Abstract:
BACKGROUND:The aim of this prospective supplement summer registry study was to evaluate the efficacy of Pycnogenol® in controlling symptoms of chronic venous insufficiency (CVI) and microcirculatory parameters: venous hypertension and microangiopathy. Pycnogenol® (Horphag Research) is the standardized extract of the bark of Pinus Pinaster. METHODS:During the summer period between June and August 142 patients were split into three groups: 1) Pycnogenol® 150 mg/day; 2) compression stockings; 3) and compression + Pycnogenol®. RESULTS:Venous pressure (ambulatory venous pressure, AVP) and refilling time (RT), microcirculatory and clinical measurements were comparable at inclusion. At 8 weeks variations in skin flux (RF), rate of ankle swelling (RAS), skin PO2-PCO2, Analogue Symptomatic Score (ASLS), Venous Disability and severity Scores and local oxidative stress (OS) indicated a statistically significant improvement by Pycnogenol® both as a single supplement and in association with compression in comparison with baseline. Pycnogenol® significantly improved the microcirculation in comparison with compression (P<0.05). The combined effects of Pycnogenol+compression produced the best results in most measurements. The summer study penalized compression - in a very hot summer - with many drops out. No side effects due to supplementation were observed; tolerability was optimal. The tolerability to stocking was less than optimal (70% of compression not correctly used). Pycnogenol® alone was more effective than compression alone. The increase (P<0.05) in skin O2 and the decrease in PCO2 were associated with the decrease in skin flux. The variations in capillary filtration (RAS) were the most important microcirculation changes. RAS is directly associated with swelling, the hallmark of CVI. Pycnogenol® in both Pycnogenol groups significantly improved RAS in comparison with compression only (P<0.05). The decrease in OS in both Pycnogenol® groups was significant in comparison with compression only (P<0.05). A lower OS is an important micro-metabolic indication of a better capillary bed with better nutritional, perfusional exchanges. The clinical measurements followed the patterns of the microcirculation with the supplement groups performing statistically better (P<0.002) than the compression-only. CONCLUSIONS:This "summer registry" study confirms the clinical and microcirculatory efficacy of Pycnogenol in CVI and venous microangiopathy. The study indicates the significant clinical role of Pycnogenol® (both as a single treatment and in association with compression) in the management, treatment and control of this common clinical problem.
journal_name
Minerva Cardioangioljournal_title
Minerva cardioangiologicaauthors
Cesarone MR,Belcaro G,Agus GB,Ippolito E,Dugall M,Hosoi M,Corsi M,Cotellese R,Feragalli B,Scipione C,Scipione V,Maione Cdoi
10.23736/S0026-4725.19.04948-Xsubject
Has Abstractpub_date
2019-08-01 00:00:00pages
280-287issue
4eissn
0026-4725issn
1827-1618pii
S0026-4725.19.04948-Xjournal_volume
67pub_type
杂志文章abstract:AIM:The best reperfusion strategy for patients of advanced age (either primary-angioplasty or thrombolysis) after a ST-segment elevation myocardial infarction (STEMI) remains controversial. Aim of the study was to test differences in morbidity and mortality regarding the reperfusion strategy adopted. METHODS:From 2007...
journal_title:Minerva cardioangiologica
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更新日期:2014-12-01 00:00:00
abstract::This paper presents a study of plethysmographic changes induced by methacholine (a derivative of acetylcholine) administered via iontophoresis in a population of 41 young women with apparently primary Raynaud's disease. All patients presented with a very clear statistically significant sphygmic increment, obviously co...
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journal_title:Minerva cardioangiologica
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abstract::Hypertension remains a major public health burden despite the plethora of therapeutic agents available for this disorder, compelling innovation of alternate therapies including interventional approaches where necessary. The kidney is a major player in the pathophysiology of this disease with increased sympathetic acti...
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更新日期:2014-02-01 00:00:00
abstract::An aneurysms of a renal vein is very uncommon an entity and even more so when a visceral vein is affected. The venous aneurysms are generally asymptomatic and are detected either at post-mortem examination or by Echography, CT scan or MR investigation. Occasionally they become symptomatic because of rupture, thrombosi...
journal_title:Minerva cardioangiologica
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更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:Intra-arterial infusion of PGE1 alpha-ciclodestrina was achieved by intrafemoral catheter in critical limb ischemia. METHODS:The acute infusion of 10 micrograms in 20 minutes, in 50 ml of saline was followed by chronic infusion 20 micrograms/die of PGE1 alpha-ciclodestrina for 5 days. Three male patients (a...
journal_title:Minerva cardioangiologica
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更新日期:1998-10-01 00:00:00
abstract::Syncope is a common symptom and accounts for approximately 1% of all emergency visits. There are four main causes of syncope: reflex, neurally mediated syncope, orthostatic hypotension and cardiac syncope. The prognosis of patients with reflex syncopes is good, whereas patients with cardiac syncope are at increased ri...
journal_title:Minerva cardioangiologica
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更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:This work aimed to study extracranial carotid dolichoarterial disease in outpatients using color Doppler ultrasonography. METHODS:A total of 1220 outpatients, 620 males and 600 females, aged between 25 and 89 years old, were enrolled in the study. Subjects were divided into three groups according to age: un...
journal_title:Minerva cardioangiologica
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更新日期:1998-03-01 00:00:00
abstract::Atrial fibrillation is the most common cardiac arrhythmia and the most frequent cause of hospitalization and utilization expense among all heart diseases. Taking into account persistent atrial fibrillation we know that, in order to cardiovert persistent atrial fibrillation, external direct current cardioversion is the...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
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更新日期:2004-04-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1991-10-01 00:00:00
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journal_title:Minerva cardioangiologica
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更新日期:1994-09-01 00:00:00
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journal_title:Minerva cardioangiologica
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更新日期:2013-02-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1992-07-01 00:00:00
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journal_title:Minerva cardioangiologica
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更新日期:2016-04-01 00:00:00
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doi:
更新日期:2012-02-01 00:00:00
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journal_title:Minerva cardioangiologica
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journal_title:Minerva cardioangiologica
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journal_title:Minerva cardioangiologica
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doi:
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journal_title:Minerva cardioangiologica
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doi:
更新日期:2002-02-01 00:00:00
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更新日期:2018-08-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章
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更新日期:1997-04-01 00:00:00
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journal_title:Minerva cardioangiologica
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journal_title:Minerva cardioangiologica
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更新日期:2016-04-20 00:00:00