Do trials that report a neutral or negative treatment effect improve the care of critically ill patients? Yes.

abstract：:Cardiac arrhythmias and circulatory collapse account for the high mortality reported after severe chloroquine poisoning. We have recently observed a 17-year-old man who ingested an 8 g chloroquine overdose. Cardiac arrest occurred within 1 h. Cardiogenic shock was refractory to epinephrine, dopamine and molar sodium l...

journal_title：Intensive care medicine

authors： Hantson P,Ronveau JL,De Coninck B,Horn JL,Mahieu P,Hassoun A

更新日期：1991-01-01 00:00:00

abstract：:The purpose of this study was noninvasive assessment of respiratory compliance and resistance in mechanically ventilated patients with acute respiratory failure (ARF). To this end, flow, change in lung volume, and airway pressure were measured at the proximal tip of the endotracheal tubes in twenty nine critically ill...

journal_title：Intensive care medicine

authors： Bernasconi M,Ploysongsang Y,Gottfried SB,Milic-Emili J,Rossi A

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the incidence and the circumstances of a moderate increase in serum creatinine early after elective abdominal aortic surgery. DESIGN:Prospective clinical observational study. SETTING:Surgical intensive care unit in a university hospital. PATIENTS:Two hundred and fifteen consecutive adult patien...

journal_title：Intensive care medicine

authors： Ryckwaert F,Alric P,Picot MC,Djoufelkit K,Colson P

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Little evidence of increased thrombotic risk is available in COVID-19 patients. Our purpose was to assess thrombotic risk in severe forms of SARS-CoV-2 infection. METHODS:All patients referred to 4 intensive care units (ICUs) from two centers of a French tertiary hospital for acute respiratory distress syndrom...

journal_title：Intensive care medicine

authors： Helms J,Tacquard C,Severac F,Leonard-Lorant I,Ohana M,Delabranche X,Merdji H,Clere-Jehl R,Schenck M,Fagot Gandet F,Fafi-Kremer S,Castelain V,Schneider F,Grunebaum L,Anglés-Cano E,Sattler L,Mertes PM,Meziani F,CRICS TR

更新日期：2020-06-01 00:00:00

abstract：:Hemorrhagic complications from transection of cervical arteries in blunt traumas are rare. We report a case of potentially fatal hemorrhage from rupture of the left vertebral artery in a closed trauma, successfully treated by endovascular injection of glue. Endovascular embolization may be considered as an alternative...

journal_title：Intensive care medicine

authors： Simionato F,Righi C,Silvani P,Torri G,Scotti G

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:To determine the value of procalcitonin (PCT) in the early diagnosis (and differentiation) of patients with SIRS, sepsis, severe sepsis, and septic shock in comparison to C-reactive protein (CRP), white blood cell and thrombocyte count, and APACHE-II score (AP-II). DESIGN:Prospective cohort study including a...

journal_title：Intensive care medicine

authors： Brunkhorst FM,Wegscheider K,Forycki ZF,Brunkhorst R

更新日期：2000-03-01 00:00:00

abstract：:To examine the right ventricular response to acute respiratory failure, serial studies of biventricular performance were analysed in 34 such patients, specifically detailing the role of associated underlying disease. During the initial study, the 34 patients with acute respiratory failure had a higher right ventricula...

journal_title：Intensive care medicine

authors： Brunet F,Dhainaut JF,Devaux JY,Huyghebaert MF,Villemant D,Monsallier JF

更新日期：1988-01-01 00:00:00

abstract：:The use of induced hypertension in head injury patients is controversial. We present the case of a 19-year-old man admitted with severe head trauma after a road accident and describe the beneficial effects that increasing arterial blood pressure had on the cerebral perfusion pressure, cerebral blood flow and jugular b...

journal_title：Intensive care medicine

authors： Ferring M,Berré J,Vincent JL

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Peripherally inserted central venous catheters (PICC) have been proposed as an alternative to central venous catheters (CVC). The aim of this study was to determine the thrombosis rate in relation to PICC placement in patients discharged from the intensive care unit (ICU). METHODS:Data of patients admitted ...

journal_title：Intensive care medicine

authors： Bonizzoli M,Batacchi S,Cianchi G,Zagli G,Lapi F,Tucci V,Martini G,Di Valvasone S,Peris A

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:The aim of this prospective study was to evaluate the value of sinus echography results to directly indicate a transnasal puncture in intubated patients with suspicion of nosocomial maxillary sinusitis. DESIGN:prospective clinical investigation. SETTING:medical intensive care unit. PATIENTS:sixty patients ...

journal_title：Intensive care medicine

authors： Vargas F,Bui HN,Boyer A,Bébear CM,Lacher-Fougére S,De-Barbeyrac BM,Salmi LR,Traissac L,Gbikpi-Benissan G,Gruson D,Hilbert G

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:Pulmonary endothelial activation caused by high pulmonary capillary pressures may be involved in the pathogenesis of cardiogenic pulmonary edema (CPE). We studied soluble selectins and soluble ICAM-1 as markers of cell activation in the systemic and pulmonary circulation of patients with respiratory failure (...

journal_title：Intensive care medicine

authors： Geppert A,Zorn G,Heinz G,Huber K,Siostrzonek P

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:Optimal respiratory support for interhospital transport of critically ill children is challenging and has been scarcely investigated. High-flow nasal cannula (HFNC) therapy has emerged as a promising support mode in the paediatric intensive care unit (PICU), but no data are available on HFNC used during interho...

journal_title：Intensive care medicine

authors： Schlapbach LJ,Schaefer J,Brady AM,Mayfield S,Schibler A

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:Hyperglycaemia is common in the critically ill. The objectives of this study were to determine the prevalence of critical illness-associated hyperglycaemia (CIAH) and recognised and unrecognised diabetes in the critically ill as well as to evaluate the impact of premorbid glycaemia on the association between ac...

journal_title：Intensive care medicine

authors： Plummer MP,Bellomo R,Cousins CE,Annink CE,Sundararajan K,Reddi BA,Raj JP,Chapman MJ,Horowitz M,Deane AM

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:To assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers. DESIGN:Two groups of eight healthy subjects were randomized to receive either two pharmacological doses of intravenous FO fat emulsion or no treatment. ...

journal_title：Intensive care medicine

authors： Pluess TT,Hayoz D,Berger MM,Tappy L,Revelly JP,Michaeli B,Carpentier YA,Chioléro RL

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate the effect of lung volume changes on end-expiratory lung impedance change (ELIC) in mechanically ventilated patients, since we hypothesized that ELIC may be a suitable parameter to monitor lung volume change at the bedside. DESIGN:Clinical trial on patients requiring m...

journal_title：Intensive care medicine

authors： Hinz J,Hahn G,Neumann P,Sydow M,Mohrenweiser P,Hellige G,Burchardi H

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To determine the steady-state trough serum and epithelial lining fluid (ELF) concentrations of teicoplanin 12 mg/kg per day in critically ill patients with ventilator associated pneumonia. DESIGN AND SETTING:Prospective, pharmacokinetic study in the surgical intensive care unit in a university hospital. PAT...

journal_title：Intensive care medicine

authors： Mimoz O,Rolland D,Adoun M,Marchand S,Breilh D,Brumpt I,Debaene B,Couet W

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:The Pediatric Index of Mortality 2 (PIM2), one of the key mortality prediction models for children in intensive care units, has not been validated in Japan. The purpose of this study was to validate the performance of PIM2 in a population of patients admitted to one pediatric intensive care unit (PICU) in Jap...

journal_title：Intensive care medicine

authors： Imamura T,Nakagawa S,Goldman RD,Fujiwara T

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:To assess the ability of quantitative pupillometry [using the Neurological Pupil index (NPi)] to predict an unfavorable neurological outcome after cardiac arrest (CA). METHODS:We performed a prospective international multicenter study (10 centers) in adult comatose CA patients. Quantitative NPi and standard ma...

journal_title：Intensive care medicine

authors： Oddo M,Sandroni C,Citerio G,Miroz JP,Horn J,Rundgren M,Cariou A,Payen JF,Storm C,Stammet P,Taccone FS

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:Critically ill patients often develop anaemia which can be related to a number of factors. However, the exact causes of anaemia in many patients remain unexplained. We hypothesized that the relationship between erythropoietin (EPO) and haematocrit may be altered in critically ill patients. DESIGN:Serum conc...

journal_title：Intensive care medicine

authors： Rogiers P,Zhang H,Leeman M,Nagler J,Neels H,Mélot C,Vincent JL

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVES:Controversies concerning the pivotal trial and negative results from other Drotrecogin alfa activated (DAA) trials have raised questions about its efficacy in severe sepsis patients. Based on all available evidence, our study aimed to respond to: (1) What is the current probability that DAA is not better tha...

journal_title：Intensive care medicine

authors： Kalil AC,Sun J

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Dislocation of the heart is a rare complication of thoracic blunt trauma. A high index of suspicion of pericardium rupture is necessary to formulate an early diagnosis to reduce morbidity and mortality. PATIENTS:A 23-year-old man suffered a blunt thoracoabdominal trauma and was admitted 3 days later to a un...

journal_title：Intensive care medicine

authors： Piazza O,De Robertis E,Fraioli G,Tufano R

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:We tested the hypothesis that synchronization to patient effort during intermittent mandatory ventilation (SIMV), when compared to conventional unsynchronized intermittent mandatory ventilation (IMV), will decrease energy expenditure, as reflected by decreased oxygen consumption (VO2). DESIGN:We used a four-...

journal_title：Intensive care medicine

authors： Smith KM,Wahlig TM,Bing DR,Georgieff MK,Boros SJ,Mammel MC

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:There are a number of potential etiologies of severe bleeding encountered in the intensive care unit. Although rare, acquired hemophilia is one such etiology that often presents with major bleeding requiring intensive care. Despite the introduction of effective treatments, the reported mortality rate of patie...

journal_title：Intensive care medicine

authors： Shander A,Walsh CE,Cromwell C

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:To investigate the hemodynamic and metabolic effects of the peroxisome proliferator-activated receptor (PPAR)-gamma ligand and nuclear-factor (NF)-kappa B inhibitor 15-deoxy-Delta12,14-prostaglandin-J2 (15d-PGJ2) during long-term, hyperdynamic porcine endotoxemia. DESIGN:Prospective, randomized, controlled e...

journal_title：Intensive care medicine

authors： Hauser B,Kick J,Iványi Z,Asfar P,Ehrmann U,Muth CM,Albicini M,Wachter U,Vogt J,Bauer M,Brückner UB,Radermacher P,Bracht H

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate and compare the accuracy of the percentage of infected cells (%IC) in bronchoalveolar lavage (BAL) for ventilator-associated pneumonia (VAP) diagnosis according to its onset from the initiation of mechanical ventilation. PATIENTS:One hundred and eight patients admitted ...

journal_title：Intensive care medicine

authors： Dupont H,Chalhoub V,Plantefève G,De Vaumas C,Kermarrec N,Paugam-Burtz C,Mantz J

更新日期：2004-08-01 00:00:00

abstract：:Myxoedema coma is a medical emergency with high mortality. In this study, clinical response and plasma variations of thyroid hormones were analysed in 7 patients, 6 presenting with myxoedema coma and one with myxoedema ileus. These patients were treated with intravenous or oral l-thyroxine (l-T4). 1000 mu l-T4 iv were...

journal_title：Intensive care medicine

authors： Arlot S,Debussche X,Lalau JD,Mesmacque A,Tolani M,Quichaud J,Fournier A

更新日期：1991-01-01 00:00:00

abstract：:Total extracorporeal lung assist (ECLA) requires a bypass flow approaching cardiac output. Recirculation of venous blood through the oxygenator is minimized with a veno-right ventricular cannulation technique which separates venous drainage from returned oxygenated blood. A case of posttraumatic ARDS was treated with ...

journal_title：Intensive care medicine

authors： Wetterberg T,Steen S

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of screening strategy and contact precautions for patients with methicillin-resistant Staphylococcus aureus (MRSA). DESIGN AND SETTING:Prospective observational cohort from 1 February 1995 to 31 December 2001 in three intensive care units (45 beds) in a French teaching hospital....

journal_title：Intensive care medicine

authors： Lucet JC,Paoletti X,Lolom I,Paugam-Burtz C,Trouillet JL,Timsit JF,Deblangy C,Andremont A,Regnier B

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:This study compared the recently introduced Microcuff endotracheal tube HVLP ICU featuring an ultrathin (7-microm) polyurethane cuff membrane with endotracheal tubes from different manufacturers regarding fluid leakage past the tube cuff. DESIGN:In vitro setup. MEASUREMENTS AND RESULTS:The following endotra...

journal_title：Intensive care medicine

authors： Dullenkopf A,Gerber A,Weiss M

更新日期：2003-10-01 00:00:00

abstract：:As a result of the previous shortage of tools to assess objectively the overall physiological status of the respiratory system in infants and young children, it has been difficult to measure the degree of physiological disorder or the response to therapy in respiratory diseases such as BPD, the pediatric version of AR...

journal_title：Intensive care medicine

authors： Hammer J,Newth CJ

更新日期：1995-09-01 00:00:00