Abstract：
OBJECTIVE:To compare isoflurane with midazolam for prolonged sedation in ventilated patients. DESIGN:Randomised controlled study. SETTING:General intensive care unit in university teaching hospital. PATIENTS:Sixty patients aged 17-80 years who required mechanical ventilation for more than 24 h. INTERVENTIONS:Sedation with either 0.1-0.6% isoflurane in an air-oxygen mixture (30 patients) or a continuous infusion of midazolam 0.02-0.20 mg/kg/h (30 patients). Sedation was assessed initially and hourly thereafter on a six point scale. The trial sedative was stopped when the patient was ready for weaning from ventilatory support. MEASUREMENTS AND RESULTS:Measurements were made of haemodynamic, respiratory and biochemical variables regularly during the period of sedation and for a week after stopping the sedative agent. There was no difference in any of the physiological or biochemical variables recorded between the two groups. Patients sedated with isoflurane recovered more rapidly and were weaned from mechanical ventilation sooner than those sedated with midazolam. CONCLUSIONS:Isoflurane is a useful agent for prolonged sedation of ventilated patients and does not have any adverse effect on the cardiorespiratory system or on hepatic, renal or adrenal function.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Spencer EM,Willatts SMdoi
10.1007/BF01694344keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
415-21issue
7eissn
0342-4642issn
1432-1238journal_volume
18pub_type
临床试验,杂志文章,随机对照试验abstract：:Six different types of continuous flush devices have been assessed for accuracy in vitro and ease of use in vivo. Only two types of device matched the manufacturers' specifications of performance. The other four gave higher flow rates than expected. ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01691259
更新日期：1983-01-01 00:00:00
abstract：:In oleic acid-induced pulmonary oedema (OAPO) sequential intrapulmonary fluid accumulation occurs leading to different expiratory flow pattern in dependent lung regions. The potential effects on efficacy of high-frequency jet ventilation (HFJV, f = 3 Hz, I: E = 0.43, FiO2 = 0.4) were studied and compared with continuo...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00295986
更新日期：1989-01-01 00:00:00
abstract：PURPOSE:Family members of patients who die in the intensive care unit (ICU) may experience symptoms of stress, anxiety, depression, posttraumatic stress disorder (PTSD), and/or prolonged grief. We evaluated whether grief symptoms were alleviated if the physician and the nurse in charge at the time of death sent the clo...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00134-016-4669-9
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:To determine the clinical impact of bedside colonoscopy for critically ill patients with acute lower gastrointestinal (GI) bleeding. DESIGN AND SETTING:A 3-year retrospective analysis (chart review). Medical intensive care unit (ICU) of a 1,312-bed tertiary-care center in Taiwan. PATIENTS AND PARTICIPANTS:F...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-005-2604-6
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:To obtain insight into the occurrence of brain death and the potential for brain dead and controlled non-heart-beating organ donors (CNHB) in patients with traumatic brain injury (TBI), subarachnoid haemorrhage (SAH) and intracerebral haemorrhage (ICH) in a large neurosurgical serving area (2.1 million inhabi...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-005-0001-9
更新日期：2006-02-01 00:00:00
abstract：OBJECTIVE:To report the first case of ARDS in children treated with nitric oxide (NO) inhalation. METHODS:A 13-months infant presented with BPD and severe hypoxemia related to RSV infection and ARDS. Inhaled NO was delivered in the ventilatory circuit of a continuous flow ventilator (Babylog 8000, Dräger) in a concent...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01711907
更新日期：1994-08-01 00:00:00
abstract：:Peritonitis has been produced in rabbits by the spreading of 5 ml of caecal contents throughout the peritoneal cavity. After sacrifice at 5 h, electron microscopy revealed a increase of 600% in PMN and 1200% in lymphocytes in the pulmonary capillaries of the test animals when compared to the sham operated group. The p...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00265119
更新日期：1987-01-01 00:00:00
abstract：:Extracorporeal life support (ECLS) can support gas exchange in patients with the acute respiratory distress syndrome (ARDS). During ECLS, venous blood is drained from a central vein via a cannula, pumped through a semipermeable membrane that permits diffusion of oxygen and carbon dioxide, and returned via a cannula to...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-020-06290-1
更新日期：2020-12-01 00:00:00
abstract：INTRODUCTION:Trials of tight glucose control have compared measures of central tendency, such as average blood glucose, and yielded conflicting results. Other metrics, such as standard deviation, reflect different properties of glucose control and are also associated with changes in outcome. It is possible, therefore, ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-010-2103-2
更新日期：2011-03-01 00:00:00
abstract：:We report a clinical observation of acute pancreatitis due to severe hypertriglyceridemia in a pregnant woman. In order to decrease the serum triglyceride level rapidly, two lipaphereses were undertaken using the double-filtration technique. This lipoprotein apheresis technique is briefly described and the efficacy in...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01709884
更新日期：1991-01-01 00:00:00
abstract：:We observed a 51-year-old woman who was admitted for severe amitriptyline overdose. Besides major cardiovascular complications, the patient developed severe hyperpyrexia with a central body temperature of more than 43 degrees C for 5 h. The patient died on day 3 from cardiocirculatory collapse and arrhythmias. Hyperth...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01712165
更新日期：1996-05-01 00:00:00
abstract：PURPOSE:We compared hemodynamic and biological effects of the Cascade system, which uses very high volume hemofiltration (HVHF) (120 mL kg(-1) h(-1)), with those of usual care in patients with septic shock. METHODS:Multicenter, prospective, randomized, open-label trial in three intensive care units (ICU). Adults with ...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00134-015-4056-y
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:Capillary leakage syndrome (CLS) is a frequent complication in sepsis, characterized by loss of intravasal fluids leading to generalized edema and hemodynamic instability despite massive fluid therapy. In spite of its importance no standardized diagnostic criteria are available for CLS. DESIGN:Prospective cl...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000601
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:The liver plays a key role in the inflammatory response during major surgery or infection. The influence of age on liver function and hepatic acute phase protein (APP) synthesis should be serially studied in elderly patients undergoing major abdominal surgery. DESIGN AND SETTING:Prospective and descriptive s...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-001-1126-0
更新日期：2001-11-01 00:00:00
abstract：OBJECTIVE:Intra-abdominal pressure (IAP) measurement is important in daily clinical practice. Most measurement techniques vary in automaticity and reproducibility. This study tested a new fully automated continuous technique for IAP measurement, the CiMON. METHODS:Three IAP measurement catheters (a Foley manometer and...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-007-0952-0
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Vasopressors are administered to critically ill patients with vasodilatory shock not responsive to volume resuscitation, and less often in cardiogenic shock, and hypovolemic shock. OBJECTIVES:The objectives are to review safety and efficacy of vasopressors, pathophysiology, agents that decrease vasopressor ...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-019-05801-z
更新日期：2019-11-01 00:00:00
abstract：:Total extracorporeal lung assist (ECLA) requires a bypass flow approaching cardiac output. Recirculation of venous blood through the oxygenator is minimized with a veno-right ventricular cannulation technique which separates venous drainage from returned oxygenated blood. A case of posttraumatic ARDS was treated with ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01691426
更新日期：1991-01-01 00:00:00
abstract：PURPOSE:Acute heart failure (AHF) causes high burden of mortality, morbidity, and repeated hospitalizations worldwide. This guidance paper describes the tailored treatment approaches of different clinical scenarios of AHF and CS, focusing on the needs of professionals working in intensive care settings. RESULTS:Tissue...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-015-4041-5
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the nursing time required for difficult-to-wean patients in a dedicated weaning center (WC) and to examine the correlation of the nursing time with nursing workload (NW) scores and with clinical severity and dependency. SETTING:Four-bed WC of a pulmonary rehabilitation department. INTERVENTION:N...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051249
更新日期：2000-06-01 00:00:00
abstract：:The increase of the inflationary lung volume created by a respiratory maneuver is critical for preventing postoperative alveolar collapse. We measured this volume as achieved with IPPB or incentive spirometry (IS) in 20 postoperative surgical patients. Using IPPB, with gas flow and peak airway pressures carefully adju...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01641120
更新日期：1977-12-01 00:00:00
abstract：OBJECTIVE:To investigate the efficacy of somatostatin for the treatment of severe acute pancreatitis. DESIGN:Prospective, randomized and unblinded study. SETTING:A general intensive care unit (ICU) in a university hospital. PATIENTS:50 patients with severe acute pancreatitis. INTERVENTIONS:All patients received the...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s001340050512
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:To compare the ventilation achieved with chest compressions (CC) or ventilation plus compressions (VC) in a pediatric animal model of cardiac arrest. DESIGN:Randomized experimental study. SETTING:Experimental department of a University Hospital. METHODS:Twelve infant pigs with asphyxial cardiac arrest. Seq...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-010-1777-9
更新日期：2010-04-01 00:00:00
abstract：:Factors influencing nitrogen balance during total parenteral nutrition have been investigated in 34 critically ill injured patients studied during the first 6 days after trauma. Basal nitrogen balance was severely negative (-0.26 +/- 0.12 (SD) g X kg-1), but improved consistently during treatment. Nitrogen intake prov...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00256262
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVE:Evaluation of an open circuit multiple breath nitrogen washout (MBNW) technique for measurement of functional residual capacity (FRC) during partial ventilatory support using corrections for gas viscosity, sampling delay time, and re-inspired nitrogen. DESIGN:Measurements in a lung model with known reference...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-003-1677-3
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVE:To evaluate clinical and microbiologic characteristics, modalities of treatment and outcome of patients with cervical necrotizing fasciitis admitted to our institution. DESIGN:Retrospective clinical investigation. PATIENTS AND METHODS:We reviewed the charts of 20 consecutive patients hospitalized in our Int...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050959
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVE:Based on limited data, Candida sp. isolates from bronchoalveolar lavage (BAL) cultures in immunocompetent patients are thought to be contaminants rather than pathogens. The objective of this study was to determine the clinical significance of Candida sp. isolated from BAL cultures in critically ill trauma pat...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-005-0065-6
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:To assess the effect of strict guidelines and a rigorous training program on variability in scoring the revised Acute Physiology and Chronic Health Evaluation (APACHE II). DESIGN AND SETTING:Prospective survey and intervention in the surgical ICU of a university teaching hospital. MEASUREMENTS:Seven experie...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s001340101012
更新日期：2001-08-01 00:00:00
abstract：OBJECTIVE:To investigate the regional partial pressure of oxygen (PO2) and partial pressure of carbon dioxide (PCO2) of the perfluorocarbon liquid (PpfcO2, PpfcCO2) during partial liquid ventilation (PLV). DESIGN:Prospective, controlled study. SETTING:A research laboratory at a university medical center. SUBJECTS:Th...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000706
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:To analyze the actual cost of pediatric intensive care and its different components, particularly the differences between various patient groups, with special reference to the variable cost and the elements included in it. DESIGN:Prospective, observational study. SETTING:Multidisciplinary 12-bed pediatric i...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050320
更新日期：1997-02-01 00:00:00
abstract：:The endothelium is a highly dynamic cell layer that is involved in a multitude of physiological functions, including the control of vascular tone, the movement of cells and nutrients, the maintenance of blood fluidity and the growth of new vessels. During severe sepsis, the endothelium becomes proadhesive, procoagulan...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-010-1893-6
更新日期：2010-08-01 00:00:00
