Paclitaxel eluting balloon: from bench to bedside.

Abstract:

:Despite the impressive progress of percutaneous treatment modalities, restenosis remains the major Achilles heel of interventional cardiology. Approximately 25% of the general population treated for coronary diseases with a bare-metal stent and about 10% of patients treated with a drug-eluting stent develop an overgrowth of vascular tissue and renarrowing inside the stent, or in-stent restenosis. These rates are even greater in diabetics and patients at higher risk of restenosis both for clinical presentation (patients in dialysis, low ejection fraction) or anatomical characteristics (ostial, bifurcation, long lesions). Non-stent based local drug delivery and particularly the use of paclitaxel eluting balloon (PEB) could be one promising strategy to reduce restenosis. This review will briefly explore the different characteristics of PEB devices currently present in the market and summarize the results obtained both in animal models and clinical practice, giving an indication of the potential field of application of this new technology.

journal_name

Minerva Cardioangiol

authors

Marzullo R,Aprile A,Clementi F,Stella P,Modena MG,Sangiorgi GM

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

597-609

issue

5

eissn

0026-4725

issn

1827-1618

pii

R05092940

journal_volume

57

pub_type

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