The emergence of HIV-1 primary drug resistance genotypes among treatment-naïve men who have sex with men in high-prevalence areas in China.

Abstract:

:The prevalence of HIV-1 infection in men who have sex with men (MSM) in China has drastically increased, and circulating strains may have acquired transmitted drug resistance (TDR). We determined TDR genotypes among antiretroviral therapy (ART)-naïve MSM in 19 provinces/cities where HIV-1 prevalence among MSM is high, and found an overall 4.9 % TDR rate. Although protease inhibitors (PI) were not in the first-line antiretroviral drug list provided through the National ART Program, 70.4 % of the detected TDR belongs to this category. Our findings confirm the urgent need for TDR surveillance in order to optimize treatment effects of the National ART Program.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Yang J,Xing H,Niu J,Liao L,Ruan Y,He X,Feng Y,Li Z,Shao Y

doi

10.1007/s00705-012-1557-7

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

839-44

issue

4

eissn

0304-8608

issn

1432-8798

journal_volume

158

pub_type

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