Galectin-3 in patients with chronic heart failure: association with oxidative stress, inflammation, renal dysfunction and prognosis.

Abstract:

BACKGROUND:Galectin-3 is a recently developed biomarker of fibrosis, which may play a role in cardiac remodeling and associated with both the progression and severity of heart failure (HF). METHODS:A prospective cohort study of 190 patients with documented prior myocardial infarction and chronic HF (NYHA class II-IV) was conducted. Patients were divided into 3 groups based on their NYHA functional class. Levels of galectin-3, NT-proBNP, CRP, IL-6, oxidized-LDL, extracellular superoxide dismutase (EC-SOD), 3-nitrotyrosine, SH-groups, cystatin-C were determined. Follow-up period was 26 months, and all-cause mortality was determined as the primary endpoint. Statistical analysis was performed and statistical significance was set at P<0.05. RESULTS:The cytokines hs-CRP, IL-6 and markers of oxidative stress had significant positive correlation with plasma galectin-3 levels in all groups of patients. The level of galectin-3 was significantly different between the groups (P<0.05). Galectin-3 was found to be the most sensitive and specific value in determination of 26 months mortality in patients with chronic HF. Logistic regression analysis showed that age, galectin-3 and cystatin-C were associated with death during the follow up period. CONCLUSIONS:Galectin-3 levels are elevated in patients with chronic HF across all NYHA functional classes. Galectin-3 shows positive correlation with markers of oxidative stress, inflammation and kidney dysfunction. Galectin-3 levels and cystatin-C levels are independent predictors of 26-month mortality in patients with chronic HF. Patients with cystatin-C level >2800 pg/mL carry a worse prognosis. Galectin-3 level >21 ng/mL associated with increased mortality.

journal_name

Minerva Cardioangiol

authors

Medvedeva EA,Berezin II,Surkova EA,Yaranov DM,Shchukin YV

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

595-602

issue

6

eissn

0026-4725

issn

1827-1618

pii

R05Y9999N00A16042701

journal_volume

64

pub_type

杂志文章
  • [Heparan sulfate: efficacy and safety in patients with chronic venous insufficiency].

    abstract::Fifty patients suffering from chronic venous disease were treated for 30 days with heparan sulphate 100 mg per os, b.i.d., or mesoglycan 50 mg per os, t.i.d., in a single blind random study. Both therapies led to a marked improvement in comparison to basal clinical values, but patients treated with heparan sulphate sh...

    journal_title:Minerva cardioangiologica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Agrati AM,De Bartolo G,Palmieri G

    更新日期:1991-10-01 00:00:00

  • [Acute effects of propranolol and its association with nifedipine in aged patients with effort stable angina. Randomized double-blind crossover study, under placebo control].

    abstract::Calcium-antagonist and B-blockers are effective in improving exercise tolerance in patients with effort angina. We studied the short effects of oral administration of nifedipine (10 mg) and propranolol (80 mg) alone and in combination in 15 elderly patients with chronic exertional angina pectoris in a double-blind, ra...

    journal_title:Minerva cardioangiologica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Santamaria F,Sestito M,Lirato C,Di Palma A,De Rosa ML,Iannuzzi L,Pandolfi E,Cicatiello AM,Parlati S

    更新日期:1993-04-01 00:00:00

  • Meta-analysis of 5-year outcomes of CABG vs PCI with stenting in patients with multivessel disease.

    abstract:AIM:The purpose of this meta-analysis was to systematically review and synthesize existing data on long term outcomes of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) with multiple stenting in patients with multivessel coronary artery disease. METHODS:Three randomized control tria...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章,meta分析

    doi:

    authors: Athappan G,Vinodhkumaradithyaa A,Srinivasan M,Jeyaseelan L,Ponniah T

    更新日期:2008-10-01 00:00:00

  • Plasma adrenomedullin concentrations in patients with renovascular or malignant hypertension.

    abstract:AIM:The aim of the present study was to investigate the behaviour of plasma adrenomedullin (AM), a hypotensive peptide, in patients with malignant (MHT) and renovascular hypertension (RVH), 2 pathologic conditions in which renin-angiotensin system (RAS) is activated and to compare them with those in essential hypertens...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:

    authors: Caliumi C,Cianci R,Celi M,Cerci S,Cotesta D,Petramala L,Fontana S,Letizia C

    更新日期:2004-08-01 00:00:00

  • Behçet syndrome: effects of Pycnogenol® supplementation during regression phases.

    abstract:BACKGROUND:The aim of this comparative registry study was to evaluate the supplementation with Pycnogenol® in subjects with Behçet syndrome (BS) with symptoms impairing their quality of life despite being in a remitting phase of the disease. METHODS:Thirty-four patients with a confirmed diagnosis of BS were divided in...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:10.23736/S0026-4725.18.04637-6

    authors: Hu S,Belcaro G,Ledda A,Corsi M,Cotellese R,Feragalli B,Hosoi M,Dugall M,Torino-Rodriguez P,Cesarone MR

    更新日期:2018-08-01 00:00:00

  • Cardiac risk stratification in patients undergoing endovascular aortic repair.

    abstract::Endovascular aortic repair (EVAR) for abdominal aortic aneurysms (AAA) is the preferred first treatment option in case of patients with advanced age and/or fit anatomy owing to shorter length of in hospital staying, less complications or laparotomy-related re-interventions, and lower initial costs. Although it is a le...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章,评审

    doi:

    authors: Biagi P,de Donato G,Setacci C

    更新日期:2016-04-01 00:00:00

  • [Clinical and capillaroscopic evaluation of chronic uncomplicated venous insufficiency with procyanidins extracted from vitis vinifera].

    abstract:BACKGROUND:The pharmacological treatment of non-complicated chronic venous insufficiency is a current and well-debated topic. The introduction of new products with action on the venous system, improved knowledge on the physiopathology of venous insufficiency and the possibility provided by new analytical instruments, h...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:

    authors: Costantini A,De Bernardi T,Gotti A

    更新日期:1999-01-01 00:00:00

  • [Dolicho-arteriopathies (kinking, coiling, tortuoosity) of the carotid arteries: study by color Doppler ultrasonography].

    abstract:BACKGROUND:This work aimed to study extracranial carotid dolichoarterial disease in outpatients using color Doppler ultrasonography. METHODS:A total of 1220 outpatients, 620 males and 600 females, aged between 25 and 89 years old, were enrolled in the study. Subjects were divided into three groups according to age: un...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章,评审

    doi:

    authors: Pellegrino L,Prencipe G,Vairo F

    更新日期:1998-03-01 00:00:00

  • [The ultrasonographic assessment of carotid plaques in relation to cerebral events and damage over 3 years].

    abstract::Three hundred carotid plaques (stenosis 45 to 65%) in 300 asymptomatic patients were included into a follow-up study considering three ultrasound types of plaques: type 1, non echogenic; type 2 intermediate, partially echogenic and type 3 highly echogenic. Types 1 and 2 had regular contour/surface while type 3 was irr...

    journal_title:Minerva cardioangiologica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Laurora G,Cesarone MR,De Sanctis MT,Belcaro G

    更新日期:1992-07-01 00:00:00

  • [Pseudoaneurysm of the right iliac artery with fistula into the cecum. A clinical case].

    abstract::A case is reported of pseudoaneurysm of the right iliac artery secondary to an endarterectomy with dacron patch due to atherosclerosis performed 4 years ago. The case presented acute anemia and massive enteric hemorrhage subsequent to arterial rupture into the cecum. Because of the dramatic onset, the patient was imme...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:

    authors: Anfossi A,Mosca L,Gori A,Brunengo M

    更新日期:1990-01-01 00:00:00

  • [Chiari's network: persistence of the embryonic remnants of the valve of the sinus venosus in the right atrium. Echocardiographic and clinical analysis in a group of subjects].

    abstract::As echocardiography is being used more often, its value and accuracy are becoming more fully appreciated, especially for identifying normal anatomic variants and their possible erroneous interpretation as pathologic states. We report the echocardiographic and clinical findings observed in sixteen subjects examined at ...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:

    authors: Chesi G,Farinelli F,Di Donato C,Marani L,Reverzani A

    更新日期:1989-07-01 00:00:00

  • Significance of elevated cardiac troponin after percutaneous coronary interventions.

    abstract::Assays for cardiac troponin have become a standard for the diagnosis of myocardial damage. Due to their high sensitivity, minor myocardial injury can be frequently detected following percutaneous coronary interventions (PCI). Minor elevations in cardiac enzymes after apparently successful PCI are rather common and eve...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章,评审

    doi:

    authors: Lavi S,Gruberg L

    更新日期:2003-10-01 00:00:00

  • Impella-protected PCI: the clinical results achieved so far.

    abstract::The ability of interventional cardiologists to identify high-risk percutaneous coronary intervention (PCI) patients, requires the integration of different features belonging to medical history, organ damage, coronary anatomy and the nature of the acute event. The selection of a subgroup of patients that could benefit ...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章,评审

    doi:10.23736/S0026-4725.18.04678-9

    authors: Pesarini G,Gratta A,Dolci G,Lunardi M,Ribichini FL

    更新日期:2018-10-01 00:00:00

  • Early versus late tracheal intubation in COVID-19 patients: a pro-con debate also considering heart-lung interactions.

    abstract::The best timing of orotracheal intubation and invasive ventilation in COVID-19 patients with acute respiratory distress syndrome is unknown. The use of non-invasive ventilation, a life-saving technique in many medical conditions, is debated in patients with ARDS since prolonged NIV and delayed intubation may be harmfu...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:10.23736/S0026-4725.20.05356-6

    authors: Cabrini L,Ghislanzoni L,Severgnini P,Landoni G,Baiardo Redaelli M,Franchi F,Romagnoli S

    更新日期:2020-10-15 00:00:00

  • Management of uncomplicated ankle sprains with topical or oral ketoprofen treatment. A registry study.

    abstract::Ankle sprains mainly caused by accidents or strenuous sport activities can often be quite painful and impair motility. If not treated immediately and correctly, sprains may lead to severe complications. The aim of the present study was to compare the efficacy and safety of topically applied ketoprofen versus orally ad...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:

    authors: Vinciguerra G,Belcaro G,Cesarone MR,Errichi BM,Di Renzo A,Errichi S,Ricci A,Gizzi G,Dugall M,Cacchio M,Ippolito E,Ruffini I,Fano F,Stuard S,Grossi MG

    更新日期:2008-10-01 00:00:00

  • [Inflammation, atherosclerosis and acute coronary syndromes].

    abstract::Inflammatory mechanisms play a pivotal role in the atherosclerotic process. At the base of atherogenesis there are complex interactions between macrophages, T lymphocytes and smooth muscle cells. A growing body of experimental evidences suggest that inflammation is involved in the pathogenesis of acute coronary syndro...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:

    authors: Biasucci LM,Santamaria M,Liuzzo G

    更新日期:2002-10-01 00:00:00

  • [Improved survival in the treatment of ruptured abdominal aortic aneurysm].

    abstract::Personal experience in the management of 70 ruptured abdominal aortic aneurysm over the past 5 years is reported dividing patients into 2 groups, before and after establishment of intensive care unit: survival was 30.76% on the first, 66.66% in the second. Factors that allowed that result are discussed. ...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:

    authors: Patrone P,Barabino G,Geddo E,Brunori C,Dagnino A,Zinicola N

    更新日期:1990-06-01 00:00:00

  • [Critical ischemia of the lower limbs: pathogenesis, clinical course and therapy. Results of authors' experience in 337 cases].

    abstract::The definition of an ischaemic condition at lower limb level, may imply any different degree of the pathology, starting from a simple chronic slight claudication up to a severe ischaemia. Critical Limb Ischaemia is the term defined to identify an ischaemic condition, which endangers the limb or part of a limb and requ...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:

    authors: Giuffrida GF,Longhi F,De Monti M,Boneschi M,Miani S,Giordanengo F

    更新日期:1993-06-01 00:00:00

  • Ex vivo and preclinical assessment of an endothelial progenitor cell capturing bioengineered stent.

    abstract::Although drug-eluting stents (DES) have significantly reduced the rates of restenosis as compared to bare metal stents, late stent thrombosis remains a major drawback, especially for "off-label" use. Delayed arterial healing, characterized by persistent fibrin deposition and poor endothelialization, has been shown to ...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章,评审

    doi:

    authors: Yazdani SK,Kolodgie FD,Virmani R

    更新日期:2012-02-01 00:00:00

  • [Main antithrombotic drugs in the therapy and prevention of arterial and venous thrombosis].

    abstract::The author reviews the use of the main antithrombotic drugs (thrombolytics, dicumarol compounds, heparins and anti-platelet drugs) in the treatment and prophylaxis of the main nosographic syndromes of arterial and venous thrombosis. In the context of arterial thrombosis the paper initially reports the results of the m...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章,评审

    doi:

    authors: Ferlito S

    更新日期:1996-06-01 00:00:00

  • Transradial artery access for percutaneous cardiovascular procedures: state-of-the-art and future directions.

    abstract::The transradial access (TRA) for cardiac catheterization and percutaneous coronary intervention (PCI) has been widely adopted in the last decades since its first description in the late forties. The transradial approach has been associated with favourable outcomes as compared with transfemoral access (TFA) in several ...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:10.23736/S0026-4725.20.05391-8

    authors: Bellamoli M,Venturi G,Pighi M,Pacchioni A

    更新日期:2020-11-04 00:00:00

  • Pharmacological treatment and prevention of chronic venous ulcers: a review.

    abstract::Chronic venous insufficiency and chronic venous ulcers represent an important medical problem, because of the high incidence and prevalence in the general population, and need to be considered as a lifelong degenerative condition, with socioeconomic consequences. Ulceration is a severe complication of the post-thrombo...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章,评审

    doi:

    authors: Cerbone AM,Tufano A,Coppola A,Cimino E,Di Minno MN,Di Minno G

    更新日期:2015-06-01 00:00:00

  • Coronary computed tomographic angiography: from anatomical to functional assessment of coronary artery disease.

    abstract::Contrast enhanced computed tomography angiography (CTA) has seen rapid progress in its utility for the assessment of coronary artery disease (CAD) in the last few years. More and more technological enhancements have widened the horizons for the use of this non-invasive modality beyond its traditional role in assessmen...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:

    authors: Rathod A

    更新日期:2013-02-01 00:00:00

  • Percutaneous transcatheter closure of patent foramen ovale.

    abstract::In presence of a patent foramen ovale (PFO) with cryptogenic cerebral embolism, traditional therapy consists of oral anticoagulation or antiplatelet therapy. Surgery was considered only in case of recurrence. Transcatheter closure of PFO is currently performed. The availability of new user friendly devices and the inc...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章,评审

    doi:

    authors: Chatterjee T,Ritz A,Rehders TC,Ince H,Kische S,Petzsch M,Nienaber CA

    更新日期:2006-02-01 00:00:00

  • [Thrombosis of the right atrial appendage. The two-dimensional echocardiographic aspect and the autopsy finding].

    abstract::We report the case of an 80-year-old man affected by hypertensive cardiomyopathy and already admitted to our Division for recurrent episodes of heart failure. He was eventually hospitalized for septic shock secondary to disseminated pneumonia with concomitant left pleural effusion. At 2D-echo examination, a highly ech...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章,评审

    doi:

    authors: Oneglia C,Sabatini T,Ghizzoni G,Simoncelli U,Gardini A,Guerini A,Rusconi C

    更新日期:1992-10-01 00:00:00

  • [Evaluation of resistance to activated protein C in myocardial infarction patients].

    abstract:BACKGROUND:It is known that resistance to activated protein C (APCR), often associated with a single point mutation (Arg506-->Gln) in the coagulation factor V gene (factor V Leiden), is the most frequent inherited abnormality of blood coagulation. It plays a key role as pathogenetic factor of venous thromboembolism, bu...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:

    authors: Avellone G,Di Garbo V,Di Raimondo D,Bono M,Abruzzese G,De Simone R,Raneli G

    更新日期:2001-12-01 00:00:00

  • [Botallo's duct with pulmonary hypertension in the adult].

    abstract::A patent ductus arteriosus in adults is a rare eventuality. After correct diagnosis, an accurate evaluation of pulmonary vascular resistances is necessary with, in case of normality, a straightforward indication to surgery, because the evolution of the disease cannot be predicted. In case of pulmonary hypertension irr...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:

    authors: Gherli T,Porcu A,Alamanni F,Marongiu G,Sale MA,Padua G,Cossu ML,Bacciu PP

    更新日期:1991-09-01 00:00:00

  • [Natural history and course of aneurysmal disease in patients operated on for abdominal aortic aneurysms].

    abstract::This study is aimed at analyzing our experience in the evolution of aneurysmatic disease after surgical treatment of the typical subrenal abdominal aortic aneurysm. In fact in some cases we reobserved these patients for the onset of a new important dilatation involving the proximal tract of the abdominal aorta or the ...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:

    authors: Miani S,Boneschi M,Arpesani A,Giorgetti PL,Giuffrida GF,Giordanengo F

    更新日期:1994-07-01 00:00:00

  • Left ventricular end-diastolic volume as early indicator of trastuzumab-related cardiotoxicity in HER2+ breast cancer patients: results from a single-center retrospective study.

    abstract:BACKGROUND:Adjuvant trastuzumab therapy increases survival rates in patients with early HER2-positive breast cancer, although it can be potentially cardiotoxic. The aim of this study was to evaluate the prevalence of left ventricular (LV) systolic dysfunction; and the relationship between the presence of cardiovascular...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:10.23736/S0026-4725.16.04278-X

    authors: Bergamini C,Torelli F,Ghiselli L,Rossi A,Trevisani L,Vinco G,Truong S,Benfari G,LA Russa F,Golia G,Molino A,Vassanelli C

    更新日期:2017-06-01 00:00:00

  • What's up on stented valves.

    abstract::Aortic valve bioprostheses are commonly implanted in the current era - also in younger patients - as they may obviate the need for anticoagulation while providing better hemodynamic performance and a more favorable quality of life. The steady increase in the use of biological valves has prompted the development of sev...

    journal_title:Minerva cardioangiologica

    pub_type: 杂志文章

    doi:

    authors: Santarpino G,Kalisnik JM,Fischlein T,Pfeiffer S

    更新日期:2016-04-20 00:00:00