High-flow nasal cannula (HFNC) support in interhospital transport of critically ill children.

Abstract:

PURPOSE:Optimal respiratory support for interhospital transport of critically ill children is challenging and has been scarcely investigated. High-flow nasal cannula (HFNC) therapy has emerged as a promising support mode in the paediatric intensive care unit (PICU), but no data are available on HFNC used during interhospital transport. We aimed to assess the safety of HFNC during retrievals of critically ill children and its impact on the need for invasive ventilation (IV). METHODS:This was a retrospective, single-centre study of children under 2 years old transported by a specialized paediatric retrieval team to PICU. We compared IV rates before (2005-2008) and after introduction of HFNC therapy (2009-2012). RESULTS:A total of 793 infants were transported. The mean transport duration was 1.4 h (range 0.25-8), with a mean distance of 205 km (2-2,856). Before introduction of HFNC, 7 % (n = 23) were retrieved on non-invasive ventilation (NIV) and 49 % (n = 163) on IV. After introduction of HFNC, 33 % (n = 150) were retrieved on HFNC, 2 % (n = 10) on NIV, whereas IV decreased to 35 % (n = 162, p < 0.001). No patients retrieved on HFNC required intubation during retrieval, or developed pneumothorax or cardiac arrest. Using HFNC was associated with a significant reduction in IV initiated by the retrieval team (multivariate OR 0.51; 95 % CI 0.27-0.95; p = 0.032). CONCLUSIONS:We report on a major change of practice in transport of critically ill children in our retrieval system. HFNC therapy was increasingly used and was not inferior to low-flow oxygen or NIV. Randomized trials are needed to assess whether HFNC can reduce the need for IV in interhospital transport of critically ill children.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Schlapbach LJ,Schaefer J,Brady AM,Mayfield S,Schibler A

doi

10.1007/s00134-014-3226-7

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

592-9

issue

4

eissn

0342-4642

issn

1432-1238

journal_volume

40

pub_type

杂志文章
  • Combined use of HFPPV with low-rate ventilation in traumatic respiratory insufficiency.

    abstract::Two patients with chest injuries, flail chest and respiratory failure were mechanically ventilated by a system composed of 2 Bennett respirators and an independent source of gas. This system provides high-frequency positive pressure ventilation (HFPPV), low-frequency conventional mechanical ventilation (LFCMV) and hig...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF00259437

    authors: Barzilay E,Lev A,Lesmes C,Fleck R,Khourieh A

    更新日期:1984-01-01 00:00:00

  • Eosinopenia, an early marker of increased mortality in critically ill medical patients.

    abstract:PURPOSE:Inflammatory markers may have a role in predicting severity of illness of intensive care unit (ICU) patients. The aim of this study is to determine whether low eosinophil count can predict 28-day mortality in medical ICU. METHODS:A prospective study over a 4-month period. To evaluate the prognosis information ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-011-2170-z

    authors: Abidi K,Belayachi J,Derras Y,Khayari ME,Dendane T,Madani N,Khoudri I,Zeggwagh AA,Abouqal R

    更新日期:2011-07-01 00:00:00

  • Effect of cyclooxygenase inhibition in a canine model of unilateral pulmonary occlusion and reperfusion.

    abstract:OBJECTIVE:To assess the effects of the cyclooxygenase inhibitor diclofenac in a canine model of pulmonary occlusion and reperfusion of the left lower lobe (LLL). DESIGN:Twelve adult beagle dogs (13-17 kg) were randomly assigned to a control group (n = 6) and a diclofenac-treated group (n = 6). Animals in the treatment...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF01700965

    authors: Segiet W,Krieter H,Stieber C,Albrecht DM,van Ackern K

    更新日期:1995-10-01 00:00:00

  • Muscle perfusion and oxygen consumption by near-infrared spectroscopy in septic-shock and non-septic-shock patients.

    abstract:OBJECTIVE:To measure muscle blood flow (Qtis) and oxygen consumption (VO(2)tis) in septic and non-septic critically ill patients by near-infrared spectroscopy (NIRS). SETTING:Surgical intensive care unit of a university hospital. PATIENTS AND PARTICIPANTS:Four patients with septic shock, eight post-surgical criticall...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-003-1805-0

    authors: Girardis M,Rinaldi L,Busani S,Flore I,Mauro S,Pasetto A

    更新日期:2003-07-01 00:00:00

  • Evaluation by polymerase chain reaction of cytomegalovirus reactivation in intensive care patients under mechanical ventilation.

    abstract:OBJECTIVE:The study was undertaken to determine if critically ill patients under mechanical ventilation could reactivate latent cytomegalovirus (CMV) in either lung or blood. DESIGN:Prospective study in critically ill patients was performed in a multidisciplinary intensive care unit in a university hospital. PATIENTS...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF01709343

    authors: Stéphan F,Méharzi D,Ricci S,Fajac A,Clergue F,Bernaudin JF

    更新日期:1996-11-01 00:00:00

  • Early and late onset bacteremia have different risk factors in trauma patients.

    abstract:OBJECTIVE:The aim of this study was to identify risk factors and to describe epidemiological patterns for early-(EOB) and late-onset bacteremias (LOB) after trauma. DESIGN:A prospective study conducted on 141 consecutive trauma patients. SETTING:A general intensive care unit (ICU) of a university hospital. PATIENTS:...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF01709514

    authors: Antonelli M,Moro ML,D'Errico RR,Conti G,Bufi M,Gasparetto A

    更新日期:1996-08-01 00:00:00

  • Incidence, risk factors and outcome of barotrauma in mechanically ventilated patients.

    abstract:OBJECTIVE:To determine the incidence, risk factors, and outcome of barotrauma in a cohort of mechanically ventilated patients where limited tidal volumes and airway pressures were used. DESIGN AND SETTING:Prospective cohort of 361 intensive care units from 20 countries. PATIENTS AND PARTICIPANTS:A total of 5183 patie...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00134-004-2187-7

    authors: Anzueto A,Frutos-Vivar F,Esteban A,Alía I,Brochard L,Stewart T,Benito S,Tobin MJ,Elizalde J,Palizas F,David CM,Pimentel J,González M,Soto L,D'Empaire G,Pelosi P

    更新日期:2004-04-01 00:00:00

  • Candida spp. airway colonization could promote antibiotic-resistant bacteria selection in patients with suspected ventilator-associated pneumonia.

    abstract:OBJECTIVE:Candida spp. airway colonization could promote development of ventilator-associated pneumonia (VAP) caused by Pseudomonas aeruginosa, a potentially multidrug-resistant (MDR) bacteria, and worsen the outcome of VAP regardless of pathogen. We therefore address the question of the risk of MDR bacteria isolation ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-012-2584-2

    authors: Hamet M,Pavon A,Dalle F,Pechinot A,Prin S,Quenot JP,Charles PE

    更新日期:2012-08-01 00:00:00

  • Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part II. Treatment.

    abstract:BACKGROUND:Invasive candidiasis and candidemia are frequently encountered in the nosocomial setting particularly in the intensive care unit (ICU). OBJECTIVE AND METHODS:To review the current management of invasive candidiasis and candidemia in non-neutropenic adult ICU patients based on a review of the literature and ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s00134-008-1339-6

    authors: Guery BP,Arendrup MC,Auzinger G,Azoulay E,Borges Sá M,Johnson EM,Müller E,Putensen C,Rotstein C,Sganga G,Venditti M,Zaragoza Crespo R,Kullberg BJ

    更新日期:2009-02-01 00:00:00

  • Isoflurane for prolonged sedation in the intensive care unit; efficacy and safety.

    abstract:OBJECTIVE:To compare isoflurane with midazolam for prolonged sedation in ventilated patients. DESIGN:Randomised controlled study. SETTING:General intensive care unit in university teaching hospital. PATIENTS:Sixty patients aged 17-80 years who required mechanical ventilation for more than 24 h. INTERVENTIONS:Sedati...

    journal_title:Intensive care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01694344

    authors: Spencer EM,Willatts SM

    更新日期:1992-01-01 00:00:00

  • Hypertensive crisis immediately after complete removal of phaeochromocytoma.

    abstract::A hypertensive crisis with an arterial blood pressure of 280/180 mmHg developed immediately after an apparently successful removal of a phaeochromocytoma. The blood pressure could not be lowered by phentolamine and not until the administration of dihydralazine and furosemide was the systemic pressure normalized. In ad...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF00315379

    authors: Johansson H,Brismar B,Hedenstierna G

    更新日期:1986-01-01 00:00:00

  • Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats.

    abstract:PURPOSE:Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate the neuropathological outcome of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to i...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-010-1913-6

    authors: Fathali N,Lekic T,Zhang JH,Tang J

    更新日期:2010-09-01 00:00:00

  • Trends in sedation practices in Danish intensive care units in 2003: a national survey.

    abstract:OBJECTIVE:The aim of the study was to explore trends and changes in sedation practices for mechanically ventilated patients in Danish intensive care units (ICUs) and to compare sedation practices in 1997 and 2003. DESIGN:The study was a follow-up survey with a descriptive and comparative cross-sectional multicenter de...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00134-005-2856-1

    authors: Egerod I,Christensen BV,Johansen L

    更新日期:2006-01-01 00:00:00

  • Diagnostic accuracy of Doppler renal resistive index for reversibility of acute kidney injury in critically ill patients.

    abstract:OBJECTIVES:Diagnosing persistent acute kidney injury (AKI) as opposed to transient AKI in critically ill patients may help physicians in making treatment decisions. This diagnosis relies chiefly on urinary indices, which may be of limited value or difficult to obtain. We assessed the performance of the Doppler renal re...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-010-2050-y

    authors: Darmon M,Schortgen F,Vargas F,Liazydi A,Schlemmer B,Brun-Buisson C,Brochard L

    更新日期:2011-01-01 00:00:00

  • Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation.

    abstract:RATIONALE:Acute respiratory distress syndrome (ARDS) is frequently associated with hemodynamic instability which appears as the main factor associated with mortality. Shock is driven by pulmonary hypertension, deleterious effects of mechanical ventilation (MV) on right ventricular (RV) function, and associated-sepsis. ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s00134-016-4326-3

    authors: Vieillard-Baron A,Matthay M,Teboul JL,Bein T,Schultz M,Magder S,Marini JJ

    更新日期:2016-05-01 00:00:00

  • Normal values of functional residual capacity in the sitting and supine positions.

    abstract::The measurement of functional residual capacity (FRC) has assumed new importance in the diagnosis of acute respiratory failure. However few reference values exist for FRC in supine positions for both sexes. We measured the FRC in 100 healthy subjects with the helium dilution closed circuit method in the sitting and su...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF01725734

    authors: Ibañez J,Raurich JM

    更新日期:1982-01-01 00:00:00

  • Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis.

    abstract:OBJECTIVE:Nuclear factor-kappaB (NF-kappaB) is a transcription factor which plays a pivotal role in the induction of genes involved in the response to injury and inflammation. Calpain I inhibitor is a potent antioxidant which is an effective inhibitor of NF-kappaB. This study examined whether the postulate that calpain...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-004-2328-z

    authors: Virlos I,Mazzon E,Serraino I,Genovese T,Di Paola R,Thiemerman C,Siriwardena A,Cuzzocrea S

    更新日期:2004-08-01 00:00:00

  • Hemodynamic effects of partial liquid ventilation with perfluorocarbon in acute lung injury.

    abstract:OBJECTIVE:To assess the effect of partial liquid ventilation with perfluorocarbons on hemodynamics and gas exchange in large pigs with induced acute lung injury (ALI). DESIGN:Randomized, prospective, double-control, experimental study. Experimental intensive care unit of a university. MATERIALS:Eighteen large pigs (5...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF01700657

    authors: Houmes RJ,Verbrugge SJ,Hendrik ER,Lachmann B

    更新日期:1995-12-01 00:00:00

  • A multi-faceted strategy to reduce ventilation-associated mortality in brain-injured patients. The BI-VILI project: a nationwide quality improvement project.

    abstract:PURPOSE:We assessed outcomes in brain-injured patients after implementation of a multi-faceted approach to reduce respiratory complications in intensive care units. METHODS:Prospective nationwide before-after trial. Consecutive adults with acute brain injury requiring mechanical ventilation for ≥24 h in 20 French inte...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00134-017-4764-6

    authors: Asehnoune K,Mrozek S,Perrigault PF,Seguin P,Dahyot-Fizelier C,Lasocki S,Pujol A,Martin M,Chabanne R,Muller L,Hanouz JL,Hammad E,Rozec B,Kerforne T,Ichai C,Cinotti R,Geeraerts T,Elaroussi D,Pelosi P,Jaber S,Dalicha

    更新日期:2017-07-01 00:00:00

  • Erythropoietin response is blunted in critically ill patients.

    abstract:OBJECTIVES:Critically ill patients often develop anaemia which can be related to a number of factors. However, the exact causes of anaemia in many patients remain unexplained. We hypothesized that the relationship between erythropoietin (EPO) and haematocrit may be altered in critically ill patients. DESIGN:Serum conc...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s001340050310

    authors: Rogiers P,Zhang H,Leeman M,Nagler J,Neels H,Mélot C,Vincent JL

    更新日期:1997-02-01 00:00:00

  • Predictors of prolonged weaning and survival during ventilator weaning in a respiratory ICU.

    abstract:PURPOSE:An International Consensus Conference proposed classifying weaning into simple, difficult, and prolonged weaning. However, the usefulness of this classification in a respiratory intensive care unit (ICU) is unknown. The aims of the study were: (1) to compare the clinical characteristics and outcomes of patients...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-011-2179-3

    authors: Sellares J,Ferrer M,Cano E,Loureiro H,Valencia M,Torres A

    更新日期:2011-05-01 00:00:00

  • Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation.

    abstract:OBJECTIVE:This study assessed parameters of free radical damage to biomolecules, mitochondrial superoxide production, superoxide dismutase, and catalase activities and their relationship to sepsis mortality. DESIGN AND SETTING:Prospective animal study in a university laboratory for experimental. SUBJECTS:140 male Wis...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-003-1789-9

    authors: Ritter C,Andrades M,Frota Júnior ML,Bonatto F,Pinho RA,Polydoro M,Klamt F,Pinheiro CT,Menna-Barreto SS,Moreira JC,Dal-Pizzol F

    更新日期:2003-10-01 00:00:00

  • Multinational development and validation of an early prediction model for delirium in ICU patients.

    abstract:RATIONALE:Delirium incidence in intensive care unit (ICU) patients is high and associated with poor outcome. Identification of high-risk patients may facilitate its prevention. PURPOSE:To develop and validate a model based on data available at ICU admission to predict delirium development during a patient's complete I...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00134-015-3777-2

    authors: Wassenaar A,van den Boogaard M,van Achterberg T,Slooter AJ,Kuiper MA,Hoogendoorn ME,Simons KS,Maseda E,Pinto N,Jones C,Luetz A,Schandl A,Verbrugghe W,Aitken LM,van Haren FM,Donders AR,Schoonhoven L,Pickkers P

    更新日期:2015-06-01 00:00:00

  • Meta-regression analysis of high-frequency ventilation vs conventional ventilation in infant respiratory distress syndrome.

    abstract:OBJECTIVE:There is considerable heterogeneity among randomized trials comparing high-frequency ventilation (HFV) with conventional mechanical ventilation (CMV) in premature neonates with respiratory distress syndrome. We investigated what factors explained differences in outcome among these trials. DESIGN:Meta-regress...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00134-007-0545-y

    authors: Bollen CW,Uiterwaal CS,van Vught AJ

    更新日期:2007-04-01 00:00:00

  • Prognostic value of relative adrenal insufficiency after out-of-hospital cardiac arrest.

    abstract:OBJECTIVE:To assess the prevalence of relative adrenal insufficiency in patients successfully resuscitated after cardiac arrest, and its prognostic role in post-resuscitation disease. DESIGN AND SETTING:A prospective observational single-center study in a medical intensive care unit. PATIENTS:64 patients hospitalised...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-005-2603-7

    authors: Pene F,Hyvernat H,Mallet V,Cariou A,Carli P,Spaulding C,Dugue MA,Mira JP

    更新日期:2005-05-01 00:00:00

  • High versus standard-volume haemofiltration in hyperdynamic porcine peritonitis: effects beyond haemodynamics?

    abstract:OBJECTIVE:The role of haemofiltration as an adjunctive treatment of sepsis remains a contentious issue. To address the role of dose and to explore the biological effects of haemofiltration we compared the effects of standard and high-volume haemofiltration (HVHF) in a peritonitis-induced model of porcine septic shock. ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-008-1318-y

    authors: Sykora R,Chvojka J,Krouzecky A,Radej J,Karvunidis T,Varnerova V,Novak I,Matejovic M

    更新日期:2009-02-01 00:00:00

  • Influenza vaccination and 1-year risk of myocardial infarction, stroke, heart failure, pneumonia, and mortality among intensive care unit survivors aged 65 years or older: a nationwide population-based cohort study.

    abstract:PURPOSE:We examined whether influenza vaccination affects 1-year risk of myocardial infarction, stroke, heart failure, pneumonia, and death among intensive care unit (ICU) survivors aged ≥ 65 years. METHODS:Danish Intensive Care Database data on all elderly ( ≥ 65 years) patients hospitalized in Danish ICUs in the per...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-019-05648-4

    authors: Christiansen CF,Thomsen RW,Schmidt M,Pedersen L,Sørensen HT

    更新日期:2019-07-01 00:00:00

  • Plasma levels of the three endothelial-specific proteins von Willebrand factor, tissue factor pathway inhibitor, and thrombomodulin do not predict the development of acute respiratory distress syndrome.

    abstract:OBJECTIVE:To determine if the plasma levels of three endothelial-specific proteins, von Willebrand factor (vWF), tissue factor pathway inhibitor (TFPI) and thrombomodulin (TM) may be useful in predicting the development of acute respiratory distress syndrome (ARDS). DESIGN:Blood samples were obtained from normal healt...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s001340051054

    authors: Bajaj MS,Tricomi SM

    更新日期:1999-11-01 00:00:00

  • Total extracorporeal lung assist--a new clinical approach.

    abstract::Total extracorporeal lung assist (ECLA) requires a bypass flow approaching cardiac output. Recirculation of venous blood through the oxygenator is minimized with a veno-right ventricular cannulation technique which separates venous drainage from returned oxygenated blood. A case of posttraumatic ARDS was treated with ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF01691426

    authors: Wetterberg T,Steen S

    更新日期:1991-01-01 00:00:00

  • Anticoagulation strategies in continuous renal replacement therapy: can the choice be evidence based?

    abstract:OBJECTIVES:Critical illness increases the tendency to both coagulation and bleeding, complicating anticoagulation for continuous renal replacement therapy (CRRT). We analyzed strategies for anticoagulation in CRRT concerning implementation, efficacy and safety to provide evidence-based recommendations for clinical prac...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00134-005-0044-y

    authors: Oudemans-van Straaten HM,Wester JPJ,de Pont ACJM,Schetz MRC

    更新日期:2006-02-01 00:00:00