Acute Physiology and Chronic Health Evaluation (APACHE) III database. SETTING:The intensive care units (ICUs) of an academic medical center. PATIENTS:38,...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-005-2751-9
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVE:Impairment of haemostasis has been described with slowly degradable medium molecular weight hydroxyethyl starch (MMW-HES), whereas rapidly degradable MMW-HES is generally considered to have no important effects on blood coagulation. This study was undertaken to investigate the effects of a rapidly degradable ...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s001340101107
更新日期：2001-11-01 00:00:00
abstract：OBJECTIVE:Pulmonary endothelial activation caused by high pulmonary capillary pressures may be involved in the pathogenesis of cardiogenic pulmonary edema (CPE). We studied soluble selectins and soluble ICAM-1 as markers of cell activation in the systemic and pulmonary circulation of patients with respiratory failure (...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000843
更新日期：2001-03-01 00:00:00
abstract：OBJECTIVE:Five commercially available oesophageal balloon catheters (OBCs) were tested to evaluate the accuracy in transmitting fast-changing pressure signals which can be observed, for example, during phrenic nerve stimulation. SETTING:Research laboratory of a university hospital. METHOD:The OBCs tested varied in le...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051182
更新日期：2000-04-01 00:00:00
abstract：OBJECTIVE:To determine the value of procalcitonin (PCT) in the early diagnosis (and differentiation) of patients with SIRS, sepsis, severe sepsis, and septic shock in comparison to C-reactive protein (CRP), white blood cell and thrombocyte count, and APACHE-II score (AP-II). DESIGN:Prospective cohort study including a...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF02900728
更新日期：2000-03-01 00:00:00
abstract：:Recent advances in analytical electrochemistry have provided highly selective potassium ion exchangers and robust polymeric membranes that can be used to measure the potassium activity in plasma or whole blood. The relationship between the activity measurement and the more familiar concentration measurement is explore...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01684390
更新日期：1978-04-01 00:00:00
abstract：:The process of fluidisation involves blowing warm air through small solid microspheres thus creating a liquid, without wetness. The warmth provides some important properties including reducing the metabolic rate in thermal injury which has a beneficial effect on mortality, modifying catabolism after surgery, providing...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/BF01701488
更新日期：1995-03-01 00:00:00
abstract：:We report the intensive care management of 23 children (age 3-15 years) following orthotopic heart (HT) and combined heart and lung transplantation (HLT) performed at our 2 institutes between February 1985 and August 1989. Cyclosporin A, azathioprine and steroids were given as routine immunosuppression, whilst anti-th...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01711219
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVE:An instrument able to estimate the direct costs of stays in Intensive Care Units (ICUs) simply would be very useful for resource allocation inside a hospital, through a global budget system. The aim of this study was to propose such a tool. DESIGN:Since 1991, a region-wide common data base has collected stan...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050619
更新日期：1998-06-01 00:00:00
