Abstract：
OBJECTIVE:Atracurium besylate and laudanosine cause excitement and seizures when introduced into the central nervous system of laboratory animals. We examined the modulation of lipid-protein interaction in the lipid environment of rat brain synaptosomal plasma membrane (SPM)-bound enzymes as a possible mechanism leading to these effects. METHODS:The effect of various concentrations of atracurium besylate and laudanosine, or of varying duration of SPM, on the activity of Na+/K+-stimulated ATPase, Mg2+-stimulated ATPase and 5'-nucleotidase were assessed. The modulation of lipid protein interaction by laudanosine was estimated on the basis of the temperature dependence and cooperative behaviour of Na+/K+-stimulated ATPase. RESULTS:The effect of atracurium besylate or laudanosine on Na+/K+-stimulated ATPase activity was biphasic. Maximal enzyme stimulation appeared at 10(-4) M atracurium besylate or 10(-8) M laudanosine, and at 30 min of pre-incubation with both drugs. Arrhenius plots of Na+/K+-stimulated ATPase showed a transition temperature of 23.0 +/- 1.2 degrees C in control SPM and shifted to 16.5 +/- 0.9 degrees C (p < 0.01) in SPM treated with 10(-8) M laudanosine. The Hill coefficients for the allosteric inhibition of Na+/K+-stimulated ATPase by fluoride decreased from 1.99 +/- 0.22 in controls to 1.06 +/- 0.11 (p < 0.001) in the presence of 10(-8) M laudanosine. CONCLUSIONS:Our results suggest that laudanosine, one of the principal metabolites of atracurium besylate, affects nerve cell function in rats through the perturbation of the membrane lipid structure accompanied by SPM-bound enzyme dysfunction.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Kamper EF,Siafaka J,Stavridis Jdoi
10.1007/s001340050605subject
Has Abstractpub_date
1998-05-01 00:00:00pages
519-25issue
5eissn
0342-4642issn
1432-1238journal_volume
24pub_type
杂志文章abstract：:Conventional PEEP ventilation has been recently reported to be deleterious in some cases of ARF with unilateral pneumonia. In such respect, two cases of unilateral bacterial pneumonia were intubated with a Carlens tracheal tube. Measurement of tidal volume, static compliance, and functional residual capacity of each l...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01683935
更新日期：1979-11-01 00:00:00
abstract：OBJECTIVE:To measure muscle blood flow (Qtis) and oxygen consumption (VO(2)tis) in septic and non-septic critically ill patients by near-infrared spectroscopy (NIRS). SETTING:Surgical intensive care unit of a university hospital. PATIENTS AND PARTICIPANTS:Four patients with septic shock, eight post-surgical criticall...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-003-1805-0
更新日期：2003-07-01 00:00:00
abstract：OBJECTIVE:To determine the impact of missing Acute Physiology Score (APS) values on risk-adjusted mortality. DESIGN:Retrospective review of prospectively collected Acute Physiology and Chronic Health Evaluation (APACHE) III database. SETTING:The intensive care units (ICUs) of an academic medical center. PATIENTS:38,...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-005-2751-9
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVE:To investigate the involvement of intestinal angiotensin II type 2 receptors in the outcome of acute severe hypovolemia as well as systemic and regional mesenteric hemodynamics and intestinal mucosal functions in anesthetized pigs. DESIGN AND SETTING:Prospective, interventional animal study in a university r...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-005-2686-1
更新日期：2005-08-01 00:00:00
abstract：OBJECTIVE:Biomarkers allowing accurate early staging of septic shock patients are lacking despite their obvious interest for patient management. Experimental models of septic shock in mouse previously noted a decrease in dendritic cell numbers. The aim of the study was to find a rapid reproducible biological test for a...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-006-0436-7
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:Chronic pulmonary hypertension (PH) therapy is poorly investigated in intensive care. Our aim was to evaluate haemodynamic and neuroendocrine effects of the dual endothelin-1 (ET-1) blocker tezosentan in monocrotaline (MCT)-induced PH. METHODS:Male Wistar rats (180-200 g, n = 194) randomly received 60 mg kg(-1...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-012-2484-5
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:To determine: (1) the proportion of small (<5 mm) or thrombosed internal jugular veins (IJV) and femoral veins (FV) in which catheter placement would be difficult without ultrasound guidance; (2) which position increases central vein sizes and may facilitate cannulation of these vessels. DESIGN:Prospective s...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-007-0875-9
更新日期：2008-02-01 00:00:00
abstract：:The purpose of this study was noninvasive assessment of respiratory compliance and resistance in mechanically ventilated patients with acute respiratory failure (ARF). To this end, flow, change in lung volume, and airway pressure were measured at the proximal tip of the endotracheal tubes in twenty nine critically ill...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00263528
更新日期：1988-01-01 00:00:00
abstract：PURPOSE:To study the incidence and clinical characteristics of delayed cerebral thrombosis in bacterial meningitis patients. METHODS:We assessed the incidence and clinical characteristics of delayed cerebral thrombosis in adults with cerebrospinal fluid (CSF) culture-proven community-acquired bacterial meningitis incl...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-012-2792-9
更新日期：2013-05-01 00:00:00
abstract：PURPOSE:Some patients presenting with acute respiratory failure and meeting the Berlin criteria for acute respiratory distress syndrome (ARDS) lack exposure to common risk factors (CRF). These so-called ARDS mimickers often lack histological diffuse alveolar damage. We aimed to describe such ARDS mimickers lacking CRF ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-015-4064-y
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:To provide recommendations and standard operating procedures for intensive care units and hospital preparedness for an influenza pandemic. METHODS:Based on a literature review and expert opinion, a Delphi process was used to define the essential topics. RESULTS:Key recommendations include: Hospitals should in...
journal_title：Intensive care medicine
pub_type： 指南,杂志文章,评审
doi：10.1007/s00134-010-1759-y
更新日期：2010-03-01 00:00:00
abstract：PURPOSE:Although low doses of oxygen (FiO2 <0.50) are considered nontoxic, recent studies have shown that even lower doses increase pulmonary inflammatory mediators. We aimed to evaluate the acute effects of reducing FiO2 on pulmonary inflammation in mechanically ventilated patients without respiratory failure. METHOD...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-012-2801-z
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Invasive candidiasis and candidemia are frequently encountered in the nosocomial setting particularly in the intensive care unit (ICU). OBJECTIVE AND METHODS:To review the current management of invasive candidiasis and candidemia in non-neutropenic adult ICU patients based on a review of the literature and ...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-008-1339-6
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:On hospital admission, the morphology of the central pulmonary artery thromboemboli is an independent predictor of 30-day mortality in patients with massive pulmonary embolism (MPE). This may be due to the differential susceptibility of thromboemboli to thrombolysis. The aim of this study was to assess haemod...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2314-5
更新日期：2004-08-01 00:00:00
abstract：PURPOSE:Gastrointestinal motility can be impaired by serious illness or medications, compromising enteral feeding in critical care patients. We compared small bowel transit time and morphology in neurosurgical critical care (ICU) patients with those in healthy subjects. METHODS:We evaluated small intestinal transit ti...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-009-1415-6
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:Definition of the changes in the activators of plasminogen, u-PA and t-PA, and examination of the possible generation of plasmin in the circulation in overwhelming sepsis. DESIGN:Serial blood analysis starting 4 h after development of symptoms of toxic shock syndrome. SETTING:Intensive care unit. PATIENT:A...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050561
更新日期：1998-03-01 00:00:00
abstract：OBJECTIVE:To analyze the effects of polymyxin B-immobilized fiber (PMX-F) on bone resorption in septic patients. DESIGN AND SETTING:Observational prospective study in intensive care units of a general hospital. PATIENTS AND PARTICIPANTS:25 patients with severe sepsis and 20 healthy controls. MEASUREMENTS AND RESULTS...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00134-004-2357-7
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVE:To validate a simple method avoiding discard volumes in pediatric patients with indwelling arterial and venous lines. DESIGN:Zero-discarding was achieved by passive extracorporeal arteriovenous backflow via standard single pressure transducer equipment. We tested backflow distances (10, 20 and 30 cm beyond t...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s001340100951
更新日期：2001-06-01 00:00:00
abstract：OBJECTIVE:Transcapillary heat transfer after injections of cold saline into the right atrium generates bronchial thermodilution curves resembling those observed in the aorta. Under the assumption that no indicator is lost or gained within the pulmonary capillary bed and changes in blood temperature are instantaneously ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050818
更新日期：1999-02-01 00:00:00
abstract：:In hypoxia sensitive cells and tissues, the rates of glucose and O2 consumption are inversely related (Pasteur Effect). Under O2 limiting conditions the demands for glucose (glycogen) in such cells may drastically rise as a means for maintaining ATP turnover close to normoxic rates; nevertheless ion and electrical pot...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00254926
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVES:To develop a simplified Therapeutic Intervention Scoring System (TISS) based on the TISS-28 items and to validate the new score in an independent database. DESIGN:Retrospective statistical analysis of a database and a prospective multicentre study. SETTING:Development in the database of the Foundation for ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050406
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:Adult studies evaluating corticosteroids have found varied efficacy. One study showing mortality benefit utilized fludrocortisone (FLU) and hydrocortisone (HC) (Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288:862-871, 2002). Use of...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-010-2090-3
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVE:To compare the effectiveness of 70-mg and 200-mg doses of intravenous erythromycin in improving gastric emptying in critically ill patients. DESIGN:Gastric emptying was measured on consecutive days; day 1 (pre-treatment), day 2 (post-treatment) after an intravenous infusion of either 70 or 200 mg erythromyci...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00134-005-2663-8
更新日期：2005-07-01 00:00:00
abstract：OBJECTIVE:To assess whether monitoring of bladder epithelial oxygen tension (BEOT) would provide an indication of regional (renal) organ perfusion in an exsanguination/fluid repletion animal model. DESIGN:Prospective non-randomized laboratory study. SETTING:Research laboratory. INTERVENTIONS:Eight anaesthetised, spo...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01700454
更新日期：1996-04-01 00:00:00
abstract：PURPOSE:Early central venous catheter (CVC) insertion in Ebola virus disease (EVD) is a novel approach and has not previously been described. This report delineates the safety, feasibility and clinical implications of early CVC insertion as the optimum means of vascular access in patients with EVD, in the setting of a ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-015-3736-y
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Changes in body temperature have important impact on measurements of blood gases. In blood gas analyzers the samples are always kept constant at a temperature of exactly 37 degrees C during the measurements, and therefore results are not correct if body temperature differs from 37 degrees C. OBJECTIVE:Lack ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2369-3
更新日期：2005-01-01 00:00:00
abstract：: ...
journal_title：Intensive care medicine
pub_type： 评论,信件
doi：10.1007/s00134-018-5461-9
更新日期：2019-01-01 00:00:00
abstract：:The side effects of positive pressure ventilation on cardiovascular function are well known. However, in most clinical studies its influence on left ventricular function was examined. In the present study right ventricular (RV) performance was studied in 13 patients undergoing coronary artery bypass grafting during me...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00256962
更新日期：1988-01-01 00:00:00
abstract：PURPOSE:This prospective observational study aimed at describing prescription patterns of tigecycline and patient outcomes in 26 French intensive care units (ICU). METHODS:Data of consecutive cases of adult patients treated with tigecycline were collected from the initiation until 7 days after the end of treatment. Re...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s00134-014-3323-7
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:The association of acute-phase reaction and outcome of patients with acute vascular diseases is controversial. The prognostic value of admission C-reactive protein (CRP) in patients with acute aortic aneurysm or dissection has not yet been investigated. DESIGN AND SETTING:Cohort study including 255 consecuti...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1299-1
更新日期：2002-06-01 00:00:00
