Abstract：
OBJECTIVES:(a). To describe the glucose content of normal human airways secretions; (b). to observe the effects of hyperglycemia and airways inflammation on airways glucose. DESIGN:Observational studies. SETTINGS:(a). St George's Hospital Medical School; (b). diabetes mellitus outpatient clinics; (c). adult general intensive care unit. PATIENTS:Nineteen healthy volunteers, 24 volunteers with acute rhinitis, 20 patients with diabetes mellitus, and 60 patients admitted to a general adult intensive care unit. MEASUREMENTS:(a). Non-ventilated patients: simultaneous measurement of blood and nasal glucose concentrations; (b). ICU patients: simultaneous blood, nasal, and endotracheal (ET) glucose concentrations. RESULTS:Nasal glucose was undetectable in all healthy volunteers. Glucose was detected in 12/24 volunteers with acute viral rhinitis [1 (1-2) mmol l(-1)] and 18/20 people with diabetes [4 (2-7) mmol l(-1)]. Glucose was detected in the ET secretions of 31/60 ventilated patients on ICU. Patients with ET glucose had significantly higher blood glucose (9.8+/-0.4 mmol l(-1)) than patients without ET glucose (7.2+/-0.3 mmol l(-1), P<0.001), and all patients with blood glucose >10.1 mmol l(-1) had glucose in ET secretions. Enteral nutrition did not affect the presence or concentration of glucose in ET secretions. CONCLUSIONS:Glucose is not normally present in airways secretions, but appears where hyperglycaemia or epithelial inflammation occur. The detection of glucose cannot reliably be used to detect enteral feed aspiration.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Philips BJ,Meguer JX,Redman J,Baker EHdoi
10.1007/s00134-003-1961-2keywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
2204-2210issue
12eissn
0342-4642issn
1432-1238pii
10.1007/s00134-003-1961-2journal_volume
29pub_type
杂志文章abstract：OBJECTIVES:To examine whether urgent orotracheal intubation (OI) can induce bacteremia. To find predictive factors for post-intubation bacteremia. DESIGN:Prospective observational study. SETTING:Seventeen-bed medical intensive care unit in a university hospital. PATIENTS:Sixty-eight adult intensive care patients und...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000841
更新日期：2001-02-01 00:00:00
abstract：OBJECTIVE:Organophosphate toxicity is the leading cause of morbidity and death in poisoning by insecticides. The clinical symptoms of pesticide toxicity range from the classic cholinergic syndrome to flaccid paralysis and intractable seizures. The mainstays of therapy are atropine, oximes, benzodiazepines and supportiv...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-005-0051-z
更新日期：2006-03-01 00:00:00
abstract：PURPOSE:To assess the impact of lung ultrasound (LU) on clinical decision making in mechanically ventilated critically ill patients. METHODS:One hundred and eighty-nine patients took part in this prospective study. The patients were enrolled in the study when LU was requested by the primary physician for (1) unexplain...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-013-3133-3
更新日期：2014-01-01 00:00:00
abstract：:We studied the influence of ventilatory frequency (1-5 Hz), tidal volume, lung volume and body position on the end-expiratory alveolar-to-tracheal pressure difference during high-frequency jet ventilation (HFJV) in Yorkshire piglets. The animals were anesthetized and paralysed. Alveolar pressure was estimated with the...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01706322
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVE:This study was undertaken to determine the delay of extubation attributable to ventilator-associated pneumonia (VAP) in comparison to other complications and complexity of surgery after repair of congenital heart lesions in neonates and children. METHODS:Cohort study in a pediatric intensive care unit of a t...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051285
更新日期：2000-07-01 00:00:00
abstract：:We analysed the case histories of 22 patients with life threatening asthma retrospectively. Fifteen patients needed mechanical ventilation. Three patients, all of them in cardiac arrest before or at the moment of admission, died. In five patients, halothane therapy was successfully used as a last resort. No major comp...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00260352
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVE:Endotoxin administration to humans is a common means to study systemic inflammation. Worldwide, thousands of volunteers have received endotoxin, and adverse events are rarely reported. The aim of this report was to increase awareness of specific risks of the intravenous administration of endotoxin to human vo...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2477-0
更新日期：2004-12-01 00:00:00
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journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-008-1078-8
更新日期：2008-07-01 00:00:00
abstract：OBJECTIVE:To compare noninvasive positive pressure ventilation (NPPV) vs. invasive mechanical ventilation in AIDS patients with Pneumocystis carinii pneumonia (PCP)-related acute respiratory failure (ARF). DESIGN:A single-center, prospective, case-control trial. SETTING:An ICU of a private tertiary hospital specializ...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s00134-002-1395-2
更新日期：2002-09-01 00:00:00
abstract：:Risk of critical illness is determined both by genetic and environmental influences, particularly those relating to infectious and cardiovascular diseases. Physiologically-based scoring systems cannot measure prior risk because they do not quantify physiological reserve independently of the acute illness. Genetic prof...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s001340051120
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVES:To study the pattern of lung emptying and expiratory resistance in mechanically ventilated patients with chronic obstructive pulmonary disease (COPD). DESIGN:A prospective physiological study. SETTING:A 12-bed Intensive Care Unit. PATIENTS:Ten patients with acute exacerbation of COPD. INTERVENTIONS:At th...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00134-004-2255-z
更新日期：2004-07-01 00:00:00
abstract：PURPOSE:We set out to summarize the current challenges in academic conflict of interest. METHODS:This is a narrative review by a multidisciplinary, multinational panel of academic officers including deans of medical/pharmacy schools. RESULTS AND CONCLUSIONS:Disclosing conflict of interest has become the appropriate p...
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pub_type： 杂志文章,评审
doi：10.1007/s00134-018-5458-4
更新日期：2019-01-01 00:00:00
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journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2233-5
更新日期：2004-09-01 00:00:00
abstract：:Cardiac arrhythmias and circulatory collapse account for the high mortality reported after severe chloroquine poisoning. We have recently observed a 17-year-old man who ingested an 8 g chloroquine overdose. Cardiac arrest occurred within 1 h. Cardiogenic shock was refractory to epinephrine, dopamine and molar sodium l...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01720684
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the origin of H+ ions participating in the generation of CO2 coming from sodium bicarbonate infusion during metabolic acidosis. We hypothesized that these H+ ions come from a back-titration of the main non-bicarbonate buffers present in the blood, i. e. the hemoglobin and the albumin, and thus pos...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051204
更新日期：2000-05-01 00:00:00
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journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01709555
更新日期：1996-12-01 00:00:00
abstract：:Administration of C1-esterase inhibitor (C1-INH) attenuates myocardial necrosis and sustains normal cardiac performance after myocardial ischemia and reperfusion in animal experiments. We report on our first experience of C1-INH application as rescue therapy in patients undergoing emergency surgical revascularization ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050629
更新日期：1998-06-01 00:00:00
abstract：OBJECTIVES:(a) To assess whether differences in lung morphology observed in patients with adult respiratory distress syndrome (ARDS) are associated with differences in cardiorespiratory parameters, lung mechanics, and outcome. (b) To propose a new ARDS Severity Score to identify patients with a high mortality risk. DE...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051317
更新日期：2000-08-01 00:00:00
abstract：PURPOSE:To study the association between early initiation of intra-arrest therapeutic hypothermia and neurologic outcome in out-of-hospital cardiac arrest. METHODS:A prespecified sub-analysis of the PRINCESS trial (NCT01400373) that randomized 677 bystander-witnessed cardiac arrests to transnasal evaporative intra-arr...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-020-06024-3
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:After resuscitation, asphyxiated neonates often develop poor cardiac function with hypotension, pulmonary hypertension and multiorgan ischemia. In a swine model of neonatal hypoxia-reoxygenation, effects of epinephrine, dobutamine and milrinone on systemic, pulmonary and regional hemodynamics and oxygen tran...
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pub_type： 杂志文章
doi：10.1007/s00134-010-1820-x
更新日期：2010-06-01 00:00:00
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journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050987
更新日期：1999-09-01 00:00:00
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journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-006-0511-0
更新日期：2007-03-01 00:00:00
abstract：:We report a clinical observation of acute pancreatitis due to severe hypertriglyceridemia in a pregnant woman. In order to decrease the serum triglyceride level rapidly, two lipaphereses were undertaken using the double-filtration technique. This lipoprotein apheresis technique is briefly described and the efficacy in...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01709884
更新日期：1991-01-01 00:00:00
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journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01707409
更新日期：1995-05-01 00:00:00
abstract：OBJECTIVE:To investigate the involvement of intestinal angiotensin II type 2 receptors in the outcome of acute severe hypovolemia as well as systemic and regional mesenteric hemodynamics and intestinal mucosal functions in anesthetized pigs. DESIGN AND SETTING:Prospective, interventional animal study in a university r...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-005-2686-1
更新日期：2005-08-01 00:00:00
abstract：PURPOSE:To evaluate the diagnostic accuracy of ultrasonography of optic nerve sheath diameter (ONSD) for assessment of intracranial hypertension. METHODS:Systematic review without language restriction based on electronic databases, with manual review of literature and conference proceedings until July 2010. Studies we...
journal_title：Intensive care medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00134-011-2224-2
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:To assess whether monitoring of bladder epithelial oxygen tension (BEOT) would provide an indication of regional (renal) organ perfusion in an exsanguination/fluid repletion animal model. DESIGN:Prospective non-randomized laboratory study. SETTING:Research laboratory. INTERVENTIONS:Eight anaesthetised, spo...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01700454
更新日期：1996-04-01 00:00:00
abstract：OBJECTIVE:To investigate the sources of hemorrhage and use of endoscopic hemostasis in patients with clinically significant upper gastrointestinal (UGI) hemorrhage after admission to the intensive care unit (ICU). DESIGN AND SETTING:Prospective study, 123 beds of ICU in a 1,629-bed medical center. MEASUREMENTS AND RE...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-003-1921-x
更新日期：2003-10-01 00:00:00
abstract：PURPOSE:Plasma immunoglobulin concentrations are acutely altered in critically ill patients with sepsis. However, the association between immunoglobulin levels on the day of sepsis diagnosis and subsequent mortality is inconsistent. METHODS:Systematic review of studies that report immunoglobulin measurements and morta...
journal_title：Intensive care medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00134-015-3845-7
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of terlipressin on oxygenation, PaO2/FIO2, heart rate, mean arterial pressure, and mortality in children with septic shock refractory to high doses of dopamine/dobutamine and adrenaline. DESIGN AND SETTING:A randomized, nonblind study in the pediatric intensive care unit of a universit...
journal_title：Intensive care medicine
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00134-007-0971-x
更新日期：2008-03-01 00:00:00
