Abstract：
PURPOSE:To evaluate the effect of the Rho-kinase inhibitor Y-27632 on postoperative inflammation and adhesion following extraocular muscle surgery in rabbits. METHODS:The superior rectus muscle reinsertion was performed on both eyes of 8 New Zealand white rabbits. After reinsertion, the rabbits received subconjunctival injections of the Rho-kinase inhibitor and saline on each eye. To assess acute and late inflammatory changes, Ki-67, CD11β+, and F4/80 were evaluated and the sites of muscle reattachment were evaluated for a postoperative adhesion score and histopathologically for collagen formation. RESULTS:F4/80 antibody expression was significantly different in the Rho-kinase inhibitor-injected group at both postoperative day 3 and week 4 (p = 0.038, 0.031). However, Ki-67 and CD11β+ were not different the between two groups. The difference in the SRM/conjunctiva adhesion score between the two groups was also significant (p = 0.034). Conclusion. Intraoperative subconjunctival injection of the Rho-kinase inhibitor may be effective for adjunctive management of inflammation and fibrosis in rabbit eyes following extraocular muscle surgery.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Moon JS,Kim HK,Shin SYdoi
10.1155/2017/8653130subject
Has Abstractpub_date
2017-01-01 00:00:00pages
8653130eissn
2090-004Xissn
2090-0058journal_volume
2017pub_type
杂志文章abstract：:Purpose. To evaluate functional and anatomical results of pars plana vitrectomy (PPV) in the retinal detachment (RD) followed by severe eye trauma. Methods. Retrospective analysis of medical records of forty-one consecutive patients treated with 23-gauge PPV due to traumatic RD. Age, gender, timing of PPV, visual acui...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/5084319
更新日期：2017-01-01 00:00:00
abstract：:Zeaxanthin is a nutritional carotenoid with a considerable amount of safety data based on regulatory studies, which form the basis of its safety evaluation. Subchronic OECD guideline studies with mice and rats receiving beadlet formulations of high purity synthetic zeaxanthin in the diet at dosages up to 1000 mg/kg bo...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2016/3690140
更新日期：2016-01-01 00:00:00
abstract：:Background. The aim of this study is to investigate the ocular thermographic profiles in age-related macular degeneration (AMD) eyes and age-matched controls to detect possible hemodynamic abnormalities, which could be involved in the pathogenesis of the disease. Methods. 32 eyes with early AMD, 37 eyes with atrophic ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2014/281010
更新日期：2014-01-01 00:00:00
abstract：Introduction:To assess long-term efficacy of bimedial rectus tendon elongation with Tutopatch in thyroid-associated orbitopathy (TAO). Materials and Methods:Retrospective chart review of 5 patients with TAO undergoing bimedial rectus recession with Tutopatch tendon elongation between 2009 and 2015. We analyzed horizon...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/1294761
更新日期：2018-07-24 00:00:00
abstract：:Macular pseudoholes (MPHs) and lamellar macular holes (LMHs) have been recently defined according to spectral domain optical coherence tomography (SD-OCT) criteria. A major feature for differentiating an MPH from an LMH remains the loss of foveal tissue. The anatomy of the foveola is peculiar with the macular pigment ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2019/4948212
更新日期：2019-02-10 00:00:00
abstract：:Purpose. To examine the clinical implications of change in choroidal neovascularization (CNV) size on indocyanine green (ICG) angiography in subjects with idiopathic CNV undergoing bevacizumab therapy. Methods. The charts of subjects with an idiopathic CNV treated by a modified PRN regimen with intravitreal bevacizuma...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2015/642624
更新日期：2015-01-01 00:00:00
abstract：:Purpose. To review the newer treatments for bacterial keratitis. Data Sources. PubMed literature search up to April 2012. Study Selection. Key words used for literature search: "infectious keratitis", "microbial keratitis", "infective keratitis", "new treatments for infectious keratitis", "fourth generation fluoroquin...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2012/831502
更新日期：2012-01-01 00:00:00
abstract：Purpose:To analyze the results of three-year outcomes of combined epithelium-on cross-linking with femtosecond laser ICRS (cross-linking PLUS) for keratoconus management. Design:A retrospective multicenter clinical study. Methods:43 eyes of 38 patients were subjected to preoperative and postoperative UCVA, BCVA, refr...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/6907573
更新日期：2018-01-17 00:00:00
abstract：Purpose:To identify the clinical characteristics and risk factors for secondary choroidal neovascularization (CNV) in central serous chorioretinopathy (CSC). Methods:In this retrospective study, we included a total of 108 eyes in 106 CSC patients. Group A was defined as patients initially diagnosed with CSC who develo...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/7217906
更新日期：2020-02-07 00:00:00
abstract：Objective:To report the 15-year trend in ophthalmic presentations to the emergency department (ED) at the only medical center in Lebanon that provides 24-hour ophthalmologic care. Methods:Retrospective review of 1967 patients presenting to the ED with eye-related complaints between September 1997 and August 1998 and b...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/4739865
更新日期：2018-03-13 00:00:00
abstract：:Purpose. To evaluate the corneal higher-order aberrations (HOA), contrast sensitivity function (CSF), and light distortion (LD) in patients undergoing orthokeratology (OK). Methods. Twenty healthy subjects (mean age: 21.40 ± 8 years) with mean spherical equivalent refractive error M = -2.19 ± 0.97 D were evaluated at ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/8453462
更新日期：2016-01-01 00:00:00
abstract：:Congenital cataract is the most common cause of the visual disability and blindness in childhood. This study aimed to identify gene mutations responsible for autosomal dominant congenital cataract (ADCC) in a Chinese family using next-generation sequencing technology. This family included eight unaffected and five aff...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/4353957
更新日期：2016-01-01 00:00:00
abstract：:Purpose. To compare the mean corneal power (Km) and total astigmatism (Ka) estimated by three methods: simulated keratometry (simK), true net power (TNP), and total corneal refractive power (TCRP) before and after femtosecond laser small incision lenticule extraction (SMILE) surgery. Methods. A retrospective, cross-se...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/9659481
更新日期：2017-01-01 00:00:00
abstract：Purpose:To characterize the relative contributions of intraocular pressure (IOP) and intracranial pressure (ICP) on lamina cribrosa (LC) behavior, specifically LC depth (LCD) and LC peak strain. Methods:An axially symmetric finite element model of the posterior eye was constructed with an elongated optic nerve and ret...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/3064949
更新日期：2019-03-17 00:00:00
abstract：Purpose:To evaluate a new tangential map-based nomogram versus the axial map-based nomogram for ICRS in keratoconus. Methods:A prospective case series study including 64 eyes of 64 patients who underwent ICRS implantation. Cone location was determined for each eye with two maps: the axial and the tangential. Appropria...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/3983508
更新日期：2020-02-19 00:00:00
abstract：:Methylglyoxal (MG) is an intermediate of glucose metabolism and the precursor of advanced glycation end products (AGEs) found in high levels in blood or tissue of diabetic patients. MG and AGEs are thought to play a major role in the pathogenesis of diabetic retinopathy. In order to determine if zebrafish is valuable ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/2746735
更新日期：2019-04-17 00:00:00
abstract：Purpose:The aim of this work was to describe the ultrastructure and behavior of peeled internal limiting membrane (ILM) in macular hole (MH) surgery. Methods:Seven patients with MH were included, and vitrectomy with ILM peeling was performed in all patients. The ILM inverted flap technique was used. Two other flaps of...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/1345683
更新日期：2019-05-02 00:00:00
abstract：Purpose:To investigate the correlation between decentration index (index of height decentration, IHD) automatically calculated by the Pentacam HR software and the manually calculated inferior minus superior (I-S) value. Setting:Al Watany Eye Hospital, Cairo, Egypt. Methods:In a retrospective study, history taking, cl...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/7875148
更新日期：2018-10-02 00:00:00
abstract：PURPOSE:To evaluate the static measurement of the accommodative stimulus-response curve with emoji symbols. METHODS:The accommodative stimulus-response curve was measured in 18 subjects using a Hartmann-Shack sensor to obtain the objective accommodative response from the Zernike defocus term. Measurements were acquire...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/4165706
更新日期：2017-01-01 00:00:00
abstract：Objective:To calculate the Q values from the human anterior corneal surface with the tangential radius of curvature and analyze its distribution characteristics in different age and refractive status groups. Methods:Tangential power maps of the anterior cornea from Orbscan II were acquired for 201 subjects' right eyes...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/7263564
更新日期：2018-04-17 00:00:00
abstract：Purpose:To analyze the "in vitro" aberrometric pattern of a refractive IOL and two extended depth of focus IOLs. Methods:A special optical bench with a Shack-Hartmann wavefront sensor (SH) was designed for the measurement. Three presbyopia correction IOLs were analyzed: Mini WELL (MW), TECNIS Symfony ZXR00 (SYM), and ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/7095734
更新日期：2017-01-01 00:00:00
abstract：Purpose:To evaluate intraoperative complications and utilization of adjunctive devices between microscope and intracameral illuminations during cataract surgery in the elderly over 75 years. Design:A retrospective, consecutive, interventional case series Participants. Two hundred eighty-six eyes of 184 patients older ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/1594152
更新日期：2019-01-10 00:00:00
abstract：:Purpose. To measure the chemotherapeutic effects of focal melphalan (intravitreal and subconjunctival) on tumor burden, hypoxia, and vasculature in LHBETATAG murine retinoblastoma model. Methods. LHBETATAG transgenic mice were treated with a single 1 mcg intravitreal injection of melphalan, 100 mcg subconjunctival inj...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2014/829879
更新日期：2014-01-01 00:00:00
abstract：Purpose:To evaluate a new technique of posterior capsulorhexis using air support to treat primary posterior capsular opacification (PCO) during cataract extraction surgery or to prevent postoperative PCO. Setting:(1) Ophthalmology department, Faculty of Medicine, Minia University, 61519, El-Minia, Egypt. (2) Security ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/3174709
更新日期：2019-12-21 00:00:00
abstract：Purpose:To assess the effect of age on elevation and pachymetric Pentacam keratoconus (KC) detection indices, and the need to adjust normative values accordingly. Methods:In a retrospective study, 95 eyes of myopic normal subjects without KC were evaluated using the OCULUS Pentacam, with an age range of 17.4 to 46.8 y...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/2016564
更新日期：2018-04-22 00:00:00
abstract：Background:Chromatic contrast may affect stereopsis. Daltonism is a common color deficiency in which the colors red and green are incorrectly detected. The aim of this study was to evaluate the stereoacuity of color-defective individuals presented with color symbols that they see defectively. Methods:Ten students diag...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/1926736
更新日期：2018-08-01 00:00:00
abstract：Introduction:Hepatitis B virus (HBV) and hepatitis C virus (HCV) and their long-term sequelae are considered a major health issue in Egypt. The aim of this study is to determine the prevalence of undiagnosed hepatitis B virus (HBV) and hepatitis C virus (HCV) among patients admitted for elective eye surgery in a specia...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/3985865
更新日期：2019-07-01 00:00:00
abstract：Purpose:To assess the effects of the 3-month period of orthokeratology (OK) treatment on corneal sensitivity in Chinese children and adolescents. Methods:Thirty subjects wore overnight OK lenses in both eyes for 3 months and were assessed at baseline, 1 day, 1 week, 1 month, and 3 months after the treatment. Changes i...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/6185919
更新日期：2018-12-23 00:00:00
abstract：:We established a chronic dacryocystitis model by injecting of 0.05, 0.1, and 0.15 ml self-curing resin via the lacrimal punctum in rabbits. Animals were randomized into four groups (n = 11 animals/group). The control group received 0.15 ml normal saline. Within three months postinjection, epiphora and eye discharge we...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/3438041
更新日期：2017-01-01 00:00:00
abstract：Purpose:The purpose of this study was to evaluate 2-year visual outcomes in patients with diabetic macular edema (DME) treated with anti-VEGF agents in a routine clinical setting. Methods:The medical records of patients treated with ranibizumab or aflibercept due to DME at the Eye Hospital, University Medical Centre L...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/6979758
更新日期：2020-03-16 00:00:00
