Abstract:
Purpose:To examine the current knowledge about the age-related processes in the anterior segment of the eye at a biological, clinical, and molecular level. Methods:We reviewed the available published literature that addresses the aging process of the anterior segment of the eye and its associated molecular and physiological events. We performed a search on PubMed, CINAHL, and Embase using the MeSH terms "eye," "anterior segment," and "age." We generated searches to account for synonyms of these keywords and MESH headings as follows: (1) "Eye" AND "ageing process" OR "anterior segment ageing" and (2) "Anterior segment" AND "ageing process" OR "anterior segment" AND "molecular changes" AND "age." Results. Among the principal causes of age-dependent alterations in the anterior segment of the eye, we found the mutation of the TGF-β gene and loss of autophagy in addition to oxidative stress, which contributes to the pathogenesis of degenerative diseases. Conclusions:In this review, we summarize the current knowledge regarding some of the molecular mechanisms related to aging in the anterior segment of the eye. We also introduce and propose potential roles of autophagy, an important mechanism responsible for maintaining homeostasis and proteostasis under stress conditions in the anterior segment during aging.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Hernandez-Zimbron LF,Gulias-Cañizo R,Golzarri MF,Martínez-Báez BE,Quiroz-Mercado H,Gonzalez-Salinas Rdoi
10.1155/2017/1295132subject
Has Abstractpub_date
2017-01-01 00:00:00pages
1295132eissn
2090-004Xissn
2090-0058journal_volume
2017pub_type
杂志文章,评审abstract::Glaucoma is one of the leading causes of blindness worldwide. Recent studies suggest that intraocular pressure (IOP) fluctuations, peaks, and rhythm are important factors in disease advancement. Yet, current glaucoma management remains hinged on single IOP measurements during clinic hours. To overcome this limitation,...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2016/4727423
更新日期:2016-01-01 00:00:00
abstract:AIM:To discuss the clinical characteristics of immune-related dry eye. METHODS:Simple dry eye (SDE) group: we selected 224 patients of simple dry eye with no systemic lesions. Immune-related dry eye (IRDE) group: we selected 207 patients of dry eye complicated with immune system diseases, including 70 cases of Sjögren...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/8532397
更新日期:2017-01-01 00:00:00
abstract::Purpose. To assess the morphology of idiopathic choroidal neovascularization (ICNV) by optical coherence tomography angiography (OCTA) and determine the therapeutic effects of intravitreal antivascular endothelial growth factor (anti-VEGF). Method. Patients with naive ICNV were assessed by spectral domain optical cohe...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/5608250
更新日期:2016-01-01 00:00:00
abstract::Purpose. To evaluate the effectiveness and safety of perfluorohexyloctane (F6H8) for intraoperative flattening of the retina and of F6H8/silicone oil (SO) 1000 cSt as a postoperative tamponade for inferior retinal detachment with inferior proliferative vitreoretinopathy. Methods. This is a retrospective review of 22 p...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/956831
更新日期:2014-01-01 00:00:00
abstract:Purpose:To evaluate the clinical classification and characteristics of hereditary optic neuropathy patients in a single center in China. Method:Retrospective case study. Patients diagnosed with hereditary optic neuropathy between January 2014 and December 2015 in the neuro-ophthalmology division in Shanghai Eye and EN...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/6186052
更新日期:2017-01-01 00:00:00
abstract:Purpose:To ascertain wet AMD (wAMD) management patterns in Spain. Methods:A two-round Delphi study conducted through a questionnaire-based survey designed from literature review and validated by an independent Steering Committee. Results:Forty-nine retina specialists experienced in wAMD participated by answering the ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/9821509
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abstract:PURPOSE:To evaluate the effect of preoperative intravitreal bevacizumab (IVB) injection on the surgical outcome of Ahmed glaucoma valve (AGV) implantation according to the angle status in neovascular glaucoma (NVG) eyes. MATERIALS AND METHODS:This retrospective study included 70 NVG patients who underwent AGV implanta...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/7672485
更新日期:2017-01-01 00:00:00
abstract:Purpose:To investigate whether the risk of subsequent stroke, ischemic stroke, hemorrhagic stroke, and all-cause mortality is increased among retinal vein occlusion (RVO) patients compared to non-RVO patients. Methods:From the entire population of the Taiwan National Health Insurance Research Database (NHIRD) from 200...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/8629429
更新日期:2018-09-09 00:00:00
abstract::Background. We aimed to evaluate the association between maternal smoking and the occurrence of childhood refractive error and amblyopia. Methods. Relevant articles were identified from PubMed and EMBASE up to May 2015. Combined odds ratio (OR) corresponding with its 95% confidence interval (CI) was calculated to eval...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/8263832
更新日期:2016-01-01 00:00:00
abstract:Background:Chromatic contrast may affect stereopsis. Daltonism is a common color deficiency in which the colors red and green are incorrectly detected. The aim of this study was to evaluate the stereoacuity of color-defective individuals presented with color symbols that they see defectively. Methods:Ten students diag...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/1926736
更新日期:2018-08-01 00:00:00
abstract:Background:The advantage of using an autostereoscopic smartphone is that it can achieve 3D effects without the need for glasses. The purpose of this study was to evaluate whether this technology could be utilized to detect stereoacuity. Methods:An autostereoscopic smartphone was used to imitate Lang stereotest I & II,...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/1570309
更新日期:2019-10-31 00:00:00
abstract::Traumatic macular hole (TMH) is not a rare clinical condition, especially in young population. Its prognosis is of complexity and uncertainty, with a relatively high rate of spontaneous closure in some cases. Modern vitrectomy surgery plays an important role in the treatment of TMH, although the functional outcomes ma...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2017/1748135
更新日期:2017-01-01 00:00:00
abstract::Fifty-two eyes of 52 patients with treatment-naïve macular edema associated with perfused branch retinal vein occlusion were retrospectively reviewed. Twenty-seven cases received PRN intravitreal bevacizumab, and 25 cases were treated by PRN intravitreal aflibercept with monthly follow-ups for 12 months. Both afliberc...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/8421940
更新日期:2016-01-01 00:00:00
abstract::Aim. To investigate the utility of fundus autofluorescence (FAF) and optical coherence tomography (OCT) in the evaluation of cystoid macular edema (CME) following cataract surgery. Materials and Methods. Forty eyes of 29 patients undergone phacoemulsification, with posterior chamber intraocular lens implantation surge...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2013/376013
更新日期:2013-01-01 00:00:00
abstract::Purpose. To measure central corneal thickness (CCT) in patients with history of nonarteritic anterior ischemic optic neuropathy (NAION). Patients and Methods. Patients older than 40 years with a history of NAION (group 1) were prospectively evaluated including full eye examination and central corneal thickness (CCT) p...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/904373
更新日期:2014-01-01 00:00:00
abstract:Purpose:To investigate the correlation between decentration index (index of height decentration, IHD) automatically calculated by the Pentacam HR software and the manually calculated inferior minus superior (I-S) value. Setting:Al Watany Eye Hospital, Cairo, Egypt. Methods:In a retrospective study, history taking, cl...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/7875148
更新日期:2018-10-02 00:00:00
abstract:Purpose:To compare two calculators for toric intraocular lens (IOL) calculation and to evaluate the prediction of refractive outcome. Methods:Sixty-four eyes of forty-five patients underwent cataract surgery followed by implantation of a toric intraocular lens (Zeiss Torbi 709 M) calculated by a standard industry calc...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/2840246
更新日期:2018-01-10 00:00:00
abstract:Purpose:To analyze the results of three-year outcomes of combined epithelium-on cross-linking with femtosecond laser ICRS (cross-linking PLUS) for keratoconus management. Design:A retrospective multicenter clinical study. Methods:43 eyes of 38 patients were subjected to preoperative and postoperative UCVA, BCVA, refr...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/6907573
更新日期:2018-01-17 00:00:00
abstract:PURPOSE:To date, the topic of amblyopic changes remains controversial. Therefore, a systematic review and meta-analysis were carried out to evaluate choroidal changes in unilateral amblyopia. METHODS:Major literature databases were searched for amblyopia-relevant studies. Using enhanced depth imaging optical coherence...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2017/2915261
更新日期:2017-01-01 00:00:00
abstract::Purpose. To evaluate the relationship between the macular ganglion cell complex (mGCC) thickness, which is the sum of the retinal nerve fiber, ganglion cell, and inner plexiform layers, measured with a spectral-domain optical coherence tomograph and the optic nerve head topography measured with a confocal scanning las...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/914250
更新日期:2011-01-01 00:00:00
abstract::Cross-linking of corneal collagen (CXL) is a promising approach for the treatment of keratoconus and secondary ectasia. Several long-term and short-term complications of CXL have been studied and documented. The possibility of a secondary infection after the procedure exists because the patient is subjected to epithel...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/869015
更新日期:2011-01-01 00:00:00
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journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/2370969
更新日期:2017-01-01 00:00:00
abstract::Objective. Compare glaucoma medication costs between the United States (USA) and Canada. Methods. We modelled glaucoma brand name and generic medication annual costs in the USA and Canada based on October 2013 Costco prices and previously reported bottle overfill rates, drops per mL, and wastage adjustment. We also ca...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/547960
更新日期:2015-01-01 00:00:00
abstract:Purpose:Studying the early effect of different extraocular muscle (EOM) surgeries on corneal biomechanics. Subjects and methods:This is a prospective, nonrandomized, interventional study, in which 42 eyes of 29 candidates for EOM surgery for strabismus correction at Cairo university hospitals, aged 14-37 years, were r...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/8072140
更新日期:2018-09-16 00:00:00
abstract::Purpose. To compare the surgically induced astigmatism from clear corneal and square posterior limbal incisions at the time of cataract surgery. Methods. Surgically induced astigmatism was calculated for a set of eyes after cataract surgery using a temporal 2.2 mm square posterior limbal incision. Results were compare...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/243170
更新日期:2011-01-01 00:00:00
abstract:Methods:A total of 287 consecutive patients diagnosed with congenital SOP and 82 control subjects were included. Congenital SOP patients were grouped according to the presence (present group) or absence (absent group) of the trochlear nerve using thin-section high-resolution MRI of cranial nerves. We developed a comput...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/9476749
更新日期:2020-12-17 00:00:00
abstract::Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. The objective of this study is to investigate the effects of vascular endothelial growth factor receptor 1 (VEGFR1) blockade on the complications of DR. Experimental models of diabetes were induced with streptozotocin (STZ) treatment or I...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/605946
更新日期:2015-01-01 00:00:00
abstract::Purpose. To evaluate functional and anatomical results of pars plana vitrectomy (PPV) in the retinal detachment (RD) followed by severe eye trauma. Methods. Retrospective analysis of medical records of forty-one consecutive patients treated with 23-gauge PPV due to traumatic RD. Age, gender, timing of PPV, visual acui...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/5084319
更新日期:2017-01-01 00:00:00
abstract:Purpose:To compare ocular biometry between children with type 1 diabetes mellitus (T1DM) and healthy children in China and to determine the correlation of ocular biometry with the glycosylated hemoglobin (HbA1c) level and diabetes duration. Methods:A case-control study was conducted at Children's Hospital of Fudan Uni...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/7216490
更新日期:2019-02-14 00:00:00
abstract:Purpose:To identify the clinical characteristics and risk factors for secondary choroidal neovascularization (CNV) in central serous chorioretinopathy (CSC). Methods:In this retrospective study, we included a total of 108 eyes in 106 CSC patients. Group A was defined as patients initially diagnosed with CSC who develo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/7217906
更新日期:2020-02-07 00:00:00