Flumazenil in the treatment of portal systemic encephalopathy--an overview.

Abstract:

:Hepatic encephalopathy is a complex neuropsychiatric syndrome associated with acute, subacute and chronic liver failure, involving increased neural inhibition by activation of the GABA/benzodiazepine inhibitory neurotransmitter system. Improvement by GABA and benzodiazepine receptor antagonists as well as by chloride ionophore blockers has been shown in animal experiments. Recent reports indicate that flumazenil may improve hepatic encephalopathy in man. To date 46 episodes of HE in 41 patients have been treated with flumazenil with a short term success rate of 72%. Most of the patients were screened for exogenous benzodiazepines and found negative. These interesting observations should now be investigated in a randomised double-blind controlled study in patients with HE to evaluate the efficiency of this therapy.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Gyr K,Meier R

doi

10.1007/BF01731153

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

S39-42

eissn

0342-4642

issn

1432-1238

journal_volume

17 Suppl 1

pub_type

杂志文章,评审
  • Trends in sedation practices in Danish intensive care units in 2003: a national survey.

    abstract:OBJECTIVE:The aim of the study was to explore trends and changes in sedation practices for mechanically ventilated patients in Danish intensive care units (ICUs) and to compare sedation practices in 1997 and 2003. DESIGN:The study was a follow-up survey with a descriptive and comparative cross-sectional multicenter de...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00134-005-2856-1

    authors: Egerod I,Christensen BV,Johansen L

    更新日期:2006-01-01 00:00:00

  • Treatment of respiratory failure using minitracheotomy and intratracheal oxygenation in selected patients with chronic lung disease.

    abstract:OBJECTIVE:To evaluate the efficacy of minitracheotomy (MT) insertion for intratracheal oxygen insufflation (ITO2) on arterial blood gases and survival in patients with respiratory failure from chronic lung disease. DESIGN:Open, prospective clinical study. SETTING:A 12-bed medical intensive care unit in a non-universi...

    journal_title:Intensive care medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01709545

    authors: Andrivet P,Richard G,Viau F,Letinier JY,Darne C,Vu Ngoc C

    更新日期:1996-12-01 00:00:00

  • Fellows' in intensive care medicine views on professionalism and how they learn it.

    abstract:INTRODUCTION:The emphasis on the importance of professionalism in a recent CoBaTrICE-IT paper was impressive. However, insight into the elements of professionalism as perceived relevant for intensivists from the fellows' view, and how these are taught and learned, is limited. OBJECTIVES AND METHODS:A nationwide study ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-009-1644-8

    authors: van Mook WN,de Grave WS,Gorter SL,Muijtjens AM,Zwaveling JH,Schuwirth LW,van der Vleuten CP

    更新日期:2010-02-01 00:00:00

  • Physiotherapy does not prevent, or hasten recovery from, ventilator-associated pneumonia in patients with acquired brain injury.

    abstract:OBJECTIVE:To investigate the effect of respiratory physiotherapy on the prevention and treatment of ventilator-associated pneumonia (VAP) for adults in an intensive care unit (ICU) with an acquired brain injury (ABI). DESIGN AND SETTING:Two-part, prospective, randomised controlled trial. PATIENTS:A total of 144 subje...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00134-008-1278-2

    authors: Patman S,Jenkins S,Stiller K

    更新日期:2009-02-01 00:00:00

  • Organophosphate poisonings with parathion and dimethoate.

    abstract:OBJECTIVE:Organophosphate toxicity is the leading cause of morbidity and death in poisoning by insecticides. The clinical symptoms of pesticide toxicity range from the classic cholinergic syndrome to flaccid paralysis and intractable seizures. The mainstays of therapy are atropine, oximes, benzodiazepines and supportiv...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-005-0051-z

    authors: Hoffmann U,Papendorf T

    更新日期:2006-03-01 00:00:00

  • Assessment of clinical risk predictive rules for invasive candidiasis in a prospective multicentre cohort of ICU patients.

    abstract:PURPOSE:To assess the generalisability of published clinical risk predictive models for invasive candidiasis in ICU patients. METHODS:The performance characteristics of published clinical risk factor-only and Candida colonisation-only predictive models for invasive candidiasis were assessed in a multicentre cohort of ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00134-009-1619-9

    authors: Playford EG,Lipman J,Kabir M,McBryde ES,Nimmo GR,Lau A,Sorrell TC

    更新日期:2009-12-01 00:00:00

  • Modulation of rat brain synaptosomal plasma membrane achieved by atracurium and its metabolite laudanosine.

    abstract:OBJECTIVE:Atracurium besylate and laudanosine cause excitement and seizures when introduced into the central nervous system of laboratory animals. We examined the modulation of lipid-protein interaction in the lipid environment of rat brain synaptosomal plasma membrane (SPM)-bound enzymes as a possible mechanism leadin...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s001340050605

    authors: Kamper EF,Siafaka J,Stavridis J

    更新日期:1998-05-01 00:00:00

  • Bile canaliculi are defective in hepatic involvement of organ failure and recovery of liver function is due to their secondary regeneration.

    abstract:OBJECTIVE:To investigate the morphological changes in the liver in patients with organ failure and hyperbilirubinemia and to correlate them to the outcome. DESIGN:A case series prospective study. SETTING:Intensive care units of two general hospitals. PATIENTS:Twelve patients in organ failure with predominant hepatic...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF01708095

    authors: Douzinas EE,Vamvasakis E,Rigas K,Pitaridis M,Kittas C,Roussos C

    更新日期:1996-06-01 00:00:00

  • Ultrasound-guided arterial catheterization: a narrative review.

    abstract::Arterial catheterization is the second most common invasive procedure performed in the intensive care unit. Despite the ubiquity of the procedure, complications including failure to place the catheter occur. While many clinicians are familiar with the use of ultrasound (US) guidance to decrease complication rates of c...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s00134-009-1699-6

    authors: Shiloh AL,Eisen LA

    更新日期:2010-02-01 00:00:00

  • Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation.

    abstract:RATIONALE:Acute respiratory distress syndrome (ARDS) is frequently associated with hemodynamic instability which appears as the main factor associated with mortality. Shock is driven by pulmonary hypertension, deleterious effects of mechanical ventilation (MV) on right ventricular (RV) function, and associated-sepsis. ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s00134-016-4326-3

    authors: Vieillard-Baron A,Matthay M,Teboul JL,Bein T,Schultz M,Magder S,Marini JJ

    更新日期:2016-05-01 00:00:00

  • Spontaneous intracerebral hemorrhage in critically ill patients: incidence over six years and associated factors.

    abstract:OBJECTIVE:Intracerebral hemorrhage (ICH) is associated with a high mortality. The present study sought to determine the incidence of spontaneous ICH in an intensive care unit (ICU) and associated factors. DESIGN:A 6 year retrospective study. SETTING:A general ICU in a university hospital. PATIENTS:All ICU patients d...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s001340050788

    authors: Oppenheim-Eden A,Glantz L,Eidelman LA,Sprung CL

    更新日期:1999-01-01 00:00:00

  • Inhibition of human neutrophil chemotaxis toward interleukin 8 with six clinical antithrombin concentrates in vitro.

    abstract:OBJECTIVE:Antithrombin exerts direct effects on neutrophils by inhibiting chemokine-induced migration. This study examined the potency of different pharmaceutical antithrombin preparations in inhibiting neutrophil chemotaxis toward interleukin 8. METHODS:Cell migration was tested by the leading front assay in modified...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-002-1432-1

    authors: Kaneider NC,Rabensteiner A,Reinisch CM,Dunzendorfer S,Wiedermann CJ

    更新日期:2002-10-01 00:00:00

  • Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients.

    abstract:OBJECTIVE:Although several advantages are attributed to tracheotomy in ICU patients requiring mechanical ventilation (MV), true benefits and the optimal timing of tracheotomy remain controversial. In this study, we compared early tracheotomy (ET) with prolonged intubation (PI) in severely ill patients requiring prolong...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00134-008-1195-4

    authors: Blot F,Similowski T,Trouillet JL,Chardon P,Korach JM,Costa MA,Journois D,Thiéry G,Fartoukh M,Pipien I,Bruder N,Orlikowski D,Tankere F,Durand-Zaleski I,Auboyer C,Nitenberg G,Holzapfel L,Tenaillon A,Chastre J,Laplanch

    更新日期:2008-10-01 00:00:00

  • Electron-microscopic description of accretions occurring on tips of infected and non-infected central venous catheters.

    abstract:OBJECTIVE:The purpose of the study was do describe the architecture of accretions occurring on the tips of central venous catheters (CVC). DESIGN:A conservative procedure was used followed by two different techniques of electron microscopy. SETTING AND PATIENTS:the study included 19 catheters which have been used on ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF01708582

    authors: Poisson DM,Touquet S,Bercault N,Arbeille B

    更新日期:1992-01-01 00:00:00

  • Current management and outcome of tracheobronchial malacia and stenosis presenting to the paediatric intensive care unit.

    abstract:OBJECTIVE:To identify factors associated with mortality and prolonged ventilatory requirements in patients admitted to our paediatric intensive care unit (PICU) with tracheobronchial malacia and stenosis diagnosed by dynamic contrast bronchograms. DESIGN:Retrospective review. SETTING:Tertiary paediatric intensive car...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s001340000822

    authors: Inwald DP,Roebuck D,Elliott MJ,Mok Q

    更新日期:2001-04-01 00:00:00

  • Colonization and infection in surgical intensive care patients--a prospective study.

    abstract::Nosocomial infections are a major problem in intensive care patients. Thirty-nine patients, requiring intensive care for 5 days or more (mean 15.8 days) were prospectively investigated, to determine the relation between colonisation and nosocomial infection. Thrice weekly, cultures from the oropharynx, respiratory and...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF00255792

    authors: Kerver AJ,Rommes JH,Mevissen-Verhage EA,Hulstaert PF,Vos A,Verhoef J,Wittebol P

    更新日期:1987-01-01 00:00:00

  • Inhaled nitric oxide for a severe respiratory syncytial virus infection in an infant with bronchopulmonary dysplasia.

    abstract:OBJECTIVE:To report the first case of ARDS in children treated with nitric oxide (NO) inhalation. METHODS:A 13-months infant presented with BPD and severe hypoxemia related to RSV infection and ARDS. Inhaled NO was delivered in the ventilatory circuit of a continuous flow ventilator (Babylog 8000, Dräger) in a concent...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF01711907

    authors: Leclerc F,Riou Y,Martinot A,Storme L,Hue V,Flurin V,Deschildre A,Sadik A

    更新日期:1994-08-01 00:00:00

  • Comparison of atracurium and pancuronium in mechanically ventilated neonates.

    abstract:OBJECTIVE:To compare haemodynamic and gas exchange effects after either atracurium or pancuronium given to ventilated neonates with respiratory failure. DESIGN:In this prospective study neonates were alternately assigned to receive either atracurium or pancuronium, intravenously. SETTING:Paediatric and neonatal ICU i...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF01724880

    authors: Piotrowski A

    更新日期:1993-01-01 00:00:00

  • Errors in tracheal pressure recording in patients with a tracheostomy tube--a model study.

    abstract::The recording of intratracheal pressure in patients breathing through a tracheostomy tube is marred by methodological problems. In model experiments it has been shown that the introduction of a recording catheter into the tracheostomy tube alters the recorded pressure by as much as 20-40%. To avoid such inaccuracy, a ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF01735176

    authors: Holst M,Striem J,Hedenstierna G

    更新日期:1990-01-01 00:00:00

  • Systemic antibiotic treatment of nosocomial pneumonia.

    abstract::Nosocomial pneumonia continues to represent a significant cause of morbidity and mortality in hospitalized patients. Bacteria are responsible for greater than 90% of the pneumonias, the most common isolates being aerobic Gram-negative bacilli and S. aureus. Cornerstones of treatment are intravenous antibiotics and sup...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1007/BF01752974

    authors: Unertl KE,Lenhart FP,Forst H,Peter K

    更新日期:1992-01-01 00:00:00

  • Time-limited trial of intensive care treatment: an overview of current literature.

    abstract::In critically ill patients, it is frequently challenging to identify who will benefit from admission to the intensive care unit and life-sustaining interventions when the chances of a meaningful outcome are unclear. In addition, the acute illness not only affects the patients but also family members or surrogates who ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s00134-018-5339-x

    authors: Vink EE,Azoulay E,Caplan A,Kompanje EJO,Bakker J

    更新日期:2018-09-01 00:00:00

  • Ultrasound evaluation of central veinsin the intensive care unit:effects of dynamic manoeuvres.

    abstract:OBJECTIVE:To determine: (1) the proportion of small (<5 mm) or thrombosed internal jugular veins (IJV) and femoral veins (FV) in which catheter placement would be difficult without ultrasound guidance; (2) which position increases central vein sizes and may facilitate cannulation of these vessels. DESIGN:Prospective s...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-007-0875-9

    authors: Samy Modeliar S,Sevestre MA,de Cagny B,Slama M

    更新日期:2008-02-01 00:00:00

  • The Multiple Organ Dysfunction Score (MODS) versus the Sequential Organ Failure Assessment (SOFA) score in outcome prediction.

    abstract:OBJECTIVE:To compare outcome prediction using the Multiple Organ Dysfunction Score (MODS) and the Sequential Organ Failure Assessment (SOFA), two of the systems most commonly used to evaluate organ dysfunction in the intensive care unit (ICU). DESIGN:Prospective, observational study. SETTING:Thirty-one-bed, universit...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-002-1491-3

    authors: Peres Bota D,Melot C,Lopes Ferreira F,Nguyen Ba V,Vincent JL

    更新日期:2002-11-01 00:00:00

  • Comparison of norepinephrine and dobutamine to epinephrine for hemodynamics, lactate metabolism, and gastric tonometric variables in septic shock: a prospective, randomized study.

    abstract:OBJECTIVES:To compare the effects of norepinephrine and dobutamine to epinephrine on hemodynamics, lactate metabolism, and gastric tonometric variables in hyperdynamic dopamine-resistant septic shock. DESIGN:A prospective, intervention, randomized clinical trial. SETTING:Adult medical/surgical intensive care unit in ...

    journal_title:Intensive care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s001340050329

    authors: Levy B,Bollaert PE,Charpentier C,Nace L,Audibert G,Bauer P,Nabet P,Larcan A

    更新日期:1997-03-01 00:00:00

  • Combined measurements of N-terminal pro-brain natriuretic peptide and cardiac troponins in potential organ donors.

    abstract:OBJECTIVE:Brain death may induce cardiac dysfunction. In potential organ donors measurements of N-terminal pro-brain natriuretic peptide (NT-proBNP) and circulating cardiac troponins T and I (cTnT and cTnI), alone or in combination, are performed to investigate the accuracy of these biomarkers for early diagnosis of le...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-007-0601-7

    authors: Nicolas-Robin A,Salvi N,Medimagh S,Amour J,Le Manach Y,Coriat P,Riou B,Langeron O

    更新日期:2007-06-01 00:00:00

  • Hyperglycaemia and mortality in critically ill patients. A prospective study.

    abstract:OBJECTIVE:To describe hyperglycaemia as a possible marker of morbidity and mortality in critically ill medical and surgical patients admitted to a multidisciplinary ICU. DESIGN:Prospective cohort study. SETTING:A 13-bed non-cardiac multidisciplinary ICU in a university hospital. PATIENTS AND PARTICIPANTS:Adult patie...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-004-2325-2

    authors: Christiansen C,Toft P,Jørgensen HS,Andersen SK,Tønnesen E

    更新日期:2004-08-01 00:00:00

  • Membranous laryngotracheobronchitis, a complication of measles.

    abstract::Membranous laryngotracheobronchitis is a very serious infection which affects the larynx, trachea and bronchi, requiring aggressive therapeutic measures. It has been recently rediscovered as a cause of disease in children. However, it is a very unusual complication of measles. Two infants with measles and membranous l...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF00273547

    authors: Labay MV,Ramos R,Hervas JA,Reynes J,Gomez B

    更新日期:1985-01-01 00:00:00

  • Vitamin therapy in critically ill patients: focus on thiamine, vitamin C, and vitamin D.

    abstract:: ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s00134-018-5107-y

    authors: Amrein K,Oudemans-van Straaten HM,Berger MM

    更新日期:2018-11-01 00:00:00

  • How I treat septic shock.

    abstract:: ...

    journal_title:Intensive care medicine

    pub_type: 社论

    doi:10.1007/s00134-018-5401-8

    authors: Vincent JL

    更新日期:2018-12-01 00:00:00

  • Prolonged severe hypercapnia complicating near fatal asthma in a 35-year-old woman.

    abstract:OBJECTIVE:We describe a patient with a prolonged and severe hypercapnia occurring during an episode of status asthmaticus induced by ophthalmic instillation of carteolol. SETTING:Prehospital Emergency Medical Service and Pulmonary Intensive Care Unit in a university hospital. PATIENT:A 35-year-old female developed an...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s001340050772

    authors: Adnet F,Plaisance P,Borron SW,Levy A,Payen D

    更新日期:1998-12-01 00:00:00