Abstract：
AIM:The aim of this study was to evaluate the effects of low-dose niacin extended-release (niacin-ER) combined with simvastatin (SV) in the treatment of patients with mixed dyslipidemia who have not normalized their lipid profile with statin therapy alone. METHODS:A prospective, clinical trial of 35 patients with mixed dyslipidemia who were treated with niacin-ER and SV. The dosage administrated were 250 mg niacin-ER plus 10 mg SV in the first two weeks, 500 mg/20 mg in the next two weeks, and 750 mg/20 mg in the final four weeks. Patients received 200 mg of acetylsalicylic acid 30 minutes before each drug administration. RESULTS:There were significant increases of apolipoprotein A-I and HDL; and decrease of apolipoprotein B, LDL, triglycerides, and total cholesterol. There was low frequency of flushing (10%) and no worsening in the control of fasting and postprandial glycemia and glycated hemoglobin. CONCLUSION:Low-dose niacin-ER associated to simvastatin may be useful for achieving improvement in lipid profile or even to achieve the targets recommended for prevention of cardiovascular disease. Other advantages are the low frequency of flushing, which improved adherence to treatment, and no worsening of insulin resistance in patients with or without diabetes mellitus.
journal_name
Minerva Cardioangioljournal_title
Minerva cardioangiologicaauthors
Salgado BJ,Salgado JV,Dos Santos AM,Casulari LAsubject
Has Abstractpub_date
2010-10-01 00:00:00pages
531-42issue
5eissn
0026-4725issn
1827-1618pii
R05103066journal_volume
58pub_type
临床试验,杂志文章abstract：:In the period 1972-1988, 209 patients (81 males, 128 females, mean age 42.4 +/- 11.9, range 20-71 years) underwent surgery for multiple valve repair (MVR) at the Italian Institution of Cardiac Surgery. Ninety-five patients had previously undergone mitral commissurotomy (MC). NTHA function class was III-IV in 89% of th...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：OBJECTIVE:A study of the protective efficiency imparted by intermittent warm blood cardioplegia (WBCP) using perfused rat heart model. METHODS:Hemodynamic parameters were monitored simultaneously with metabolic changes in high-energy phosphates using 31P-NMR spectroscopy. Following 30 min perfusion with Krebs-Henselei...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：OBJECTIVE:To analyze the usefulness of autologous blood salvage and intraoperative isovolemic hemodilution in conjunction with autologous blood salvage in cardiac surgery, and also to compare two different autologous blood salvage methods. EXPERIMENTAL DESIGN:Retrospective analysis of transfusion practice in cardiac s...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：:Colchicine was introduced in 1987 for the treatment of recurrent pericarditis. Up to the present, papers have been published on a total of 117 patients treated with colchicine after the failure of treatment with FANS, corticosteroids and repeated pericardiocentesis. Here two cases of chronic pericardial effusion, one ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2000-10-01 00:00:00
abstract：:Congenital thrombophilia, specifically thrombophilia due to Leiden modified factor V as the cause of thromboembolic disease, is discussed. Thromboembolic disease is potentially fatal and disabling. A clinical case is presented of a girl of 15 with Leiden factor V thrombophilia in which all the typical thromboembolic e...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND:To assess the prevalence of masked hypertension (MH) in young Saudi National Guard soldiers based on 24h ambulatory blood pressure monitoring (ABPM). METHODS:A prospective study of 196 soldiers, aged between 21-50 years, without a history of hypertension or antihypertensive medication use. Each participant ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.20.05288-3
更新日期：2020-06-10 00:00:00
abstract：AIM:In-stent restenosis still affects 10-50% of long-term outcome after percutaneous coronary intervention (PCI). Large clinical trials have shown that sirolimus-eluting stents (SES) have reduced restenosis rate to 0-9% in lesions at low-moderate risk. The aim of this study was to evaluate long-term clinical and angiog...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Prolonged periods of atrial fibrillation (AF) or high frequency atrial pacing lead to a significant shortening of atrial refractory periods. This time-dependent electric remodelling is reduced significantly by the administration of verapamil. METHODS:The present series consists of 24 patients all suffering ...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：2003-02-01 00:00:00
abstract：:Three hundred carotid plaques (stenosis 45 to 65%) in 300 asymptomatic patients were included into a follow-up study considering three ultrasound types of plaques: type 1, non echogenic; type 2 intermediate, partially echogenic and type 3 highly echogenic. Types 1 and 2 had regular contour/surface while type 3 was irr...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1992-07-01 00:00:00
abstract：:Deep venous thrombosis (DVT) is often difficult to diagnose based on objective data alone (sensitivity 60-66%, specificity 20-72%, according to a number of studies) and this leads to the possible misuse of instrumental tests. It is important to establish standard clinical protocols to select those cases that call for ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:The aim of this comparative registry study was to evaluate the supplementation with Pycnogenol® in subjects with Behçet syndrome (BS) with symptoms impairing their quality of life despite being in a remitting phase of the disease. METHODS:Thirty-four patients with a confirmed diagnosis of BS were divided in...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.18.04637-6
更新日期：2018-08-01 00:00:00
abstract：:Thrombophilia is characterised by elevated thrombotic and embolic risk and may be caused by congenital or acquired coagulating inhibitor deficit. A young man was repeatedly admitted to Emergency Medicine Units because of pain, oedema and slight functional impairment of the left leg, and recurrent thrombophlebitis was ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:Aneurysms are a later consequence of acute myocardial infarction, developing in about 20% of patients with transmural infarcts. Pathologically aneurysms have two general forms: the first type has large endocardial fibroelastosis overlying the infarct size, the second type contains little or no endocardial fibroelastos...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:Atrial fibrillation is the most common sustained cardiac arrhythmia and with an aging population its prevalence will increase. In addition to appropriate anticoagulation to reduce the thromboembolic risk, there has been an increasing need for a personalized approach in identifying which patients are likely to benefit ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：10.23736/S0026-4725.17.04371-7
更新日期：2017-08-01 00:00:00
abstract：:Twenty-three consecutive subjects (age 46.7 +/- 21, range 13-78) addressed to our attention for symptoms attributed to documented or suspected supra ventricular arrhythmias underwent transesophageal electrophysiologic study. On the basis of the preliminary investigations 15 proved free from organic heart disease, 2 we...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：:The worldwide prevalence of heart failure is increasing in part due to an ageing population. In the developed world, heart failure affects 1-2% of the general population, accounting for 5% of adult hospital admissions. There is now convincing evidence supporting the beneficial effects of cardiac resynchronization ther...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2005-08-01 00:00:00
abstract：:Cardiac tamponade may be caused by erosion of the right cardiac walls or of the intrapericardial superior vena cava in subjects with a central venous catheter. The underlying cause of this rare complication is direct parietal trauma by the catheter and endarterial damage produced by infused hyperosmolar solutions. Hig...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:A retrospective clinico-epidemiological study of the incidence of all arteriopathy hospitalization in the Region of Piemonte over a twelve year period (1976-1987) has been performed: among all the cases, patients affected by aortic aneurysm show an average of hospitalization of 0.8 cases per 24 hours. The prevalence o...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：INTRODUCTION:Cognitive decline and dementia recognize multiple risk factors and pathophysiological mechanisms, often involved simultaneously with complex interactions. Several studies have shown that both arterial hypertension and hypotension are associated with a greater risk of cognitive decline and dementia, but cli...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.20.05452-3
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:It is known that resistance to activated protein C (APCR), often associated with a single point mutation (Arg506-->Gln) in the coagulation factor V gene (factor V Leiden), is the most frequent inherited abnormality of blood coagulation. It plays a key role as pathogenetic factor of venous thromboembolism, bu...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:With radioisotopes it is possible to study the heart obtaining complementary or substitutive informations to those provided by the most common noninvasive methods of myocardial assessment and by coronarography. This paper aim is to report experience with thallium 201 and 99mTc isonitrile in the diagnosis and followup ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:This report describes a rare case of concurrent abdominal aortic aneurysm and bilateral renal ectopia. Preoperative work-up included intravenous pyelography and angiography to assess renal function, renal artery anatomy, and ureter position. Conventional surgery was performed without renal protection. No deterioration...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2008-10-01 00:00:00
abstract：AIM:To evaluate any differences in ventricular pre-excitation secondary to Wolff Parkinson White syndrome in the aged compared to young and adult patients. METHODS: EXPERIMENTAL DESIGN:a clinical study was performed using a comparative prospective criterion with retrospective analysis. The duration of follow-up range...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:In a controlled study of 100 patients, mean age 65 years old, suffering from chronic peripheral obliterative arterial disease, Leriche's stage II, were randomised in two groups treated respectively with defibrotide (400 mg bid) or heparan-sulfate (40 mg bid) by the oral route for a period of 6 months. At basal and aft...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Infection due to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), i.e. coronavirus-associated disease 2019 (COVID-2019), may occasionally lead to acute respiratory distress syndrome (ARDS), requiring in the most severe cases extracorporeal membrane oxygenation (ECMO). Yet, limited data, if any, ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.20.05328-1
更新日期：2020-10-01 00:00:00
abstract：:Use of definite molecular weight heparan sulphate in a protocol for the prevention of deep venous thrombosis in the total joint replacement surgery. The authors propose a working protocol for the prevention of deep venous thrombosis in prosthetic orthopaedic surgery. It requires that integration of pharmacological, an...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:Clopidogrel is an oral tyenopiridin with a central role in the management of acute coronary syndromes and after stent implantation. Despite the use of this drug, many patients continue to experience thrombotic events which are usually referred as "therapy failure". Actually, to date, only stent thrombosis is considere...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2013-12-01 00:00:00
abstract：:In patients with atrial fibrillation (AF) warfarin has been the mainstay therapy for stroke prevention. In recent randomized clinical trials (RCTs) oral direct thrombin inhibitor (Dabigatran) and factor Xa inhibitors (Rivaroxaban and Apixaban) challenged the efficacy and safety benchmarks set by warfarin. These drugs ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2012-08-01 00:00:00
abstract：:Non-invasive imaging plays an increasingly important role in the diagnosis and risk stratification of coronary artery disease (CAD). Several techniques such as stress echocardiography and myocardial perfusion imaging have become available to assess cardiac function and myocardial perfusion. With the arrival of multi-s...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2008-04-01 00:00:00
abstract：:Intraoperative transesophageal echocardiography (IOTEE) has become an important diagnostic and monitoring tool in the operating theatre during cardiac and noncardiac operations. However, its routine application during valve replacement operations has not received universal recognition. The cumulative experience, broug...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2007-04-01 00:00:00
