Steady-state trough serum and epithelial lining fluid concentrations of teicoplanin 12 mg/kg per day in patients with ventilator-associated pneumonia.

abstract：:Neuromuscular blocking agents (NMBAs) inhibit patient-initiated active breath and the risk of high tidal volumes and consequent high transpulmonary pressure swings, and minimize patient/ ventilator asynchrony in acute respiratory distress syndrome (ARDS). Minimization of volutrauma and ventilator-induced lung injury (...

journal_title：Intensive care medicine

authors： Hraiech S,Yoshida T,Annane D,Duggal A,Fanelli V,Gacouin A,Heunks L,Jaber S,Sottile PD,Papazian L

更新日期：2020-12-01 00:00:00

abstract：:A retrospective study of the medical records of 115 consecutive cases of meningococcal disease with 11 fatalities was carried out in order to evaluate the power of 15 clinical and laboratory variables available on admission in predicting a fatal outcome. On linear discriminant analysis, six variables showed a signific...

journal_title：Intensive care medicine

authors： Gårdlund B

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To describe changes in hemodynamic variables, sedation, and pain score after discontinuation of prolonged infusions of dexmedetomidine in a pediatric population of critically ill cardiac patients. METHODS:Retrospective case series of patients who received continuous infusions of dexmedetomidine for longer than...

journal_title：Intensive care medicine

authors： Burbano NH,Otero AV,Berry DE,Orr RA,Munoz RA

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:To determine the oxygen affinity for optimal tissue oxygen delivery with a hemoglobin-hydroxyethyl starch conjugate (HRC 101). METHODS:Anesthetized rats were hemodiluted (180 ml kg(-1)) with low (P(50) approximately 70 mmHg) or high affinity (P(50) approximately 14 mmHg) HRC 101 at hemoglobin (Hb) concentratio...

journal_title：Intensive care medicine

authors： Hare GM,Liu E,Baker AJ,Mazer CD

更新日期：2009-11-01 00:00:00

abstract：:Paediatric admissions to a general ITU are briefly reviewed. Although it may not be an ideal arrangement it is suggested that children can be safely cared for in such a unit. The problems created by the child with acute upper airway obstruction are discussed to demonstrate the way in which the unit is organized to rec...

journal_title：Intensive care medicine

authors： Eastham EJ,Papadatos J,Cook S,Stoddart JC

更新日期：1985-01-01 00:00:00

abstract：:A technique for the estimation of LVEF from first passage radionuclide angiocardiography was adapted to provide estimates of RVEF. In 17 subjects with no history of cardiovascular disease mean LVEF was 0.71 +/- 0.08 and mean RVEF 0.65 +/- 0.08. Mean values for 15 subjects with coronary artery disease but no previous h...

journal_title：Intensive care medicine

authors： Walton S,Rowlands DJ,Shields RA,Testa HJ

更新日期：1979-09-01 00:00:00

abstract：PURPOSE:A retrieval program was developed in New South Wales (NSW), Australia to provide extracorporeal membrane oxygenation support (ECMO) for the safe transport of adults with severe, acute respiratory or cardiac failure. We describe the development and results of this program and the impact of the 2009 H1N1 epidemic...

journal_title：Intensive care medicine

authors： Forrest P,Ratchford J,Burns B,Herkes R,Jackson A,Plunkett B,Torzillo P,Nair P,Granger E,Wilson M,Pye R

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:To assess the impact of lung ultrasound (LU) on clinical decision making in mechanically ventilated critically ill patients. METHODS:One hundred and eighty-nine patients took part in this prospective study. The patients were enrolled in the study when LU was requested by the primary physician for (1) unexplain...

journal_title：Intensive care medicine

authors： Xirouchaki N,Kondili E,Prinianakis G,Malliotakis P,Georgopoulos D

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Adverse respiratory and gasometrical effects have been described in patients with acute respiratory failure (ARF) undergoing noninvasive ventilation (NIV) with standard heat and moisture exchangers (HME). We decided to evaluate respiratory parameters and arterial blood gases (ABG) of patients during NIV with ...

journal_title：Intensive care medicine

authors： Boyer A,Vargas F,Hilbert G,Gruson D,Mousset-Hovaere M,Castaing Y,Dreyfuss D,Ricard JD

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Clinical examination is often the first step to diagnose shock and estimate cardiac index. In the Simple Intensive Care Studies-I, we assessed the association and diagnostic performance of clinical signs for estimation of cardiac index in critically ill patients. METHODS:In this prospective, single-centre coho...

journal_title：Intensive care medicine

authors： Hiemstra B,Koster G,Wiersema R,Hummel YM,van der Harst P,Snieder H,Eck RJ,Kaufmann T,Scheeren TWL,Perner A,Wetterslev J,de Smet AMGA,Keus F,van der Horst ICC,SICS Study Group.

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:To determine incidence, risk factors and outcome of tracheal ischemic lesions related to intubation. METHODS:Planned post hoc analysis using patients from a previous randomized controlled study. Fiberoptic tracheoscopy was performed during the 24 h following extubation. In patients with >2 ischemic lesions, ul...

journal_title：Intensive care medicine

authors： Touat L,Fournier C,Ramon P,Salleron J,Durocher A,Nseir S

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To assess procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations and clearance in nonseptic end-stage renal failure patients undergoing their first three hemodialysis sessions. DESIGN AND SETTING:Prospective observational consecutive clinical study at a university hospital. PATIENTS:The stud...

journal_title：Intensive care medicine

authors： Dahaba AA,Rehak PH,List WF

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVES:(1) To demonstrate that metabolic parameters are better indicators of tissue hypoxia than regional and whole oxygen consumption (VO(2)). (2) To compare intramucosal pH (pHi) in different gastrointestinal segments. DESIGN:Prospective, interventional study. SETTING:Research laboratory at a university center....

journal_title：Intensive care medicine

authors： Dubin A,Estenssoro E,Murias G,Canales H,Sottile P,Badie J,Barán M,Pálizas F,Laporte M,Rivas Díaz M

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:To determine the value of procalcitonin (PCT) in the early diagnosis (and differentiation) of patients with SIRS, sepsis, severe sepsis, and septic shock in comparison to C-reactive protein (CRP), white blood cell and thrombocyte count, and APACHE-II score (AP-II). DESIGN:Prospective cohort study including a...

journal_title：Intensive care medicine

authors： Brunkhorst FM,Wegscheider K,Forycki ZF,Brunkhorst R

更新日期：2000-03-01 00:00:00

abstract：:Extracorporeal CO2-removal (EC-CO2-R) using a membrane lung system was applied for 12 and 20 days respectively in two young men with adult respiratory distress syndrome (ARDS). Neuropathological examination revealed only moderate hypoxic changes of unusual distribution. In the first case nerve cell loss in Sommer's se...

journal_title：Intensive care medicine

authors： Krajewski S,Seitz RJ,Schober R,Breulmann M,Falke KJ

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:Controversy over the optimal intravenous fluid for volume resuscitation continues unabated. Our objectives were to characterize the demographics of physicians who prescribe intravenous colloids and determine factors that enter into their decision to choose a colloid. DESIGN:Questionnaire with 61 items. PAR...

journal_title：Intensive care medicine

authors： Miletin MS,Stewart TE,Norton PG

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVES:Critically ill patients often develop anaemia which can be related to a number of factors. However, the exact causes of anaemia in many patients remain unexplained. We hypothesized that the relationship between erythropoietin (EPO) and haematocrit may be altered in critically ill patients. DESIGN:Serum conc...

journal_title：Intensive care medicine

authors： Rogiers P,Zhang H,Leeman M,Nagler J,Neels H,Mélot C,Vincent JL

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:To assess the prevalence of relative adrenal insufficiency in patients successfully resuscitated after cardiac arrest, and its prognostic role in post-resuscitation disease. DESIGN AND SETTING:A prospective observational single-center study in a medical intensive care unit. PATIENTS:64 patients hospitalised...

journal_title：Intensive care medicine

authors： Pene F,Hyvernat H,Mallet V,Cariou A,Carli P,Spaulding C,Dugue MA,Mira JP

更新日期：2005-05-01 00:00:00

abstract：:Total extracorporeal lung assist (ECLA) requires a bypass flow approaching cardiac output. Recirculation of venous blood through the oxygenator is minimized with a veno-right ventricular cannulation technique which separates venous drainage from returned oxygenated blood. A case of posttraumatic ARDS was treated with ...

journal_title：Intensive care medicine

authors： Wetterberg T,Steen S

更新日期：1991-01-01 00:00:00

abstract：:Optimal fluid management is one of the main challenges in the care of the critically ill. However, the physiological parameters that are commonly monitored and used to guide fluid management are often inadequate and even misleading. From 1987 to 1989 we published four experimental studies which described a method for ...

journal_title：Intensive care medicine

authors： Perel A,Pizov R,Cotev S

更新日期：2014-06-01 00:00:00

abstract：:The use of induced hypertension in head injury patients is controversial. We present the case of a 19-year-old man admitted with severe head trauma after a road accident and describe the beneficial effects that increasing arterial blood pressure had on the cerebral perfusion pressure, cerebral blood flow and jugular b...

journal_title：Intensive care medicine

authors： Ferring M,Berré J,Vincent JL

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:To examine the relationship of fluid balance and weaning outcomes. METHODS:We prospectively collected demographic, physiological, daily fluid balance (measured inputs minus outputs), and weaning data from 87 mechanically ventilated patients. PATIENTS:We examined 87 patients, a median age of 66 years, APACHE...

journal_title：Intensive care medicine

authors： Upadya A,Tilluckdharry L,Muralidharan V,Amoateng-Adjepong Y,Manthous CA

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:To examine whether an appropriately designed combination of an index of ventilatory endurance and the frequency divided by tidal volume ratio (f/VT) provides prognostic information for weaning outcome not offered by any index alone. DESIGN AND SETTING:Prospective study in a multidisciplinary intensive care u...

journal_title：Intensive care medicine

authors： Vassilakopoulos T,Routsi C,Sotiropoulou C,Bitsakou C,Stanopoulos I,Roussos C,Zakynthinos S

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:To assess acute cardiorespiratory effects of recruitment manoeuvres in experimental acute lung injury. DESIGN:Experimental study in animal models of acute lung injury. SETTING:Experimental laboratory at a University Medical Centre. ANIMALS:Ten pigs with bronchoalveolar lavage and eight pigs with endotoxin-...

journal_title：Intensive care medicine

authors： Odenstedt H,Aneman A,Kárason S,Stenqvist O,Lundin S

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the sensitivity, specificity and overall accuracy of a model based on the presence or absence of organ dysfunctions and/or infection (ODIN) to predict the outcome for intensive care unit patients. DESIGN:Prospective study. SETTING:General intensive care unit in a university teaching hospital. P...

journal_title：Intensive care medicine

authors： Fagon JY,Chastre J,Novara A,Medioni P,Gibert C

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Caloric insufficiency during the first week of intensive care unit (ICU) stay was reported to be associated with increased infection rates, especially ICU-acquired bloodstream infection (ICU-BSI). However, the predisposition to ICU-BSI by a given pathogen remains not well known. We aimed to determine the impact...

journal_title：Intensive care medicine

authors： Ekpe K,Novara A,Mainardi JL,Fagon JY,Faisy C

更新日期：2014-12-01 00:00:00

abstract：:As part of a nationwide evaluation of intensive care, we examined patient- and hospital-related factors which could influence the patterns of utilization of arterial cannulae and central venous and pulmonary artery catheters. We also studied the possible impact of these interventions on the short-term outcome among 14...

journal_title：Intensive care medicine

authors： Saarela E,Kari A,Nikki P,Rauhala V,Iisalo E,Kaukinen L

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To compare isoflurane with midazolam for prolonged sedation in ventilated patients. DESIGN:Randomised controlled study. SETTING:General intensive care unit in university teaching hospital. PATIENTS:Sixty patients aged 17-80 years who required mechanical ventilation for more than 24 h. INTERVENTIONS:Sedati...

journal_title：Intensive care medicine

authors： Spencer EM,Willatts SM

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To investigate the theoretical interactions between ventilator settings, tracheal gas insufflation (TGI), and alveolar ventilation. DESIGN:We derived differential equations governing compartmental volume changes in a one-compartment model of TGI-assisted ventilation and equations governing gas dilution in th...

journal_title：Intensive care medicine

authors： Hotchkiss JR Jr,Crooke PS 3rd,Marini JJ

更新日期：1996-10-01 00:00:00

abstract：PURPOSE:Protective mechanical ventilation based on multiple ventilator parameters such as tidal volume, plateau pressure, and driving pressure has been widely used in acute respiratory distress syndrome (ARDS). More recently, mechanical power (MP) was found to be associated with mortality. The study aimed to investigat...

journal_title：Intensive care medicine

authors： Zhang Z,Zheng B,Liu N,Ge H,Hong Y

更新日期：2019-06-01 00:00:00