Abstract:
AIM:In-stent restenosis still affects 10-50% of long-term outcome after percutaneous coronary intervention (PCI). Large clinical trials have shown that sirolimus-eluting stents (SES) have reduced restenosis rate to 0-9% in lesions at low-moderate risk. The aim of this study was to evaluate long-term clinical and angiographic outcome of SES in a real world population, at very high risk of restenosis. METHODS:Ninety lesions at high risk of restenosis (lesion length >20 mm, target vessel diameter <2.5 mm, in-stent diffuse restenosis, total occlusions and complex lesions on bypass grafts and bifurcations) were treated in 75 patients. A follow-up was scheduled at 6 months. RESULTS:Restenosis rate was 16.6% with a focal pattern of presentation in most cases. Subacute in-stent thrombosis occurred in 2.2%. Resteno-sis occurred mainly in small vessels, diabetic patients and in vessels previously treated with brachytherapy. CONCLUSION:The treatment of lesions at high risk of restenosis with SES is safe with a low restenosis rate at follow-up. An aggressive and prolonged antiplatelet regimen is mandatory because of high subacute in-stent thrombosis rates.
journal_name
Minerva Cardioangioljournal_title
Minerva cardioangiologicaauthors
Presbitero P,Zavalloni D,Scatturin M,Marisco F,Pagnotta P,Boccuzzi Gkeywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
189-94issue
3eissn
0026-4725issn
1827-1618journal_volume
52pub_type
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journal_title:Minerva cardioangiologica
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journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章,评审
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journal_title:Minerva cardioangiologica
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更新日期:1991-10-01 00:00:00
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journal_title:Minerva cardioangiologica
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doi:
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pub_type: 杂志文章
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更新日期:2001-08-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章
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更新日期:1997-04-01 00:00:00
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更新日期:2002-10-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:
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