Abstract:
Purpose:Although optical coherence tomography (OCT) is essential for ophthalmologists, reading of findings requires expertise. The purpose of this study is to test deep learning with image augmentation for automated detection of chorioretinal diseases. Methods:A retina specialist diagnosed 1,200 OCT images. The diagnoses involved normal eyes (n=570) and those with wet age-related macular degeneration (AMD) (n=136), diabetic retinopathy (DR) (n=104), epiretinal membranes (ERMs) (n=90), and another 19 diseases. Among them, 1,100 images were used for deep learning training, augmented to 59,400 by horizontal flipping, rotation, and translation. The remaining 100 images were used to evaluate the trained convolutional neural network (CNN) model. Results:Automated disease detection showed that the first candidate disease corresponded to the doctor's decision in 83 (83%) images and the second candidate disease in seven (7%) images. The precision and recall of the CNN model were 0.85 and 0.97 for normal eyes, 1.00 and 0.77 for wet AMD, 0.78 and 1.00 for DR, and 0.75 and 0.75 for ERMs, respectively. Some of rare diseases such as Vogt-Koyanagi-Harada disease were correctly detected by image augmentation in the CNN training. Conclusion:Automated detection of macular diseases from OCT images might be feasible using the CNN model. Image augmentation might be effective to compensate for a small image number for training.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Kuwayama S,Ayatsuka Y,Yanagisono D,Uta T,Usui H,Kato A,Takase N,Ogura Y,Yasukawa Tdoi
10.1155/2019/6319581subject
Has Abstractpub_date
2019-04-09 00:00:00pages
6319581eissn
2090-004Xissn
2090-0058journal_volume
2019pub_type
杂志文章abstract:Purpose:To identify and correlate age-related changes in outer retinal layers' thickness and choroidal thickness (CT) in the normal eyes using spectral-domain optical coherence tomography (SD-OCT) and to investigate factors affecting these changes. Study Design:Observational cross-sectional study. Subjects and Method...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/1698967
更新日期:2019-07-31 00:00:00
abstract:Purpose:Retinal vein occlusion (RVO) is the second most common retinal vascular disease and a major cause of visual impairment. In this study, we aimed to observe whether RVO cases have different antibody profiles as a new potential risk factor and whether a conversion of retinal vein occlusion (RVO) to neovascular gla...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/8386160
更新日期:2020-07-29 00:00:00
abstract::Purpose. This study investigated the effects of oral propolis on the progression of galactose-induced sugar cataracts in rats and the in vitro effects of propolis on high-glucose-induced reactive oxygen species (ROS) and cell death in cultured rat lens cells (RLECs). Methods. Galactose-fed rats and RLECs cultured in h...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1917093
更新日期:2016-01-01 00:00:00
abstract::Purpose. To determine the efficacy of povidone-iodine (P-I) prophylaxis for ophthalmia neonatorum (ON) in Angola and to document maternal prevalence and mother-to-child transmission rates. Methods. Endocervical samples from mothers (n = 317) and newborn conjunctival smears (n = 245) were analysed by multiplex polymera...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/326526
更新日期:2015-01-01 00:00:00
abstract::Congenital cataract is the most common cause of the visual disability and blindness in childhood. This study aimed to identify gene mutations responsible for autosomal dominant congenital cataract (ADCC) in a Chinese family using next-generation sequencing technology. This family included eight unaffected and five aff...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/4353957
更新日期:2016-01-01 00:00:00
abstract::Background. The effect of angiotensin converting enzyme inhibitors (ACEi) on regression of retinopathy in type 2 diabetics is still ill defined. Methods. We compared the incidence of retinopathy regression in 90 hypertensive type 2 diabetics randomized to at least 3-year blinded ACEi with trandolapril (2 mg/day) or no...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2010/106384
更新日期:2010-01-01 00:00:00
abstract::Early diagnosis and positive outcomes of retinoblastoma in childhood have been positively correlated with the economic wealth of high-income countries (HICs) worldwide. Adequate curability and survival rates, adherence to treatment, presence of poor prognostic initial clinical signs, and metastatic disease at diagnosi...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2020/1953602
更新日期:2020-08-10 00:00:00
abstract:Purpose:To evaluate changes in flow density after the implantation of a trabecular microbypass stent (iStent) in combination with cataract surgery. Methods:A total of 48 eyes of 48 patients, who underwent either cataract surgery alone (cataract group) or cataract surgery with implantation of two iStent inject devices ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/2890357
更新日期:2018-01-31 00:00:00
abstract:Background:To evaluate the outcome and complications of transscleral suture-fixated posterior chamber intraocular lens (PCIOL) implantation combined with Ahmed glaucoma valve (AGV) surgery in Asian eyes. Design:This was a retrospective study that included 22 eyes from 22 participants. The surgeries were performed at S...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/9824035
更新日期:2018-03-25 00:00:00
abstract::The costs for glaucoma care are rising worldwide. The main reason is the increase of life expectancy and the increasing variety of diagnostic tests and therapeutically options by implants and devices. How can we influence the increase in costs? Does a relationship exist between the rising costs and the behavior of pat...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2020/5901537
更新日期:2020-04-08 00:00:00
abstract::Diabetic retinal complications, including macular edema (DME) and proliferative diabetic retinopathy (PDR), are the leading cause of new cases of blindness among adults aged 20-74. Chronic hyperglycemia, considered the underlying cause of diabetic retinopathy, is thought to act first through violation of the pericyte-...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2012/209538
更新日期:2012-01-01 00:00:00
abstract::We established a chronic dacryocystitis model by injecting of 0.05, 0.1, and 0.15 ml self-curing resin via the lacrimal punctum in rabbits. Animals were randomized into four groups (n = 11 animals/group). The control group received 0.15 ml normal saline. Within three months postinjection, epiphora and eye discharge we...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/3438041
更新日期:2017-01-01 00:00:00
abstract::Background. The vision with diffractive toric multifocal intraocular lenses after cataract surgery in long eyes has not been studied previously. Objectives. To report visual performance after bilateral implantation of a diffractive toric multifocal intraocular lens in high myopes. Methods. Prospective, observational c...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/5320105
更新日期:2016-01-01 00:00:00
abstract::Purpose. To validate clinically a new method for estimating the corneal power (P c ) using a variable keratometric index (n kadj) in eyes with previous laser refractive surgery. Setting. University of Alicante and Medimar International Hospital (Oftalmar), Alicante, (Spain). Design. Retrospective case series. Methods....
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/824293
更新日期:2015-01-01 00:00:00
abstract::Purpose. To construct an inexpensive, convenient, and portable attachment for smartphones for the acquisition of still and live retinal images. Methods. A small optical device based on the principle of direct ophthalmoscopy was designed to be magnetically attached to a smartphone. Representative images of normal and p...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/823139
更新日期:2015-01-01 00:00:00
abstract::Graves' ophthalmopathy (GO) is an autoimmune inflammatory disorder associated with thyroid disease which affects ocular and orbital tissues. GO follows a biphasic course in which an initial active phase of progression is followed by a subsequent partial regression and a static inactive phase. Although the majority of ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2015/249125
更新日期:2015-01-01 00:00:00
abstract::Purpose. To evaluate functional and anatomical results of pars plana vitrectomy (PPV) in the retinal detachment (RD) followed by severe eye trauma. Methods. Retrospective analysis of medical records of forty-one consecutive patients treated with 23-gauge PPV due to traumatic RD. Age, gender, timing of PPV, visual acui...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/5084319
更新日期:2017-01-01 00:00:00
abstract::The retinal degeneration 11 (rd11) mouse is a new animal model with rapid photoreceptor degeneration. The long-term efficacy of gene therapy has a direct relationship with the onset of photoreceptor degeneration or apoptosis, whereas the degeneration or apoptosis patterns of photoreceptors are still unclear in rd11 mi...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/9721362
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:Popular beliefs exert an impact of lunar phases on elective surgery. The aim of our study was to evaluate potential correlations between complications in cataract surgery and the phases of the moon during its passage through the zodiac and Fridays that fall on the 13th. METHODS:Patients with complications duri...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/1946527
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To evaluate sequential changes in choroidal thickness at the affected area in patients with acute zonal occult outer retinopathy (AZOOR). METHODS:This retrospective observational case series included 14 affected eyes and 6 unaffected fellow eyes from 10 AZOOR patients with impaired macular area. Using enhanced...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/2371032
更新日期:2017-01-01 00:00:00
abstract::Purpose. To evaluate intraobserver and interobserver agreement in locating the scleral spur landmark (SSL) and anterior chamber angle measurements obtained using Fourier Domain Anterior Segment Optical Coherence Tomography (ASOCT) images. Methods. Two independent, masked observers (SR and AZC) identified SSLs on ASOCT...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2012/487309
更新日期:2012-01-01 00:00:00
abstract::Purpose. To evaluate the relationship between self-reported vision-related quality of life (VRQL) and visual field (VF) loss in people from glaucoma clinics. Methods. A postal survey using the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) was administered to people with a range of VF loss identifie...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/1621640
更新日期:2017-01-01 00:00:00
abstract::Purpose. To investigate the association of birth parameters with refractive status in different age groups of Caucasian children. Materials and Methods. This cross-sectional study included 564 eyes of 282 children aged 4 to 17 years. All children underwent complete ophthalmologic examination. The children were divided...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/635682
更新日期:2015-01-01 00:00:00
abstract::Objective. We aimed to assess peripheral vascular endothelial function in open-angle glaucoma (POAG) by measuring flow-mediated dilatation (FMD). Materials and Methods. The study included 20 cases with POAG (group 1, mean age 58.68 ± 13.3 years) and 30 healthy individuals (group 2, mean age 58.68 ± 13.6 years). In all...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/529082
更新日期:2014-01-01 00:00:00
abstract:Methods:A total of 287 consecutive patients diagnosed with congenital SOP and 82 control subjects were included. Congenital SOP patients were grouped according to the presence (present group) or absence (absent group) of the trochlear nerve using thin-section high-resolution MRI of cranial nerves. We developed a comput...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/9476749
更新日期:2020-12-17 00:00:00
abstract::The new type implantable Collamer lens with a central hole (V4c-ICL) is widely used to treat myopia. However, halos occur in some patients after surgery. The aim is to evaluate the effect of V4c-ICL implantation on vision-related daily activities. This retrospective study included 42 patients. Uncorrected visual acuit...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/5717932
更新日期:2016-01-01 00:00:00
abstract:Objective:In a group case series, the clinical characteristics of congenital membranous cataract in children were studied to establish a system of classification and determine the surgical method suited for each type. Methods:Children (18 eyes) with congenital membranous cataract were examined by slit lamp, ultrasound...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/2370969
更新日期:2017-01-01 00:00:00
abstract:Purpose:To assess the effects of the 3-month period of orthokeratology (OK) treatment on corneal sensitivity in Chinese children and adolescents. Methods:Thirty subjects wore overnight OK lenses in both eyes for 3 months and were assessed at baseline, 1 day, 1 week, 1 month, and 3 months after the treatment. Changes i...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/6185919
更新日期:2018-12-23 00:00:00
abstract::Purpose. To measure the chemotherapeutic effects of focal melphalan (intravitreal and subconjunctival) on tumor burden, hypoxia, and vasculature in LHBETATAG murine retinoblastoma model. Methods. LHBETATAG transgenic mice were treated with a single 1 mcg intravitreal injection of melphalan, 100 mcg subconjunctival inj...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/829879
更新日期:2014-01-01 00:00:00
abstract::Purpose. To report a new clinical finding related to Fabry disease. Methods. Fabry subjects were enrolled in the study, matched for age and sex with healthy individuals as a control group. This is a prospective review of all upper lid pictures taken for every subject at their last visit. A 4-step grading scale is prop...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2013/207573
更新日期:2013-01-01 00:00:00