Abstract:
:Individualized treatment regimens may reduce patient burden with satisfactory patient outcomes in neovascular age-related macular degeneration. Intravitreal anti-VEGF drugs are the current gold standard. Fixed monthly injections offer the best visual outcome but this regimen is not commonly followed outside clinical trials. A PRN regimen requires monthly visits where the patient is treated in the presence of signs of lesion activity. Therefore, an early detection of reactivation of the disease with immediate retreatment is crucial to prevent visual acuity loss. Several trials suggest that "treat and extend" and other proactive regimens provide a reasonable approach. The rationale of the proactive regimens is to perform treatment anticipating relapses or recurrences and therefore avoid drops in vision while individualizing patient followup. Treat and extend study results in significant direct medical cost savings from fewer treatments and office visits compared to monthly treatment. Current data suggest that, for one year, PRN is less expensive, but treat and extend regimen would likely be less expensive for subsequent years. Once a patient is not a candidate to continue with treatment, he/she should be sent to an outpatient unit with adequate resources to follow nAMD patients in order to reduce the burden of specialized ophthalmologist services.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
García-Layana A,Figueroa MS,Arias L,Araiz J,Ruiz-Moreno JM,García-Arumí J,Gómez-Ulla F,López-Gálvez MI,Cabrera-López F,García-Campos JM,Monés J,Cervera E,Armadá F,Gallego-Pinazo Rdoi
10.1155/2015/412903subject
Has Abstractpub_date
2015-01-01 00:00:00pages
412903eissn
2090-004Xissn
2090-0058journal_volume
2015pub_type
杂志文章,评审abstract::Cross-linking of corneal collagen (CXL) is a promising approach for the treatment of keratoconus and secondary ectasia. Several long-term and short-term complications of CXL have been studied and documented. The possibility of a secondary infection after the procedure exists because the patient is subjected to epithel...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/869015
更新日期:2011-01-01 00:00:00
abstract:Purpose:Studying the early effect of different extraocular muscle (EOM) surgeries on corneal biomechanics. Subjects and methods:This is a prospective, nonrandomized, interventional study, in which 42 eyes of 29 candidates for EOM surgery for strabismus correction at Cairo university hospitals, aged 14-37 years, were r...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/8072140
更新日期:2018-09-16 00:00:00
abstract:PURPOSE:To investigate neovascular age-related macular degeneration (AMD) in patients aged ≥90 years from several perspectives for a comprehensive overview: prevalence, presenting characteristics, treatment adherence, reasons for discontinuation, and efficacy of antivascular endothelial growth factor (VEGF) treatment c...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/7194927
更新日期:2017-01-01 00:00:00
abstract::Purpose. To investigate the agreement between morphometric optic nerve head parameters assessed with the confocal laser ophthalmoscope HRT III and the stereoscopic fundus camera Kowa nonmyd WX3D retrospectively. Methods. Morphometric optic nerve head parameters of 40 eyes of 40 patients with primary open angle glaucom...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/4764857
更新日期:2016-01-01 00:00:00
abstract::Keratoconus is typically diagnosed through changes at the anterior ocular surface. However, we wished to assess if macular parameter changes might also occur in these patients. We assessed posterior changes through the use of optical coherence tomography and compared to a nonkeratoconus patient group. All subjects und...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/245953
更新日期:2015-01-01 00:00:00
abstract::Congenital cataract is the most common cause of the visual disability and blindness in childhood. This study aimed to identify gene mutations responsible for autosomal dominant congenital cataract (ADCC) in a Chinese family using next-generation sequencing technology. This family included eight unaffected and five aff...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/4353957
更新日期:2016-01-01 00:00:00
abstract:Purpose:The objective of this study was to evaluate the microbiological spectrum and antibiotic susceptibilities of isolates in posttraumatic endophthalmitis over a 15-year period. Methods:A retrospective study of 3,163 posttraumatic endophthalmitis cases was conducted between July 2004 and July 2019. The outcome meas...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/5053923
更新日期:2020-04-29 00:00:00
abstract::Purpose. To report a new clinical finding related to Fabry disease. Methods. Fabry subjects were enrolled in the study, matched for age and sex with healthy individuals as a control group. This is a prospective review of all upper lid pictures taken for every subject at their last visit. A 4-step grading scale is prop...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2013/207573
更新日期:2013-01-01 00:00:00
abstract:Purpose:Retinal vein occlusion (RVO) is the second most common retinal vascular disease and a major cause of visual impairment. In this study, we aimed to observe whether RVO cases have different antibody profiles as a new potential risk factor and whether a conversion of retinal vein occlusion (RVO) to neovascular gla...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/8386160
更新日期:2020-07-29 00:00:00
abstract:Purpose:Activating transcription factor 4 (ATF4) is induced by various stressors. Here, we investigated the expression of ATF4 in the host inflammatory response to Aspergillus fumigatus (A. fumigatus) keratitis. Methods:A. fumigatus keratitis mouse models developed by intrastromal injection as well as corneal epitheli...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/5830202
更新日期:2018-12-13 00:00:00
abstract:Purpose:To investigate the effects of capsulotomy shape on the visual acuity and visual quality after neodymium: yttrium aluminum garnet laser capsulotomy. Methods:In this study, a total of 42 eyes from 35 patients with posterior capsule opacification were divided into the circular and cruciate groups. The corrected d...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/4153109
更新日期:2020-03-23 00:00:00
abstract:Purpose:The correlations between the axial length-to-corneal radius (AL/CR) ratio and corneal astigmatism (CA) were studied by prospectively analyzing and comparing survey data from school children in the Beijing urban area from 2014 to 2015. Methods:In this longitudinal study, a total of 2,970 students were enrolled ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/4209236
更新日期:2018-08-30 00:00:00
abstract::Objective. To compare macular thickness (MT) and retinal nerve fiber layers (RNFL) between women with polycystic ovary syndrome (PCOS) and healthy women. Materials and Methods. The study included 45 women with PCOS and 47 ovulatory women undergoing clinical-gynecological and ophthalmic evaluations, including measureme...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/193078
更新日期:2015-01-01 00:00:00
abstract::Aim. The aim of this study was to determine the intra- and interobserver variability of two Scheimpflug based camera systems, Pentacam and Sirius. In addition, the comparability of the measurements was tested in healthy subjects, subjects with regular astigmatism, and keratoconus patients. Methods. Intra- and interobs...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/315281
更新日期:2015-01-01 00:00:00
abstract:Objective:To determine whether accommodation induced by reading alters intraocular pressure (IOP) in healthy, young, emmetropic adults and to document the duration and magnitude of this effect. Design:Cross-sectional study. Participants. Fifteen healthy, emmetropic young adults. Methods:Subjects performed 20 minutes ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/1352434
更新日期:2020-01-28 00:00:00
abstract::Aims. Increasing evidence shows that imbalanced suppressive drive prior to binocular combination may be the key factor in amblyopia. We described a novel binocular approach, interocular shift of visual attention (ISVA), for treatment of amblyopia in adult patients. Methods. Visual stimuli were presented anaglyphically...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/615213
更新日期:2014-01-01 00:00:00
abstract:Purpose:To compare the outcomes of Ex-PRESS glaucoma filtration device and transscleral cyclophotocoagulation (TSCP) in the management of neovascular glaucoma (NVG). Patients and Methods. A total of 30 eyes (12 express shunts and 18 TSCP) of 28 patients were included. The eyes had NVG with intraocular pressure (IOP) mo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/3781249
更新日期:2020-05-17 00:00:00
abstract:Purpose:To evaluate the efficacy and safety of MyoRing implantation in eyes with keratoconus managed at a tertiary eye hospital in the Eastern Province of Saudi Arabia. Methods:This one-armed historical cohort study included keratoconus patients operated for MyoRing implant. The cases were assessed before and 6 months...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/2630704
更新日期:2019-08-29 00:00:00
abstract:Purpose:To examine the morphological changes in the meibomian glands of patients with keratoconus as well as to study the relationship between these changes in the morphology and several tear film parameters. Methods:Examination of the meibomian gland (MG) of 300 keratoconus patients presenting to the center using inf...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/2965872
更新日期:2019-06-02 00:00:00
abstract::Purpose. To assess the morphology of idiopathic choroidal neovascularization (ICNV) by optical coherence tomography angiography (OCTA) and determine the therapeutic effects of intravitreal antivascular endothelial growth factor (anti-VEGF). Method. Patients with naive ICNV were assessed by spectral domain optical cohe...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/5608250
更新日期:2016-01-01 00:00:00
abstract::The ciliary body ablation is still considered as a last resort treatment to reduce the intraocular pressure (IOP) in uncontrolled glaucoma. Several ablation techniques have been proposed over the years, all presenting a high rate of complications, nonselectivity for the target organ, and unpredictable dose-effect rela...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2017/7136275
更新日期:2017-01-01 00:00:00
abstract::Purpose. To report a comparative prospective long-term functional analysis after Riboflavin UV A corneal cross-linking (CXL) in three different age groups of patients affected by progressive keratoconus (KC). Methods. Functional analysis comprised paediatric patients (≤18 years) included 152 eyes (29.5%); intermediate...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/608041
更新日期:2011-01-01 00:00:00
abstract::Purpose. To present a series of retinal disease cases that were imaged by spectral domain optical coherence tomography (SD-OCT) in order to illustrate the potential and limitations of this new imaging modality. Methods. The series comprised four selected cases (one case each) of age-related macular degeneration (ARMD)...
journal_title:Journal of ophthalmology
pub_type:
doi:10.1155/2011/764183
更新日期:2011-01-01 00:00:00
abstract::The functional visual acuity test which is the average of the visual acuities measured during a specific time frame (standard, 60 seconds) has been used recently to assess the visual function in various conditions. The availability of a shorter version of the functional visual acuity test promises to be patient friend...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/8950418
更新日期:2019-09-10 00:00:00
abstract::Idiopathic full-thickness macular hole is a severe visual impairment disease. Pars plana vitrectomy remains the primary treatment option for idiopathic full-thickness macular holes, and over 90% idiopathic full-thickness macular holes are closed by vitrectomy surgery. However, the full-thickness macular hole may close...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2019/4793764
更新日期:2019-03-13 00:00:00
abstract:Purpose:To investigate the association between regional solar radiation and myopia occurrence in South Korean children. Materials and Methods:A population-based cross-sectional study using data of 1218 children aged 7-9 years from the Korea National Health and Nutritional Examination Survey was conducted from January ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/7643850
更新日期:2019-06-10 00:00:00
abstract:PURPOSE:Popular beliefs exert an impact of lunar phases on elective surgery. The aim of our study was to evaluate potential correlations between complications in cataract surgery and the phases of the moon during its passage through the zodiac and Fridays that fall on the 13th. METHODS:Patients with complications duri...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/1946527
更新日期:2017-01-01 00:00:00
abstract::Background. The vision with diffractive toric multifocal intraocular lenses after cataract surgery in long eyes has not been studied previously. Objectives. To report visual performance after bilateral implantation of a diffractive toric multifocal intraocular lens in high myopes. Methods. Prospective, observational c...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/5320105
更新日期:2016-01-01 00:00:00
abstract:Purpose:To evaluate early changes in visual function and visual quality parameters after Descemet membrane endothelial keratoplasty (DMEK) and to compare the outcomes with healthy controls. Methods:Thirteen patients who underwent DMEK and 14 controls were evaluated. All subjects underwent visual function evaluation, i...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/2012560
更新日期:2018-09-23 00:00:00
abstract:PURPOSE:To evaluate sequential changes in choroidal thickness at the affected area in patients with acute zonal occult outer retinopathy (AZOOR). METHODS:This retrospective observational case series included 14 affected eyes and 6 unaffected fellow eyes from 10 AZOOR patients with impaired macular area. Using enhanced...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/2371032
更新日期:2017-01-01 00:00:00