Abstract:
PURPOSE:Ventricular-arterial (V-A) decoupling decreases myocardial efficiency and is exacerbated by tachycardia that increases static arterial elastance (Ea). We thus investigated the effects of heart rate (HR) reduction on Ea in septic shock patients using the beta-blocker esmolol. We hypothesized that esmolol improves Ea by positively affecting the tone of arterial vessels and their responsiveness to HR-related changes in stroke volume (SV). METHODS:After at least 24 h of hemodynamic optimization, 45 septic shock patients, with an HR ≥95 bpm and requiring norepinephrine to maintain mean arterial pressure (MAP) ≥65 mmHg, received a titrated esmolol infusion to maintain HR between 80 and 94 bpm. Ea was calculated as MAP/SV. All measurements, including data from right heart catheterization, echocardiography, arterial waveform analysis, and norepinephrine requirements, were obtained at baseline and at 4 h after commencing esmolol. RESULTS:Esmolol reduced HR in all patients and this was associated with a decrease in Ea (2.19 ± 0.77 vs. 1.72 ± 0.52 mmHg l(-1)), arterial dP/dt max (1.08 ± 0.32 vs. 0.89 ± 0.29 mmHg ms(-1)), and a parallel increase in SV (48 ± 14 vs. 59 ± 18 ml), all p < 0.05. Cardiac output and ejection fraction remained unchanged, whereas norepinephrine requirements were reduced (0.7 ± 0.7 to 0.58 ± 0.5 µg kg(-1) min(-1), p < 0.05). CONCLUSIONS:HR reduction with esmolol effectively improved Ea while allowing adequate systemic perfusion in patients with severe septic shock who remained tachycardic despite standard volume resuscitation. As Ea is a major determinant of V-A coupling, its reduction may contribute to improving cardiovascular efficiency in septic shock.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Morelli A,Singer M,Ranieri VM,D'Egidio A,Mascia L,Orecchioni A,Piscioneri F,Guarracino F,Greco E,Peruzzi M,Biondi-Zoccai G,Frati G,Romano SMdoi
10.1007/s00134-016-4351-2subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1528-1534issue
10eissn
0342-4642issn
1432-1238pii
10.1007/s00134-016-4351-2journal_volume
42pub_type
杂志文章abstract::A case of brainstem encephalitis complicated by torsade de pointes is described. The possible occurrence of ventricular arrhythmias may contribute to the mortality in this condition. We recommend the admission of patients with brainstem encephalitis to an intensive care unit, for a period of electrocardiographic monit...
journal_title:Intensive care medicine
pub_type: 杂志文章
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journal_title:Intensive care medicine
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journal_title:Intensive care medicine
pub_type: 杂志文章
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journal_title:Intensive care medicine
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journal_title:Intensive care medicine
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pub_type: 临床试验,杂志文章
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更新日期:2003-09-01 00:00:00
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更新日期:2006-05-01 00:00:00
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journal_title:Intensive care medicine
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journal_title:Intensive care medicine
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journal_title:Intensive care medicine
pub_type: 杂志文章,评审
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更新日期:1994-07-01 00:00:00
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更新日期:2011-08-01 00:00:00