Abstract：
:Despite advances in clinical interventions, drug therapy and preventative strategies for cardiovascular disease, heart disease remains the number one cause of death in the United States. A major cause of heart failure leading to death is myocardial ischemic disease. Terminal heart failure can be salvaged in some cases by cardiac transplants, but this therapeutic approach is limited by lack of supply, high cost, and problems with immunosuppression. An attractive alternative approach proposed over the last 1-2 decades is the replacement of myocardium at the level of the myocyte, which has focused on stem cell therapy. This form of therapy has been successful for hematopoietic replacement. Similar therapy has been proposed to treat hearts ravaged by ischemic necrosis and apoptosis. However, the experimental studies have not been effectively translated to patients with myocardial infarction or heart failure. This review discusses the current literature and points out key studies that are required for future directions, focusing on key roles for microenvironmental factors, such as cytokines, in stem cells responses when placed at sites of cardiac injuries. In the case of mesenchymal stem cells (MSCs), they exert both immune- enhancer and -suppressor functions, which are referred to as immune plasticity. This type of immune properties by MSCs is significant to therapeutic outcomes. Thus, the plasticity of MSCs, with regards to immune responses, has to be considered carefully in tissue repair and replacement and in gene delivery systems. The route by which cytokines are delivered as adjuvant to cell therapy, or as methods to mobilize stem cells, will show varied results, depending on the degree of injury, underlying clinical disorders and other diverse parameters, such as ethnicity, age and genomic profile. In addition to MSCs, roles exist for other stem cells, such as those from placenta, cord blood, hematopoietic stem/progenitor cells and cardiac stem cells.
journal_name
Minerva Cardioangioljournal_title
Minerva cardioangiologicaauthors
Rameshwar P,Qiu H,Vatner SFsubject
Has Abstractpub_date
2010-02-01 00:00:00pages
127-46issue
1eissn
0026-4725issn
1827-1618pii
R05102909journal_volume
58pub_type
杂志文章,评审abstract：:Cardiac mixoma in the elderly. A clinical study. The clinical features of 13 cardiac myxomas surgically resected are presented. The mean age at presentation was 68 years. Ten were in the left atrium, 5 near the fossa ovalis, 3 at the base of the atrial septum, 1 at the inferior wall and 1 on the anterior leaflet of mi...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:The effectiveness of a new alpha-blocking agent with additional mechanism of action was evaluated during intraoperative hypertensive crises. Urapidil was administered both in bolus form and as a continuous infusion in order to compare the two routes of delivery. During the study systolic, diastolic, mean pressure and ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:Coronary artery disease among women presents differences in terms of clinical presentation and pathophysiology. To date, women present worse prognoses with more events and higher mortality rate. One the one hand, they are less likely addressed for invasive therapy. One the other hand, revascularization procedures, whe...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.20.05203-2
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:The pharmacological treatment of non-complicated chronic venous insufficiency is a current and well-debated topic. The introduction of new products with action on the venous system, improved knowledge on the physiopathology of venous insufficiency and the possibility provided by new analytical instruments, h...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:The definition of an ischaemic condition at lower limb level, may imply any different degree of the pathology, starting from a simple chronic slight claudication up to a severe ischaemia. Critical Limb Ischaemia is the term defined to identify an ischaemic condition, which endangers the limb or part of a limb and requ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：BACKGROUND, MATERIALS AND METHODS:To compare the relative use of verapamil and beta-blockers, which have shown comparable efficacy in reducing mortality and reinfarction rates in selected patients with myocardial infarction (MI), we retrospectively evaluated the ongoing treatment at the time of the pre-discharge evalua...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：AIM:The purpose of this paper was to verify whether there is any sign of involvement of the cardiovascular system in the early stages of collagen diseases. METHODS:Seventeen patients (10 female and 7 male, average age 41.35 +/- 9.85 years) (group A) recruited at the Ambulatory of Internal Medicine for suspected collag...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Takotsubo Cardiomyopathy (TTC) is classified into 4 types dependent on anatomical area affected identified on gross visual assessment. We have sought to understand if it is feasible and advantageous to use left ventricular global longitudinal strain (LVGLS), LV segmental longitudinal strain and right ventric...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.20.05386-4
更新日期：2021-01-11 00:00:00
abstract：:After the introduction of coronary balloon angioplasty, bare-metal, and drug-eluting stents, fully bioresorbable scaffolds (BRS) could be the fourth revolution in interventional cardiology. The BRS technology shares the advantages of metallic stents regarding acute gain and prevention of acute vessel occlusion by prov...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2013-04-01 00:00:00
abstract：:This report describes a rare case of concurrent abdominal aortic aneurysm and bilateral renal ectopia. Preoperative work-up included intravenous pyelography and angiography to assess renal function, renal artery anatomy, and ureter position. Conventional surgery was performed without renal protection. No deterioration...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2008-10-01 00:00:00
abstract：AIM:Balloon aortic valvuloplasty (BAV) has reemerged with transcatheter valve therapy. Cylindrical balloons have been the device of choice despite limitations. An hour glass shaped balloon may permit enhanced fixation and broader leaflet opening without annular compromise. METHODS:We report our initial BAV experience ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Arrhythmias are frequent pathology in patients with chronic hemodialysis. We evaluated whether a relatively new technique, signal averaging, could be useful in predicting the development of complex arrhythmias in these patients. METHODS:Thirty-three patients, 18 male and 15 female, subjected to thrice weekl...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：AIM:In about 30% of patients with ST elevated myocardial infarction (STEMI), in which a TIMI 3 flow is obtained in the infarct related artery (IRA) after primary percutaneous transluminal coronary angioplasty (PTCA), it's not possible to obtain a good perfusion of coronary microcirculation (no reflow). Aim of the study...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2005-06-01 00:00:00
abstract：:We assessed the safety and efficacy of intravenous propafenone in the treatment of atrial fibrillation and flutter of recent onset (1-10 days). The drug was administered, at a dosage of 2 mg/kg, to 46 consecutive patients (with age variable from 35 to 86 years), 36 with atrial fibrillation, 10 with atrial flutter. The...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:In patients with atrial fibrillation (AF) warfarin has been the mainstay therapy for stroke prevention. In recent randomized clinical trials (RCTs) oral direct thrombin inhibitor (Dabigatran) and factor Xa inhibitors (Rivaroxaban and Apixaban) challenged the efficacy and safety benchmarks set by warfarin. These drugs ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2012-08-01 00:00:00
abstract：:Radial approach has been used since 1989 to perform coronary angiography as an alternative to femoral access. During past decades, the development of dedicated equipment has led to high efficacy also in complex procedures. ST elevation myocardial infarction (STEMI) is known to be a high bleeding risk setting and in tu...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2016-06-01 00:00:00
abstract：AIM:The aim of this study was to describe the five-year prognosis of an Italian cohort of patients following acute myocardial infarction (AMI) occurred at age ≤ 45 years and to investigate the potential role of risk predictors for future cardiovascular events (CVE). METHODS:The study enrolled 112 consecutive patients ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2010-08-01 00:00:00
abstract：:Congenital thrombophilia, specifically thrombophilia due to Leiden modified factor V as the cause of thromboembolic disease, is discussed. Thromboembolic disease is potentially fatal and disabling. A clinical case is presented of a girl of 15 with Leiden factor V thrombophilia in which all the typical thromboembolic e...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:Intraoperative transesophageal echocardiography (IOTEE) has become an important diagnostic and monitoring tool in the operating theatre during cardiac and noncardiac operations. However, its routine application during valve replacement operations has not received universal recognition. The cumulative experience, broug...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2007-04-01 00:00:00
abstract：:Atrial fibrillation is the most common cardiac arrhythmia and the most frequent cause of hospitalization and utilization expense among all heart diseases. Taking into account persistent atrial fibrillation we know that, in order to cardiovert persistent atrial fibrillation, external direct current cardioversion is the...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2004-04-01 00:00:00
abstract：:The best timing of orotracheal intubation and invasive ventilation in COVID-19 patients with acute respiratory distress syndrome is unknown. The use of non-invasive ventilation, a life-saving technique in many medical conditions, is debated in patients with ARDS since prolonged NIV and delayed intubation may be harmfu...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.20.05356-6
更新日期：2020-10-15 00:00:00
abstract：BACKGROUND:Prolonged periods of atrial fibrillation (AF) or high frequency atrial pacing lead to a significant shortening of atrial refractory periods. This time-dependent electric remodelling is reduced significantly by the administration of verapamil. METHODS:The present series consists of 24 patients all suffering ...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：2003-02-01 00:00:00
abstract：:The clinical introduction of catheter ablation in 1981 revolutionized the treatment of cardiac arrhythmias. Implementation of radiofrequency as an alternative energy source, with the advantages of higher selectivity and less collateral damage, provided an expansion of catheter ablation therapy. Today the majority of a...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2002-06-01 00:00:00
abstract：:Assays for cardiac troponin have become a standard for the diagnosis of myocardial damage. Due to their high sensitivity, minor myocardial injury can be frequently detected following percutaneous coronary interventions (PCI). Minor elevations in cardiac enzymes after apparently successful PCI are rather common and eve...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND:The aim of this study to investigate the correlation of the peripheral concentrations of one representative estrogen, E2 estradiol, with various indicators reflecting different aspects of cardiac structures and functions. METHODS:A total of 84 typical patients with hypertrophic cardiomyopathy (HCM) and 77 h...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2016-08-01 00:00:00
abstract：:The risk of venous thromboembolism (VTE) increases up to 5-10-fold during pregnancy and VTE represents the first cause of maternal mortality. The annual incidence of VTE is 0.97 per 1000 women during pregnancy and 7.19 per 1000 in the puerperium. The risk is higher in carriers of inherited thrombophilia. Prophylaxis o...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2006-12-01 00:00:00
abstract：:An aneurysms of a renal vein is very uncommon an entity and even more so when a visceral vein is affected. The venous aneurysms are generally asymptomatic and are detected either at post-mortem examination or by Echography, CT scan or MR investigation. Occasionally they become symptomatic because of rupture, thrombosi...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：:Chronic venous insufficiency and chronic venous ulcers represent an important medical problem, because of the high incidence and prevalence in the general population, and need to be considered as a lifelong degenerative condition, with socioeconomic consequences. Ulceration is a severe complication of the post-thrombo...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2015-06-01 00:00:00
abstract：:Clopidogrel is an oral tyenopiridin with a central role in the management of acute coronary syndromes and after stent implantation. Despite the use of this drug, many patients continue to experience thrombotic events which are usually referred as "therapy failure". Actually, to date, only stent thrombosis is considere...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2013-12-01 00:00:00
abstract：:The metabolic abnormalities associated with diabetes mellitus result in macrovascular and microvascular complications in multiple organ systems; it is the cardiovascular impact that accounts for the greatest morbidity and mortality associated with this disease. Heart failure, both with reduced and preserved systolic f...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2004-12-01 00:00:00
