Abstract：
BACKGROUND:Aim of this registry study was the evaluation of the stability of carotid plaques by ultrasound in asymptomatic subjects with high oxidative stress following supplementation with a combination of the extract from bark of Pinus pinaster, Pycnogenol®, with an extract from Centella asiatica leaves, Centellicum®. METHODS:50 patients, mean age 61.5 years, with carotid plaques (<50% stenosis) and high oxidative stress were included in this 3 months registry study. 26 patients received the combination of Pycnogenol® and Centellicum® and standard management, a control group received standard management only. The 2 groups were comparable. RESULTS:The combination of Pycnogenol® and Centellicum® reduced significantly (p<0.05) plaque height and length as well as the number of plaques relative to controls. The plaque stability index, based on the echogenicity in the ultrasound picture of the "white" components of the plaque, increased significantly (p<0.01) in the verum group, no changes were observed in the controls. Plasma free radicals were significantly (p<0.05) decreased by the combination product, whereas the levels of plasma free radicals remained unchanged in the control group. No unwanted effects or abnormal laboratory tests were recorded. CONCLUSIONS:This registry study revealed a significant increase in stability of plaques, indicated by an enhanced density of the plaques, following supplementation with the combination of Pycnogenol® and Centellicum®. As size and number of plaques was simultaneously reduced, the combination of the two plant extracts could be a safe option for prevention of cardiovascular events for patients with carotid plaques.
journal_name
Minerva Cardioangioljournal_title
Minerva cardioangiologicaauthors
Luzzi R,Belcaro G,Ippolito Esubject
Has Abstractpub_date
2016-12-01 00:00:00pages
603-9issue
6eissn
0026-4725issn
1827-1618pii
R05Y9999N00A150051journal_volume
64pub_type
杂志文章abstract：BACKGROUND:Sutureless aortic valve prostheses have the potential to augment the adoption of alternative incision approaches for aortic valve replacement (AVR). Still, we lack the evidence on which surgical approach is best associated with sutureless AVR. METHODS:Data on 483 patients undergoing sutureless small incisio...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.17.04568-6
更新日期：2018-04-01 00:00:00
abstract：:A carotid stenosis is responsible for about 30% of strokes occurring. Carotid endarterectomy (CEA) is considered to be the gold standard treatment of a carotid stenosis. Carotid angioplasty and stenting (CAS) is emerging as a new alternative treatment for a carotid artery stenosis, but the risk of neurological complic...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2007-02-01 00:00:00
abstract：:Some cases of coronary aneurysms studied echocardiographically in children suffering from Kawasaki's disease are reported. In the fourth case, bidimensional echocardiography highlighted a uniform dilatation of the right and left coronary proximal segments which had retreated at subsequent controls. In the third case, ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND:High sensitivity cardiac troponins I (hs-cTnI) and T (hs-cTnT) and natriuretic peptides (BNP and NT-proBNP) are universally recognized as cardiac reference biomarkers in patients with acute coronary syndromes and heart failure respectively. However, while on one hand the high sensitivity methods of cardiac b...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.20.05281-0
更新日期：2020-08-01 00:00:00
abstract：:The incidence of district (cardiac, cerebral, renal) and systemic vascular complications was studied in a population of 3992 hypertensive in-patients during the period from 1984 to 1988. The total number of male hypertensive patients was always higher (2355) than that of female hypertensive patients (1637). From the a...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the effects of the standardized supplement Robuvit® (oak wood extract) in defined diffuse, minimal lymphatic "retention" (DMLR). METHODS:Robuvit® has already been investigated in both primary and secondary (post-surgical, post chemo-radiotherapy) lymphatic insufficiency...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.19.05026-6
更新日期：2020-06-01 00:00:00
abstract：:Despite advances in clinical interventions, drug therapy and preventative strategies for cardiovascular disease, heart disease remains the number one cause of death in the United States. A major cause of heart failure leading to death is myocardial ischemic disease. Terminal heart failure can be salvaged in some cases...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2010-02-01 00:00:00
abstract：:Stenting of symptomatic myocardial bridges is a therapeutic option with documented good short-term outcome. However, limited data on the long term outcome of myocardial bridge stenting has shown a higher restenosis rate comparing to stenting of de novo atherosclerotic lesions. Drug-eluting stenting of de novo atherosc...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
abstract：BACKGROUD:This study aimed to analyze the correlations between anterior wall motion velocity of ascending aorta measured by quantitative tissue velocity image (QTVI) technique and left ventricular geometry as well as left heart function to evaluate its value of clinical application. METHODS:One hundred ten hypertensio...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.17.04535-2
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:It is known that resistance to activated protein C (APCR), often associated with a single point mutation (Arg506-->Gln) in the coagulation factor V gene (factor V Leiden), is the most frequent inherited abnormality of blood coagulation. It plays a key role as pathogenetic factor of venous thromboembolism, bu...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:An aortic thrombus may be detected by using transesophageal echocardiography after an embolic event. Clinical features are variable and may include cardiac and neurologic symptoms, such as the stroke. We report a case of a woman with an acute ischemic stroke, a myocardial infarction and a free floating aortic thrombus...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
abstract：:Three hundred carotid plaques (stenosis 45 to 65%) in 300 asymptomatic patients were included into a follow-up study considering three ultrasound types of plaques: type 1, non echogenic; type 2 intermediate, partially echogenic and type 3 highly echogenic. Types 1 and 2 had regular contour/surface while type 3 was irr...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1992-07-01 00:00:00
abstract：:The development of drug-eluting stents is one of the major revolutions in the field of Interventional Cardiology. Restenosis rate has been significantly reduced, in comparison to bare metal stents. The ideal drug to prevent restenosis must have an anti-proliferative and anti-migratory effect on smooth muscle cells but...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2005-10-01 00:00:00
abstract：:The paper reports the study of 12 patients admitted to hospital between January 1992 and October 1994. The patients were almost all neonates. Clinical, electrocardiographic and radiological data led to the suspected diagnosis of complete transposition of the great vessels. 2-D echocardiography consistently showed the ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：:We assessed the safety and efficacy of intravenous propafenone in the treatment of atrial fibrillation and flutter of recent onset (1-10 days). The drug was administered, at a dosage of 2 mg/kg, to 46 consecutive patients (with age variable from 35 to 86 years), 36 with atrial fibrillation, 10 with atrial flutter. The...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Cardiac hydatid disease represents 0.02-2% of the possible locations of the parasite. The case of an asymptomatic 60-year-old male patient, hospitalised for mnesic and cognitive disease, and with history of hepatic and pulmonary echinococcosis is reported. The patient showed a cardiac cyst localised in the mediobasal ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Prolonged periods of atrial fibrillation (AF) or high frequency atrial pacing lead to a significant shortening of atrial refractory periods. This time-dependent electric remodelling is reduced significantly by the administration of verapamil. METHODS:The present series consists of 24 patients all suffering ...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：2003-02-01 00:00:00
abstract：:This report describes a rare case of concurrent abdominal aortic aneurysm and bilateral renal ectopia. Preoperative work-up included intravenous pyelography and angiography to assess renal function, renal artery anatomy, and ureter position. Conventional surgery was performed without renal protection. No deterioration...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：2008-10-01 00:00:00
abstract：:Aneurysms are a later consequence of acute myocardial infarction, developing in about 20% of patients with transmural infarcts. Pathologically aneurysms have two general forms: the first type has large endocardial fibroelastosis overlying the infarct size, the second type contains little or no endocardial fibroelastos...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:Left main coronary artery (LMCA) disease has been reported in up to 10% of all patients with coronary artery disease (CAD) and in the majority of cases are associated with severe three-vessel CAD. Among patients with chronic coronary syndrome revascularization of significant LMCA disease improves prognosis, while ther...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.20.05198-1
更新日期：2020-10-01 00:00:00
abstract：:The definition of an ischaemic condition at lower limb level, may imply any different degree of the pathology, starting from a simple chronic slight claudication up to a severe ischaemia. Critical Limb Ischaemia is the term defined to identify an ischaemic condition, which endangers the limb or part of a limb and requ...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：:Report of a case of a 54-year-old man who, during acute anterior myocardial infarction developed an apical thrombus and an embolism of the right leg. The serial echocardiographic study demonstrates how the original shape of the thrombus acutely changed at the same time of the embolic episode and how the new morphology...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Arrhythmias are frequent pathology in patients with chronic hemodialysis. We evaluated whether a relatively new technique, signal averaging, could be useful in predicting the development of complex arrhythmias in these patients. METHODS:Thirty-three patients, 18 male and 15 female, subjected to thrice weekl...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：:The aneurysm of the interatrial septum (ASA) is a rare congenital heart disease, easily recognizable by real time cross sectional two dimensional echocardiography. The ASA occurs as an isolated entity or may be associated with congenital heart disease. Usually ASA may cause serious complications such as embolic phenom...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Pathophysiological remodeling of cardiac function occurs at multiple levels, spanning the spectrum from molecular and sub-cellular changes to those occurring at the organ-system levels. Of key importance to arrhythmias are changes in the electrophysiological substrate at the tissue level. In this manuscript, we provid...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章,评审
doi：
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Coronary perforations (CP) have been described as a rare but potentially fatal complication in percutaneous coronary interventions (PCI). Our aim is to compare temporal trends in frequency, management and outcomes of coronary perforations (CP). METHODS:All cases of CP recorded in our prospective institution...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：10.23736/S0026-4725.18.04433-X
更新日期：2018-08-01 00:00:00
abstract：:Myocardial infarction in the under-40s is rare. A series of 19 patients, 3.07% of a two-year series of coronary cases, is presented with a view to evaluating the incidence of risk factors, with special attention to familial factors and dyslipoproteinaemia. Risk factors are discussed together with the statistical impor...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:A comparative analysis of arrhythmias by "basal" electrocardiogram (ECG) and by continuous 24-hour Holter electrocardiogram monitoring was performed in 17 patients with systemic sclerosis (16 women and one man). Our study confirms that rhythm disturbances are better detectable using Holter monitoring. In fact, no pati...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：:A case is reported of pseudoaneurysm of the right iliac artery secondary to an endarterectomy with dacron patch due to atherosclerosis performed 4 years ago. The case presented acute anemia and massive enteric hemorrhage subsequent to arterial rupture into the cecum. Because of the dramatic onset, the patient was imme...
journal_title：Minerva cardioangiologica
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：AIM:The aim of this study was to evaluate the effects of low-dose niacin extended-release (niacin-ER) combined with simvastatin (SV) in the treatment of patients with mixed dyslipidemia who have not normalized their lipid profile with statin therapy alone. METHODS:A prospective, clinical trial of 35 patients with mixe...
journal_title：Minerva cardioangiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：2010-10-01 00:00:00
