Abstract：
:Purpose. To review the newer treatments for bacterial keratitis. Data Sources. PubMed literature search up to April 2012. Study Selection. Key words used for literature search: "infectious keratitis", "microbial keratitis", "infective keratitis", "new treatments for infectious keratitis", "fourth generation fluoroquinolones", "moxifloxacin", "gatifloxacin", "collagen cross-linking", and "photodynamic therapy". Data Extraction. Over 2400 articles were retrieved. Large scale studies or publications at more recent dates were selected. Data Synthesis. Broad spectrum antibiotics have been the main stay of treatment for bacterial keratitis but with the emergence of bacterial resistance; there is a need for newer antimicrobial agents and treatment methods. Fourth-generation fluoroquinolones and corneal collagen cross-linking are amongst the new treatments. In vitro studies and prospective clinical trials have shown that fourth-generation fluoroquinolones are better than the older generation fluoroquinolones and are as potent as combined fortified antibiotics against common pathogens that cause bacterial keratitis. Collagen cross-linking was shown to improve healing of infectious corneal ulcer in treatment-resistant cases or as an adjunct to antibiotics treatment. Conclusion. Fourth-generation fluoroquinolones are good alternatives to standard treatment of bacterial keratitis using combined fortified topical antibiotics. Collagen cross-linking may be considered in treatment-resistant infectious keratitis or as an adjunct to antibiotics therapy.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Wong RL,Gangwani RA,Yu LW,Lai JSdoi
10.1155/2012/831502subject
Has Abstractpub_date
2012-01-01 00:00:00pages
831502eissn
2090-004Xissn
2090-0058journal_volume
2012pub_type
杂志文章abstract：:Purpose. Ischemic central retinal vein occlusion (CRVO) eyes are at high risk of developing neovascular glaucoma (NVG). Our purpose is to investigate the effect of anti-VEGF therapy for macular edema after CRVO on the development of neovascular glaucoma (NVG) in ischemic CRVO eyes. Methods. This is a retrospective cas...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2014/317694
更新日期：2014-01-01 00:00:00
abstract：Purpose:To examine the current knowledge about the age-related processes in the anterior segment of the eye at a biological, clinical, and molecular level. Methods:We reviewed the available published literature that addresses the aging process of the anterior segment of the eye and its associated molecular and physiol...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2017/1295132
更新日期：2017-01-01 00:00:00
abstract：:Individualized treatment regimens may reduce patient burden with satisfactory patient outcomes in neovascular age-related macular degeneration. Intravitreal anti-VEGF drugs are the current gold standard. Fixed monthly injections offer the best visual outcome but this regimen is not commonly followed outside clinical t...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2015/412903
更新日期：2015-01-01 00:00:00
abstract：Background:Uveal melanoma (UM) is the most common primary intraocular tumor in adults and arises from the uvea. Marital status was a vital factor among physical conditions and social networks of cancer patients. Our study aimed to evaluate the impact of marital status on the outcomes among patients with UM. Methods:Pa...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/7012940
更新日期：2020-12-04 00:00:00
abstract：:Quantitative measurement of the orbital soft tissue volume plays a very important role in the study of orbital diseases. The purpose of this study is to establish a computed tomography- (CT-) based three-dimensional (3D) reconstruction model and measure the orbital soft tissue volume in Chinese adults. We collected da...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/9721085
更新日期：2019-07-02 00:00:00
abstract：:Purpose. To evaluate interobserver, intervisit, and interinstrument agreements for gonioscopy and Fourier domain anterior segment optical coherence tomography (FD ASOCT) for classifying open and narrow angle eyes. Methods. Eighty-six eyes with open or narrow anterior chamber angles were included. The superior angle wa...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/1727039
更新日期：2016-01-01 00:00:00
abstract：PURPOSE:To evaluate the effect of the Rho-kinase inhibitor Y-27632 on postoperative inflammation and adhesion following extraocular muscle surgery in rabbits. METHODS:The superior rectus muscle reinsertion was performed on both eyes of 8 New Zealand white rabbits. After reinsertion, the rabbits received subconjunctiva...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/8653130
更新日期：2017-01-01 00:00:00
abstract：:Purpose. To determine the efficacy of 23-gauge pars plana vitrectomy (PPV) for symptomatic posterior vitreous detachment (PVD) on visual acuity (VA) and quality after multifocal intraocular lenses (IOLs). Methods. In this prospective case series, patients who developed symptomatic PVD and were not satisfied with visua...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2015/156910
更新日期：2015-01-01 00:00:00
abstract：Purpose:To report a novel technique of cross-knotted suture basket and to test its effectiveness in large nonmagnetic intraocular foreign body (IOFB) removal. Methods:A 7/0 Vicryl suture was cut in half and cross-knotted, and four ends were introduced into a 23G needle to form a basket. Pig eyes were used to set up th...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/1061462
更新日期：2020-04-25 00:00:00
abstract：:Aim. The aim of this study was to determine the intra- and interobserver variability of two Scheimpflug based camera systems, Pentacam and Sirius. In addition, the comparability of the measurements was tested in healthy subjects, subjects with regular astigmatism, and keratoconus patients. Methods. Intra- and interobs...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2015/315281
更新日期：2015-01-01 00:00:00
abstract：Purpose:Studying the early effect of different extraocular muscle (EOM) surgeries on corneal biomechanics. Subjects and methods:This is a prospective, nonrandomized, interventional study, in which 42 eyes of 29 candidates for EOM surgery for strabismus correction at Cairo university hospitals, aged 14-37 years, were r...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/8072140
更新日期：2018-09-16 00:00:00
abstract：Purpose:Evaluation of the indications, anatomical and functional results, and complications of total penetrating keratoplasty (TPK) in disorders involving whole cornea. Materials and Methods:We analyzed outcomes of the surgical treatment of 47 eyes of 46 patients that underwent TPK. Indications were infectious keratit...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/9580292
更新日期：2018-04-19 00:00:00
abstract：:Objective. Compare glaucoma medication costs between the United States (USA) and Canada. Methods. We modelled glaucoma brand name and generic medication annual costs in the USA and Canada based on October 2013 Costco prices and previously reported bottle overfill rates, drops per mL, and wastage adjustment. We also ca...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2015/547960
更新日期：2015-01-01 00:00:00
abstract：:Objective. We aimed to assess peripheral vascular endothelial function in open-angle glaucoma (POAG) by measuring flow-mediated dilatation (FMD). Materials and Methods. The study included 20 cases with POAG (group 1, mean age 58.68 ± 13.3 years) and 30 healthy individuals (group 2, mean age 58.68 ± 13.6 years). In all...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2014/529082
更新日期：2014-01-01 00:00:00
abstract：:Purpose. To investigate tear function, ocular manifestations, and squamous metaplasia of the conjunctival epithelium (SMCE) in children with end stage renal failure (ESRF) on dialysis. Methods. Thirty children with ESRF and 20 age and sex matched controls during the period from January 2014 to May 2015 underwent full ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/4767819
更新日期：2016-01-01 00:00:00
abstract：:Purpose. To evaluate the ability of spectral-domain optical coherence tomography to detect subtle amounts of retinal fluid when the choroidal neovascularization is detected as inactive via time-domain optical coherence tomography and clinical examination in neovascular age-related macular degeneration (nAMD) patients....
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2013/786107
更新日期：2013-01-01 00:00:00
abstract：Purpose:Activating transcription factor 4 (ATF4) is induced by various stressors. Here, we investigated the expression of ATF4 in the host inflammatory response to Aspergillus fumigatus (A. fumigatus) keratitis. Methods:A. fumigatus keratitis mouse models developed by intrastromal injection as well as corneal epitheli...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/5830202
更新日期：2018-12-13 00:00:00
abstract：Purpose:Although optical coherence tomography (OCT) is essential for ophthalmologists, reading of findings requires expertise. The purpose of this study is to test deep learning with image augmentation for automated detection of chorioretinal diseases. Methods:A retina specialist diagnosed 1,200 OCT images. The diagno...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/6319581
更新日期：2019-04-09 00:00:00
abstract：Purpose:To evaluate the efficacy and safety of MyoRing implantation in eyes with keratoconus managed at a tertiary eye hospital in the Eastern Province of Saudi Arabia. Methods:This one-armed historical cohort study included keratoconus patients operated for MyoRing implant. The cases were assessed before and 6 months...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/2630704
更新日期：2019-08-29 00:00:00
abstract：:Purpose. To compare anterior chamber depth (ACD), representing the distance between the anterior corneal surface and anterior lens surface measurements between the Galilei Dual Scheimpflug Analyzer and the IOLMaster. Methods. A retrospective review of 65 individual patient eyes with normal anterior segments, and no pr...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2012/430249
更新日期：2012-01-01 00:00:00
abstract：Purpose:The aim of this work was to describe the ultrastructure and behavior of peeled internal limiting membrane (ILM) in macular hole (MH) surgery. Methods:Seven patients with MH were included, and vitrectomy with ILM peeling was performed in all patients. The ILM inverted flap technique was used. Two other flaps of...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/1345683
更新日期：2019-05-02 00:00:00
abstract：:Purpose. To evaluate visual and safety outcomes of 23-gauge (G) pars plana vitrectomy (PPV) with application of perfluorocarbon liquid (PFCL) for intraoperative protection of the macula during intraocular foreign body (IOFB) removal. Methods. Retrospective study of 42 patients who underwent 23 G PPV for IOFB removal f...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/6232151
更新日期：2017-01-01 00:00:00
abstract：:Purpose. To compare the corneal endothelial cell loss after phacoemulsification, alone or combined with microinvasive glaucoma surgery (MIGS), in nonglaucomatous versus primary open angle glaucoma (POAG) eyes affected by age-related cataract. Methods. 62 eyes of 62 patients were divided into group 1 (n = 25, affected ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2015/769289
更新日期：2015-01-01 00:00:00
abstract：:Purpose. To report a new clinical finding related to Fabry disease. Methods. Fabry subjects were enrolled in the study, matched for age and sex with healthy individuals as a control group. This is a prospective review of all upper lid pictures taken for every subject at their last visit. A 4-step grading scale is prop...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2013/207573
更新日期：2013-01-01 00:00:00
abstract：:Aim. To assess the effects of mydriatics commonly used in clinical practice on choroidal thickness and anterior chamber change. Methods. This was a prospective, randomized, controlled, double-blinded study including a single eye of the participants. The subjects were assigned into 4 groups to receive tropicamide 1%, p...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2015/981274
更新日期：2015-01-01 00:00:00
abstract：:The new type implantable Collamer lens with a central hole (V4c-ICL) is widely used to treat myopia. However, halos occur in some patients after surgery. The aim is to evaluate the effect of V4c-ICL implantation on vision-related daily activities. This retrospective study included 42 patients. Uncorrected visual acuit...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/5717932
更新日期：2016-01-01 00:00:00
abstract：Purpose:To assess the effects of the 3-month period of orthokeratology (OK) treatment on corneal sensitivity in Chinese children and adolescents. Methods:Thirty subjects wore overnight OK lenses in both eyes for 3 months and were assessed at baseline, 1 day, 1 week, 1 month, and 3 months after the treatment. Changes i...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/6185919
更新日期：2018-12-23 00:00:00
abstract：Aims:To determine the accuracy and repeatability of new software to automatically quantify GA areas associated to age-related macular degeneration (AMD) by swept-source optical coherence tomography (SS-OCT). Settings and Design. Tertiary referral hospital in Spain. Cross-sectional and noninterventional. Methods and Mat...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/8204641
更新日期：2020-08-05 00:00:00
abstract：AIM:To discuss the clinical characteristics of immune-related dry eye. METHODS:Simple dry eye (SDE) group: we selected 224 patients of simple dry eye with no systemic lesions. Immune-related dry eye (IRDE) group: we selected 207 patients of dry eye complicated with immune system diseases, including 70 cases of Sjögren...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/8532397
更新日期：2017-01-01 00:00:00
abstract：Objective:To report the 15-year trend in ophthalmic presentations to the emergency department (ED) at the only medical center in Lebanon that provides 24-hour ophthalmologic care. Methods:Retrospective review of 1967 patients presenting to the ED with eye-related complaints between September 1997 and August 1998 and b...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/4739865
更新日期：2018-03-13 00:00:00
