当前位置： SCI文献检索 > INTENSIVE CARE MEDICINE期刊下所有文献 > Severe acute pancreatitis: treatment with somatostatin.

Severe acute pancreatitis: treatment with somatostatin.

Abstract：

OBJECTIVE:To investigate the efficacy of somatostatin for the treatment of severe acute pancreatitis. DESIGN:Prospective, randomized and unblinded study. SETTING:A general intensive care unit (ICU) in a university hospital. PATIENTS:50 patients with severe acute pancreatitis. INTERVENTIONS:All patients received the conventional treatment for this clinical condition. The study group received, in addition, somatostatin over a 10-day period. MEASUREMENTS AND RESULTS:We evaluated age, gender, etiology of the pancreatitis, severity of the illness, complications, length of hospitalization, and mortality in the ICU. The patients were classified as severe (Acute Physiology and Chronic Health Evaluation II score, Ranson's criteria, and computed tomography Balthazar classification). Biliary lithiasis was the most common etiologic factor (63.6% in the control group, 37.5% in study group; NS). The study group required fewer overall surgical interventions than the control group (45.8 vs 86.4%; p = 0.005). Late surgical procedures related to the evolution of pancreatic necrosis were more common in the controls (63.6 vs 37.5%; p = 0.07). No differences in length of stay in hospital or mortality in the ICU were observed. CONCLUSION:The only advantage of somatostatin administration in the patients studied was a slight reduction in the need for surgery due to local complications.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Planas M,Pérez A,Iglesia R,Porta I,Masclans JR,Bermejo B

doi

10.1007/s001340050512

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

37-9

issue

1

eissn

0342-4642

issn

1432-1238

journal_volume

24

pub_type

临床试验,杂志文章,随机对照试验

相关文献

INTENSIVE CARE MEDICINE文献大全
  • Acute respiratory distress syndrome among trauma patients: trends in ICU mortality, risk factors, complications and resource utilization.

    abstract：OBJECTIVE:To evaluate trends in mortality and related factors among trauma patients who developed acute respiratory distress syndrome (ARDS). STUDY:Observational study based on data prospectively gathered in computerized trauma registry. SETTING:Trauma intensive care unit (ICU) of 48 beds in level I trauma center. P...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340100955

    authors： Navarrete-Navarro P,Rodriguez A,Reynolds N,West R,Habashi N,Rivera R,Chiu WC,Scalea T

    更新日期：2001-07-01 00:00:00

  • Bedside colonoscopy for critically ill patients with acute lower gastrointestinal bleeding.

    abstract：OBJECTIVE:To determine the clinical impact of bedside colonoscopy for critically ill patients with acute lower gastrointestinal (GI) bleeding. DESIGN AND SETTING:A 3-year retrospective analysis (chart review). Medical intensive care unit (ICU) of a 1,312-bed tertiary-care center in Taiwan. PATIENTS AND PARTICIPANTS:F...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-005-2604-6

    authors： Lin CC,Lee YC,Lee H,Lin JT,Ho WC,Chen TH,Wang HP

    更新日期：2005-05-01 00:00:00

  • Time to intra-arrest therapeutic hypothermia in out-of-hospital cardiac arrest patients and its association with neurologic outcome: a propensity matched sub-analysis of the PRINCESS trial.

    abstract：PURPOSE:To study the association between early initiation of intra-arrest therapeutic hypothermia and neurologic outcome in out-of-hospital cardiac arrest. METHODS:A prespecified sub-analysis of the PRINCESS trial (NCT01400373) that randomized 677 bystander-witnessed cardiac arrests to transnasal evaporative intra-arr...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-020-06024-3

    authors： Awad A,Taccone FS,Jonsson M,Forsberg S,Hollenberg J,Truhlar A,Ringh M,Abella BS,Becker LB,Vincent JL,Svensson L,Nordberg P

    更新日期：2020-07-01 00:00:00

  • Will my patient survive? Look for creatinine in the urine!

    abstract：: ...

    journal_title：Intensive care medicine

    pub_type： 评论,社论

    doi：10.1007/s00134-018-5399-y

    authors： Darmon M,Kashani K,Schetz M

    更新日期：2018-11-01 00:00:00

  • The influence of the airway driving pressure on pulsed pressure variation as a predictor of fluid responsiveness.

    abstract：OBJECTIVE:Assessing pulse pressure variation (PPV) to predict fluid responsiveness in mechanically ventilated patients with tidal volume (VT) and the impact of VT and airway driving pressure (P(plat) - PEEP) on the ability of PPV for predicting fluid responsiveness. DESIGN:Prospective interventional study. SETTING:IC...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-009-1686-y

    authors： Muller L,Louart G,Bousquet PJ,Candela D,Zoric L,de La Coussaye JE,Jaber S,Lefrant JY

    更新日期：2010-03-01 00:00:00

  • Alterations of soluble L- and P-selectins during cardiac arrest and CPR.

    abstract：OBJECTIVE:To investigate the relationship between cytokines and the inflammatory responses in patients with out-of-hospital cardiac arrest, we examined the changes of cytokines as well as alterations in the markers of neutrophil activation, platelet and endothelial activation, and endothelial injury. DESIGN:Prospectiv...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章

    doi：10.1007/s001340050907

    authors： Gando S,Nanzaki S,Morimoto Y,Kobayashi S,Kemmotsu O

    更新日期：1999-06-01 00:00:00

  • Albumin supplementation during the first week after a burn does not mobilise tissue oedema in humans.

    abstract：OBJECTIVE:To measure water balance and changes in distribution, and the effect of giving supplementary albumin, early after a burn injury. DESIGN:Consecutive patients (matched groups) and healthy controls. SETTING:National burn unit in a Swedish university hospital. PATIENTS AND SUBJECTS:Eighteen patients with 18%-9...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340100935

    authors： Zdolsek HJ,Lisander B,Jones AW,Sjöberg F

    更新日期：2001-05-01 00:00:00

  • Combined measurements of N-terminal pro-brain natriuretic peptide and cardiac troponins in potential organ donors.

    abstract：OBJECTIVE:Brain death may induce cardiac dysfunction. In potential organ donors measurements of N-terminal pro-brain natriuretic peptide (NT-proBNP) and circulating cardiac troponins T and I (cTnT and cTnI), alone or in combination, are performed to investigate the accuracy of these biomarkers for early diagnosis of le...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-007-0601-7

    authors： Nicolas-Robin A,Salvi N,Medimagh S,Amour J,Le Manach Y,Coriat P,Riou B,Langeron O

    更新日期：2007-06-01 00:00:00

  • Theophylline and ethylenediamine pharmacokinetics following administration of aminophylline to septic patients with multiorgan failure.

    abstract：:The pharmacokinetics of theophylline and ethylenediamine were examined in 6 patients with septicaemia and multiorgan failure (MOF). The patients received a bolus injection of 4 mg/kg aminophylline. Aminophylline is the ethylenediamine salt of theophylline. The clearance of theophylline was reduced in all our patients ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01690768

    authors： Toft P,Heslet L,Hansen M,Klitgaard NA

    更新日期：1991-01-01 00:00:00

  • Respiratory mechanics by least squares fitting in mechanically ventilated patients: applications during paralysis and during pressure support ventilation.

    abstract：OBJECTIVE:To evaluate a least squares fitting technique for the purpose of measuring total respiratory compliance (Crs) and resistance (Rrs) in patients submitted to partial ventilatory support, without the need for esophageal pressure measurement. DESIGN:Prospective, randomized study. SETTING:A general ICU of a Univ...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF01707409

    authors： Iotti GA,Braschi A,Brunner JX,Smits T,Olivei M,Palo A,Veronesi R

    更新日期：1995-05-01 00:00:00

  • Gender-based differences in children with sepsis and ARDS: the ESPNIC ARDS Database Group.

    abstract：:Male gender predisposes to severe sepsis and septic shock. This effect has been ascribed to higher levels of testosterone. The ESPNIC ARDS database was searched, to determine if there was evidence of a similar male preponderance in severe sepsis in prepubertal patients in spite of low levels of male sex hormones at th...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-003-1948-z

    authors： Bindl L,Buderus S,Dahlem P,Demirakca S,Goldner M,Huth R,Kohl M,Krause M,Kühl P,Lasch P,Lewandowski K,Merz U,Moeller J,Mohamad Y,Peters M,Porz W,Vierzig A,Rüchard J,Scharf J,Varnholt V,ESPNIC ARDS Database Group.

    更新日期：2003-10-01 00:00:00

  • Tracheostomy practice and timing in traumatic brain-injured patients: a CENTER-TBI study.

    abstract：PURPOSE:Indications and optimal timing for tracheostomy in traumatic brain-injured (TBI) patients are uncertain. This study aims to describe the patients' characteristics, timing, and factors related to the decision to perform a tracheostomy and differences in strategies among different countries and assess the effect ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-020-05935-5

    authors： Robba C,Galimberti S,Graziano F,Wiegers EJA,Lingsma HF,Iaquaniello C,Stocchetti N,Menon D,Citerio G,CENTER-TBI ICU Participants and Investigators.

    更新日期：2020-05-01 00:00:00

  • Influence of parenteral fat administration on the pulmonary vascular system in man.

    abstract：:In 16 patients with multiple injuries the effect of parenteral administration of a fat emulsion on the pulmonary vascular system has been studied. Using the Hewlett Packard 5600 A Intensive Care System, which allows vital parameters to be sampled at a rate of two values per min, pulmonary artery pressure (PAP) was mon...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01699260

    authors： van Deyk K,Hempel V,Münch F,Kopp M,Graf H,Epple E

    更新日期：1983-01-01 00:00:00

  • Fluid leakage past tracheal tube cuffs: evaluation of the new Microcuff endotracheal tube.

    abstract：OBJECTIVE:This study compared the recently introduced Microcuff endotracheal tube HVLP ICU featuring an ultrathin (7-microm) polyurethane cuff membrane with endotracheal tubes from different manufacturers regarding fluid leakage past the tube cuff. DESIGN:In vitro setup. MEASUREMENTS AND RESULTS:The following endotra...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-003-1933-6

    authors： Dullenkopf A,Gerber A,Weiss M

    更新日期：2003-10-01 00:00:00

  • Autoregulation of ventilation with neurally adjusted ventilatory assist on extracorporeal lung support.

    abstract：PURPOSE:Extracorporeal membrane oxygenation (ECMO) can support oxygenation and carbon dioxide elimination in severe lung failure. Usually it is accompanied by controlled mechanical ventilation. Neurally adjusted ventilatory assist (NAVA) is a new mode of ventilation triggered by the diaphragmatic electrical activity an...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-010-1982-6

    authors： Karagiannidis C,Lubnow M,Philipp A,Riegger GA,Schmid C,Pfeifer M,Mueller T

    更新日期：2010-12-01 00:00:00

  • Steady-state trough serum and epithelial lining fluid concentrations of teicoplanin 12 mg/kg per day in patients with ventilator-associated pneumonia.

    abstract：OBJECTIVE:To determine the steady-state trough serum and epithelial lining fluid (ELF) concentrations of teicoplanin 12 mg/kg per day in critically ill patients with ventilator associated pneumonia. DESIGN AND SETTING:Prospective, pharmacokinetic study in the surgical intensive care unit in a university hospital. PAT...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-006-0136-3

    authors： Mimoz O,Rolland D,Adoun M,Marchand S,Breilh D,Brumpt I,Debaene B,Couet W

    更新日期：2006-05-01 00:00:00

  • Inhibition of human neutrophil chemotaxis toward interleukin 8 with six clinical antithrombin concentrates in vitro.

    abstract：OBJECTIVE:Antithrombin exerts direct effects on neutrophils by inhibiting chemokine-induced migration. This study examined the potency of different pharmaceutical antithrombin preparations in inhibiting neutrophil chemotaxis toward interleukin 8. METHODS:Cell migration was tested by the leading front assay in modified...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-002-1432-1

    authors： Kaneider NC,Rabensteiner A,Reinisch CM,Dunzendorfer S,Wiedermann CJ

    更新日期：2002-10-01 00:00:00

  • Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study.

    abstract：PURPOSE:Ventricular-arterial (V-A) decoupling decreases myocardial efficiency and is exacerbated by tachycardia that increases static arterial elastance (Ea). We thus investigated the effects of heart rate (HR) reduction on Ea in septic shock patients using the beta-blocker esmolol. We hypothesized that esmolol improve...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-016-4351-2

    authors： Morelli A,Singer M,Ranieri VM,D'Egidio A,Mascia L,Orecchioni A,Piscioneri F,Guarracino F,Greco E,Peruzzi M,Biondi-Zoccai G,Frati G,Romano SM

    更新日期：2016-10-01 00:00:00

  • Value of brain natriuretic peptide in the perioperative follow-up of children with valvular disease.

    abstract：OBJECTIVE:To characterize N-terminal pro-brain natriuretic peptide (N-proBNP) and troponin I (TnI) profile following mitral and/or aortic valve surgery and to evaluate correlations with echocardiography measures and outcome criteria. DESIGN AND SETTING:Prospective cross-controlled study in a university children's hosp...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-008-1025-8

    authors： Tissières P,da Cruz E,Habre W,Aggoun Y,Mensi N,Kalangos A,Beghetti M

    更新日期：2008-06-01 00:00:00

  • Age-dependent effects of gradual decreases in cerebral perfusion pressure on the neurochemical response in swine.

    abstract：OBJECTIVE:There is still a lack of knowledge on the age-dependent relation between a reduction in cerebral perfusion pressure (CPP) and compromised brain perfusion leading to excessive transmitter release and brain damage cascades. The hypothesis is that an age-dependent lower threshold of cerebral blood flow (CBF) aut...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-010-1846-0

    authors： Walter B,Aisenpreis K,Fritz HG,Soukup J,Eiselt M,Bauer R

    更新日期：2010-06-01 00:00:00

  • Effects of terlipressin on systemic and regional haemodynamics in catecholamine-treated hyperkinetic septic shock.

    abstract：OBJECTIVES:To determine the effects of an intravenous bolus dose of a vasopressin analogue, terlipressin (1 mg), on systemic haemodynamic parameters and gastric mucosal perfusion (GMP) in patients with catecholamine-treated septic shock using a gastric tonometry and laser-Doppler flowmetry technique. DESIGN:Prospectiv...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00134-003-2094-3

    authors： Morelli A,Rocco M,Conti G,Orecchioni A,De Gaetano A,Cortese G,Coluzzi F,Vernaglione E,Pelaia P,Pietropaoli P

    更新日期：2004-04-01 00:00:00

  • Plasma exchange in rhabdomyolysis.

    abstract：:The effect of plasma exchange (PE) was evaluated in 4 patients with rhabdomyolysis. A single 21 PE produced a transient fall of creatinine phosphokinase and did not prevent renal failure. Theoretically PE would need to be performed very frequently to remove toxins in appropriate amounts. Since renal failure in myoglob...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF00273565

    authors： Cornelissen JJ,Haanstra W,Haarman HJ,Derksen RH

    更新日期：1989-01-01 00:00:00

  • Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis.

    abstract：PURPOSE:Sepsis is a major health burden worldwide. Preclinical investigations in animals and retrospective studies in patients have suggested that inhibition of platelets may improve the outcome of sepsis. In this study we investigated whether chronic antiplatelet therapy impacts on the presentation and outcome of seps...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-015-4171-9

    authors： Wiewel MA,de Stoppelaar SF,van Vught LA,Frencken JF,Hoogendijk AJ,Klein Klouwenberg PMC,Horn J,Bonten MJ,Zwinderman AH,Cremer OL,Schultz MJ,van der Poll T,MARS Consortium.

    更新日期：2016-03-01 00:00:00

  • The effect of sepsis and its inflammatory response on mechanical clot characteristics: a prospective observational study.

    abstract：PURPOSE:Sepsis and its progression are known to have a major influence on the coagulation system. Current coagulation tests are of limited use when assessing coagulation in sepsis patients. This study aims to assess the potential for a new functional biomarker of clot microstructure, fractal dimension, to identify chan...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-016-4496-z

    authors： Davies GR,Pillai S,Lawrence M,Mills GM,Aubrey R,D'Silva L,Battle C,Williams R,Brown R,Thomas D,Morris K,Evans PA

    更新日期：2016-12-01 00:00:00

  • Dosing of medications in morbidly obese patients in the intensive care unit setting.

    abstract：OBJECTIVE:To derive recommendations for the dosing of commonly used medications in the morbidly obese patient in the ICU. DATA SOURCES:Articles were obtained through computerized searches involving MEDLINE. The bibliographies of retrieved publications and textbooks were reviewed for additional references. STUDY SELEC...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s00134-003-2059-6

    authors： Erstad BL

    更新日期：2004-01-01 00:00:00

  • The costs of septic syndromes in the intensive care unit and influence of hospital-acquired sepsis.

    abstract：OBJECTIVE:To document the costs and outcomes of the various forms of the septic syndromes [systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock), particularly those associated with infection acquired in an intensive care unit (ICU). DESIGN:Prospective data collection for all septic patie...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-003-1877-x

    authors： Brun-Buisson C,Roudot-Thoraval F,Girou E,Grenier-Sennelier C,Durand-Zaleski I

    更新日期：2003-09-01 00:00:00

  • The management of arrhythmias following an acute myocardial infarction.

    abstract：:Arrhythmias are extremely common early after AMI. An arrhythmia is defined by exclusion, either because the sequence of myocardial depolarisation is other than normal or because certain arbitrary limits are exceeded. It follows that the term "arrhythmia" encompasses a complex heterogenous group. Although arrhythmias a...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01683131

    authors： Rowlands DJ

    更新日期：1978-01-01 00:00:00

  • Retraction Note to: Volume therapy in the intensive care patient - we are still confused, but..

    abstract：:The Editor-in-Chief has retracted this article [1] because a number of studies included in this review [2, 3, 4] (originally cited as references 98, 128, 129) have since been retracted. Consequently, this has rendered the content of the review unreliable. ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,撤回出版物

    doi：10.1007/s00134-020-06068-5

    authors： Editorial Office of Intensive Care Medicine.

    更新日期：2020-06-01 00:00:00

  • Increasing consumption of MRSA-active drugs without increasing MRSA in German ICUs.

    abstract：PURPOSE:The aim of our study was to analyze changes in the consumption of MRSA-active antibiotics and in the burden of methicillin-resistant S. aureus (MRSA) over a period of 9 years in a network of German intensive care units (ICU). METHODS:Data from 55 ICUs in Germany were analyzed from 2001 through 2009. The term "...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-011-2335-9

    authors： Meyer E,Schwab F,Schroeren-Boersch B,Gastmeier P

    更新日期：2011-10-01 00:00:00

  • Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis.

    abstract：OBJECTIVE:Nuclear factor-kappaB (NF-kappaB) is a transcription factor which plays a pivotal role in the induction of genes involved in the response to injury and inflammation. Calpain I inhibitor is a potent antioxidant which is an effective inhibitor of NF-kappaB. This study examined whether the postulate that calpain...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-004-2328-z

    authors： Virlos I,Mazzon E,Serraino I,Genovese T,Di Paola R,Thiemerman C,Siriwardena A,Cuzzocrea S

    更新日期：2004-08-01 00:00:00