Abstract:
BACKGROUND:Of the main aspects of hypertension, left ventricular hypertrophy and appearance of cardiac dysfunction seem to be the most common and to produce an early and severe cardiac deterioration. Even in the presence of normal systolic function diastolic filling abnormalities are described. The efficacy of many antihypertensive drugs to decrease blood pressure and to reduce left ventricular hypertrophy has already been demonstrated. Cilazapril is a new ACE-inhibitor that in previous studies showed a very important antihypertensive effect. To assess its capacity, in long-term treatment, to reduce left ventricular hypertrophy we performed a prospective study on patients with mild hypertension. MATERIAL AND METHODS:Nineteen patients (aged 48 +/- 15 years) with mild hypertension (mean arterial pressure automatically recorded for 24 hours with blood pressure ambulatorial monitoring) were treated with cilazapril (5 mg/day) for 1 year. Doppler echocardiography was performed: at the beginning, after 6 months and after one year of therapy. The following parameters were evaluated: interventricular septal and posterior wall thickness, LV end-diastolic diameter, LV mass index, early (E) and late (A) diastolic filling flow velocities and the ratio E/A. RESULTS:A significant decrease was observed in mean arterial pressure (from 130 +/- 14 mmHg at beginning to 102 +/- 11 mmHg at six months of therapy and to 103 +/- 9 mmHg at one year of therapy). A significant reduction in LV hypertrophy and an improved diastolic filling pattern of the left ventricle was shown after six months of therapy with cilazapril; this improvement still remained after 1 year of therapy. CONCLUSIONS:In this study antihypertensive efficacy of cilazapril has been confirmed. Moreover, in long treatment, cilazapril has been useful to reduce left ventricular hypertrophy and to improve diastolic filling without significant side effects.
journal_name
Minerva Cardioangioljournal_title
Minerva cardioangiologicaauthors
De Simone R,Irace L,Perna B,Caruso C,Guida M,Iacono Asubject
Has Abstractpub_date
1993-05-01 00:00:00pages
205-9issue
5eissn
0026-4725issn
1827-1618journal_volume
41pub_type
杂志文章abstract::Despite the impressive progress of percutaneous treatment modalities, restenosis remains the major Achilles heel of interventional cardiology. Approximately 25% of the general population treated for coronary diseases with a bare-metal stent and about 10% of patients treated with a drug-eluting stent develop an overgro...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2009-10-01 00:00:00
abstract::Palliative care is an alternate therapeutic approach that involves specialised medical care of a patient diagnosed with serious life threatening illness like heart failure (HF). The prime aim of the palliative care is to provide patient with relief from the symptoms, pain, physical stress, and mental stress of the dia...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The aim of this comparative registry study was to evaluate the supplementation with Pycnogenol® in subjects with Behçet syndrome (BS) with symptoms impairing their quality of life despite being in a remitting phase of the disease. METHODS:Thirty-four patients with a confirmed diagnosis of BS were divided in...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:10.23736/S0026-4725.18.04637-6
更新日期:2018-08-01 00:00:00
abstract::Despite advances in clinical interventions, drug therapy and preventative strategies for cardiovascular disease, heart disease remains the number one cause of death in the United States. A major cause of heart failure leading to death is myocardial ischemic disease. Terminal heart failure can be salvaged in some cases...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2010-02-01 00:00:00
abstract::In obesity, the systemic resistances (SR) are reduced while the blood volume is increased. The rise of cardiac output (CO), stress-induced, produces an increase in blood pressure (BP), as an hypertensive behavior of the stress-response. The aim of our study is to evaluate if, in obese subjects, the considerable increa...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::After the introduction of coronary balloon angioplasty, bare-metal, and drug-eluting stents, fully bioresorbable scaffolds (BRS) could be the fourth revolution in interventional cardiology. The BRS technology shares the advantages of metallic stents regarding acute gain and prevention of acute vessel occlusion by prov...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2013-04-01 00:00:00
abstract::Atrial fibrillation (AF) is the most common observed cardiac arrhythmia and is the most frequent condition associated with thromboembolic events in patients with or without mitral valve disease. The source of cardiac emboli is the left atrium, the left atrial appendage or, less frequently, the left ventricle. Emboli m...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2003-06-01 00:00:00
abstract:AIM:To evaluate the relationship between body mass index (BMI), body fat distribution and some coronary heart disease risk factors like hyperlipidemia, hypertension and cigarette smoking. STUDY DESIGN:Cross-sectional. PLACE:Tiriolo, a little town close to Catanzaro, of prevalent rural economy. PARTICIPANTS:Volunteer...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::Hypertension remains a major public health burden despite the plethora of therapeutic agents available for this disorder, compelling innovation of alternate therapies including interventional approaches where necessary. The kidney is a major player in the pathophysiology of this disease with increased sympathetic acti...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2014-02-01 00:00:00
abstract::Some cases of coronary aneurysms studied echocardiographically in children suffering from Kawasaki's disease are reported. In the fourth case, bidimensional echocardiography highlighted a uniform dilatation of the right and left coronary proximal segments which had retreated at subsequent controls. In the third case, ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::The ECGs of four patients with implanted dual chamber VDD and DDD PMKs are shown to demonstrate the difficulty of their interpretation and show some arrhythmias related to dual chamber pacing. In the first patient the DDD PMK caused a high ventricular frequency synchronizing on the atrial fibrillation "f" waves which ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract:INTRODUCTION:The impact of the 'International Criteria' for ECG interpretation in athletes has further improved the diagnostic accuracy of the 12-lead ECG use for pre-participation screening (PPS) and these criteria have been evaluated in different populations of athletes and settings proving good results. EVIDENCE AC...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:10.23736/S0026-4725.20.05347-5
更新日期:2020-09-30 00:00:00
abstract::The efficacy and safety of the treatment of arterial hypertension with the ACE-inhibitor quinapril, were evaluated in a multicentre study conducted in Italy. The study, lasting 14 weeks, after a preliminary wash-out period, allowed response-based titration of quinapril dose from 10 mg to 40 mg once a day, with provisi...
journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1992-03-01 00:00:00
abstract::We assessed the safety and efficacy of intravenous propafenone in the treatment of atrial fibrillation and flutter of recent onset (1-10 days). The drug was administered, at a dosage of 2 mg/kg, to 46 consecutive patients (with age variable from 35 to 86 years), 36 with atrial fibrillation, 10 with atrial flutter. The...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::Intraoperative transesophageal echocardiography (IOTEE) has become an important diagnostic and monitoring tool in the operating theatre during cardiac and noncardiac operations. However, its routine application during valve replacement operations has not received universal recognition. The cumulative experience, broug...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2007-04-01 00:00:00
abstract::The number of women who become ill and die from acute myocardial infarction (AMI) increases steadily with age. It is not yet clearly defined whether and why women suffer from a higher in-hospital mortality rate after AMI. In this study we evaluated the importance of the female sex as a risk factor for in-hospital mort...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:1997-06-01 00:00:00
abstract::Cardiovascular diseases are the major cause of morbidity and mortality in the Western countries and their prevalence is increasing in developing world. The final biological evolution of atherosclerotic process, supporting development and progression of cardiovascular diseases, is thrombosis. In the most recent years s...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2005-12-01 00:00:00
abstract:AIM:The purpose of this paper was to verify whether there is any sign of involvement of the cardiovascular system in the early stages of collagen diseases. METHODS:Seventeen patients (10 female and 7 male, average age 41.35 +/- 9.85 years) (group A) recruited at the Ambulatory of Internal Medicine for suspected collag...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2006-02-01 00:00:00
abstract::Inflammatory mechanisms play a pivotal role in the atherosclerotic process. At the base of atherogenesis there are complex interactions between macrophages, T lymphocytes and smooth muscle cells. A growing body of experimental evidences suggest that inflammation is involved in the pathogenesis of acute coronary syndro...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract::Cell based therapy has become a new and attractive option for the treatment of cardiac disease and heart failure. Although it has been demonstrated in vitro and in vivo that differentiation of non-differentiated cells (progenitor cells) into cardiomyocytes is able even in adult hearts the potential use of such transdi...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2009-04-01 00:00:00
abstract::A patent ductus arteriosus in adults is a rare eventuality. After correct diagnosis, an accurate evaluation of pulmonary vascular resistances is necessary with, in case of normality, a straightforward indication to surgery, because the evolution of the disease cannot be predicted. In case of pulmonary hypertension irr...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract::The carotid artery is one of the most important sites in the progression of atherosclerotic lesions. Atherosclerosis is known to be determined by a variety of factors, among which arterial hypertension is one of the most important. Blood pressure control by antihypertensive treatment is thus of great benefit in manage...
journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::Clopidogrel is an oral tyenopiridin with a central role in the management of acute coronary syndromes and after stent implantation. Despite the use of this drug, many patients continue to experience thrombotic events which are usually referred as "therapy failure". Actually, to date, only stent thrombosis is considere...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2013-12-01 00:00:00
abstract::Recent studies have demonstrated the usefulness of myocardial contrast echocardiography (MCE) in studying myocardial perfusion. Several first and second generation contrast agent such as Levovist, Sonovue, Optison, Definity and Imagent are commercially available or close to be introduced into the market. Use of MCE al...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2003-12-01 00:00:00
abstract::We have verified the utility of echo-dipyridamole test in the diagnosis of chest pain of unsure origin, especially in patients who cannot be quickly submitted to exercise stress test because of permanent abnormalities at basal ECG or because of clinical reasons. 17 patients with chest pain, abnormalities at basal ECG ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::The aim of this study was to provide a further contribution to the study on the alterations of left ventricular diastolic function induced by dialysis, using simple indexes of diastolic function obtained with Doppler. The study is conduced in 15 patients with renal failure aged between 22 and 51 years old by means of ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::A case is reported of pseudoaneurysm of the right iliac artery secondary to an endarterectomy with dacron patch due to atherosclerosis performed 4 years ago. The case presented acute anemia and massive enteric hemorrhage subsequent to arterial rupture into the cecum. Because of the dramatic onset, the patient was imme...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::The dilatation of the vascular grafts is a well known phenomenon. It is usually evaluated by means of ultrasounds or, in selected cases, by CT scans or MRI; nevertheless its characteristics are far beyond to be fully recognized. Following our promising preliminary experience with helical CT as sole preoperative imagin...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Aim of this registry study was the evaluation of the stability of carotid plaques by ultrasound in asymptomatic subjects with high oxidative stress following supplementation with a combination of the extract from bark of Pinus pinaster, Pycnogenol®, with an extract from Centella asiatica leaves, Centellicum®...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the effects of the standardized supplement Robuvit® (oak wood extract) in defined diffuse, minimal lymphatic "retention" (DMLR). METHODS:Robuvit® has already been investigated in both primary and secondary (post-surgical, post chemo-radiotherapy) lymphatic insufficiency...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:10.23736/S0026-4725.19.05026-6
更新日期:2020-06-01 00:00:00