当前位置： SCI文献检索 > INTENSIVE CARE MEDICINE期刊下所有文献 > Increasing consumption of MRSA-active drugs without increasing MRSA in German ICUs.

Increasing consumption of MRSA-active drugs without increasing MRSA in German ICUs.

Abstract：

PURPOSE:The aim of our study was to analyze changes in the consumption of MRSA-active antibiotics and in the burden of methicillin-resistant S. aureus (MRSA) over a period of 9 years in a network of German intensive care units (ICU). METHODS:Data from 55 ICUs in Germany were analyzed from 2001 through 2009. The term "old MRSA-active antibiotics" included vancomycin, teicoplanin and fosfomycin, whereas the term "new MRSA-active antibiotics" included quinupristin/dalfopristin, linezolid and daptomycin. The burden of MRSA was defined as MRSA per 1,000 patient-days. RESULTS:A total of 1,584,995 patient-days and 32,450 S. aureus isolates were analyzed. The burden of MRSA was 4.4, and the pooled mean MRSA resistance proportion was 21.8%. Both parameters did not change significantly over time. In contrast, MRSA-active antibiotics more than doubled from 44 defined daily doses per 1,000 patient-days in 2001 to 92 in 2009. This was due to the significant increase of new MRSA-active antibiotics (from 1 to 40), whereas old MRSA antibiotics stayed stable (43 in 2001 and 52 in 2009). CONCLUSION:New MRSA-active antibiotics did not replace old ones, but were added on top. The use of new MRSA-active antibiotics-mainly linezolid-steadily increased over a period of 9 years, although the burden of MRSA stayed stable, as did the proportion of MRSA (%).

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Meyer E,Schwab F,Schroeren-Boersch B,Gastmeier P

doi

10.1007/s00134-011-2335-9

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

1628-32

issue

10

eissn

0342-4642

issn

1432-1238

journal_volume

37

pub_type

杂志文章

相关文献

INTENSIVE CARE MEDICINE文献大全
  • Family members' experiences of "wait and see" as a communication strategy in end-of-life decisions.

    abstract：PURPOSE:The aim of this study is to examine family members' experiences of end-of-life decision-making processes in Norwegian intensive care units (ICUs) to ascertain the degree to which they felt included in the decision-making process and whether they received necessary information. Were they asked about the patient'...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-011-2253-x

    authors： Lind R,Lorem GF,Nortvedt P,Hevrøy O

    更新日期：2011-07-01 00:00:00

  • Acute respiratory distress syndrome mimickers lacking common risk factors of the Berlin definition.

    abstract：PURPOSE:Some patients presenting with acute respiratory failure and meeting the Berlin criteria for acute respiratory distress syndrome (ARDS) lack exposure to common risk factors (CRF). These so-called ARDS mimickers often lack histological diffuse alveolar damage. We aimed to describe such ARDS mimickers lacking CRF ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-015-4064-y

    authors： Gibelin A,Parrot A,Maitre B,Brun-Buisson C,Mekontso Dessap A,Fartoukh M,de Prost N

    更新日期：2016-02-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus bloodstream infections are associated with a higher energy deficit than other ICU-acquired bacteremia.

    abstract：PURPOSE:Caloric insufficiency during the first week of intensive care unit (ICU) stay was reported to be associated with increased infection rates, especially ICU-acquired bloodstream infection (ICU-BSI). However, the predisposition to ICU-BSI by a given pathogen remains not well known. We aimed to determine the impact...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-014-3502-6

    authors： Ekpe K,Novara A,Mainardi JL,Fagon JY,Faisy C

    更新日期：2014-12-01 00:00:00

  • Predictors of mortality and multiple organ failure in children with sepsis.

    abstract：OBJECTIVES:To assess the markers of perfusion which best discriminate survivors from non-survivors of childhood sepsis and to compare the information derived from gastric tonometry with conventionally measured haemodynamic and laboratory parameters. DESIGN:Prospective clinical study of children with sepsis syndrome or...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340050394

    authors： Duke TD,Butt W,South M

    更新日期：1997-06-01 00:00:00

  • Implementation, reliability testing, and compliance monitoring of the Confusion Assessment Method for the Intensive Care Unit in trauma patients.

    abstract：OBJECTIVE:To implement delirium monitoring, test reliability, and monitor compliance of performing the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) in trauma patients. DESIGN AND SETTING:Prospective, observational study in a level 1 trauma unit of a tertiary care, university-based medical center. ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00134-008-1031-x

    authors： Soja SL,Pandharipande PP,Fleming SB,Cotton BA,Miller LR,Weaver SG,Lee BT,Ely EW

    更新日期：2008-07-01 00:00:00

  • Multinational development and validation of an early prediction model for delirium in ICU patients.

    abstract：RATIONALE:Delirium incidence in intensive care unit (ICU) patients is high and associated with poor outcome. Identification of high-risk patients may facilitate its prevention. PURPOSE:To develop and validate a model based on data available at ICU admission to predict delirium development during a patient's complete I...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00134-015-3777-2

    authors： Wassenaar A,van den Boogaard M,van Achterberg T,Slooter AJ,Kuiper MA,Hoogendoorn ME,Simons KS,Maseda E,Pinto N,Jones C,Luetz A,Schandl A,Verbrugghe W,Aitken LM,van Haren FM,Donders AR,Schoonhoven L,Pickkers P

    更新日期：2015-06-01 00:00:00

  • Respiratory variations in the arterial pressure during mechanical ventilation reflect volume status and fluid responsiveness.

    abstract：:Optimal fluid management is one of the main challenges in the care of the critically ill. However, the physiological parameters that are commonly monitored and used to guide fluid management are often inadequate and even misleading. From 1987 to 1989 we published four experimental studies which described a method for ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s00134-014-3285-9

    authors： Perel A,Pizov R,Cotev S

    更新日期：2014-06-01 00:00:00

  • Acquired hemophilia: a rare but life-threatening potential cause of bleeding in the intensive care unit.

    abstract：OBJECTIVE:There are a number of potential etiologies of severe bleeding encountered in the intensive care unit. Although rare, acquired hemophilia is one such etiology that often presents with major bleeding requiring intensive care. Despite the introduction of effective treatments, the reported mortality rate of patie...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s00134-011-2258-5

    authors： Shander A,Walsh CE,Cromwell C

    更新日期：2011-08-01 00:00:00

  • Variability in the concentrations of intravenous drug infusions prepared in a critical care unit.

    abstract：OBJECTIVE:To quantify the variability in the concentration of drug infusions prepared on an intensive care unit and establish whether there was a relationship between the quality of syringe labeling and drug preparation. DESIGN:Audit carried out over 3 weeks in May 2006 and completed in May 2007. SETTING:The adult ne...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-008-1113-9

    authors： Wheeler DW,Degnan BA,Sehmi JS,Burnstein RM,Menon DK,Gupta AK

    更新日期：2008-08-01 00:00:00

  • Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part II. Treatment.

    abstract：BACKGROUND:Invasive candidiasis and candidemia are frequently encountered in the nosocomial setting particularly in the intensive care unit (ICU). OBJECTIVE AND METHODS:To review the current management of invasive candidiasis and candidemia in non-neutropenic adult ICU patients based on a review of the literature and ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s00134-008-1339-6

    authors： Guery BP,Arendrup MC,Auzinger G,Azoulay E,Borges Sá M,Johnson EM,Müller E,Putensen C,Rotstein C,Sganga G,Venditti M,Zaragoza Crespo R,Kullberg BJ

    更新日期：2009-02-01 00:00:00

  • Patients' preferences concerning medical information and surrogacy: results of a prospective study in a French emergency department.

    abstract：OBJECTIVE:To study the wishes of a sample of French patients about medical information and surrogacy, at a time when the French Ministry of Health is supporting increased patient autonomy. DESIGN:A cohort of competent patients with non-critical illnesses or injuries completed an intention-to-act questionnaire on the a...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340050011

    authors： Roupie E,Santin A,Boulme R,Wartel JS,Lepage E,Lemaire F,Lejonc JL,Montagne O

    更新日期：2000-01-01 00:00:00

  • Invasive group A streptococcal disease and intensive care unit admissions.

    abstract：OBJECTIVE:To determine the clinical epidemiology of invasive group A streptococcal disease (IGASD) and identify predictors of admissions into an intensive care unit (ICU). DESIGN:A cross-sectional study. SETTING:Retrospective review of data. PATIENTS:A total of 204 patients hospitalized throughout the state of Flori...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-002-1538-5

    authors： Mulla ZD

    更新日期：2002-12-01 00:00:00

  • Anti-phospholipid antibodies in serum from patients with Guillain-Barré syndrome.

    abstract：OBJECTIVE:The Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy related to autoimmunity. However, no conclusive etiological concept has yet been found. We examined the variation in autoantibodies to lipids in serum of GBS patients in response to the course of the disease but investigated titer modif...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-005-2736-8

    authors： Nakos G,Tziakou E,Maneta-Peyret L,Nassis C,Lekka ME

    更新日期：2005-10-01 00:00:00

  • Volumetric capnography as a bedside monitoring of thrombolysis in major pulmonary embolism.

    abstract：OBJECTIVE:To describe the use of volumetric capnography, a plot of expired CO(2) concentration against expired volume, in monitoring fibrinolytic treatment of major pulmonary embolism. DESIGN AND SETTING:Two case reports in the emergency department of a teaching hospital. PATIENTS:Two conscious and spontaneously brea...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-004-2444-9

    authors： Verschuren F,Heinonen E,Clause D,Roeseler J,Thys F,Meert P,Marion E,El Gariani A,Col J,Reynaert M,Liistro G

    更新日期：2004-11-01 00:00:00

  • In vitro activity of fleroxacin against multiresistant gram-negative bacilli isolated from patients with nosocomial infections.

    abstract：:In order to evaluate the in vitro activity of fleroxacin against nosocomial gram-negative organisms, 263 multiresistant gram-negative bacilli (203 Enterobacteriaceae and 60 non-fermenting gram-negative bacilli) were isolated from adult patients with nosocomial infections. The different patterns of resistance to eight ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340050675

    authors： Araque M,Velazco E

    更新日期：1998-08-01 00:00:00

  • End-of-life decision making in the intensive care unit.

    abstract：:Physicians are increasingly involved in how their critically ill patients die [72]. The more this happens, the more physicians will have to understand not only how their own backgrounds and biases influence their medical management, but also the cultural and religious backgrounds of the patient and surrogate [72, 73]....

    journal_title：Intensive care medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s001340000641

    authors： Nyman DJ,Sprung CL

    更新日期：2000-10-01 00:00:00

  • Effects of pulmonary blood volume on vascular reactivity in the lung.

    abstract：OBJECTIVE:Pulmonary flow resistance is mainly determined by vessel calibres, resulting from the interaction of volume-passive distension and active vasomotion. However, quantitative information on the interplay between these counteracting forces in the lung is lacking. Therefore, we aimed at quantifying (1) the effects...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340051090

    authors： Ding ZP,Scheeren TW,Arndt JO

    更新日期：1999-12-01 00:00:00

  • The effect of sepsis and its inflammatory response on mechanical clot characteristics: a prospective observational study.

    abstract：PURPOSE:Sepsis and its progression are known to have a major influence on the coagulation system. Current coagulation tests are of limited use when assessing coagulation in sepsis patients. This study aims to assess the potential for a new functional biomarker of clot microstructure, fractal dimension, to identify chan...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-016-4496-z

    authors： Davies GR,Pillai S,Lawrence M,Mills GM,Aubrey R,D'Silva L,Battle C,Williams R,Brown R,Thomas D,Morris K,Evans PA

    更新日期：2016-12-01 00:00:00

  • Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema.

    abstract：OBJECTIVE:The primary objective was to test the hypothesis that clinical re-expansion pulmonary edema is predominantly due to increased permeability of the alveolar-capillary barrier. A secondary objective was to determine if the alveolar epithelium was functionally intact in patients with re-expansion pulmonary edema ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-004-2379-1

    authors： Sue RD,Matthay MA,Ware LB

    更新日期：2004-10-01 00:00:00

  • Ultrasound evaluation of central veinsin the intensive care unit:effects of dynamic manoeuvres.

    abstract：OBJECTIVE:To determine: (1) the proportion of small (<5 mm) or thrombosed internal jugular veins (IJV) and femoral veins (FV) in which catheter placement would be difficult without ultrasound guidance; (2) which position increases central vein sizes and may facilitate cannulation of these vessels. DESIGN:Prospective s...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-007-0875-9

    authors： Samy Modeliar S,Sevestre MA,de Cagny B,Slama M

    更新日期：2008-02-01 00:00:00

  • Improving ultrasonic measurement of diaphragmatic excursion after cardiac surgery using the anatomical M-mode: a randomized crossover study.

    abstract：PURPOSE:Motion-mode (MM) echography allows precise measurement of diaphragmatic excursion when the ultrasound beam is parallel to the diaphragmatic displacement. However, proper alignment is difficult to obtain in patients after cardiac surgery; thus, measurements might be inaccurate. A new imaging modality named the a...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00134-014-3625-9

    authors： Pasero D,Koeltz A,Placido R,Fontes Lima M,Haun O,Rienzo M,Marrache D,Pirracchio R,Safran D,Cholley B

    更新日期：2015-04-01 00:00:00

  • Monitoring of neuromuscular blockade: a comparison of train-of-four and the Campbell diagram.

    abstract：: ...

    journal_title：Intensive care medicine

    pub_type： 信件

    doi：10.1007/s00134-018-5420-5

    authors： Baedorf Kassis E,Train S,MacNeil B,Loring SH,Talmor D

    更新日期：2018-12-01 00:00:00

  • Acute hypoxemic respiratory failure in children: case mix and the utility of respiratory severity indices.

    abstract：OBJECTIVE:Acute hypoxemic respiratory failure (AHRF) is a common reason for emergency pediatric intensive care. An objective assessment of disease severity from acute physiological parameters would be of value in clinical practice and in the design of clinical trials. We hypothesised that there was a difference in the ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340050647

    authors： Peters MJ,Tasker RC,Kiff KM,Yates R,Hatch DJ

    更新日期：1998-07-01 00:00:00

  • Will my patient survive? Look for creatinine in the urine!

    abstract：: ...

    journal_title：Intensive care medicine

    pub_type： 评论,社论

    doi：10.1007/s00134-018-5399-y

    authors： Darmon M,Kashani K,Schetz M

    更新日期：2018-11-01 00:00:00

  • Early and late onset bacteremia have different risk factors in trauma patients.

    abstract：OBJECTIVE:The aim of this study was to identify risk factors and to describe epidemiological patterns for early-(EOB) and late-onset bacteremias (LOB) after trauma. DESIGN:A prospective study conducted on 141 consecutive trauma patients. SETTING:A general intensive care unit (ICU) of a university hospital. PATIENTS:...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01709514

    authors： Antonelli M,Moro ML,D'Errico RR,Conti G,Bufi M,Gasparetto A

    更新日期：1996-08-01 00:00:00

  • Delayed cerebral thrombosis in bacterial meningitis: a prospective cohort study.

    abstract：PURPOSE:To study the incidence and clinical characteristics of delayed cerebral thrombosis in bacterial meningitis patients. METHODS:We assessed the incidence and clinical characteristics of delayed cerebral thrombosis in adults with cerebrospinal fluid (CSF) culture-proven community-acquired bacterial meningitis incl...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-012-2792-9

    authors： Lucas MJ,Brouwer MC,van de Beek D

    更新日期：2013-05-01 00:00:00

  • Current management and outcome of tracheobronchial malacia and stenosis presenting to the paediatric intensive care unit.

    abstract：OBJECTIVE:To identify factors associated with mortality and prolonged ventilatory requirements in patients admitted to our paediatric intensive care unit (PICU) with tracheobronchial malacia and stenosis diagnosed by dynamic contrast bronchograms. DESIGN:Retrospective review. SETTING:Tertiary paediatric intensive car...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340000822

    authors： Inwald DP,Roebuck D,Elliott MJ,Mok Q

    更新日期：2001-04-01 00:00:00

  • Decreased circulating levels of von Willebrand factor after intravenous administration of a rapidly degradable hydroxyethyl starch (HES 200/0.5/6) in healthy human subjects.

    abstract：OBJECTIVE:Impairment of haemostasis has been described with slowly degradable medium molecular weight hydroxyethyl starch (MMW-HES), whereas rapidly degradable MMW-HES is generally considered to have no important effects on blood coagulation. This study was undertaken to investigate the effects of a rapidly degradable ...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s001340101107

    authors： de Jonge E,Levi M,Büller HR,Berends F,Kesecioglu J

    更新日期：2001-11-01 00:00:00

  • Impact of hypoxic hepatitis on mortality in the intensive care unit.

    abstract：PURPOSE:Hypoxic hepatitis (HH) is a form of hepatic injury following arterial hypoxemia, ischemia, and passive congestion of the liver. We investigated the incidence and the prognostic implications of HH in the medical intensive care unit (ICU). METHODS:A total of 1,066 consecutive ICU admissions at three medical ICUs...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-011-2248-7

    authors： Fuhrmann V,Kneidinger N,Herkner H,Heinz G,Nikfardjam M,Bojic A,Schellongowski P,Angermayr B,Schöniger-Hekele M,Madl C,Schenk P

    更新日期：2011-08-01 00:00:00

  • Urgent bedside endoscopy for clinically significant upper gastrointestinal hemorrhage after admission to the intensive care unit.

    abstract：OBJECTIVE:To investigate the sources of hemorrhage and use of endoscopic hemostasis in patients with clinically significant upper gastrointestinal (UGI) hemorrhage after admission to the intensive care unit (ICU). DESIGN AND SETTING:Prospective study, 123 beds of ICU in a 1,629-bed medical center. MEASUREMENTS AND RE...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-003-1921-x

    authors： Lee YC,Wang HP,Wu MS,Yang CS,Chang YT,Lin JT

    更新日期：2003-10-01 00:00:00