Abstract：
:Recent studies have demonstrated the usefulness of myocardial contrast echocardiography (MCE) in studying myocardial perfusion. Several first and second generation contrast agent such as Levovist, Sonovue, Optison, Definity and Imagent are commercially available or close to be introduced into the market. Use of MCE allowed the clinical demonstration of no-reflow phenomenon in patients with acute myocardial infarction (AMI) after recanalization of the infarct related artery (IRA). Coronary angiography is unable to assess the microvascular damage as showed by the poor correlation between TIMI grading and perfusion score evaluated by MCE. Furthermore, the use of MCE is important to determine coronary stenosis, to identify microvascular damage during ischaemia-reperfusion and to evaluate the presence of collateral circulation in the area at risk. MCE seems to be the most effective technique for assessing microvascular integrity after reperfusion as compared to TIMI myocardial perfusion grade, nuclear myocardial perfusion imaging and magnetic resonance imaging. These techniques are expensive, invasive and not available in most of the hospitals. Furthermore, as compared to nuclear medicine and echo-dobutamine, MCE has greater specificity and higher accuracy in detecting coronary artery disease. Recent studies showed that not only primary percutaneous coronary intervention (PCI) but also rescue and delayed PCI reduced microvascular damage and that MCE play a key role in assessing myocardial salvage after reperfusion. The most exciting aspect of MCE is the independent role in predicting left ventricular (LV) remodelling and functional recovery. The extent on no-reflow is an important predictor of LV dysfunction and remodelling at follow-up. Several studies have demonstrated that the extent of infarct-zone viability is a powerful independent predictor of LV dilation. There is a close relationship between the extent of microvascular damage, the extension of necrosis, the site of AMI and LV remodelling. We demonstrated that MCE performed 24 hours after reperfusion, at 1 week and 6 months appears to provide important prognostic information. These data support the daily use of MCE in coronary care unit and could establish a strategy for clinical decision making in patients with AMI.
journal_name
Minerva Cardioangioljournal_title
Minerva cardioangiologicaauthors
Madonna M,Celani F,Funaro S,De Maio F,Agati Lkeywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
647-60issue
6eissn
0026-4725issn
1827-1618journal_volume
51pub_type
杂志文章,评审abstract：:The PAP/PEA (Prevalence of Early Atherosclerosis) study aims to define the prevalence of subclinical atherosclerosis in a typical population of central Italy. A concomitant study evaluates the prevalence of venous diseases. The first group of 850 patients evaluated, indicated the prevalence of superficial ve-nous dise...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:The meaning of the term biomarker has been standardized by a working group of the National Institutes of Health as "a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention". The ability of...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2012-04-01 00:00:00
abstract：:Saphenous vein is nowadays the material of choice performing on femoro-distal revascularisation; when this is not available, it is important to use a material which gives the closest approximation of an ideal conduit and for same time an easy handling during the execution of the anastomosis. Although vein's degenerati...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:Myocardial infarction in the under-40s is rare. A series of 19 patients, 3.07% of a two-year series of coronary cases, is presented with a view to evaluating the incidence of risk factors, with special attention to familial factors and dyslipoproteinaemia. Risk factors are discussed together with the statistical impor...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：AIM:The aim of the present study was to compare the safety and efficacy of amiodarone and procainamide in the acute cardiology setting. METHODS:The study population consisted of 223 patients with symptomatic atrial fibrillation (AF). After administration of digoxin for ventricular rate control, all patients who failed...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:The aim of this study to investigate the correlation of the peripheral concentrations of one representative estrogen, E2 estradiol, with various indicators reflecting different aspects of cardiac structures and functions. METHODS:A total of 84 typical patients with hypertrophic cardiomyopathy (HCM) and 77 h...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2016-08-01 00:00:00
abstract：:The incidence of district (cardiac, cerebral, renal) and systemic vascular complications was studied in a population of 3992 hypertensive in-patients during the period from 1984 to 1988. The total number of male hypertensive patients was always higher (2355) than that of female hypertensive patients (1637). From the a...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：:Vasodilators represent one of the main steps for the medical treatment of pulmonary hypertension; the rationale for their use is the reversibility of the pulmonary vasoconstriction, to be tested with a correct pharmacological trial. In this report the authors consider the use of calcium-channel blockers, prostaglandin...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
abstract：:The Post-CABG trial was designed to assess the effects of 2 different lipid lowering strategies and low dose warfarin vs placebo (2 x 2 factorial) design on the progression of atherosclerosis in saphenous vein grafts. Atherosclerotic progression was determined by comparing baseline and follow-up angiograms (mean inter...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章,评审
doi：
更新日期：2002-08-01 00:00:00
abstract：:Fifty patients suffering from chronic venous disease were treated for 30 days with heparan sulphate 100 mg per os, b.i.d., or mesoglycan 50 mg per os, t.i.d., in a single blind random study. Both therapies led to a marked improvement in comparison to basal clinical values, but patients treated with heparan sulphate sh...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-10-01 00:00:00
abstract：AIM:Drug-coated balloon (DCB) technology has emerged as a promising therapy particularly in the treatment of coronary in-stent restenosis. Although a variety of devices are available for clinical use, clinical outcomes have been variable and scope for significant improvement exists. METHODS:In a preclinical study, a t...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：:The decision to offer patients with myocardial ischemia a coronary artery bypass graft (CABG) surgery has been largely determined by extent of coronary artery disease (CAD) and left ventricular function, since the early 1970's. Based upon subset analyses, and long-term follow-up, of three moderate-sized trials of stab...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2006-10-01 00:00:00
abstract：:The Authors report their experience of the surgical treatment of cardiac prosthetic endocarditis. Between September 1974 and December 1988, 2,796 cardiac prostheses were implanted. An endocarditis in the follow-up of 23 patients involving 27 prostheses was diagnosed. The operative mortality was high in patients with m...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：:Personal experience in the management of 70 ruptured abdominal aortic aneurysm over the past 5 years is reported dividing patients into 2 groups, before and after establishment of intensive care unit: survival was 30.76% on the first, 66.66% in the second. Factors that allowed that result are discussed. ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:Aortic valve bioprostheses are commonly implanted in the current era - also in younger patients - as they may obviate the need for anticoagulation while providing better hemodynamic performance and a more favorable quality of life. The steady increase in the use of biological valves has prompted the development of sev...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2016-04-20 00:00:00
abstract：:Endovascular aortic repair (EVAR) for abdominal aortic aneurysms (AAA) is the preferred first treatment option in case of patients with advanced age and/or fit anatomy owing to shorter length of in hospital staying, less complications or laparotomy-related re-interventions, and lower initial costs. Although it is a le...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2016-04-01 00:00:00
abstract：:Left main coronary artery (LMCA) disease has been reported in up to 10% of all patients with coronary artery disease (CAD) and in the majority of cases are associated with severe three-vessel CAD. Among patients with chronic coronary syndrome revascularization of significant LMCA disease improves prognosis, while ther...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.20.05198-1
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:The proposal of this study is to compare the efficacy of lisinopril and theophylline, alone or in association, on erythrocytosis in renal-transplanted patients. DESIGN:Prospectic, case-control study. PATIENTS/ENVIRONMENT: 15 inpatients meeting 3 main criteria: 1) ACE therapy for past erythrocytosis, 2) actua...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章,评审
doi：
更新日期：1997-11-01 00:00:00
abstract：AIM:The aim of the present study was to investigate the behaviour of plasma adrenomedullin (AM), a hypotensive peptide, in patients with malignant (MHT) and renovascular hypertension (RVH), 2 pathologic conditions in which renin-angiotensin system (RAS) is activated and to compare them with those in essential hypertens...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Prolonged periods of atrial fibrillation (AF) or high frequency atrial pacing lead to a significant shortening of atrial refractory periods. This time-dependent electric remodelling is reduced significantly by the administration of verapamil. METHODS:The present series consists of 24 patients all suffering ...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：2003-02-01 00:00:00
abstract：:Ultrasound contrast agents, used with contrast-specific imaging techniques, have an established role for diagnostic cardiovascular imaging in the echocardiography laboratory. The advent of tissue harmonic imaging, albeit a significant advancement in ultrasound technology, still fail to produce diagnostically useful im...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2009-08-01 00:00:00
abstract：:The authors present the results of a research on 3,888 patients (1,768 males and 2,120 females) admitted to the 1st Internal Medicine Department of Leghorn Hospital during two years (from July 1993 to June 1995). The research is intended to value the hyperlipidaemia's incidence in hospitalized patients, and the associ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:An epidemiological investigation of certain lipaemic parameters in some expressions of atherosclerotic disease with particular reference to HDL-cholesterol fractions is reported. The series consists of 94 normal weight subjects (45 m, 49 f, average age 61 +/- 5) subdivided as follows: 38 suffering from cerebral vascul...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:In routine clinical practice, a sizeable proportion of patients with suspected coronary artery disease (CAD) undergo coronary angiography without prior non-invasive functional evaluation. In this situation, the decision wheter to perform revascularization is taken solely on the basis of angiographic parameters, which ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2011-02-01 00:00:00
abstract：:The efficacy and safety of the treatment of arterial hypertension with the ACE-inhibitor quinapril, were evaluated in a multicentre study conducted in Italy. The study, lasting 14 weeks, after a preliminary wash-out period, allowed response-based titration of quinapril dose from 10 mg to 40 mg once a day, with provisi...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1992-03-01 00:00:00
abstract：BACKGROUND:Arrhythmias are frequent pathology in patients with chronic hemodialysis. We evaluated whether a relatively new technique, signal averaging, could be useful in predicting the development of complex arrhythmias in these patients. METHODS:Thirty-three patients, 18 male and 15 female, subjected to thrice weekl...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：:Clopidogrel is an oral tyenopiridin with a central role in the management of acute coronary syndromes and after stent implantation. Despite the use of this drug, many patients continue to experience thrombotic events which are usually referred as "therapy failure". Actually, to date, only stent thrombosis is considere...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2013-12-01 00:00:00
abstract：:Inflammatory mechanisms play a pivotal role in the atherosclerotic process. At the base of atherogenesis there are complex interactions between macrophages, T lymphocytes and smooth muscle cells. A growing body of experimental evidences suggest that inflammation is involved in the pathogenesis of acute coronary syndro...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：:Stenting of symptomatic myocardial bridges is a therapeutic option with documented good short-term outcome. However, limited data on the long term outcome of myocardial bridge stenting has shown a higher restenosis rate comparing to stenting of de novo atherosclerotic lesions. Drug-eluting stenting of de novo atherosc...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
abstract：:Chronic venous insufficiency and chronic venous ulcers represent an important medical problem, because of the high incidence and prevalence in the general population, and need to be considered as a lifelong degenerative condition, with socioeconomic consequences. Ulceration is a severe complication of the post-thrombo...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2015-06-01 00:00:00
