Abstract：
OBJECTIVE:The primary objective was to test the hypothesis that clinical re-expansion pulmonary edema is predominantly due to increased permeability of the alveolar-capillary barrier. A secondary objective was to determine if the alveolar epithelium was functionally intact in patients with re-expansion pulmonary edema by measuring net alveolar epithelial fluid transport in a subset of patients. DESIGN:Retrospective study of mechanically ventilated patients with re-expansion pulmonary edema. SETTING:Two academic tertiary care hospitals. PATIENTS:Seven patients with acute onset of re-expansion pulmonary edema after tube thoracostomy or thoracentesis. INTERVENTIONS:Pulmonary edema fluid and plasma were collected at the time of onset of re-expansion edema. MEASUREMENTS AND RESULTS:Contrary to our hypothesis, the mean initial edema fluid to plasma protein ratio was 0.58+/-0.21, supporting a hydrostatic mechanism of edema formation. Four of the patients had an initial edema fluid to plasma protein ratio of less than 0.65, consistent with pure hydrostatic pulmonary edema, while the others had a slight increase in permeability (edema fluid to plasma ratios of 0.67, 0.71 and 0.77), perhaps due to capillary stress failure from hydrostatic stress. Alveolar fluid clearance (mean 9.8+/-8.0%/h) was intact in the subset of three patients in whom it was measured. CONCLUSIONS:This study provides the first direct evidence that hydrostatic forces may contribute to the development of re-expansion pulmonary edema.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Sue RD,Matthay MA,Ware LBdoi
10.1007/s00134-004-2379-1keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
1921-6issue
10eissn
0342-4642issn
1432-1238journal_volume
30pub_type
杂志文章abstract：:In the first study 6 patients with raised intracranial pressure due to brain oedema following head injury were given dihydroergotamine because of low perfusion pressure. The intracranial pressure fell simultaneously with the increase in arterial pressure. The intracranial pressure fell from 24 +/- 2 mmHg by a maximum ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00273564
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:To assess whether monitoring of bladder epithelial oxygen tension (BEOT) would provide an indication of regional (renal) organ perfusion in an exsanguination/fluid repletion animal model. DESIGN:Prospective non-randomized laboratory study. SETTING:Research laboratory. INTERVENTIONS:Eight anaesthetised, spo...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01700454
更新日期：1996-04-01 00:00:00
abstract：:An 18-month-old male infant presented with hypoglycemic coma and clinical signs of bronchopneumonia. He was suspected of suffering from septic shock. The patient progressed to irreversible multiple organ failure before the diagnosis of adrenal crisis was established. Plasma levels of ACTH and cortisol remained undetec...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050021
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:Postoperative pneumonia is a potentially devastating complication associated with high mortality in intensive care unit (ICU)-patients. One of the major predisposing factors is the perioperative occurrence of atelectatic formations in non-dependent lung areas. Perioperative ventilation/perfusion mismatch due ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-008-1122-8
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:To examine the relationship of fluid balance and weaning outcomes. METHODS:We prospectively collected demographic, physiological, daily fluid balance (measured inputs minus outputs), and weaning data from 87 mechanically ventilated patients. PATIENTS:We examined 87 patients, a median age of 66 years, APACHE...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-005-2801-3
更新日期：2005-12-01 00:00:00
abstract：OBJECTIVE:The role of critical care pharmacists in the United States has recently been documented; however, little information exists about the role of international critical care pharmacists. The objective of this study was to describe the duties and activities of international pharmacists who practice in critical car...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-007-0918-2
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:To define the mechanisms of the stable and prolonged post-operative plasma volume expansion observed with Hydroxyethyl Starches (HES) and to determine whether a partial intravascular hydrolysis of large molecules contribute to reinforce the colloid-osmotic effect. DESIGN:Prospective, pharmacologic study usin...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF01700163
更新日期：1995-07-01 00:00:00
abstract：:Fifteen polytrauma patients with asymmetric pulmonary contusion were treated with differential lung ventilation (DLV) for a mean of 106 hours (range 24-298, median 83). The differential time constant (Tc), compliance (Ct), inspiratory and expiratory airway resistance (Rawinsp, Rawexp) and peak-airway pressure (Pawpeak...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00255602
更新日期：1989-01-01 00:00:00
abstract：PURPOSE:Relatives of intensive care unit (ICU) patients suffer emotional distress that impairs their ability to acquire the information they need from the staff. We sought to evaluate whether providing relatives with a list of important questions was associated with better comprehension on day 5. METHODS:Randomized, p...
journal_title：Intensive care medicine
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00134-018-5423-2
更新日期：2018-11-01 00:00:00
abstract：:Hemorrhagic complications from transection of cervical arteries in blunt traumas are rare. We report a case of potentially fatal hemorrhage from rupture of the left vertebral artery in a closed trauma, successfully treated by endovascular injection of glue. Endovascular embolization may be considered as an alternative...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051033
更新日期：1999-10-01 00:00:00
abstract：:Of 28 consecutive patients over 64 years old, in whom endoscopy revealed gastro-duodenal ulcers with signs of recent hemorrhage (active bleeding, non-bleeding vessel or adherent clot), 14 were randomly assigned to receive endoscopic alcoholization of the lesions preceded by intragastric instillation of norepinephrine,...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01724799
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVE:To measure water balance and changes in distribution, and the effect of giving supplementary albumin, early after a burn injury. DESIGN:Consecutive patients (matched groups) and healthy controls. SETTING:National burn unit in a Swedish university hospital. PATIENTS AND SUBJECTS:Eighteen patients with 18%-9...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340100935
更新日期：2001-05-01 00:00:00
abstract：:We studied the effect of thiopental loading during resuscitation of 53 patients following cardiopulmonary arrest and compared the outcome with that found in 54 patients treated conventionally in the 30 previous months. Thiopental therapy (10 mg/kg i.v.) was begun within 30 min of the arrest once hemodynamic stability ...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF00265112
更新日期：1987-01-01 00:00:00
abstract：: ...
journal_title：Intensive care medicine
pub_type： 信件
doi：10.1007/s00134-018-5420-5
更新日期：2018-12-01 00:00:00
abstract：INTRODUCTION:Most anxiolytics and sedative regimens in the intensive care unit (ICU) impair intellectual function, reducing patient autonomy, and often add to patient morbidity. Using an ICU-validated cognitive assessment tool Adapted Cognitive Exam (ACE), we performed a comparison between dexmedetomidine (DEX) and pro...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00134-010-1874-9
更新日期：2010-09-01 00:00:00
abstract：:The treatment of severe tetanus with autonomic dysfunction is discussed, with emphasis on the use of magnesium sulphate. An exemplary case is reported, describing the inadequate response to magnesium, but the previously unreported and successful use of clonidine to control sympathetic overactivity. The properties of c...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/BF02575297
更新日期：1990-01-01 00:00:00
abstract：PURPOSE:Computerized clinical decision support systems (CDSS) for intensive insulin therapy (IIT) generate recommendations using blood glucose (BG) values manually transcribed from testing devices to computers, a potential source of error. We quantified the frequency and effect of blood glucose transcription mismatches...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-010-1868-7
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVE:Candidemia is increasingly encountered in critically ill patients with a high fatality rate. The available data in the critically ill suggest that patients with prior surgery are at a higher risk than others. However, little is known about candidemia in medical settings. The main goal of this study was to com...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-003-2002-x
更新日期：2003-12-01 00:00:00
abstract：:Myxoedema coma is a medical emergency with high mortality. In this study, clinical response and plasma variations of thyroid hormones were analysed in 7 patients, 6 presenting with myxoedema coma and one with myxoedema ileus. These patients were treated with intravenous or oral l-thyroxine (l-T4). 1000 mu l-T4 iv were...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01708403
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:a) to describe a non-barotraumatic ventilatory setting for independent lung ventilation (ILV); b) to determine the utility of single lung end-tidal CO(2) (EtCO(2)) monitoring to evaluate the ventilation to perfusion (V/Q) matching in each lung during ILV and for ILV weaning. DESIGN:prospective study. SETTIN...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s00134-001-1149-6
更新日期：2001-12-01 00:00:00
abstract：:In the past two years several guidelines for suggested components of emergency medical systems for children have been suggested, and for the first time, specific standards of pediatric trauma care have also been formulated. The American Academy of Pediatrics new Provisional Committee on Emergency Medicine has been cha...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00260888
更新日期：1989-01-01 00:00:00
abstract：:We report the intensive care management of 23 children (age 3-15 years) following orthotopic heart (HT) and combined heart and lung transplantation (HLT) performed at our 2 institutes between February 1985 and August 1989. Cyclosporin A, azathioprine and steroids were given as routine immunosuppression, whilst anti-th...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01711219
更新日期：1990-01-01 00:00:00
abstract：:Arterial blood ketone body ratio, reflecting hepatic mitochondrial redox state, was measured in 26 brain-dead patients who were hypotensive but hemodynamically stable. All of them had substantially normal hepatic function. In 18 of the patients, blood ketone body ratio was maintained within the normal range in spite o...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01691432
更新日期：1991-01-01 00:00:00
abstract：PURPOSE:To estimate the direct and indirect (contextual) effects of the factorized constituents of selective digestive decontamination and selective oropharyngeal decontamination (SDD/SOD), being topical antibiotic (TA) and protocolized antifungal prophylaxis (PAFP), on ICU-acquired candidemia. METHODS:A broad range o...
journal_title：Intensive care medicine
pub_type： 杂志文章,meta分析
doi：10.1007/s00134-015-4004-x
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of nicotinamide (NIC), an inhibitor of poly(ADP-ribose) synthetase (PARS), on intestinal and liver perfusion, O2 kinetics, and energy metabolism over 24 h of hyperdynamic porcine endotoxemia. DESIGN:Prospective, randomized, controlled experimental study with repeated measures. SET...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000842
更新日期：2001-03-01 00:00:00
abstract：:A case of metabolic acidosis, acute renal failure and hepatic failure following paracetamol ingestion is presented. The diagnostic difficulty at presentation is highlighted. Continuous arteriovenous haemofiltration proved a valuable means of maintaining fluid and electrolyte balance. The patient recovered. ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00262905
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:To compare the effects of patient-initiated, pressure-regulated, volume-controlled ventilation (PRVC) with pressure-preset intermittent mandatory ventilation (IMV) in neonates with respiratory failure. DESIGN:Randomised, prospective study. SETTING:Intensive care unit (14 beds) in a 300-bed paediatric teachi...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s001340050441
更新日期：1997-09-01 00:00:00
abstract：OBJECTIVE:Evaluation of an open circuit multiple breath nitrogen washout (MBNW) technique for measurement of functional residual capacity (FRC) during partial ventilatory support using corrections for gas viscosity, sampling delay time, and re-inspired nitrogen. DESIGN:Measurements in a lung model with known reference...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-003-1677-3
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVE:To determine the frequency and the eventual clinical characteristics of nosocomial sinusitis with anaerobic bacteria isolation in patients in the intensive care unit (ICU). DESIGN:Retrospective study. SETTING:A 12-bed medical ICU in a teaching hospital. PATIENTS:30 adult patients with documented nosocomial...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051013
更新日期：1999-10-01 00:00:00
abstract：OBJECTIVES:Diagnosing persistent acute kidney injury (AKI) as opposed to transient AKI in critically ill patients may help physicians in making treatment decisions. This diagnosis relies chiefly on urinary indices, which may be of limited value or difficult to obtain. We assessed the performance of the Doppler renal re...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-010-2050-y
更新日期：2011-01-01 00:00:00
