Abstract:
BACKGROUND:The pharmacological treatment of non-complicated chronic venous insufficiency is a current and well-debated topic. The introduction of new products with action on the venous system, improved knowledge on the physiopathology of venous insufficiency and the possibility provided by new analytical instruments, have given new impulse to the consolidation of the clinical value of phlebotonics in this indication. METHODS:In light of this, 24 patients with non-complicated chronic venous insufficiency were treated with oral administration of Oligomeric Proanthocyanidins (Pycnogenols-OPC) 100 mg/day. To evaluate the therapeutic efficacy of the treatment, an instrumental evaluation by optical probe capillaroscope was employed in addition to the traditional subjective clinical parameters: swelling, itching, heaviness and pain. The videocapillaroscope examination was performed at the lower third of the leg and the first toe. Edema in the capillaroscopic field, the number of observable capillaries and the capillary dilatation were the parameter chosen to evaluate the efficacy of treatment. All patients completed the study with no reports of adverse events during the period of observation. RESULTS:The results obtained show a positive clinical response (improved or absent symptoms) in over 80% of patients, with significant improvement of symptoms already evident after the first 10 days of treatment. The mechanism of action of the OPCs explains the rapid reduction of the swelling of the lower limbs and correlated with this are the other evaluable symptoms: heaviness and itching. Particularly striking results were observed for itching and pain which completely disappeared during the course of therapy in 80% and 53% of the patients respectively. Noteworthy is the good correlation between the clinical and instrumental data, with improvement in a total of 70% of patients. CONCLUSIONS:The results obtained in the course of this clinical experience, with evident improvement already during the first weeks of treatment, the absence of adverse events added to the benefit of a once-a-day administration, justify the use of OPC in the treatment of non-complicated chronic venous insufficiency.
journal_name
Minerva Cardioangioljournal_title
Minerva cardioangiologicaauthors
Costantini A,De Bernardi T,Gotti Akeywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
39-46issue
1-2eissn
0026-4725issn
1827-1618journal_volume
47pub_type
杂志文章abstract:BACKGROUND:To assess the prevalence of masked hypertension (MH) in young Saudi National Guard soldiers based on 24h ambulatory blood pressure monitoring (ABPM). METHODS:A prospective study of 196 soldiers, aged between 21-50 years, without a history of hypertension or antihypertensive medication use. Each participant ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:10.23736/S0026-4725.20.05288-3
更新日期:2020-06-10 00:00:00
abstract::Stenting of symptomatic myocardial bridges is a therapeutic option with documented good short-term outcome. However, limited data on the long term outcome of myocardial bridge stenting has shown a higher restenosis rate comparing to stenting of de novo atherosclerotic lesions. Drug-eluting stenting of de novo atherosc...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
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abstract::Inflammation is an important contributor to atherothrombosis. The C-reactive protein (CRP) is not only an excellent biomarker of inflammation, but it is also a direct participant in atherogenesis. CRP consistently predicts new coronary events, including myocardial infarction and death, in patients with ischemic heart ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2005-02-01 00:00:00
abstract::Despite some technical limits ambulatory blood pressure monitoring must be considered as a careful instrument for blood pressure measurement. After demonstration of its sensibility and specificity in experimental trials, the use of blood pressure monitoring has been extended to clinical evaluation. The recent Consensu...
journal_title:Minerva cardioangiologica
pub_type: 社论
doi:
更新日期:1996-10-01 00:00:00
abstract::A comparative analysis of arrhythmias by "basal" electrocardiogram (ECG) and by continuous 24-hour Holter electrocardiogram monitoring was performed in 17 patients with systemic sclerosis (16 women and one man). Our study confirms that rhythm disturbances are better detectable using Holter monitoring. In fact, no pati...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
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abstract::Myocardial infarction in the under-40s is rare. A series of 19 patients, 3.07% of a two-year series of coronary cases, is presented with a view to evaluating the incidence of risk factors, with special attention to familial factors and dyslipoproteinaemia. Risk factors are discussed together with the statistical impor...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract::Atrial fibrillation frequently coexists with heart failure, and these two chronic disease states often physiologically exacerbate one another. Clinical trials comparing rate versus rhythm control strategies have not demonstrated superiority with one strategy over the other, with pharmacologically based rhythm manageme...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2008-12-01 00:00:00
abstract:AIM:The aim of this study was to describe the five-year prognosis of an Italian cohort of patients following acute myocardial infarction (AMI) occurred at age ≤ 45 years and to investigate the potential role of risk predictors for future cardiovascular events (CVE). METHODS:The study enrolled 112 consecutive patients ...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2010-08-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:10.23736/S0026-4725.18.04793-X
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2015-04-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2003-08-01 00:00:00
abstract::Percutaneous coronary intervention (PCI) has been a mainstay in the management of coronary artery disease since its introduction in the late 1970s. Bare-metal stent (BMS) and then first- and second-generation drug-eluting stents (DES) have enhanced the results of PCI by improving early results and reducing the risk of...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2015-06-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:A study of the protective efficiency imparted by intermittent warm blood cardioplegia (WBCP) using perfused rat heart model. METHODS:Hemodynamic parameters were monitored simultaneously with metabolic changes in high-energy phosphates using 31P-NMR spectroscopy. Following 30 min perfusion with Krebs-Henselei...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2000-06-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-01-01 00:00:00
abstract:AIM:Drug-coated balloon (DCB) technology has emerged as a promising therapy particularly in the treatment of coronary in-stent restenosis. Although a variety of devices are available for clinical use, clinical outcomes have been variable and scope for significant improvement exists. METHODS:In a preclinical study, a t...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Of the main aspects of hypertension, left ventricular hypertrophy and appearance of cardiac dysfunction seem to be the most common and to produce an early and severe cardiac deterioration. Even in the presence of normal systolic function diastolic filling abnormalities are described. The efficacy of many ant...
journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
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journal_title:Minerva cardioangiologica
pub_type: 临床试验,杂志文章,评审
doi:
更新日期:2002-08-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:1989-06-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2013-04-01 00:00:00
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
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journal_title:Minerva cardioangiologica
pub_type: 杂志文章,评审
doi:
更新日期:2009-08-01 00:00:00