The serological markers of acute infection with hepatitis A, B, C, D, E and G viruses revisited.

Abstract:

:Viral hepatitis is a liver infection caused by one of the six hepatitis viruses: hepatitis A, B, C, D, E, and G virus (HAV to HEV and HGV). These agents differ in their biological, immunological, pathological and epidemiological characteristics. They cause infections that, when symptomatic, lead to clinical manifestations and laboratory findings that are not specific to a particular virus, often making differential diagnosis difficult, especially when no knowledge is available regarding the patient's medical history or the epidemiological background. A number of acute-phase serological markers, such as anti-HAV, anti-HBc, anti-HDV and anti-HEV IgM antibodies, are able to provide a clear indication of an infection caused by HAV, HBV, HDV or HEV. Anti-HCV antibodies and HGV/RNA are used for the diagnosis of HCV and HGV infections. The importance of each of these markers will be reviewed, and different factors that can interfere with the diagnosis of acute infections caused by these viruses will be described.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Pondé RAA

doi

10.1007/s00705-017-3538-3

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

3587-3602

issue

12

eissn

0304-8608

issn

1432-8798

pii

10.1007/s00705-017-3538-3

journal_volume

162

pub_type

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