Could resuscitation be based on microcirculation data? We are not sure.

abstract：OBJECTIVE:To determine the relationship between the clinically evaluated depth of midazolam-induced sedation and the cardiac beat-to-beat variability (RR variability) in ICU patients in the intensive care unit (ICU). DESIGN:Prospective study. SETTING:ICU of a university hospital. PATIENTS:20 consecutive patients stu...

journal_title：Intensive care medicine

authors： Haberthür C,Lehmann F,Ritz R

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:To obtain insight into the occurrence of brain death and the potential for brain dead and controlled non-heart-beating organ donors (CNHB) in patients with traumatic brain injury (TBI), subarachnoid haemorrhage (SAH) and intracerebral haemorrhage (ICH) in a large neurosurgical serving area (2.1 million inhabi...

journal_title：Intensive care medicine

authors： Kompanje EJO,Bakker J,Slieker FJA,IJzermans JNM,Maas AIR

更新日期：2006-02-01 00:00:00

abstract：:Specific regulations regarding oversight of research in children vary from country to country, but most share common principles derived from major consensus documents. Whereas the permissibility of research on adults depends heavily upon the informed consent of the subject, the regulation of research in pediatrics is ...

journal_title：Intensive care medicine

authors： Truog RD

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:To estimate the direct and indirect (contextual) effects of the factorized constituents of selective digestive decontamination and selective oropharyngeal decontamination (SDD/SOD), being topical antibiotic (TA) and protocolized antifungal prophylaxis (PAFP), on ICU-acquired candidemia. METHODS:A broad range o...

journal_title：Intensive care medicine

authors： Hurley JC

更新日期：2015-11-01 00:00:00

abstract：:The abundance of literature related to nutritional support reflects its recently recognised role in preventing metabolic complications and gut dysfunction during critical illness. However, some published studies lack relevance to critically ill patients, as a result of the selection of subjects and outcome variables, ...

journal_title：Intensive care medicine

authors： Preiser JC,Chioléro R,Wernerman J,ESICM(European Society of Intensive Care Medicine) Working Group on Nutrition and Metabolism.

更新日期：2003-02-01 00:00:00

abstract：:Streptococcus pneumoniae is responsible for two-thirds of ICU admissions due to community-acquired pneumonia (CAP) and is the leading cause of CAP-related death. Early death is principally due to cardiovascular collapse, whereas late death is associated with hypoxemic respiratory failure. Outcome depends on interactio...

journal_title：Intensive care medicine

authors： Luján M,Gallego M,Rello J

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:We evaluated whether oscillatory compliance (C(X5)) measured by forced oscillation technique (FOT) at 5 Hz may be useful for positive end-expiratory pressure (PEEP) optimisation. METHODS:We studied seven pigs in which lung injury was induced by broncho-alveolar lavage. The animals were ventilated in volume con...

journal_title：Intensive care medicine

authors： Dellacà RL,Zannin E,Kostic P,Olerud MA,Pompilio PP,Hedenstierna G,Pedotti A,Frykholm P

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:This study assessed parameters of free radical damage to biomolecules, mitochondrial superoxide production, superoxide dismutase, and catalase activities and their relationship to sepsis mortality. DESIGN AND SETTING:Prospective animal study in a university laboratory for experimental. SUBJECTS:140 male Wis...

journal_title：Intensive care medicine

authors： Ritter C,Andrades M,Frota Júnior ML,Bonatto F,Pinho RA,Polydoro M,Klamt F,Pinheiro CT,Menna-Barreto SS,Moreira JC,Dal-Pizzol F

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the sensitivity, specificity and overall accuracy of a model based on the presence or absence of organ dysfunctions and/or infection (ODIN) to predict the outcome for intensive care unit patients. DESIGN:Prospective study. SETTING:General intensive care unit in a university teaching hospital. P...

journal_title：Intensive care medicine

authors： Fagon JY,Chastre J,Novara A,Medioni P,Gibert C

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To evaluate the development of demographics and outcome of very old (>80 years) critically ill patients admitted to intensive care units. SETTING:All consecutive patients admitted to 41 Austrian intensive care units (ICUs) over an 11-year period. METHODS:We performed a retrospective cohort study of prospectiv...

journal_title：Intensive care medicine

authors： Ihra GC,Lehberger J,Hochrieser H,Bauer P,Schmutz R,Metnitz B,Metnitz PG

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:Frail patients are known to experience poor outcomes. Nevertheless, we know less about how frailty manifests itself in patients' physiology during critical illness and how it affects resource use in intensive care units (ICU). We aimed to assess the association of frailty with short-term outcomes and organ supp...

journal_title：Intensive care medicine

authors： Zampieri FG,Iwashyna TJ,Viglianti EM,Taniguchi LU,Viana WN,Costa R,Corrêa TD,Moreira CEN,Maia MO,Moralez GM,Lisboa T,Ferez MA,Freitas CEF,de Carvalho CB,Mazza BF,Lima MFA,Ramos GV,Silva AR,Bozza FA,Salluh JIF,Soar

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Patients undergoing cardiac surgery often require transfusions of red blood cells, plasma and platelets. These components differ widely in both indications for use and composition. However, from a statistical point of view there is a significant colinearity between the components. This study explores the relati...

journal_title：Intensive care medicine

authors： Bjursten H,Dardashti A,Ederoth P,Brondén B,Algotsson L

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of two different comorbidity measures on the 6-month mortality of severely ill cancer patients. DESIGN AND SETTING:Prospective cohort study in a ten-bed oncological medical-surgical intensive care unit (ICU). PATIENTS:A total of 772 consecutive patients were included over a 45-month p...

journal_title：Intensive care medicine

authors： Soares M,Salluh JI,Ferreira CG,Luiz RR,Spector N,Rocco JR

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:Type 1 angiotensin II (AT1) receptor antagonists have anti-inflammatory effects in vitro and in patients. The purpose of this study was to investigate whether losartan (LOS), an AT1 receptor antagonist, reduces lung damage by inhibiting the induction of high mobility group box 1 (HMGB1) protein and cytokines by...

journal_title：Intensive care medicine

authors： Hagiwara S,Iwasaka H,Hidaka S,Hasegawa A,Koga H,Noguchi T

更新日期：2009-08-01 00:00:00

abstract：:Induced hypothermia can be used to protect the brain from post-ischemic and traumatic neurological injury. Potential clinical applications and the available evidence are discussed in a separate paper. This review focuses on the practical aspects of cooling and physiological changes induced by hypothermia, as well as t...

journal_title：Intensive care medicine

authors： Polderman KH

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:Processed EEG monitoring has been suggested for sedation depth evaluation in intensive care unit (ICU) patients. The present study investigated the efficacy of two processed EEG monitors using SEF90% or SEF95% and BIS to differentiate between conscious (Ramsay score 4) and unconscious sedation (Ramsay score ...

journal_title：Intensive care medicine

authors： Walder B,Suter PM,Romand JA

更新日期：2001-01-01 00:00:00

abstract：:Optimal fluid management is one of the main challenges in the care of the critically ill. However, the physiological parameters that are commonly monitored and used to guide fluid management are often inadequate and even misleading. From 1987 to 1989 we published four experimental studies which described a method for ...

journal_title：Intensive care medicine

authors： Perel A,Pizov R,Cotev S

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To determine the diagnostic performance of a Bayesian Decision-Support System (BDSS) for ventilator-associated pneumonia (VAP). DESIGN:A previously developed BDSS, automatically obtaining patient data from patient information systems, provides likelihood predictions of VAP. In a prospectively studied cohort ...

journal_title：Intensive care medicine

authors： Schurink CA,Visscher S,Lucas PJ,van Leeuwen HJ,Buskens E,Hoff RG,Hoepelman AI,Bonten MJ

更新日期：2007-08-01 00:00:00

abstract：:Achievement of a mean blood pressure (MBP) target is one of the hemodynamic goals to ensure an adequate blood perfusion pressure in critically ill patients. Arterial catheter allows for a continuous and precise monitoring of arterial pressure signal. In addition to giving a precise MBP monitoring, analysis of the bloo...

journal_title：Intensive care medicine

authors： Augusto JF,Teboul JL,Radermacher P,Asfar P

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Definition of the changes in the activators of plasminogen, u-PA and t-PA, and examination of the possible generation of plasmin in the circulation in overwhelming sepsis. DESIGN:Serial blood analysis starting 4 h after development of symptoms of toxic shock syndrome. SETTING:Intensive care unit. PATIENT:A...

journal_title：Intensive care medicine

authors： Haj MA,Robbie LA,Croll A,Adey GD,Bennett B

更新日期：1998-03-01 00:00:00

abstract：:Recent advances in analytical electrochemistry have provided highly selective potassium ion exchangers and robust polymeric membranes that can be used to measure the potassium activity in plasma or whole blood. The relationship between the activity measurement and the more familiar concentration measurement is explore...

journal_title：Intensive care medicine

authors： Treasure T

更新日期：1978-04-01 00:00:00

abstract：PURPOSE:Assessment of the cost utility (CU) of acute renal replacement therapy (RRT) from a societal perspective during a 5-year follow-up. METHODS:This was a cross-sectional cohort study in a medical-surgical intensive care unit and an acute RRT unit of 410 consecutive patients treated with acute RRT in Helsinki Univ...

journal_title：Intensive care medicine

authors： Laukkanen A,Emaus L,Pettilä V,Kaukonen KM

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:The interchangeability of continuous measurement of cardiac output (CO) with the traditional bolus method in patients after cardiopulmonary bypass (CPB) is uncertain. DESIGN:Prospective observational clinical study. SETTING:A 20-bed surgical ICU at a university hospital. PATIENTS:Fourteen deeply sedated, v...

journal_title：Intensive care medicine

authors： Bendjelid K,Schütz N,Suter PM,Romand JA

更新日期：2006-06-01 00:00:00

abstract：:We investigated the levels of auto-PEEP and dynamic hyperinflation during high frequency jet ventilation (HFJV) and controlled mechanical ventilation (CMV) in six patients with chronic obstructive pulmonary disease within the first 36 h of acute exacerbation. The comparative evaluation was performed at similar conditi...

journal_title：Intensive care medicine

authors： Conti G,Bufi M,Rocco M,Calzecchi E,De Blasi RA,Antonelli M,Pelaia P,Gasparetto A

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Although low doses of oxygen (FiO2 <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing FiO2 on pulmonary inflammation in mechanically ventilated patients without respiratory failure. METHOD...

journal_title：Intensive care medicine

authors： Fernandez R,Gili G,Villagra A,Lopez-Aguilar J,Artigas A

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To assess the ability of the Clinical Risk Index for Babies (CRIB) to predict long-term neurodevelopmental impairment in very low birth weight (VLBW) infants. DESIGN:Single-center cohort study. SETTING:Tertiary neonatal care hospital and follow-up clinic. PATIENTS:Four hundred fifty-five VLBW infants conse...

journal_title：Intensive care medicine

authors： Bührer C,Grimmer I,Metze B,Obladen M

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To study the association between early initiation of intra-arrest therapeutic hypothermia and neurologic outcome in out-of-hospital cardiac arrest. METHODS:A prespecified sub-analysis of the PRINCESS trial (NCT01400373) that randomized 677 bystander-witnessed cardiac arrests to transnasal evaporative intra-arr...

journal_title：Intensive care medicine

authors： Awad A,Taccone FS,Jonsson M,Forsberg S,Hollenberg J,Truhlar A,Ringh M,Abella BS,Becker LB,Vincent JL,Svensson L,Nordberg P

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:Critically ill patients often develop anaemia which can be related to a number of factors. However, the exact causes of anaemia in many patients remain unexplained. We hypothesized that the relationship between erythropoietin (EPO) and haematocrit may be altered in critically ill patients. DESIGN:Serum conc...

journal_title：Intensive care medicine

authors： Rogiers P,Zhang H,Leeman M,Nagler J,Neels H,Mélot C,Vincent JL

更新日期：1997-02-01 00:00:00

abstract：:The increase of the inflationary lung volume created by a respiratory maneuver is critical for preventing postoperative alveolar collapse. We measured this volume as achieved with IPPB or incentive spirometry (IS) in 20 postoperative surgical patients. Using IPPB, with gas flow and peak airway pressures carefully adju...

journal_title：Intensive care medicine

authors： Pfenninger J,Roth F

更新日期：1977-12-01 00:00:00

abstract：:Acute renal failure in critically ill patients is seldom an isolated problem but is more usually associated with multiple organ failure. When choosing an extracorporeal kidney replacement therapy, these other failing organs must be taken into account. Therefore the choice of an artificial kidney in patients requiring ...

journal_title：Intensive care medicine

authors： Schetz M,Lauwers PM,Ferdinande P

更新日期：1989-01-01 00:00:00