Automated Detection of Macular Diseases by Optical Coherence Tomography and Artificial Intelligence Machine Learning of Optical Coherence Tomography Images.

Abstract:

Purpose:Although optical coherence tomography (OCT) is essential for ophthalmologists, reading of findings requires expertise. The purpose of this study is to test deep learning with image augmentation for automated detection of chorioretinal diseases. Methods:A retina specialist diagnosed 1,200 OCT images. The diagnoses involved normal eyes (n=570) and those with wet age-related macular degeneration (AMD) (n=136), diabetic retinopathy (DR) (n=104), epiretinal membranes (ERMs) (n=90), and another 19 diseases. Among them, 1,100 images were used for deep learning training, augmented to 59,400 by horizontal flipping, rotation, and translation. The remaining 100 images were used to evaluate the trained convolutional neural network (CNN) model. Results:Automated disease detection showed that the first candidate disease corresponded to the doctor's decision in 83 (83%) images and the second candidate disease in seven (7%) images. The precision and recall of the CNN model were 0.85 and 0.97 for normal eyes, 1.00 and 0.77 for wet AMD, 0.78 and 1.00 for DR, and 0.75 and 0.75 for ERMs, respectively. Some of rare diseases such as Vogt-Koyanagi-Harada disease were correctly detected by image augmentation in the CNN training. Conclusion:Automated detection of macular diseases from OCT images might be feasible using the CNN model. Image augmentation might be effective to compensate for a small image number for training.

journal_name

J Ophthalmol

journal_title

Journal of ophthalmology

authors

Kuwayama S,Ayatsuka Y,Yanagisono D,Uta T,Usui H,Kato A,Takase N,Ogura Y,Yasukawa T

doi

10.1155/2019/6319581

subject

Has Abstract

pub_date

2019-04-09 00:00:00

pages

6319581

eissn

2090-004X

issn

2090-0058

journal_volume

2019

pub_type

杂志文章
  • Outer Retinal Layers' Thickness Changes in relation to Age and Choroidal Thickness in Normal Eyes.

    abstract:Purpose:To identify and correlate age-related changes in outer retinal layers' thickness and choroidal thickness (CT) in the normal eyes using spectral-domain optical coherence tomography (SD-OCT) and to investigate factors affecting these changes. Study Design:Observational cross-sectional study. Subjects and Method...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2019/1698967

    authors: Kamal Abdellatif M,Abdelmaguid Mohamed Elzankalony Y,Abdelmonsef Abdelhamid Ebeid A,Mohamed Ebeid W

    更新日期:2019-07-31 00:00:00

  • Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients.

    abstract:Purpose:Retinal vein occlusion (RVO) is the second most common retinal vascular disease and a major cause of visual impairment. In this study, we aimed to observe whether RVO cases have different antibody profiles as a new potential risk factor and whether a conversion of retinal vein occlusion (RVO) to neovascular gla...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2020/8386160

    authors: Bell K,Beutgen VM,Nickels S,Lorenz K,Scheller Y,Elbaz H,Peto T,Ponto KA,Schulz A,Wild PS,Münzel T,Lackner KJ,Schmidtmann I,Beutel M,Pfeiffer N,Grus FH,Schuster AK

    更新日期:2020-07-29 00:00:00

  • Propolis, a Constituent of Honey, Inhibits the Development of Sugar Cataracts and High-Glucose-Induced Reactive Oxygen Species in Rat Lenses.

    abstract::Purpose. This study investigated the effects of oral propolis on the progression of galactose-induced sugar cataracts in rats and the in vitro effects of propolis on high-glucose-induced reactive oxygen species (ROS) and cell death in cultured rat lens cells (RLECs). Methods. Galactose-fed rats and RLECs cultured in h...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2016/1917093

    authors: Shibata T,Shibata S,Shibata N,Kiyokawa E,Sasaki H,Singh DP,Kubo E

    更新日期:2016-01-01 00:00:00

  • First attempt to implement ophthalmia neonatorum prophylaxis in angola: microorganisms, efficacy, and obstacles.

    abstract::Purpose. To determine the efficacy of povidone-iodine (P-I) prophylaxis for ophthalmia neonatorum (ON) in Angola and to document maternal prevalence and mother-to-child transmission rates. Methods. Endocervical samples from mothers (n = 317) and newborn conjunctival smears (n = 245) were analysed by multiplex polymera...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2015/326526

    authors: Alexandre I,Justel M,Martinez P,Ortiz de Lejarazu R,Pastor JC

    更新日期:2015-01-01 00:00:00

  • A Novel CRYBB2 Stopgain Mutation Causing Congenital Autosomal Dominant Cataract in a Chinese Family.

    abstract::Congenital cataract is the most common cause of the visual disability and blindness in childhood. This study aimed to identify gene mutations responsible for autosomal dominant congenital cataract (ADCC) in a Chinese family using next-generation sequencing technology. This family included eight unaffected and five aff...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2016/4353957

    authors: Zhou Y,Zhai Y,Huang L,Gong B,Li J,Hao F,Wu Z,Shi Y,Yang Y

    更新日期:2016-01-01 00:00:00

  • Effect of trandolapril on regression of retinopathy in hypertensive patients with type 2 diabetes: a prespecified analysis of the benedict trial.

    abstract::Background. The effect of angiotensin converting enzyme inhibitors (ACEi) on regression of retinopathy in type 2 diabetics is still ill defined. Methods. We compared the incidence of retinopathy regression in 90 hypertensive type 2 diabetics randomized to at least 3-year blinded ACEi with trandolapril (2 mg/day) or no...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2010/106384

    authors: Ruggenenti P,Iliev I,Filipponi M,Tadini S,Perna A,Ganeva M,Ene-Iordache B,Cravedi P,Trevisan R,Bossi A,Remuzzi G

    更新日期:2010-01-01 00:00:00

  • Challenge of Retinoblastoma in Mexico in 2020: Perspectives and Solutions.

    abstract::Early diagnosis and positive outcomes of retinoblastoma in childhood have been positively correlated with the economic wealth of high-income countries (HICs) worldwide. Adequate curability and survival rates, adherence to treatment, presence of poor prognostic initial clinical signs, and metastatic disease at diagnosi...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1155/2020/1953602

    authors: Garza-Garza LA,Ruiz-Lozano RE,Rebolledo-Méndez G,Ibarra-Nava I,Morales-Garza HJ,Ancona-Lezama D

    更新日期:2020-08-10 00:00:00

  • Changes in Flow Density Measured Using Optical Coherence Tomography Angiography after iStent Insertion in Combination with Phacoemulsification in Patients with Open-Angle Glaucoma.

    abstract:Purpose:To evaluate changes in flow density after the implantation of a trabecular microbypass stent (iStent) in combination with cataract surgery. Methods:A total of 48 eyes of 48 patients, who underwent either cataract surgery alone (cataract group) or cataract surgery with implantation of two iStent inject devices ...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2018/2890357

    authors: Alnawaiseh M,Müller V,Lahme L,Merté RL,Eter N

    更新日期:2018-01-31 00:00:00

  • Outcomes and Complications of Scleral-Fixated Intraocular Lens Combined with Ahmed Tube Surgery.

    abstract:Background:To evaluate the outcome and complications of transscleral suture-fixated posterior chamber intraocular lens (PCIOL) implantation combined with Ahmed glaucoma valve (AGV) surgery in Asian eyes. Design:This was a retrospective study that included 22 eyes from 22 participants. The surgeries were performed at S...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2018/9824035

    authors: Sachdev N,Aquino MC,Loon SC,Chan YH,Chew P,Koh V

    更新日期:2018-03-25 00:00:00

  • Influence of Cost of Care and Adherence in Glaucoma Management: An Update.

    abstract::The costs for glaucoma care are rising worldwide. The main reason is the increase of life expectancy and the increasing variety of diagnostic tests and therapeutically options by implants and devices. How can we influence the increase in costs? Does a relationship exist between the rising costs and the behavior of pat...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1155/2020/5901537

    authors: Meier-Gibbons F,Töteberg-Harms M

    更新日期:2020-04-08 00:00:00

  • Vascular complications and diabetes: current therapies and future challenges.

    abstract::Diabetic retinal complications, including macular edema (DME) and proliferative diabetic retinopathy (PDR), are the leading cause of new cases of blindness among adults aged 20-74. Chronic hyperglycemia, considered the underlying cause of diabetic retinopathy, is thought to act first through violation of the pericyte-...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2012/209538

    authors: Willard AL,Herman IM

    更新日期:2012-01-01 00:00:00

  • Modeling Chronic Dacryocystitis in Rabbits by Nasolacrimal Duct Obstruction with Self-Curing Resin.

    abstract::We established a chronic dacryocystitis model by injecting of 0.05, 0.1, and 0.15 ml self-curing resin via the lacrimal punctum in rabbits. Animals were randomized into four groups (n = 11 animals/group). The control group received 0.15 ml normal saline. Within three months postinjection, epiphora and eye discharge we...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2017/3438041

    authors: Hou K,Ai T,Liu R,Xiang N,Jin J,Hu W,Luo B

    更新日期:2017-01-01 00:00:00

  • Visual Performance after Bilateral Implantation of a Four-Haptic Diffractive Toric Multifocal Intraocular Lens in High Myopes.

    abstract::Background. The vision with diffractive toric multifocal intraocular lenses after cataract surgery in long eyes has not been studied previously. Objectives. To report visual performance after bilateral implantation of a diffractive toric multifocal intraocular lens in high myopes. Methods. Prospective, observational c...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2016/5320105

    authors: Chang JS,Chan VK,Ng JC,Law AK

    更新日期:2016-01-01 00:00:00

  • Clinical Validation of Adjusted Corneal Power in Patients with Previous Myopic Lasik Surgery.

    abstract::Purpose. To validate clinically a new method for estimating the corneal power (P c ) using a variable keratometric index (n kadj) in eyes with previous laser refractive surgery. Setting. University of Alicante and Medimar International Hospital (Oftalmar), Alicante, (Spain). Design. Retrospective case series. Methods....

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2015/824293

    authors: Camps VJ,Piñero DP,Mateo V,García C,Artola A,Pérez-Cambrodi R,Ruiz-Fortes P

    更新日期:2015-01-01 00:00:00

  • A Novel Device to Exploit the Smartphone Camera for Fundus Photography.

    abstract::Purpose. To construct an inexpensive, convenient, and portable attachment for smartphones for the acquisition of still and live retinal images. Methods. A small optical device based on the principle of direct ophthalmoscopy was designed to be magnetically attached to a smartphone. Representative images of normal and p...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2015/823139

    authors: Russo A,Morescalchi F,Costagliola C,Delcassi L,Semeraro F

    更新日期:2015-01-01 00:00:00

  • Graves' Ophthalmopathy: VISA versus EUGOGO Classification, Assessment, and Management.

    abstract::Graves' ophthalmopathy (GO) is an autoimmune inflammatory disorder associated with thyroid disease which affects ocular and orbital tissues. GO follows a biphasic course in which an initial active phase of progression is followed by a subsequent partial regression and a static inactive phase. Although the majority of ...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1155/2015/249125

    authors: Barrio-Barrio J,Sabater AL,Bonet-Farriol E,Velázquez-Villoria Á,Galofré JC

    更新日期:2015-01-01 00:00:00

  • Surgical Management of Traumatic Retinal Detachment with Primary Vitrectomy in Adult Patients.

    abstract::Purpose. To evaluate functional and anatomical results of pars plana vitrectomy (PPV) in the retinal detachment (RD) followed by severe eye trauma. Methods. Retrospective analysis of medical records of forty-one consecutive patients treated with 23-gauge PPV due to traumatic RD. Age, gender, timing of PPV, visual acui...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2017/5084319

    authors: Nowomiejska K,Choragiewicz T,Borowicz D,Brzozowska A,Moneta-Wielgos J,Maciejewski R,Jünemann AG,Rejdak R

    更新日期:2017-01-01 00:00:00

  • The Degeneration and Apoptosis Patterns of Cone Photoreceptors in rd11 Mice.

    abstract::The retinal degeneration 11 (rd11) mouse is a new animal model with rapid photoreceptor degeneration. The long-term efficacy of gene therapy has a direct relationship with the onset of photoreceptor degeneration or apoptosis, whereas the degeneration or apoptosis patterns of photoreceptors are still unclear in rd11 mi...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2017/9721362

    authors: Zhang H,Li X,Dai X,Han J,Zhang Y,Qi Y,He Y,Liu Y,Chang B,Pang JJ

    更新日期:2017-01-01 00:00:00

  • The Influence of Lunar Phases on Complications in Cataract Surgery: An Analysis of 16,965 Patients.

    abstract:PURPOSE:Popular beliefs exert an impact of lunar phases on elective surgery. The aim of our study was to evaluate potential correlations between complications in cataract surgery and the phases of the moon during its passage through the zodiac and Fridays that fall on the 13th. METHODS:Patients with complications duri...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2017/1946527

    authors: Faschinger EM,Vécsei-Marlovits PV,Rabensteiner DF,Weingessel B

    更新日期:2017-01-01 00:00:00

  • Relationship between Choroidal Thickness and Visual Field Impairment in Acute Zonal Occult Outer Retinopathy.

    abstract:PURPOSE:To evaluate sequential changes in choroidal thickness at the affected area in patients with acute zonal occult outer retinopathy (AZOOR). METHODS:This retrospective observational case series included 14 affected eyes and 6 unaffected fellow eyes from 10 AZOOR patients with impaired macular area. Using enhanced...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2017/2371032

    authors: Hashimoto Y,Saito W,Saito M,Hasegawa Y,Takita A,Mori S,Noda K,Ishida S

    更新日期:2017-01-01 00:00:00

  • Reproducibility of scleral spur identification and angle measurements using fourier domain anterior segment optical coherence tomography.

    abstract::Purpose. To evaluate intraobserver and interobserver agreement in locating the scleral spur landmark (SSL) and anterior chamber angle measurements obtained using Fourier Domain Anterior Segment Optical Coherence Tomography (ASOCT) images. Methods. Two independent, masked observers (SR and AZC) identified SSLs on ASOCT...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2012/487309

    authors: Cumba RJ,Radhakrishnan S,Bell NP,Nagi KS,Chuang AZ,Lin SC,Mankiewicz KA,Feldman RM

    更新日期:2012-01-01 00:00:00

  • Gradually Then Suddenly? Decline in Vision-Related Quality of Life as Glaucoma Worsens.

    abstract::Purpose. To evaluate the relationship between self-reported vision-related quality of life (VRQL) and visual field (VF) loss in people from glaucoma clinics. Methods. A postal survey using the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) was administered to people with a range of VF loss identifie...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2017/1621640

    authors: Jones L,Bryan SR,Crabb DP

    更新日期:2017-01-01 00:00:00

  • Association of birth parameters with refractive status in a sample of caucasian children aged 4-17 years.

    abstract::Purpose. To investigate the association of birth parameters with refractive status in different age groups of Caucasian children. Materials and Methods. This cross-sectional study included 564 eyes of 282 children aged 4 to 17 years. All children underwent complete ophthalmologic examination. The children were divided...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2015/635682

    authors: Akova-Budak B,Kıvanç SA,Olcaysü OO

    更新日期:2015-01-01 00:00:00

  • Systemic endothelial function in primary open-angle glaucoma.

    abstract::Objective. We aimed to assess peripheral vascular endothelial function in open-angle glaucoma (POAG) by measuring flow-mediated dilatation (FMD). Materials and Methods. The study included 20 cases with POAG (group 1, mean age 58.68 ± 13.3 years) and 30 healthy individuals (group 2, mean age 58.68 ± 13.6 years). In all...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2014/529082

    authors: Atas M,Arifoglu HB,Hashas AS,Sarli B,Demircan S,Ozkose A,Goktas A

    更新日期:2014-01-01 00:00:00

  • Characteristics of Facial Asymmetry in Congenital Superior Oblique Palsy according to Trochlear Nerve Absence.

    abstract:Methods:A total of 287 consecutive patients diagnosed with congenital SOP and 82 control subjects were included. Congenital SOP patients were grouped according to the presence (present group) or absence (absent group) of the trochlear nerve using thin-section high-resolution MRI of cranial nerves. We developed a comput...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2020/9476749

    authors: Yang HK,Jung S,WhangBo TK,Hwang JM

    更新日期:2020-12-17 00:00:00

  • Effects of V4c-ICL Implantation on Myopic Patients' Vision-Related Daily Activities.

    abstract::The new type implantable Collamer lens with a central hole (V4c-ICL) is widely used to treat myopia. However, halos occur in some patients after surgery. The aim is to evaluate the effect of V4c-ICL implantation on vision-related daily activities. This retrospective study included 42 patients. Uncorrected visual acuit...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2016/5717932

    authors: Liu T,Linghu S,Pan L,Shi R

    更新日期:2016-01-01 00:00:00

  • Clinical Characteristics and Surgical Procedures for Children with Congenital Membranous Cataract.

    abstract:Objective:In a group case series, the clinical characteristics of congenital membranous cataract in children were studied to establish a system of classification and determine the surgical method suited for each type. Methods:Children (18 eyes) with congenital membranous cataract were examined by slit lamp, ultrasound...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2017/2370969

    authors: Long J,Xiang D,Guo Z,Chen L,Chen F,Wang J,Xie W,He S

    更新日期:2017-01-01 00:00:00

  • Short-Term Effects of Overnight Orthokeratology on Corneal Sensitivity in Chinese Children and Adolescents.

    abstract:Purpose:To assess the effects of the 3-month period of orthokeratology (OK) treatment on corneal sensitivity in Chinese children and adolescents. Methods:Thirty subjects wore overnight OK lenses in both eyes for 3 months and were assessed at baseline, 1 day, 1 week, 1 month, and 3 months after the treatment. Changes i...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2018/6185919

    authors: Jin W,Ye J,Zhang J,Zhu Y,Thorn F,Liu N,Deng R

    更新日期:2018-12-23 00:00:00

  • Intravitreal and subconjunctival melphalan for retinoblastoma in transgenic mice.

    abstract::Purpose. To measure the chemotherapeutic effects of focal melphalan (intravitreal and subconjunctival) on tumor burden, hypoxia, and vasculature in LHBETATAG murine retinoblastoma model. Methods. LHBETATAG transgenic mice were treated with a single 1 mcg intravitreal injection of melphalan, 100 mcg subconjunctival inj...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2014/829879

    authors: Shah NV,Pham DG,Murray TG,Decatur C,Hernandez E,Shah NN,Cavalcante M,Houston SK

    更新日期:2014-01-01 00:00:00

  • Vascular tortuosities of the upper eyelid: a new clinical finding in fabry patient screening.

    abstract::Purpose. To report a new clinical finding related to Fabry disease. Methods. Fabry subjects were enrolled in the study, matched for age and sex with healthy individuals as a control group. This is a prospective review of all upper lid pictures taken for every subject at their last visit. A 4-step grading scale is prop...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2013/207573

    authors: Michaud L

    更新日期:2013-01-01 00:00:00