Abstract:
BACKGROUND:Adjuvant trastuzumab therapy increases survival rates in patients with early HER2-positive breast cancer, although it can be potentially cardiotoxic. The aim of this study was to evaluate the prevalence of left ventricular (LV) systolic dysfunction; and the relationship between the presence of cardiovascular risk factors, cardiac therapy and/or echocardiographic parameters of systolic function at baseline and the development of cardiotoxicity in such patients. METHODS:A total of 227 patients were retrospectively reviewed. Cardiotoxicity was defined as a decrease in LV ejection fraction (EF) below 50% or an absolute decrease of >10 points below the baseline value or any indication of heart failure. Each patient underwent echocardiography at baseline and at follow-up every three months. RESULTS:The prevalence of cardiotoxicity was 17.6% (15.4% asymptomatic, 2.2% symptomatic). Patients developing LV dysfunction presented hypertension (P=0.041) and diabetes (P=0.01) and used cardiac therapy at baseline more frequently. Smoke habit, age >50 and use of angiotensin-converting enzyme (ACE)-inhibitors, were independent predictors of cardiac damage. Furthermore, patients with LV dysfunction showed baseline LV end-diastolic volume (EDV) higher than those who did not and baseline EDV (OR=1.02; 95% CI: 1.00-1.04; P=0.027) independently predicted cardiotoxicity with 58 mL/m2 as best cut-off point (AUC=0.65, 95% CI: 0.55-0.75]). CONCLUSIONS:The prevalence of trastuzumab-related cardiotoxicity in patients with HER2-positive early breast cancer is relatively frequent, although asymptomatic in most cases. Baseline EDV resulted as independent predictor of cardiotoxicity suggesting that EDV may be more reliable than LVEF to identify patients at higher risk of developing cardiac damage.
journal_name
Minerva Cardioangioljournal_title
Minerva cardioangiologicaauthors
Bergamini C,Torelli F,Ghiselli L,Rossi A,Trevisani L,Vinco G,Truong S,Benfari G,LA Russa F,Golia G,Molino A,Vassanelli Cdoi
10.23736/S0026-4725.16.04278-Xsubject
Has Abstractpub_date
2017-06-01 00:00:00pages
278-287issue
3eissn
0026-4725issn
1827-1618pii
R05Y9999N00A16112502journal_volume
65pub_type
杂志文章abstract::The Authors report their experience of the surgical treatment of cardiac prosthetic endocarditis. Between September 1974 and December 1988, 2,796 cardiac prostheses were implanted. An endocarditis in the follow-up of 23 patients involving 27 prostheses was diagnosed. The operative mortality was high in patients with m...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
abstract::Transcatheter aortic valve implantation (TAVI) is the treatment of choice among patients with symptomatic severe aortic stenosis (AS) deemed inoperable and a valuable alternative to surgical aortic valve replacement for high-risk surgical patients. Over the years, this procedure proved to be relatively safe, but despi...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2016-06-01 00:00:00
abstract::Percutaneous coronary interventions (PCI) have gained widespread acceptation among cardiologists and among the general population for a variety of clinical indications, comprising from stable angina to ST-elevation acute myocardial infarction, due to the undisputed clinical benefit they provide and to their large avai...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2013-10-01 00:00:00
abstract::After recalling that cardiovascular complications represent the most frequent cause of mortality and morbidity in hypertensive patients, the author describes the main mechanism responsible for increased plasma level concentrations of Angiotensin in this syndrome. He subsequently illustrates the effects of ACE-inhibito...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2001-10-01 00:00:00
abstract::The decision to offer patients with myocardial ischemia a coronary artery bypass graft (CABG) surgery has been largely determined by extent of coronary artery disease (CAD) and left ventricular function, since the early 1970's. Based upon subset analyses, and long-term follow-up, of three moderate-sized trials of stab...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2006-10-01 00:00:00
abstract:AIM:In mitral stenosis (MS) patients with a poor symptom-echocardiography correlation, dobutamine stress echocardiography (DSE) still does not have a confirmed utility and predictive value. Our aim is to evaluate usefulness of DSE in assessing 2 and 5 years clinical outcomes. METHODS:Forty-four consecutive patients wi...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Among the acute effects of cigarette smoking there are an increase in the arterial blood pressure and a decrease in skin temperature. The aim of this study is to evaluate whether these effects are more evident in hypertensive subjects (HTS) than in normotensive (NTS) ones. METHODS:A monitored Ambulatory Blo...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2003-08-01 00:00:00
abstract::The carotid artery is one of the most important sites in the progression of atherosclerotic lesions. Atherosclerosis is known to be determined by a variety of factors, among which arterial hypertension is one of the most important. Blood pressure control by antihypertensive treatment is thus of great benefit in manage...
journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Precise calcium evaluation in the aortic complex may be complicated. We aimed to assess the usefulness of a novel semi-automatic algorithm for multi slice computed tomography-derived (MSCT) quantitative estimation of aortic valve calcifications (AVC) in patients with severe aortic stenosis (AS) undergoing tr...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:10.23736/S0026-4725.18.04793-X
更新日期:2019-02-01 00:00:00
abstract::Recent studies have demonstrated the usefulness of myocardial contrast echocardiography (MCE) in studying myocardial perfusion. Several first and second generation contrast agent such as Levovist, Sonovue, Optison, Definity and Imagent are commercially available or close to be introduced into the market. Use of MCE al...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:Sutureless aortic valve prostheses have the potential to augment the adoption of alternative incision approaches for aortic valve replacement (AVR). Still, we lack the evidence on which surgical approach is best associated with sutureless AVR. METHODS:Data on 483 patients undergoing sutureless small incisio...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:10.23736/S0026-4725.17.04568-6
更新日期:2018-04-01 00:00:00
abstract:AIM:The purpose of this paper was to verify whether there is any sign of involvement of the cardiovascular system in the early stages of collagen diseases. METHODS:Seventeen patients (10 female and 7 male, average age 41.35 +/- 9.85 years) (group A) recruited at the Ambulatory of Internal Medicine for suspected collag...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2006-02-01 00:00:00
abstract::Cardiac hydatid disease represents 0.02-2% of the possible locations of the parasite. The case of an asymptomatic 60-year-old male patient, hospitalised for mnesic and cognitive disease, and with history of hepatic and pulmonary echinococcosis is reported. The patient showed a cardiac cyst localised in the mediobasal ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:It is known that resistance to activated protein C (APCR), often associated with a single point mutation (Arg506-->Gln) in the coagulation factor V gene (factor V Leiden), is the most frequent inherited abnormality of blood coagulation. It plays a key role as pathogenetic factor of venous thromboembolism, bu...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract::Ultrasound contrast agents, used with contrast-specific imaging techniques, have an established role for diagnostic cardiovascular imaging in the echocardiography laboratory. The advent of tissue harmonic imaging, albeit a significant advancement in ultrasound technology, still fail to produce diagnostically useful im...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2009-08-01 00:00:00
abstract:AIM:Paroxysmal supraventricular tachycardia (PSVT) is a very frequent type of arrhythmia. Atrioventricular nodal reciprocating tachycardia (AVNRT) and atrioventricular reciprocating tachycardia through extranodal accessory pathways (AVRT) are the most common types of paroxysmal supraventricular tachycardia. We describe...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2006-06-01 00:00:00
abstract::The ECGs of four patients with implanted dual chamber VDD and DDD PMKs are shown to demonstrate the difficulty of their interpretation and show some arrhythmias related to dual chamber pacing. In the first patient the DDD PMK caused a high ventricular frequency synchronizing on the atrial fibrillation "f" waves which ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND, MATERIALS AND METHODS:To compare the relative use of verapamil and beta-blockers, which have shown comparable efficacy in reducing mortality and reinfarction rates in selected patients with myocardial infarction (MI), we retrospectively evaluated the ongoing treatment at the time of the pre-discharge evalua...
journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract:AIM:The aim of this study was to analyze restenosis after percutaneous coronary intervention, factors related to restenosis after coronary artery stenting and the degree of the risk of restenosis were evaluated. METHODS:The study enrolled 181 patients (249 lesions) who underwent the first coronary artery stenting. Mul...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2008-06-01 00:00:00
abstract::An aneurysms of a renal vein is very uncommon an entity and even more so when a visceral vein is affected. The venous aneurysms are generally asymptomatic and are detected either at post-mortem examination or by Echography, CT scan or MR investigation. Occasionally they become symptomatic because of rupture, thrombosi...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::Calcium-antagonist and B-blockers are effective in improving exercise tolerance in patients with effort angina. We studied the short effects of oral administration of nifedipine (10 mg) and propranolol (80 mg) alone and in combination in 15 elderly patients with chronic exertional angina pectoris in a double-blind, ra...
journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1993-04-01 00:00:00
abstract::Clopidogrel is an oral tyenopiridin with a central role in the management of acute coronary syndromes and after stent implantation. Despite the use of this drug, many patients continue to experience thrombotic events which are usually referred as "therapy failure". Actually, to date, only stent thrombosis is considere...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2013-12-01 00:00:00
abstract::Percutaneous coronary intervention (PCI) has been a mainstay in the management of coronary artery disease since its introduction in the late 1970s. Bare-metal stent (BMS) and then first- and second-generation drug-eluting stents (DES) have enhanced the results of PCI by improving early results and reducing the risk of...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:The aim of this prospective supplement summer registry study was to evaluate the efficacy of Pycnogenol® in controlling symptoms of chronic venous insufficiency (CVI) and microcirculatory parameters: venous hypertension and microangiopathy. Pycnogenol® (Horphag Research) is the standardized extract of the ba...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:10.23736/S0026-4725.19.04948-X
更新日期:2019-08-01 00:00:00
abstract::An epidemiological investigation of certain lipaemic parameters in some expressions of atherosclerotic disease with particular reference to HDL-cholesterol fractions is reported. The series consists of 94 normal weight subjects (45 m, 49 f, average age 61 +/- 5) subdivided as follows: 38 suffering from cerebral vascul...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:High sensitivity cardiac troponins I (hs-cTnI) and T (hs-cTnT) and natriuretic peptides (BNP and NT-proBNP) are universally recognized as cardiac reference biomarkers in patients with acute coronary syndromes and heart failure respectively. However, while on one hand the high sensitivity methods of cardiac b...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:10.23736/S0026-4725.20.05281-0
更新日期:2020-08-01 00:00:00
abstract::Hypertrophic cardiomyopathy is a disease characterised by massive ventricular hypertrophy, reduced diastolic function and excessive ventricular contraction. It involves sections of both ventricles, but in particular the left ventricle. Although it was initially thought that this pathology might depend on a modified sy...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::Palliative care is an alternate therapeutic approach that involves specialised medical care of a patient diagnosed with serious life threatening illness like heart failure (HF). The prime aim of the palliative care is to provide patient with relief from the symptoms, pain, physical stress, and mental stress of the dia...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2016-02-01 00:00:00
abstract::We report the case of a 56-year-old male heart transplant recipient, who underwent postoperative pacemaker implantation through a left sided superior vena cava (LSVC) via anonymous vein. We describe our successful management of this case. We suggest that the specific anatomic conditions should be considered in all hea...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
abstract::Atrial fibrillation is the most common sustained cardiac arrhythmia and with an aging population its prevalence will increase. In addition to appropriate anticoagulation to reduce the thromboembolic risk, there has been an increasing need for a personalized approach in identifying which patients are likely to benefit ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:10.23736/S0026-4725.17.04371-7
更新日期:2017-08-01 00:00:00