Abstract：
BACKGROUND:High sensitivity cardiac troponins I (hs-cTnI) and T (hs-cTnT) and natriuretic peptides (BNP and NT-proBNP) are universally recognized as cardiac reference biomarkers in patients with acute coronary syndromes and heart failure respectively. However, while on one hand the high sensitivity methods of cardiac biomarkers have provided answers to fundamental pathophysiological and clinical questions in patients with heart disease, less information is available on their assessment in paraphysiological conditions, such as high intensity exercise in healthy athletes. The aim of this study was to evaluate hs-cTnI and NT-proBNP in highly trained runners after a 50 km ultramarathon. METHODS:We have enrolled 20 highly trained male athletes who have run a 50 km ultramarathon. Blood samples were collected 2 hours before the start of the race (T0) and 20 minutes after the end of the race (T1). The blood concentrations of hs-cTnI and NT-proBNP measured before the race were within reference intervals in all runners. RESULTS:Hs-cTnI significantly increased after the end of the race (median: 19 ng/L [IQR: 12.5-25.75] versus 6 ng/L [IQR: 4.25-8.0]; P<0.001), in three cases over the upper reference limit (URL) of 34 ng/L. NT-proBNP also significantly increased (median: 78 ng/L [IQR: 68.25-87.75] versus 22 ng/L [IQR: 18.25-26.75]; P<0.001). Three other athletes reached concentration over the URL (125 ng/L). CONCLUSIONS:Our study showed a significant increase in hs-cTnI and NT-proBNP in highly trained athletes after a 50 km ultramarathon race, and 30% of runners had the values of cardiac biomarkers above URL. More studies with a larger number of athletes will be needed to better understand the effects of intense exercise on the heart of trained athletes.
journal_name
Minerva Cardioangioljournal_title
Minerva cardioangiologicaauthors
Perrone MA,Macrini M,Maregnani A,Ammirabile M,Clerico A,Bernardini S,Romeo Fdoi
10.23736/S0026-4725.20.05281-0subject
Has Abstractpub_date
2020-08-01 00:00:00pages
305-312issue
4eissn
0026-4725issn
1827-1618pii
S0026-4725.20.05281-0journal_volume
68pub_type
杂志文章abstract：:Cell based therapy has become a new and attractive option for the treatment of cardiac disease and heart failure. Although it has been demonstrated in vitro and in vivo that differentiation of non-differentiated cells (progenitor cells) into cardiomyocytes is able even in adult hearts the potential use of such transdi...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2009-04-01 00:00:00
abstract：:A carotid stenosis is responsible for about 30% of strokes occurring. Carotid endarterectomy (CEA) is considered to be the gold standard treatment of a carotid stenosis. Carotid angioplasty and stenting (CAS) is emerging as a new alternative treatment for a carotid artery stenosis, but the risk of neurological complic...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:Coronary perforations (CP) have been described as a rare but potentially fatal complication in percutaneous coronary interventions (PCI). Our aim is to compare temporal trends in frequency, management and outcomes of coronary perforations (CP). METHODS:All cases of CP recorded in our prospective institution...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.18.04433-X
更新日期：2018-08-01 00:00:00
abstract：:The Impella left ventricular support system consists of two main components: a family of different ventricular support catheters with a microaxial pump to be placed across the aortic valve and a single external controller which is connected to activate and control the pump function. Four Impella left ventricular suppo...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：10.23736/S0026-4725.18.04703-5
更新日期：2018-10-01 00:00:00
abstract：:We report the case of an 80-year-old man affected by hypertensive cardiomyopathy and already admitted to our Division for recurrent episodes of heart failure. He was eventually hospitalized for septic shock secondary to disseminated pneumonia with concomitant left pleural effusion. At 2D-echo examination, a highly ech...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：1992-10-01 00:00:00
abstract：:The Post-CABG trial was designed to assess the effects of 2 different lipid lowering strategies and low dose warfarin vs placebo (2 x 2 factorial) design on the progression of atherosclerosis in saphenous vein grafts. Atherosclerotic progression was determined by comparing baseline and follow-up angiograms (mean inter...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章,评审
doi：
更新日期：2002-08-01 00:00:00
abstract：:The author reviews the use of the main antithrombotic drugs (thrombolytics, dicumarol compounds, heparins and anti-platelet drugs) in the treatment and prophylaxis of the main nosographic syndromes of arterial and venous thrombosis. In the context of arterial thrombosis the paper initially reports the results of the m...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND:The aim of this study to investigate the correlation of the peripheral concentrations of one representative estrogen, E2 estradiol, with various indicators reflecting different aspects of cardiac structures and functions. METHODS:A total of 84 typical patients with hypertrophic cardiomyopathy (HCM) and 77 h...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2016-08-01 00:00:00
abstract：AIM:The purpose of this paper was to verify whether there is any sign of involvement of the cardiovascular system in the early stages of collagen diseases. METHODS:Seventeen patients (10 female and 7 male, average age 41.35 +/- 9.85 years) (group A) recruited at the Ambulatory of Internal Medicine for suspected collag...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2006-02-01 00:00:00
abstract：:Torsade de pointes is a form of polymorphous ventricular tachycardia in which the polarity of the QRS complex exhibits phasic alterations in both axis. Traditionally, torsade de pointes has been described in association with a congenital or acquired (including drug and metabolic) causes of QT prolongation. Clinical ou...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:Fragments of synthetic prostheses in knitted Dacron velour implanted years previously have been examined. Macrophages were found which fragment elements of the prostheses. It is concluded that synthetic knitted velour prostheses are biodegradable. ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:As echocardiography is being used more often, its value and accuracy are becoming more fully appreciated, especially for identifying normal anatomic variants and their possible erroneous interpretation as pathologic states. We report the echocardiographic and clinical findings observed in sixteen subjects examined at ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:Segmentary isolated stenosis or obstructions of the superficial femoral artery in young people are rarely reported. In patients, most of them women, affected by chronic symptomatology of the lower limbs, the aetiology has been referred to fibromuscular dysplasia with unusual localization. We report a case of acute low...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:An aortic thrombus may be detected by using transesophageal echocardiography after an embolic event. Clinical features are variable and may include cardiac and neurologic symptoms, such as the stroke. We report a case of a woman with an acute ischemic stroke, a myocardial infarction and a free floating aortic thrombus...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
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journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-01-01 00:00:00
abstract：AIM:It is not known whether therapy assisted by determinations of serum B-type natriuretic peptide (BNP) may improve the outcome for outpatients with chronic heart failure (CHF). METHODS:A retrospective case-control study was carried out, enrolling patients with acutely decompensated heart failure (ADHF) who were foll...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2013-08-01 00:00:00
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journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2012-08-01 00:00:00
abstract：UNLABELLED:Currently, there are not reliable data on the incidence and prevalence of post-phlebitic syndrome (PTS) after an episode of asymptomatic postoperative deep vein thrombosis (DVT). In order to evaluate the epidemiology and the clinical course of PTS in patients who were submitted to hip and knee replacement, w...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:Cardiac tamponade may be caused by erosion of the right cardiac walls or of the intrapericardial superior vena cava in subjects with a central venous catheter. The underlying cause of this rare complication is direct parietal trauma by the catheter and endarterial damage produced by infused hyperosmolar solutions. Hig...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:The Authors report their experience of the surgical treatment of cardiac prosthetic endocarditis. Between September 1974 and December 1988, 2,796 cardiac prostheses were implanted. An endocarditis in the follow-up of 23 patients involving 27 prostheses was diagnosed. The operative mortality was high in patients with m...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
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journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
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journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2011-12-01 00:00:00
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journal_title：Minerva cardioangiologica
pub_type： 杂志文章,meta分析,评审
doi：10.23736/S0026-4725.17.04323-7
更新日期：2017-10-01 00:00:00
abstract：AIM:The aim of the present study was to compare the safety and efficacy of amiodarone and procainamide in the acute cardiology setting. METHODS:The study population consisted of 223 patients with symptomatic atrial fibrillation (AF). After administration of digoxin for ventricular rate control, all patients who failed...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2007-08-01 00:00:00
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journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2016-04-20 00:00:00
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journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：1992-11-01 00:00:00
abstract：BACKGROUND:Aim of the present comparative clinical study was to demonstrate the efficacy of the topical application of mesoglycan, a profibrinolytic agent, for healing of leg ulcers in patients with chronic venous insufficiency. METHODS:Forty patients, observed in our outpatients department, with venous leg ulcers hav...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:Coronary artery disease and atherothrombosis are complex pathologic entities. The intricate interplay between anatomical, cellular and molecular factors characterizes their pathogenesis and determines their clinical manifestations. Coronary artery revascularization strategies, by restoring myocardial blood perfusion, ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2015-08-01 00:00:00
abstract：:Pulmonary thromboembolism is a relatively common disease in an Emergency Department. Diagnosis, often difficult, is based on careful evaluation of risk factors, clinical examination, radiological and laboratory investigations. Plasma D-dimer, a degradation product of cross-linked fibrin with low specificity and very h...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
abstract：:The dilatation of the vascular grafts is a well known phenomenon. It is usually evaluated by means of ultrasounds or, in selected cases, by CT scans or MRI; nevertheless its characteristics are far beyond to be fully recognized. Following our promising preliminary experience with helical CT as sole preoperative imagin...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
