Abstract：
AIM:Drug-coated balloon (DCB) technology has emerged as a promising therapy particularly in the treatment of coronary in-stent restenosis. Although a variety of devices are available for clinical use, clinical outcomes have been variable and scope for significant improvement exists. METHODS:In a preclinical study, a total of 10 juvenile healthy farm pigs underwent catheter-based DCB deployment in coronary arteries with angiographic and pathological follow-up at 7 or 28 days. Animals were randomly allocated to the PRIMUS or Dior® DCB (N.=10 per group) and evaluated by histopathology and morphometric analysis. In a first-in-man clinical study a total of 19 consecutive patients presenting with restenosis within drug-eluting stents were treated with the PRIMUS DCB. Clinical follow-up was performed out to 6 months. RESULTS:Neointimal thickness was similar between the PRIMUS and Dior® DCB groups, while fibrin deposition and inflammation were more sustained in the PRIMUS group at 28 days. In 19 consecutive patients presenting with in-stent restenosis of drug-eluting stents, treatment with the PRIMUS DCB catheter resulted in high procedural efficacy. There were no adverse clinical events observed out to 6 months. CONCLUSION:The PRIMUS DCB demonstrates high preclinical safety and excellent acute performance and safety. Further studies are needed to delineate the relative merits of this novel DCB compared to other devices.
journal_name
Minerva Cardioangioljournal_title
Minerva cardioangiologicaauthors
Briguori C,Virmani R,Kolodgie F,Byrne RA,Steigerwald K,Orlowski M,Joner Msubject
Has Abstractpub_date
2012-10-01 00:00:00pages
507-15issue
5eissn
0026-4725issn
1827-1618pii
R05123335journal_volume
60pub_type
杂志文章abstract：:Pulmonary embolism is a quite frequent event (incidence 1/10000/year), and blood stasis, endothelial lesions and coagulation disorders are predisposable factors. Elective treatment is heparin, but the use of this medication is associated with a possible ipercoagulative rebound effect. The case presented is a patient w...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND:Aim of the present comparative clinical study was to demonstrate the efficacy of the topical application of mesoglycan, a profibrinolytic agent, for healing of leg ulcers in patients with chronic venous insufficiency. METHODS:Forty patients, observed in our outpatients department, with venous leg ulcers hav...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND:Coronary perforations (CP) have been described as a rare but potentially fatal complication in percutaneous coronary interventions (PCI). Our aim is to compare temporal trends in frequency, management and outcomes of coronary perforations (CP). METHODS:All cases of CP recorded in our prospective institution...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.18.04433-X
更新日期：2018-08-01 00:00:00
abstract：:This study is aimed at analyzing our experience in the evolution of aneurysmatic disease after surgical treatment of the typical subrenal abdominal aortic aneurysm. In fact in some cases we reobserved these patients for the onset of a new important dilatation involving the proximal tract of the abdominal aorta or the ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:Radial approach has been used since 1989 to perform coronary angiography as an alternative to femoral access. During past decades, the development of dedicated equipment has led to high efficacy also in complex procedures. ST elevation myocardial infarction (STEMI) is known to be a high bleeding risk setting and in tu...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2016-06-01 00:00:00
abstract：:Endovascular aortic repair (EVAR) for abdominal aortic aneurysms (AAA) is the preferred first treatment option in case of patients with advanced age and/or fit anatomy owing to shorter length of in hospital staying, less complications or laparotomy-related re-interventions, and lower initial costs. Although it is a le...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2016-04-01 00:00:00
abstract：AIM:The purpose of this paper was to verify whether there is any sign of involvement of the cardiovascular system in the early stages of collagen diseases. METHODS:Seventeen patients (10 female and 7 male, average age 41.35 +/- 9.85 years) (group A) recruited at the Ambulatory of Internal Medicine for suspected collag...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2006-02-01 00:00:00
abstract：:The Authors describe a case of a patient showing, during an episode of chest pain, an ecg-pattern of wide and tall "Q" wave simulating inferior myocardial infarction. In fact, a further ecg recorded during sinus rhythm denotes that the "Q" wave was a retrograde P wave generated by a nodal rhythm. The other known cause...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:In order to assess left ventricular structure and diastolic function, 50 hypertensive male subjects, 25 with and 25 without a history of alcohol abuse, and 20 normotensive male controls underwent Doppler echocardiographic examination followed by ambulatory blood pressure monitoring for 24 hours. Left ventricular mass ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Coronary artery disease and atherothrombosis are complex pathologic entities. The intricate interplay between anatomical, cellular and molecular factors characterizes their pathogenesis and determines their clinical manifestations. Coronary artery revascularization strategies, by restoring myocardial blood perfusion, ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2015-08-01 00:00:00
abstract：:Deep venous thrombosis (DVT) is often difficult to diagnose based on objective data alone (sensitivity 60-66%, specificity 20-72%, according to a number of studies) and this leads to the possible misuse of instrumental tests. It is important to establish standard clinical protocols to select those cases that call for ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:Among the acute effects of cigarette smoking there are an increase in the arterial blood pressure and a decrease in skin temperature. The aim of this study is to evaluate whether these effects are more evident in hypertensive subjects (HTS) than in normotensive (NTS) ones. METHODS:A monitored Ambulatory Blo...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:The pharmacological treatment of non-complicated chronic venous insufficiency is a current and well-debated topic. The introduction of new products with action on the venous system, improved knowledge on the physiopathology of venous insufficiency and the possibility provided by new analytical instruments, h...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Drug-coated balloons (DCB) are widely used for several types of coronary artery disease, especially in-stent restenosis and de-novo small vessel disease. The role of correct lesion preparation is of paramount importance before DCB use. In the last years, the use of scoring balloons to achieve this goal has emerged as ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：10.23736/S0026-4725.19.05091-6
更新日期：2020-02-01 00:00:00
abstract：:Bacterial endocarditis in pregnancy is uncommon. We described two cases: the first case of endocarditis, caused by staphylococcus epidermidis (at the 35th week of pregnancy) was complicated by severe aortic valvular insufficiency; the second case, endocarditis caused by streptococcus alpha hemolytic (at the 32nd week ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:Since its initial description by Gramiak and Shah in 1968, contrast echocardiography has become an established practice world-wide. Microbubbles have the unique property of being pure intravascular tracers. The basic rationale behind bubble imaging is the characteristic responses to ultrasound power that results in en...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Of the main aspects of hypertension, left ventricular hypertrophy and appearance of cardiac dysfunction seem to be the most common and to produce an early and severe cardiac deterioration. Even in the presence of normal systolic function diastolic filling abnormalities are described. The efficacy of many ant...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：AIM:The aim of this study was to describe the five-year prognosis of an Italian cohort of patients following acute myocardial infarction (AMI) occurred at age ≤ 45 years and to investigate the potential role of risk predictors for future cardiovascular events (CVE). METHODS:The study enrolled 112 consecutive patients ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2010-08-01 00:00:00
abstract：:The universal definition of myocardial infarction has proved how important the role of biomarkers in the assessment of acute coronary syndrome (ACS) has become. As a result, management of patients with ACS today is more specific and personalized than ever, but there is still a lot of room for improvement. Unmet needs ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2011-06-01 00:00:00
abstract：:After recalling that cardiovascular complications represent the most frequent cause of mortality and morbidity in hypertensive patients, the author describes the main mechanism responsible for increased plasma level concentrations of Angiotensin in this syndrome. He subsequently illustrates the effects of ACE-inhibito...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2001-10-01 00:00:00
abstract：AIM:To evaluate any differences in ventricular pre-excitation secondary to Wolff Parkinson White syndrome in the aged compared to young and adult patients. METHODS: EXPERIMENTAL DESIGN:a clinical study was performed using a comparative prospective criterion with retrospective analysis. The duration of follow-up range...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:A case of pseudoaneurysm of the superficial femoral artery identified preoperatively by Magnetic Resonance is reported. The number of different parameters and planes covered by the technique permitted an accurate assessment of the site, extent, internal conformation and staging of the thrombotic deposits inside the ps...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：:Myocardial infarction in the under-40s is rare. A series of 19 patients, 3.07% of a two-year series of coronary cases, is presented with a view to evaluating the incidence of risk factors, with special attention to familial factors and dyslipoproteinaemia. Risk factors are discussed together with the statistical impor...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：BACKGROUND:Galectin-3 is a recently developed biomarker of fibrosis, which may play a role in cardiac remodeling and associated with both the progression and severity of heart failure (HF). METHODS:A prospective cohort study of 190 patients with documented prior myocardial infarction and chronic HF (NYHA class II-IV) ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2016-12-01 00:00:00
abstract：:A case of double unruptured intracranial aneurysm associated with aortic coarctation is presented. The main characteristics of the unusual association, the diagnostic criteria and the surgical strategies are reviewed. ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:A study of the protective efficiency imparted by intermittent warm blood cardioplegia (WBCP) using perfused rat heart model. METHODS:Hemodynamic parameters were monitored simultaneously with metabolic changes in high-energy phosphates using 31P-NMR spectroscopy. Following 30 min perfusion with Krebs-Henselei...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：:Despite the impressive progress of percutaneous treatment modalities, restenosis remains the major Achilles heel of interventional cardiology. Approximately 25% of the general population treated for coronary diseases with a bare-metal stent and about 10% of patients treated with a drug-eluting stent develop an overgro...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2009-10-01 00:00:00
abstract：:The efficacy and safety of the treatment of arterial hypertension with the ACE-inhibitor quinapril, were evaluated in a multicentre study conducted in Italy. The study, lasting 14 weeks, after a preliminary wash-out period, allowed response-based titration of quinapril dose from 10 mg to 40 mg once a day, with provisi...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1992-03-01 00:00:00
abstract：:The metabolic abnormalities associated with diabetes mellitus result in macrovascular and microvascular complications in multiple organ systems; it is the cardiovascular impact that accounts for the greatest morbidity and mortality associated with this disease. Heart failure, both with reduced and preserved systolic f...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:Coronary sinus type atrial defect is the result of an incomplete formation of the atriovenous fold. This is a rare anomaly that in a very few cases took advantage of echocardiographic diagnosis before surgery. We report on a case of coronary sinus type atrial septal defect diagnosed by means of transthoracic...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
