Abstract：
OBJECTIVE:To assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers. DESIGN:Two groups of eight healthy subjects were randomized to receive either two pharmacological doses of intravenous FO fat emulsion or no treatment. The FO group received twice 0.5 g/kg 10% emulsion (Omegaven) 48 and 24h before investigation. LPS (2 ng/kg) was injected as a bolus on the investigation day. Systemic parameters, indirect calorimetry, heart rate variability, and platelet membrane phospholipid composition were measured. RESULTS:Basal EPA and DHA content in platelet phospholipids was low (0.28% and 2.54%, respectively) and increased significantly after FO to 1.68% and 3.32%. LPS induced reproducible effects in all subjects. Fever was higher in the control [corrected] group than in FO group [corrected] the difference was significant from t (120) until t (360). FO blunted the neuroendocrine response: the rise in plasma norepinephrine was sevenfold lower at t (120) while the ACTH peak was fourfold lower. Tumor necrosis factor alpha was significantly lower between t (360) and t (180) in the FO group. CONCLUSIONS:Two doses of intravenous FO fat emulsion modified the phospholipid composition of platelets in healthy subjects. FO blunted fever and increased the neuroendocrine and the inflammatory responses to LPS.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Pluess TT,Hayoz D,Berger MM,Tappy L,Revelly JP,Michaeli B,Carpentier YA,Chioléro RLdoi
10.1007/s00134-007-0591-5subject
Has Abstractpub_date
2007-05-01 00:00:00pages
789-797issue
5eissn
0342-4642issn
1432-1238pii
10.1007/s00134-007-0591-5journal_volume
33pub_type
杂志文章,随机对照试验abstract：OBJECTIVES:To establish priorities for research in critical care medicine in the UK using survey and nominal group (NG) techniques. DESIGN:The senior doctor and nurse from 325 intensive care units (ICUs) in the UK were invited to contribute up to ten research questions relevant to intensive care organisation, practice...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000628
更新日期：2000-10-01 00:00:00
abstract：OBJECTIVE:Intracerebral hemorrhage (ICH) is associated with a high mortality. The present study sought to determine the incidence of spontaneous ICH in an intensive care unit (ICU) and associated factors. DESIGN:A 6 year retrospective study. SETTING:A general ICU in a university hospital. PATIENTS:All ICU patients d...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050788
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:To assess the safety and efficacy of sustained inflations (SI) as lung recruitment maneuvers (RMs) in ventilated pediatric intensive care unit (PICU) patients. DESIGN:Observational, prospective data collection. SETTING:Tertiary-care PICU. PATIENTS AND PARTICIPANTS:Thirty-two consecutive ventilated pediatri...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-007-0764-2
更新日期：2007-10-01 00:00:00
abstract：PURPOSE:Septic shock induces a decrease in dendritic cells (DCs) that may contribute to sepsis-induced immunosuppression. We analyzed the time course of circulating DCs in patients with septic shock and its relation to susceptibility to intensive care unit (ICU)-acquired infections. METHODS:We enrolled adult patients ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-011-2306-1
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVE:Biomarkers allowing accurate early staging of septic shock patients are lacking despite their obvious interest for patient management. Experimental models of septic shock in mouse previously noted a decrease in dendritic cell numbers. The aim of the study was to find a rapid reproducible biological test for a...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-006-0436-7
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of prone positioning on systemic hemodynamics, intra-abdominal pressure (IAP), plasma disappearance rate of indocyanine green (PDR(ICG)), and gastric intramucosal to arterial PCO2 difference (Pi-aCO2). DESIGN AND SETTING:Prospective randomized study in the intensive care unit of a ...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00134-001-1166-5
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:To investigate whether serum procalcitonin (PCT) levels could be useful to differentiate between systemic infection and the activity of the underlying disease in autoimmune disease. METHODS:In 18 patients with systemic lupus erythematodes (SLE) and 35 patients with systemic antineutrophil cytoplasmic antibod...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF02900738
更新日期：2000-03-01 00:00:00
abstract：:The original version of this article unfortunately contained a mistake. ...
journal_title：Intensive care medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00134-020-06009-2
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate the neuropathological outcome of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to i...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-010-1913-6
更新日期：2010-09-01 00:00:00
abstract：PURPOSE:To use the World Health Organisation's International Classification of Functioning to measure disability following critical illness using patient-reported outcomes. METHODS:A prospective, multicentre cohort study conducted in five metropolitan intensive care units (ICU). Participants were adults who had been a...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s00134-017-4830-0
更新日期：2017-07-01 00:00:00
abstract：: ...
journal_title：Intensive care medicine
pub_type： 信件
doi：10.1007/s00134-018-5180-2
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:To examine the association of intravenous iodinated contrast material administration with the subsequent development of post-contrast AKI (PC-AKI), emergent dialysis, and short-term mortality using a propensity score-adjusted analysis of a cohort of intensive care unit (ICU) patients who underwent CT examinatio...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-017-4699-y
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:To obtain insight into the occurrence of brain death and the potential for brain dead and controlled non-heart-beating organ donors (CNHB) in patients with traumatic brain injury (TBI), subarachnoid haemorrhage (SAH) and intracerebral haemorrhage (ICH) in a large neurosurgical serving area (2.1 million inhabi...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-005-0001-9
更新日期：2006-02-01 00:00:00
abstract：:Since the introduction of synchronized intermittent mandatory ventilation (SIMV) several advantages have been attributed to this ventilatory mode, one of them being a more homogeneous distribution of ventilation and perfusion than during controlled mechanical ventilation (CMV). Up to now no data are available to confi...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01704716
更新日期：1991-01-01 00:00:00
abstract：: ...
journal_title：Intensive care medicine
pub_type： 社论
doi：10.1007/s00134-018-5401-8
更新日期：2018-12-01 00:00:00
abstract：:Peritonitis has been produced in rabbits by the spreading of 5 ml of caecal contents throughout the peritoneal cavity. After sacrifice at 5 h, electron microscopy revealed a increase of 600% in PMN and 1200% in lymphocytes in the pulmonary capillaries of the test animals when compared to the sham operated group. The p...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00265119
更新日期：1987-01-01 00:00:00
abstract：INTRODUCTION:Most anxiolytics and sedative regimens in the intensive care unit (ICU) impair intellectual function, reducing patient autonomy, and often add to patient morbidity. Using an ICU-validated cognitive assessment tool Adapted Cognitive Exam (ACE), we performed a comparison between dexmedetomidine (DEX) and pro...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00134-010-1874-9
更新日期：2010-09-01 00:00:00
abstract：:Helicobacter pylori is estimated to infect over 50% of the world's population, the majority of whom are asymptomatic. Although most research to date has focused on local gastroduodenal disease manifestations, the potential impact of H. pylori infection and the associated chronic active inflammation on systemic disease...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-003-1838-4
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVE:To quantify the variability in the concentration of drug infusions prepared on an intensive care unit and establish whether there was a relationship between the quality of syringe labeling and drug preparation. DESIGN:Audit carried out over 3 weeks in May 2006 and completed in May 2007. SETTING:The adult ne...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-008-1113-9
更新日期：2008-08-01 00:00:00
abstract：:608 patients admitted to a general Intensive Care Unit (ICU) over a 30 month period were analyzed according to the Apache II Severity of Disease Classification System on day one of admission. Hospital outcome details were available on 583 patients in the series. The mean Apache II scores for survivors (396) and non-su...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00263531
更新日期：1988-01-01 00:00:00
abstract：:A veno-venous to-and-fro bypass method through a single blood access for extracorporeal lung assist with an artificial membrane lung is introduced. A premature newborn with severe respiratory distress was treated with this method. A 12 Fr. single lumen catheter with a spiral-embedded thin-wall, 0.25 mm in wall thickne...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00271065
更新日期：1989-01-01 00:00:00
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journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1331-5
更新日期：2002-07-01 00:00:00
abstract：:Nosocomial pneumonia continues to represent a significant cause of morbidity and mortality in hospitalized patients. Bacteria are responsible for greater than 90% of the pneumonias, the most common isolates being aerobic Gram-negative bacilli and S. aureus. Cornerstones of treatment are intravenous antibiotics and sup...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/BF01752974
更新日期：1992-01-01 00:00:00
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journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01705416
更新日期：1995-04-01 00:00:00
abstract：OBJECTIVE:To determine the magnitude and time course of adrenergic effects on metabolism in volunteers and possible implications for the use of sympathomimetics in the critically ill. DESIGN:Descriptive laboratory investigation. SUBJECTS:7 volunteers. INTERVENTION:Primed continuous infusions of stable isotope tracer...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01707665
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVE:The aim of the present study was (1) to determine the prevalence of intensive care unit (ICU) admissions due to an adverse drug reaction (ADR), and (2) to compare affected patients with patients admitted to the ICU for the treatment of deliberate self-poisoning using medical drugs. DESIGN:Prospective observa...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-008-1250-1
更新日期：2009-02-01 00:00:00
abstract：:This narrative review focuses on thoracic ultrasonography (lung and pleural) with the aim of outlining its utility for the critical care clinician. The article summarizes the applications of thoracic ultrasonography for the evaluation and management of pneumothorax, pleural effusion, acute dyspnea, pulmonary edema, pu...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-019-05725-8
更新日期：2019-09-01 00:00:00
abstract：:Two patients with severe hepatic and renal failure underwent emergency hepatic retransplantation (2nd and 6th day after transplantation). Continuous arteriovenous haemodialysis was begun before surgery and successfully performed, without any incident, during the retransplantation with a biospal (SCU/CAVH AN 69 S) devi...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01706360
更新日期：1990-01-01 00:00:00
abstract：:Extracorporeal life support (ECLS) can support gas exchange in patients with the acute respiratory distress syndrome (ARDS). During ECLS, venous blood is drained from a central vein via a cannula, pumped through a semipermeable membrane that permits diffusion of oxygen and carbon dioxide, and returned via a cannula to...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-020-06290-1
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:To assess the relationship between the base deficit value in the immediate postoperative period of coronary surgery for cardiopulmonary bypass and the length of stay in the ICU. DESIGN AND SETTING:Prospective descriptive study in the department of anesthesia and cardiovascular surgery of a university hospita...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1587-9
更新日期：2003-02-01 00:00:00
