Abstract:
:Coronary artery disease and atherothrombosis are complex pathologic entities. The intricate interplay between anatomical, cellular and molecular factors characterizes their pathogenesis and determines their clinical manifestations. Coronary artery revascularization strategies, by restoring myocardial blood perfusion, only partially treat ischemic heart disease in its complexity. Pharmacological therapies targeting molecular and cellular components involved in the pathophysiology of atherothrombosis are mandatory in order to prevent cardiovascular complications during and after revascularization and therefore improve clinical outcomes. The developments of antithrombotic pharmacotherapies occurred as a result of an improved understanding of the mechanisms underlying atherothrombotic disease. Unfortunately, the optimal antithrombotic therapy, in both acute and chronic settings, often set significant challenges in daily practice. The main objective of optimal antithrombotic therapies, targeting coagulation factors or the platelet system, is to maximize the anti-thrombotic efficacy while minimizing the bleeding risk. The subtle balance between ischemic and bleeding risk is a complex clinical conundrum that involves pharmacologic factors, the clinical phenotype of coronary artery disease and patient's clinical comorbidities. In a contemporary era, in which a broad armamentarium of pharmacologic agents and diagnostic tools are available, physician practice should shift toward a progressively more customized patient care. For this purpose, selection of the optimal acute and chronic percutaneous coronary intervention (PCI) pharmacotherapy, in terms of potency, duration and adherence, cannot disregard an individualized and careful evaluation of the patient's ischemic and hemorrhagic risk. It is within this context that in the present review article we sought to expose the current topics of debate and controversies in acute and chronic anticoagulant and antiplatelet therapies in patients undergoing PCI.
journal_name
Minerva Cardioangioljournal_title
Minerva cardioangiologicaauthors
Giustino G,Mehran Rsubject
Has Abstractpub_date
2015-08-01 00:00:00pages
275-96issue
4eissn
0026-4725issn
1827-1618pii
R05Y9999N00A150021journal_volume
63pub_type
杂志文章,评审abstract::The division of the venous circulation in to two sectors, one constituted by the superficial and deep venous trunks (macrocirculation) and the other by the capillaries and precapillary venules (microcirculation), is surely schematical but aids the comprehension of many hemodynamic effects connected to hampered venous ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:1992-11-01 00:00:00
abstract::The meaning of the term biomarker has been standardized by a working group of the National Institutes of Health as "a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention". The ability of...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2012-04-01 00:00:00
abstract::Atrial fibrillation is the most common cardiac arrhythmia and the most frequent cause of hospitalization and utilization expense among all heart diseases. Taking into account persistent atrial fibrillation we know that, in order to cardiovert persistent atrial fibrillation, external direct current cardioversion is the...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2004-04-01 00:00:00
abstract::Vasodilators represent one of the main steps for the medical treatment of pulmonary hypertension; the rationale for their use is the reversibility of the pulmonary vasoconstriction, to be tested with a correct pharmacological trial. In this report the authors consider the use of calcium-channel blockers, prostaglandin...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::In patients with atrial fibrillation (AF) warfarin has been the mainstay therapy for stroke prevention. In recent randomized clinical trials (RCTs) oral direct thrombin inhibitor (Dabigatran) and factor Xa inhibitors (Rivaroxaban and Apixaban) challenged the efficacy and safety benchmarks set by warfarin. These drugs ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2012-08-01 00:00:00
abstract::Palliative care is an alternate therapeutic approach that involves specialised medical care of a patient diagnosed with serious life threatening illness like heart failure (HF). The prime aim of the palliative care is to provide patient with relief from the symptoms, pain, physical stress, and mental stress of the dia...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2016-02-01 00:00:00
abstract::Aortic valve bioprostheses are commonly implanted in the current era - also in younger patients - as they may obviate the need for anticoagulation while providing better hemodynamic performance and a more favorable quality of life. The steady increase in the use of biological valves has prompted the development of sev...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2016-04-20 00:00:00
abstract::We report the case of an 80-year-old man affected by hypertensive cardiomyopathy and already admitted to our Division for recurrent episodes of heart failure. He was eventually hospitalized for septic shock secondary to disseminated pneumonia with concomitant left pleural effusion. At 2D-echo examination, a highly ech...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:1992-10-01 00:00:00
abstract::Twenty-three consecutive subjects (age 46.7 +/- 21, range 13-78) addressed to our attention for symptoms attributed to documented or suspected supra ventricular arrhythmias underwent transesophageal electrophysiologic study. On the basis of the preliminary investigations 15 proved free from organic heart disease, 2 we...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
abstract:AIM:The purpose of this meta-analysis was to systematically review and synthesize existing data on long term outcomes of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) with multiple stenting in patients with multivessel coronary artery disease. METHODS:Three randomized control tria...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,meta分析
doi:
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Arrhythmias are frequent pathology in patients with chronic hemodialysis. We evaluated whether a relatively new technique, signal averaging, could be useful in predicting the development of complex arrhythmias in these patients. METHODS:Thirty-three patients, 18 male and 15 female, subjected to thrice weekl...
journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract::The risk of venous thromboembolism (VTE) increases up to 5-10-fold during pregnancy and VTE represents the first cause of maternal mortality. The annual incidence of VTE is 0.97 per 1000 women during pregnancy and 7.19 per 1000 in the puerperium. The risk is higher in carriers of inherited thrombophilia. Prophylaxis o...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2006-12-01 00:00:00
abstract::Aneurysms are a later consequence of acute myocardial infarction, developing in about 20% of patients with transmural infarcts. Pathologically aneurysms have two general forms: the first type has large endocardial fibroelastosis overlying the infarct size, the second type contains little or no endocardial fibroelastos...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract::The number of women who become ill and die from acute myocardial infarction (AMI) increases steadily with age. It is not yet clearly defined whether and why women suffer from a higher in-hospital mortality rate after AMI. In this study we evaluated the importance of the female sex as a risk factor for in-hospital mort...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:It is known that resistance to activated protein C (APCR), often associated with a single point mutation (Arg506-->Gln) in the coagulation factor V gene (factor V Leiden), is the most frequent inherited abnormality of blood coagulation. It plays a key role as pathogenetic factor of venous thromboembolism, bu...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract::Three hundred carotid plaques (stenosis 45 to 65%) in 300 asymptomatic patients were included into a follow-up study considering three ultrasound types of plaques: type 1, non echogenic; type 2 intermediate, partially echogenic and type 3 highly echogenic. Types 1 and 2 had regular contour/surface while type 3 was irr...
journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1992-07-01 00:00:00
abstract::The aneurysm of the interatrial septum (ASA) is a rare congenital heart disease, easily recognizable by real time cross sectional two dimensional echocardiography. The ASA occurs as an isolated entity or may be associated with congenital heart disease. Usually ASA may cause serious complications such as embolic phenom...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Brief periods of non-lethal ischemia and reperfusion render the myocardium more resistant to subsequent ischemia. This adaption occurs in a biphasic pattern: the first being active immediately and lasting for 2-3 hrs (early preconditioning), the second starting at 24 hrs until 72 hrs after the initial ischemia (delaye...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2002-12-01 00:00:00
abstract::The authors report a 57 year old patient affected by rhinopharyngeal NH lymphoma that appeared as a parapharyngeal space lesions-syncope syndrome. The activation of a cardioinhybitory reflex by the stimulation of the glossopharyngeal nerve seems to be the pathogenetic basis for his syndrome. ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract:AIM:It is not known whether therapy assisted by determinations of serum B-type natriuretic peptide (BNP) may improve the outcome for outpatients with chronic heart failure (CHF). METHODS:A retrospective case-control study was carried out, enrolling patients with acutely decompensated heart failure (ADHF) who were foll...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:Cognitive decline and dementia recognize multiple risk factors and pathophysiological mechanisms, often involved simultaneously with complex interactions. Several studies have shown that both arterial hypertension and hypotension are associated with a greater risk of cognitive decline and dementia, but cli...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:10.23736/S0026-4725.20.05452-3
更新日期:2020-12-01 00:00:00
abstract::The PAP/PEA (Prevalence of Early Atherosclerosis) study aims to define the prevalence of subclinical atherosclerosis in a typical population of central Italy. A concomitant study evaluates the prevalence of venous diseases. The first group of 850 patients evaluated, indicated the prevalence of superficial ve-nous dise...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Takotsubo Cardiomyopathy (TTC) is classified into 4 types dependent on anatomical area affected identified on gross visual assessment. We have sought to understand if it is feasible and advantageous to use left ventricular global longitudinal strain (LVGLS), LV segmental longitudinal strain and right ventric...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:10.23736/S0026-4725.20.05386-4
更新日期:2021-01-11 00:00:00
abstract:AIM:The aim of this study was to describe the five-year prognosis of an Italian cohort of patients following acute myocardial infarction (AMI) occurred at age ≤ 45 years and to investigate the potential role of risk predictors for future cardiovascular events (CVE). METHODS:The study enrolled 112 consecutive patients ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2010-08-01 00:00:00
abstract::Some cases of coronary aneurysms studied echocardiographically in children suffering from Kawasaki's disease are reported. In the fourth case, bidimensional echocardiography highlighted a uniform dilatation of the right and left coronary proximal segments which had retreated at subsequent controls. In the third case, ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract:OBJECTIVES:To examine the relationship between patients gender, age and the development of different types of internal carotid artery plaque. DESIGN:Prospective open clinical study. METHODS:455 carotid duplex scans with a greater than 50% stenosis were analysed in terms of gender, age, degree of stenosis symptoms and...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::Colchicine was introduced in 1987 for the treatment of recurrent pericarditis. Up to the present, papers have been published on a total of 117 patients treated with colchicine after the failure of treatment with FANS, corticosteroids and repeated pericardiocentesis. Here two cases of chronic pericardial effusion, one ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2000-10-01 00:00:00
abstract::The paper reports the study of 12 patients admitted to hospital between January 1992 and October 1994. The patients were almost all neonates. Clinical, electrocardiographic and radiological data led to the suspected diagnosis of complete transposition of the great vessels. 2-D echocardiography consistently showed the ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::Over the last years, endovascular intervention have become an important part of treatment in patients with congenital heart disease particularly for residual defects after surgery done in infancy. These transcatheter procedures can be described as dilatation of stenotic sites (angioplasty, endovascular stenting and va...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2007-10-01 00:00:00
abstract::The search for the ideal antihypertensive drug is ongoing. Carvedilol is a new beta-adrenoceptor antagonist which also causes peripheral vasodilation primarily via alpha 1-adrenergic blockade. Twenty patients with mild to moderate essential hypertension and previous intolerance and side effects to other antihypertensi...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00