Abstract：
Purpose:Activating transcription factor 4 (ATF4) is induced by various stressors. Here, we investigated the expression of ATF4 in the host inflammatory response to Aspergillus fumigatus (A. fumigatus) keratitis. Methods:A. fumigatus keratitis mouse models developed by intrastromal injection as well as corneal epithelium scratching were examined daily with a slit lamp microscope for corneal opacification and ulceration. Subsequent in vitro experimentation was carried out in human corneal epithelial cells (HCECs) as well as THP-1 macrophages infected with A. fumigatus. Inhibitors, including CLI-095, Poly (I), SCH772984, and SP600125, were used to assess the role of proteins like toll-like receptor 4 (TLR4), lectin-type oxidized LDL receptor 1 (LOX-1), extracellular signal-regulated kinases (ERK1/2), and c-Jun N-terminal kinase (JNK) in ATF4 expression as a response to A. fumigatus infection. This assessment was made in both mouse models and HCECs using western blot. Results:Compared to the controls, ATF4 was increased in corneas from two kinds of A. fumigatus keratitis models at 3 days after infection. ATF4 expression was upregulated with A. fumigatus conidia both in HCECs and THP-1 macrophages 16 hours after stimulation. Furthermore, ATF4 expression in response to A. fumigatus infection was shown to be dependent on TLR4 and LOX-1 expression, and ERK1/2 and JNK contributed to the expression of ATF4 in response to A. fumigatus. Conclusion:Our results clearly indicate that ATF4 was involved in the host antifungal immune response to A. fumigatus keratitis; expression was found to be dependent on TLR4, LOX-1 expression, and MAPKs pathway.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Zhang S,Meng P,Liu G,Liu K,Che Cdoi
10.1155/2018/5830202subject
Has Abstractpub_date
2018-12-13 00:00:00pages
5830202eissn
2090-004Xissn
2090-0058journal_volume
2018pub_type
杂志文章abstract：Purpose:To investigate the effects of capsulotomy shape on the visual acuity and visual quality after neodymium: yttrium aluminum garnet laser capsulotomy. Methods:In this study, a total of 42 eyes from 35 patients with posterior capsule opacification were divided into the circular and cruciate groups. The corrected d...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/4153109
更新日期：2020-03-23 00:00:00
abstract：:Macular pseudoholes (MPHs) and lamellar macular holes (LMHs) have been recently defined according to spectral domain optical coherence tomography (SD-OCT) criteria. A major feature for differentiating an MPH from an LMH remains the loss of foveal tissue. The anatomy of the foveola is peculiar with the macular pigment ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2019/4948212
更新日期：2019-02-10 00:00:00
abstract：:Objective. To describe the clinicoradiological and histopathological findings in a case of lacrimal gland enlargement secondary to lymphomatoid granulomatosis (LG) and to review the literature. Design. Case report and systematic literature review. Methods. A 75-year-old woman presented with right ptosis. Computerised ...
journal_title：Journal of ophthalmology
pub_type：
doi：10.1155/2010/358121
更新日期：2010-01-01 00:00:00
abstract：Purpose:To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes. Methods:Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy co...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/1825819
更新日期：2019-08-07 00:00:00
abstract：:Aims. Increasing evidence shows that imbalanced suppressive drive prior to binocular combination may be the key factor in amblyopia. We described a novel binocular approach, interocular shift of visual attention (ISVA), for treatment of amblyopia in adult patients. Methods. Visual stimuli were presented anaglyphically...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2014/615213
更新日期：2014-01-01 00:00:00
abstract：:Purpose. The aim of this study is to investigate the etiology and the clinical, microbiological, histopathological, and radiological findings of acquired dacryocystoceles. Methods. In this retrospective study, we reviewed the clinical records of 10 eyes of 8 patients with dacryocystoceles who underwent external dacryo...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2014/396782
更新日期：2014-01-01 00:00:00
abstract：Objective:To report the 15-year trend in ophthalmic presentations to the emergency department (ED) at the only medical center in Lebanon that provides 24-hour ophthalmologic care. Methods:Retrospective review of 1967 patients presenting to the ED with eye-related complaints between September 1997 and August 1998 and b...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/4739865
更新日期：2018-03-13 00:00:00
abstract：PURPOSE:To evaluate the effect of preoperative intravitreal bevacizumab (IVB) injection on the surgical outcome of Ahmed glaucoma valve (AGV) implantation according to the angle status in neovascular glaucoma (NVG) eyes. MATERIALS AND METHODS:This retrospective study included 70 NVG patients who underwent AGV implanta...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/7672485
更新日期：2017-01-01 00:00:00
abstract：:Traumatic macular hole (TMH) is not a rare clinical condition, especially in young population. Its prognosis is of complexity and uncertainty, with a relatively high rate of spontaneous closure in some cases. Modern vitrectomy surgery plays an important role in the treatment of TMH, although the functional outcomes ma...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2017/1748135
更新日期：2017-01-01 00:00:00
abstract：PURPOSE:Popular beliefs exert an impact of lunar phases on elective surgery. The aim of our study was to evaluate potential correlations between complications in cataract surgery and the phases of the moon during its passage through the zodiac and Fridays that fall on the 13th. METHODS:Patients with complications duri...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/1946527
更新日期：2017-01-01 00:00:00
abstract：Background:For so long, corneal diseases have been known as one of the leading causes to blindness in the global. This blindness might be due to failure to accept the corneal transplantation. Therefore, this study aimed to determine the prevalence and the root challenges for corneal transplantation acceptance at the Un...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/4560649
更新日期：2019-12-13 00:00:00
abstract：:Zeaxanthin is a nutritional carotenoid with a considerable amount of safety data based on regulatory studies, which form the basis of its safety evaluation. Subchronic OECD guideline studies with mice and rats receiving beadlet formulations of high purity synthetic zeaxanthin in the diet at dosages up to 1000 mg/kg bo...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2016/3690140
更新日期：2016-01-01 00:00:00
abstract：:Purpose. We evaluated the ability of novel optical coherence tomography (OCT) parameters to predict postoperative best-corrected visual acuity (BCVA) in macula-off rhegmatogenous retinal detachment (RRD) eyes. Methods. We reviewed the medical records of 56 consecutive eyes with macula-off RRD. Clinical findings were a...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2014/269837
更新日期：2014-01-01 00:00:00
abstract：Purpose:To evaluate the efficacy and safety of MyoRing implantation in eyes with keratoconus managed at a tertiary eye hospital in the Eastern Province of Saudi Arabia. Methods:This one-armed historical cohort study included keratoconus patients operated for MyoRing implant. The cases were assessed before and 6 months...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/2630704
更新日期：2019-08-29 00:00:00
abstract：:Purpose. To investigate the effect of cigarette smoking on the ocular tear film. Methods. Thirty healthy young male cigarette smokers (20-38 years old) and 30 healthy age matched nonsmokers were enrolled in the study. McMonnies questionnaire, slit lamp, and PRT test were used to screen the subjects. Tear samples were ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/8154315
更新日期：2016-01-01 00:00:00
abstract：Purpose:To evaluate the outcomes of femtosecond laser-assisted implantation of a 355-degree intracorneal ring (ICR) (Keraring) in patients with keratoconus in the three-year follow-up. Setting:Future Femtolaser Center, Sohag, Egypt. Design:Prospective interventional case series. Patients and Methods:A prospective ca...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/6783181
更新日期：2019-10-09 00:00:00
abstract：PURPOSE:To evaluate the static measurement of the accommodative stimulus-response curve with emoji symbols. METHODS:The accommodative stimulus-response curve was measured in 18 subjects using a Hartmann-Shack sensor to obtain the objective accommodative response from the Zernike defocus term. Measurements were acquire...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/4165706
更新日期：2017-01-01 00:00:00
abstract：:Here we review evidence that loss of photoreceptors due to degenerative retinal disease causes an increase in the rate of spontaneous ganglion spike discharge. Information about persistent spike activity is important since it is expected to add noise to the communication between the eye and the brain and thus impact t...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2011/507037
更新日期：2011-01-01 00:00:00
abstract：Purpose:Retinal vein occlusion (RVO) is the second most common retinal vascular disease and a major cause of visual impairment. In this study, we aimed to observe whether RVO cases have different antibody profiles as a new potential risk factor and whether a conversion of retinal vein occlusion (RVO) to neovascular gla...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/8386160
更新日期：2020-07-29 00:00:00
abstract：Purpose:To investigate the refraction and ocular biometry characteristics and to examine the prevalence of refractive errors in preschool children aged 3 to 6 years in Shanghai, China. Methods:A school-based cross-sectional study was conducted in Jiading and Xuhui District, Shanghai, in 2013. We randomly selected 7 ki...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/5205946
更新日期：2018-03-05 00:00:00
abstract：:Cross-linking of corneal collagen (CXL) is a promising approach for the treatment of keratoconus and secondary ectasia. Several long-term and short-term complications of CXL have been studied and documented. The possibility of a secondary infection after the procedure exists because the patient is subjected to epithel...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2011/869015
更新日期：2011-01-01 00:00:00
abstract：:Purpose. This study aims to explore the safety and efficacy of a novel treatment-intense pulsed light (IPL) in MGD eyes. Methods. This study is a prospective and open label study. Forty eyes of 40 MGD patients were recruited in the study and received 4 consecutive IPL treatments on day 1, day 15, day 45, and day 75. T...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/1910694
更新日期：2016-01-01 00:00:00
abstract：:Purpose. To review the newer treatments for bacterial keratitis. Data Sources. PubMed literature search up to April 2012. Study Selection. Key words used for literature search: "infectious keratitis", "microbial keratitis", "infective keratitis", "new treatments for infectious keratitis", "fourth generation fluoroquin...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2012/831502
更新日期：2012-01-01 00:00:00
abstract：:This paper demonstrates multiple benefits of intravitreal bevacizumab (IVB) on diabetic retinopathy (DR) including diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) at 24 months of followup. This is a retrospective multicenter interventional comparative case series of intravitreal injections of...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2011/584238
更新日期：2011-01-01 00:00:00
abstract：:Purpose. To present a series of retinal disease cases that were imaged by spectral domain optical coherence tomography (SD-OCT) in order to illustrate the potential and limitations of this new imaging modality. Methods. The series comprised four selected cases (one case each) of age-related macular degeneration (ARMD)...
journal_title：Journal of ophthalmology
pub_type：
doi：10.1155/2011/764183
更新日期：2011-01-01 00:00:00
abstract：Purpose:To identify and correlate age-related changes in outer retinal layers' thickness and choroidal thickness (CT) in the normal eyes using spectral-domain optical coherence tomography (SD-OCT) and to investigate factors affecting these changes. Study Design:Observational cross-sectional study. Subjects and Method...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/1698967
更新日期：2019-07-31 00:00:00
abstract：Purpose:To compare the outcomes of Ex-PRESS glaucoma filtration device and transscleral cyclophotocoagulation (TSCP) in the management of neovascular glaucoma (NVG). Patients and Methods. A total of 30 eyes (12 express shunts and 18 TSCP) of 28 patients were included. The eyes had NVG with intraocular pressure (IOP) mo...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/3781249
更新日期：2020-05-17 00:00:00
abstract：:Aim. To investigate the utility of fundus autofluorescence (FAF) and optical coherence tomography (OCT) in the evaluation of cystoid macular edema (CME) following cataract surgery. Materials and Methods. Forty eyes of 29 patients undergone phacoemulsification, with posterior chamber intraocular lens implantation surge...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2013/376013
更新日期：2013-01-01 00:00:00
abstract：:Quantitative measurement of the orbital soft tissue volume plays a very important role in the study of orbital diseases. The purpose of this study is to establish a computed tomography- (CT-) based three-dimensional (3D) reconstruction model and measure the orbital soft tissue volume in Chinese adults. We collected da...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/9721085
更新日期：2019-07-02 00:00:00
abstract：PURPOSE:To evaluate sequential changes in choroidal thickness at the affected area in patients with acute zonal occult outer retinopathy (AZOOR). METHODS:This retrospective observational case series included 14 affected eyes and 6 unaffected fellow eyes from 10 AZOOR patients with impaired macular area. Using enhanced...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/2371032
更新日期：2017-01-01 00:00:00
