Abstract:
BACKGROUND:Galectin-3 is a recently developed biomarker of fibrosis, which may play a role in cardiac remodeling and associated with both the progression and severity of heart failure (HF). METHODS:A prospective cohort study of 190 patients with documented prior myocardial infarction and chronic HF (NYHA class II-IV) was conducted. Patients were divided into 3 groups based on their NYHA functional class. Levels of galectin-3, NT-proBNP, CRP, IL-6, oxidized-LDL, extracellular superoxide dismutase (EC-SOD), 3-nitrotyrosine, SH-groups, cystatin-C were determined. Follow-up period was 26 months, and all-cause mortality was determined as the primary endpoint. Statistical analysis was performed and statistical significance was set at P<0.05. RESULTS:The cytokines hs-CRP, IL-6 and markers of oxidative stress had significant positive correlation with plasma galectin-3 levels in all groups of patients. The level of galectin-3 was significantly different between the groups (P<0.05). Galectin-3 was found to be the most sensitive and specific value in determination of 26 months mortality in patients with chronic HF. Logistic regression analysis showed that age, galectin-3 and cystatin-C were associated with death during the follow up period. CONCLUSIONS:Galectin-3 levels are elevated in patients with chronic HF across all NYHA functional classes. Galectin-3 shows positive correlation with markers of oxidative stress, inflammation and kidney dysfunction. Galectin-3 levels and cystatin-C levels are independent predictors of 26-month mortality in patients with chronic HF. Patients with cystatin-C level >2800 pg/mL carry a worse prognosis. Galectin-3 level >21 ng/mL associated with increased mortality.
journal_name
Minerva Cardioangioljournal_title
Minerva cardioangiologicaauthors
Medvedeva EA,Berezin II,Surkova EA,Yaranov DM,Shchukin YVsubject
Has Abstractpub_date
2016-12-01 00:00:00pages
595-602issue
6eissn
0026-4725issn
1827-1618pii
R05Y9999N00A16042701journal_volume
64pub_type
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journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::Calcium-antagonist and B-blockers are effective in improving exercise tolerance in patients with effort angina. We studied the short effects of oral administration of nifedipine (10 mg) and propranolol (80 mg) alone and in combination in 15 elderly patients with chronic exertional angina pectoris in a double-blind, ra...
journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Minerva cardioangiologica
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journal_title:Minerva cardioangiologica
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journal_title:Minerva cardioangiologica
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journal_title:Minerva cardioangiologica
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journal_title:Minerva cardioangiologica
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