Vitamin therapy in critically ill patients: focus on thiamine, vitamin C, and vitamin D.

abstract：OBJECTIVE:The liver plays a key role in the inflammatory response during major surgery or infection. The influence of age on liver function and hepatic acute phase protein (APP) synthesis should be serially studied in elderly patients undergoing major abdominal surgery. DESIGN AND SETTING:Prospective and descriptive s...

journal_title：Intensive care medicine

authors： Suttner SW,Sürder C,Lang K,Piper SN,Kumle B,Boldt J

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To determine the magnitude and time course of adrenergic effects on metabolism in volunteers and possible implications for the use of sympathomimetics in the critically ill. DESIGN:Descriptive laboratory investigation. SUBJECTS:7 volunteers. INTERVENTION:Primed continuous infusions of stable isotope tracer...

journal_title：Intensive care medicine

authors： Ensinger H,Träger K,Geisser W,Anhäupl T,Ahnefeld FW,Vogt J,Georgieff M

更新日期：1994-01-01 00:00:00

abstract：:The influence of varying cardiac output (CO) on thermal-dye extravascular lung water (EVLW) was investigated in a total of 40 cardiac surgery patients before the onset of the operation. EVLW was measured by means of the double indicator dilution technique with indocyanine green as the non-diffusible indicator and a mi...

journal_title：Intensive care medicine

authors： Boldt J,Kling D,von Bormann B,Scheld HH,Hempelmann G

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Antipyrine metabolism is a "gold standard" measure of mixed cytochrome P450 (CYP) mediated drug metabolism in humans. Cytokines (e.g., interleukin-6) and nitric oxide reduce CYP 450 activity in vitro and in vivo. Because interleukin-6 and nitric oxide production increases in children with sepsis-induced multi...

journal_title：Intensive care medicine

authors： Carcillo JA,Doughty L,Kofos D,Frye RF,Kaplan SS,Sasser H,Burckart GJ

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:There are a number of potential etiologies of severe bleeding encountered in the intensive care unit. Although rare, acquired hemophilia is one such etiology that often presents with major bleeding requiring intensive care. Despite the introduction of effective treatments, the reported mortality rate of patie...

journal_title：Intensive care medicine

authors： Shander A,Walsh CE,Cromwell C

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate the effect of lung volume changes on end-expiratory lung impedance change (ELIC) in mechanically ventilated patients, since we hypothesized that ELIC may be a suitable parameter to monitor lung volume change at the bedside. DESIGN:Clinical trial on patients requiring m...

journal_title：Intensive care medicine

authors： Hinz J,Hahn G,Neumann P,Sydow M,Mohrenweiser P,Hellige G,Burchardi H

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To describe hyperglycaemia as a possible marker of morbidity and mortality in critically ill medical and surgical patients admitted to a multidisciplinary ICU. DESIGN:Prospective cohort study. SETTING:A 13-bed non-cardiac multidisciplinary ICU in a university hospital. PATIENTS AND PARTICIPANTS:Adult patie...

journal_title：Intensive care medicine

authors： Christiansen C,Toft P,Jørgensen HS,Andersen SK,Tønnesen E

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:To assess the effects of alveolar recruitment maneuvers (ARMs) on clinical outcomes in patients with acute respiratory distress syndrome (ARDS). METHODS:We conducted a search of the MEDLINE, EMBASE, LILACS, CINAHL, CENTRAL, Scopus, and Web of Science (from inception to July 2014) databases for all (i.e. no lan...

journal_title：Intensive care medicine

authors： Suzumura EA,Figueiró M,Normilio-Silva K,Laranjeira L,Oliveira C,Buehler AM,Bugano D,Passos Amato MB,Ribeiro Carvalho CR,Berwanger O,Cavalcanti AB

更新日期：2014-09-01 00:00:00

abstract：:The arterial oxygen and carbon dioxide tensions, pulmonary and systemic haemodynamics and pulmonary shunting and mechanics were measured during the first 30 min after intravenous labetalol administration. Thirty patients, recovering in the intensive care unit after neurosurgical interventions were randomly divided in ...

journal_title：Intensive care medicine

authors： De Hert SG,Heytens LG,De Jongh RG,Vercauteren MP,Boeckx EA,Adriaensen HF

更新日期：1988-01-01 00:00:00

abstract：:In oleic acid-induced pulmonary oedema (OAPO) sequential intrapulmonary fluid accumulation occurs leading to different expiratory flow pattern in dependent lung regions. The potential effects on efficacy of high-frequency jet ventilation (HFJV, f = 3 Hz, I: E = 0.43, FiO2 = 0.4) were studied and compared with continuo...

journal_title：Intensive care medicine

authors： Hachenberg T,Wendt M,Hermeyer G,Ludwig E,Meyer J,Lawin P

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:To determine the value of procalcitonin (PCT) in the early diagnosis (and differentiation) of patients with SIRS, sepsis, severe sepsis, and septic shock in comparison to C-reactive protein (CRP), white blood cell and thrombocyte count, and APACHE-II score (AP-II). DESIGN:Prospective cohort study including a...

journal_title：Intensive care medicine

authors： Brunkhorst FM,Wegscheider K,Forycki ZF,Brunkhorst R

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To determine the oxygen affinity for optimal tissue oxygen delivery with a hemoglobin-hydroxyethyl starch conjugate (HRC 101). METHODS:Anesthetized rats were hemodiluted (180 ml kg(-1)) with low (P(50) approximately 70 mmHg) or high affinity (P(50) approximately 14 mmHg) HRC 101 at hemoglobin (Hb) concentratio...

journal_title：Intensive care medicine

authors： Hare GM,Liu E,Baker AJ,Mazer CD

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:Spasms in patients with generalized tetanus can be suppressed by a spinal intrathecal infusion of baclofen. We report on four patients and review reported cases treated by this method elsewhere. DESIGN:Intrathecal baclofen infusion was started with a bolus dose (300-500 micrograms) and continued at a steady ...

journal_title：Intensive care medicine

authors： Dressnandt J,Konstanzer A,Weinzierl FX,Pfab R,Klingelhöfer J

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:Impairment of haemostasis has been described with slowly degradable medium molecular weight hydroxyethyl starch (MMW-HES), whereas rapidly degradable MMW-HES is generally considered to have no important effects on blood coagulation. This study was undertaken to investigate the effects of a rapidly degradable ...

journal_title：Intensive care medicine

authors： de Jonge E,Levi M,Büller HR,Berends F,Kesecioglu J

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To compare the effectiveness of 70-mg and 200-mg doses of intravenous erythromycin in improving gastric emptying in critically ill patients. DESIGN:Gastric emptying was measured on consecutive days; day 1 (pre-treatment), day 2 (post-treatment) after an intravenous infusion of either 70 or 200 mg erythromyci...

journal_title：Intensive care medicine

authors： Ritz MA,Chapman MJ,Fraser RJ,Finnis ME,Butler RN,Cmielewski P,Davidson GP,Rea D

更新日期：2005-07-01 00:00:00

abstract：:A 42 year old pregnant woman was admitted in acute respiratory failure. Viral pneumonia was suspected and oxygen therapy, CPAP, water restriction and diuretics were started with good response. She remained febrile and had an abnormal chest X-ray, a diagnosis of miliary tuberculosis was confirmed by transbronchial fibr...

journal_title：Intensive care medicine

authors： Raimondi AC,Olmedo G,Roncoroni AJ

更新日期：1978-11-01 00:00:00

abstract：OBJECTIVE:To determine the influence of religious affiliation and culture on end-of-life decisions in European intensive care units (ICUs). DESIGN AND SETTING:A prospective, observational study of European ICUs was performed on consecutive patients with any limitation of therapy. Prospectively defined end-of-life prac...

journal_title：Intensive care medicine

authors： Sprung CL,Maia P,Bulow HH,Ricou B,Armaganidis A,Baras M,Wennberg E,Reinhart K,Cohen SL,Fries DR,Nakos G,Thijs LG,Ethicus Study Group.

更新日期：2007-10-01 00:00:00

abstract：:This article was originally published under a CC BY-NC 4.0 license, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...

journal_title：Intensive care medicine

authors： Harris S,Singer M,Sanderson C,Grieve R,Harrison D,Rowan K

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:To investigate the relationship between hemoglobin (Hgb) and brain tissue oxygen tension (PbtO(2)) after severe traumatic brain injury (TBI) and to examine its impact on outcome. METHODS:This was a retrospective analysis of a prospective cohort of severe TBI patients whose PbtO(2) was monitored. The relationsh...

journal_title：Intensive care medicine

authors： Oddo M,Levine JM,Kumar M,Iglesias K,Frangos S,Maloney-Wilensky E,Le Roux PD

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:Nuclear factor-kappaB (NF-kappaB) is a transcription factor which plays a pivotal role in the induction of genes involved in the response to injury and inflammation. Calpain I inhibitor is a potent antioxidant which is an effective inhibitor of NF-kappaB. This study examined whether the postulate that calpain...

journal_title：Intensive care medicine

authors： Virlos I,Mazzon E,Serraino I,Genovese T,Di Paola R,Thiemerman C,Siriwardena A,Cuzzocrea S

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:We assessed feasibility and safety of extracorporeal carbon dioxide removal (ECCO2R) to facilitate ultra-protective ventilation (VT 4 mL/kg and PPLAT ≤ 25 cmH2O) in patients with moderate acute respiratory distress syndrome (ARDS). METHODS:Prospective multicenter international phase 2 study. Primary endpoint w...

journal_title：Intensive care medicine

authors： Combes A,Fanelli V,Pham T,Ranieri VM,European Society of Intensive Care Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Infection is the most frequent cause of acute respiratory distress syndrome (ARDS). However, little is known about the influence of infection sites on ARDS. This study aimed to assess the associations of infection sites with ARDS development and mortality in critically ill infected patients. DESIGN:Prospecti...

journal_title：Intensive care medicine

authors： Sheu CC,Gong MN,Zhai R,Bajwa EK,Chen F,Thompson BT,Christiani DC

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:An instrument able to estimate the direct costs of stays in Intensive Care Units (ICUs) simply would be very useful for resource allocation inside a hospital, through a global budget system. The aim of this study was to propose such a tool. DESIGN:Since 1991, a region-wide common data base has collected stan...

journal_title：Intensive care medicine

authors： Sznajder M,Leleu G,Buonamico G,Auvert B,Aegerter P,Merlière Y,Dutheil M,Guidet B,Le Gall JR

更新日期：1998-06-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Perner A,Finfer S

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To describe Enterococcus faecalis colonisation and endocarditis in 5 intensive care patients after treatment with selective decontamination (SDD). SETTING:Intensive care unit (ICU) in a general hospital. PATIENTS:The patients were admitted to the ICU because of adult respiratory distress syndrome, polytraum...

journal_title：Intensive care medicine

authors： Sijpkens YW,Buurke EJ,Ulrich C,van Asselt GJ

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the physiological effects of decannulation on breathing patterns and respiratory mechanics by comparing mouth breathing (MB) to tracheal breathing (TB) in tracheostomized patients. DESIGN AND SETTING:Prospective cross-over study in a critical and neuromuscular care unit. PATIENTS AND METHODS:Nin...

journal_title：Intensive care medicine

authors： Chadda K,Louis B,Benaïssa L,Annane D,Gajdos P,Raphaël JC,Lofaso F

更新日期：2002-12-01 00:00:00

abstract：:608 patients admitted to a general Intensive Care Unit (ICU) over a 30 month period were analyzed according to the Apache II Severity of Disease Classification System on day one of admission. Hospital outcome details were available on 583 patients in the series. The mean Apache II scores for survivors (396) and non-su...

journal_title：Intensive care medicine

authors： Jacobs S,Chang RW,Lee B,Lee B

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To describe the use of volumetric capnography, a plot of expired CO(2) concentration against expired volume, in monitoring fibrinolytic treatment of major pulmonary embolism. DESIGN AND SETTING:Two case reports in the emergency department of a teaching hospital. PATIENTS:Two conscious and spontaneously brea...

journal_title：Intensive care medicine

authors： Verschuren F,Heinonen E,Clause D,Roeseler J,Thys F,Meert P,Marion E,El Gariani A,Col J,Reynaert M,Liistro G

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:(1) To describe the pattern of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in a group of severe head-injured patients, (2) to quantify complications of ICP monitoring, and (3) to describe a management protocol and its results. DESIGN:Prospective observational study. SETTING:General int...

journal_title：Intensive care medicine

authors： Stocchetti N,Rossi S,Buzzi F,Mattioli C,Paparella A,Colombo A

更新日期：1999-04-01 00:00:00

abstract：:One hundred consecutive patients were interviewed between the 3rd and 7th days, inclusive, of their discharge from an intensive care unit to a general ward. The patients' recall of events related to their admission to the ICU was generally poor, and 41% of them felt that they had been confused at some time during thei...

journal_title：Intensive care medicine

authors： Jones J,Hoggart B,Withey J,Donaghue K,Ellis BW

更新日期：1979-05-01 00:00:00