Abstract：
BACKGROUND:In critical illness, serum total cortisol (TC) may not adequately reflect adrenal function because of reduced cortisol-binding globulin (CBG). AIM:To evaluate adrenal function of critically ill children, using free cortisol index (FCI), calculated free cortisol (cFC), and TC levels. METHODS:Thirty-two critically ill and 36 healthy children were included. All children underwent the 1 microg cosyntropin test. TC and CBG levels were measured. Basal and peak TC, FCI, and cFC were determined. RESULTS:Basal and peak TC, FCI, and cFC of critically ill children were significantly higher than those of the controls. Compared with TC, both basal and peak FCI and cFC of the patients were higher than those of controls to a greater degree. Use of FCI or cFC to diagnose adrenal insufficiency (AI) reduced the frequency of diagnosis of AI by 50%. CONCLUSION:FCI and cFC better reflect the dynamic changes of adrenal function of critically ill children.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Poomthavorn P,Lertbunrian R,Preutthipan A,Sriphrapradang A,Khlairit P,Mahachoklertwattana Pdoi
10.1007/s00134-009-1480-xsubject
Has Abstractpub_date
2009-07-01 00:00:00pages
1281-5issue
7eissn
0342-4642issn
1432-1238journal_volume
35pub_type
杂志文章abstract：:We studied the effect of thiopental loading during resuscitation of 53 patients following cardiopulmonary arrest and compared the outcome with that found in 54 patients treated conventionally in the 30 previous months. Thiopental therapy (10 mg/kg i.v.) was begun within 30 min of the arrest once hemodynamic stability ...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF00265112
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVE:To assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers. DESIGN:Two groups of eight healthy subjects were randomized to receive either two pharmacological doses of intravenous FO fat emulsion or no treatment. ...
journal_title：Intensive care medicine
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00134-007-0591-5
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:To describe the incidence, risk factors, and impact on mortality of acute kidney injury (AKI) in patients with 2009 influenza A (H1N1) viral pneumonia requiring mechanical ventilation. DESIGN:Observational cohort study. PATIENTS AND METHODS:AKI was defined as risk, injury or failure, according to the RIFLE ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-011-2167-7
更新日期：2011-05-01 00:00:00
abstract：:The effects of 142 intravenous boluses of althesin (0.05 ml/kg) on cerebral perfusion pressure (CPP) were studied in twelve head injured comatose patients. The data were divided into those where the mean pre-bolus intracranial pressure (ICP) was above or below 20 mmHg and then subdivided into those where the minimum p...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00257469
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:The Pediatric Index of Mortality 2 (PIM2), one of the key mortality prediction models for children in intensive care units, has not been validated in Japan. The purpose of this study was to validate the performance of PIM2 in a population of patients admitted to one pediatric intensive care unit (PICU) in Jap...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-011-2460-5
更新日期：2012-04-01 00:00:00
abstract：:Two hundred and seventy-three acute hemorrhagic shocks were treated in 1984 in a pre-hospital emergency care unit. Twenty patients (7%) had a paradoxical bradycardia: they were conscious, 9 of them had an undetectable systolic arterial pressure with the sphygmomanometric method but the femoral pulse was still present....
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00254705
更新日期：1987-01-01 00:00:00
abstract：PURPOSE:Plasma immunoglobulin concentrations are acutely altered in critically ill patients with sepsis. However, the association between immunoglobulin levels on the day of sepsis diagnosis and subsequent mortality is inconsistent. METHODS:Systematic review of studies that report immunoglobulin measurements and morta...
journal_title：Intensive care medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00134-015-3845-7
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVES:To investigate at what time the peak level should be determined under conventional thrice daily (t.i.d.) administration of the aminoglycoside netilmicin and to study its serum concentrations under once daily (od) treatment to define the required daily dose and to gain information about convenient drug monito...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01694773
更新日期：1993-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of different infusion pump models on continuity of drug delivery during vertical displacement of syringe pumps. DESIGN:Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same syringe in three different models of syringe pump after l...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000784
更新日期：2001-01-01 00:00:00
abstract：:This article was originally published under a CC BY-NC 4.0 license, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...
journal_title：Intensive care medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00134-018-5254-1
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:Sepsis-evoked myocardial dysfunction is possibly due to decreased myofilament calcium sensitivity, and a calcium sensitizer may thus specifically improve contractility in sepsis by enhancing myofilament calcium sensitivity. We examined whether the calcium sensitizer levosimendan mitigates myocardial dysfuncti...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-003-1879-8
更新日期：2003-10-01 00:00:00
abstract：:Type III procollagen N-peptides (PIIINPs) are believed to be released in stoichiometric amounts as type III collagen molecules are secreted from cells. We hypothesized that if the human lung actively produces type III collagen a detectable transpulmonary gradient in PIIINPs would exist in normal individuals that might...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01706477
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:To investigate the effectiveness of an enhanced software Model Predictive Control (eMPC) algorithm for intravenous insulin infusion, targeted at tight glucose control in critically ill patients, over 72 h, in two intensive care units with different management protocols. DESIGN:Comparison with standard care i...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00134-008-1236-z
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:To examine whether an appropriately designed combination of an index of ventilatory endurance and the frequency divided by tidal volume ratio (f/VT) provides prognostic information for weaning outcome not offered by any index alone. DESIGN AND SETTING:Prospective study in a multidisciplinary intensive care u...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-006-0104-y
更新日期：2006-05-01 00:00:00
abstract：:A 42 year old pregnant woman was admitted in acute respiratory failure. Viral pneumonia was suspected and oxygen therapy, CPAP, water restriction and diuretics were started with good response. She remained febrile and had an abnormal chest X-ray, a diagnosis of miliary tuberculosis was confirmed by transbronchial fibr...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01902549
更新日期：1978-11-01 00:00:00
abstract：OBJECTIVE:We examined in rabbits the effects of more than 48 h of mechanical ventilation on the contractile properties and fiber type adaptations of the respiratory muscles. DESIGN AND SETTING:Experimental prospective study in a university laboratory. ANIMALS AND INTERVENTIONS:Nineteen rabbits were randomly allocated...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1548-3
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:Spasms in patients with generalized tetanus can be suppressed by a spinal intrathecal infusion of baclofen. We report on four patients and review reported cases treated by this method elsewhere. DESIGN:Intrathecal baclofen infusion was started with a bolus dose (300-500 micrograms) and continued at a steady ...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s001340050429
更新日期：1997-08-01 00:00:00
abstract：OBJECTIVE:Nuclear factor-kappaB (NF-kappaB) is a transcription factor which plays a pivotal role in the induction of genes involved in the response to injury and inflammation. Calpain I inhibitor is a potent antioxidant which is an effective inhibitor of NF-kappaB. This study examined whether the postulate that calpain...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2328-z
更新日期：2004-08-01 00:00:00
abstract：OBJECTIVE:To investigate the morphological changes in the liver in patients with organ failure and hyperbilirubinemia and to correlate them to the outcome. DESIGN:A case series prospective study. SETTING:Intensive care units of two general hospitals. PATIENTS:Twelve patients in organ failure with predominant hepatic...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01708095
更新日期：1996-06-01 00:00:00
abstract：:The pharmacokinetics of theophylline and ethylenediamine were examined in 6 patients with septicaemia and multiorgan failure (MOF). The patients received a bolus injection of 4 mg/kg aminophylline. Aminophylline is the ethylenediamine salt of theophylline. The clearance of theophylline was reduced in all our patients ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01690768
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:The role of haemofiltration as an adjunctive treatment of sepsis remains a contentious issue. To address the role of dose and to explore the biological effects of haemofiltration we compared the effects of standard and high-volume haemofiltration (HVHF) in a peritonitis-induced model of porcine septic shock. ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-008-1318-y
更新日期：2009-02-01 00:00:00
abstract：:A retrospective study of the medical records of 115 consecutive cases of meningococcal disease with 11 fatalities was carried out in order to evaluate the power of 15 clinical and laboratory variables available on admission in predicting a fatal outcome. On linear discriminant analysis, six variables showed a signific...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00261740
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVE:To determine the clinical epidemiology of invasive group A streptococcal disease (IGASD) and identify predictors of admissions into an intensive care unit (ICU). DESIGN:A cross-sectional study. SETTING:Retrospective review of data. PATIENTS:A total of 204 patients hospitalized throughout the state of Flori...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1538-5
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:Inhalation of high concentrations of nitric oxide (NO) has been shown to improve gas exchange and to reduce pulmonary vascular resistance in individuals with ischemia-reperfusion injury following orthotopic lung transplantation. We assessed the cardiopulmonary effects of low doses of NO in early allograft dys...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s001340050741
更新日期：1998-11-01 00:00:00
abstract：:The use of ultrasonography has become increasingly popular in the everyday management of critically ill patients. It has been demonstrated to be a safe and handy bedside tool that allows rapid hemodynamic assessment and visualization of the thoracic, abdominal and major vessels structures. More recently, M-mode ultras...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-013-2823-1
更新日期：2013-05-01 00:00:00
abstract：PURPOSE:Acute kidney injury (AKI) frequently occurs after heart transplantation (HTx), but its relation to preoperative right heart hemodynamic (RHH) parameters remains unknown. Therefore, we aimed to determine their predictive properties for postoperative AKI severity within 30 days after HTx. METHODS:From 1984 to 20...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-018-5159-z
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:To assess the effects of the cyclooxygenase inhibitor diclofenac in a canine model of pulmonary occlusion and reperfusion of the left lower lobe (LLL). DESIGN:Twelve adult beagle dogs (13-17 kg) were randomly assigned to a control group (n = 6) and a diclofenac-treated group (n = 6). Animals in the treatment...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01700965
更新日期：1995-10-01 00:00:00
abstract：PURPOSE:Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate the neuropathological outcome of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to i...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-010-1913-6
更新日期：2010-09-01 00:00:00
abstract：:We studied the influence of ventilatory frequency (1-5 Hz), tidal volume, lung volume and body position on the end-expiratory alveolar-to-tracheal pressure difference during high-frequency jet ventilation (HFJV) in Yorkshire piglets. The animals were anesthetized and paralysed. Alveolar pressure was estimated with the...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01706322
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVE:To compare isoflurane with midazolam for prolonged sedation in ventilated patients. DESIGN:Randomised controlled study. SETTING:General intensive care unit in university teaching hospital. PATIENTS:Sixty patients aged 17-80 years who required mechanical ventilation for more than 24 h. INTERVENTIONS:Sedati...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01694344
更新日期：1992-01-01 00:00:00
