Abstract:
:Individualized treatment regimens may reduce patient burden with satisfactory patient outcomes in neovascular age-related macular degeneration. Intravitreal anti-VEGF drugs are the current gold standard. Fixed monthly injections offer the best visual outcome but this regimen is not commonly followed outside clinical trials. A PRN regimen requires monthly visits where the patient is treated in the presence of signs of lesion activity. Therefore, an early detection of reactivation of the disease with immediate retreatment is crucial to prevent visual acuity loss. Several trials suggest that "treat and extend" and other proactive regimens provide a reasonable approach. The rationale of the proactive regimens is to perform treatment anticipating relapses or recurrences and therefore avoid drops in vision while individualizing patient followup. Treat and extend study results in significant direct medical cost savings from fewer treatments and office visits compared to monthly treatment. Current data suggest that, for one year, PRN is less expensive, but treat and extend regimen would likely be less expensive for subsequent years. Once a patient is not a candidate to continue with treatment, he/she should be sent to an outpatient unit with adequate resources to follow nAMD patients in order to reduce the burden of specialized ophthalmologist services.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
García-Layana A,Figueroa MS,Arias L,Araiz J,Ruiz-Moreno JM,García-Arumí J,Gómez-Ulla F,López-Gálvez MI,Cabrera-López F,García-Campos JM,Monés J,Cervera E,Armadá F,Gallego-Pinazo Rdoi
10.1155/2015/412903subject
Has Abstractpub_date
2015-01-01 00:00:00pages
412903eissn
2090-004Xissn
2090-0058journal_volume
2015pub_type
杂志文章,评审abstract:Purpose:To compare ocular biometry between children with type 1 diabetes mellitus (T1DM) and healthy children in China and to determine the correlation of ocular biometry with the glycosylated hemoglobin (HbA1c) level and diabetes duration. Methods:A case-control study was conducted at Children's Hospital of Fudan Uni...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/7216490
更新日期:2019-02-14 00:00:00
abstract::LASIK eye surgery has become a very common practice for myopic people, especially those in the military. Sometimes undertaken by people who need to keep a specific medical aptitude, this surgery could be performed in secret from the hierarchy and from the institute medical staff. However, even though the eyes have bee...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/762364
更新日期:2014-01-01 00:00:00
abstract::Aim. To examine subscale and total scores of NEI-VFQ questionnaire of type 2 diabetes patients at different diabetic retinopathy (DRP) stages. Methods. A total number of 201 patients have been included. Prior to ophthalmological examination all patients participated in the NEI-VFQ questionnaire. The patients were divi...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1549318
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Popular beliefs exert an impact of lunar phases on elective surgery. The aim of our study was to evaluate potential correlations between complications in cataract surgery and the phases of the moon during its passage through the zodiac and Fridays that fall on the 13th. METHODS:Patients with complications duri...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/1946527
更新日期:2017-01-01 00:00:00
abstract::Methylglyoxal (MG) is an intermediate of glucose metabolism and the precursor of advanced glycation end products (AGEs) found in high levels in blood or tissue of diabetic patients. MG and AGEs are thought to play a major role in the pathogenesis of diabetic retinopathy. In order to determine if zebrafish is valuable ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/2746735
更新日期:2019-04-17 00:00:00
abstract:Purpose:To evaluate the feasibility and the initial outcomes of a novel standardized surgical technique of femtosecond laser- (FSL-) assisted big-bubble deep anterior lamellar keratoplasty (BBDALK) for eyes with keratoconus. Methods:This prospective interventional case series included 11 consecutive FSL-assisted BBDAL...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/5496162
更新日期:2020-09-03 00:00:00
abstract::Objective. To compare macular thickness (MT) and retinal nerve fiber layers (RNFL) between women with polycystic ovary syndrome (PCOS) and healthy women. Materials and Methods. The study included 45 women with PCOS and 47 ovulatory women undergoing clinical-gynecological and ophthalmic evaluations, including measureme...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/193078
更新日期:2015-01-01 00:00:00
abstract:Purpose:To assess anterior corneal surface stability 12 months following hyperopic LASIK correction with a light propagation algorithm. Setting:Vissum Instituto Oftalmológico de Alicante, Universidad Miguel Hernández, Alicante, Spain. Methods:This retrospective consecutive observational study includes 37 eyes of 37 p...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/3060939
更新日期:2018-03-28 00:00:00
abstract:PURPOSE:To evaluate the effect of the Rho-kinase inhibitor Y-27632 on postoperative inflammation and adhesion following extraocular muscle surgery in rabbits. METHODS:The superior rectus muscle reinsertion was performed on both eyes of 8 New Zealand white rabbits. After reinsertion, the rabbits received subconjunctiva...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/8653130
更新日期:2017-01-01 00:00:00
abstract:Purpose:To evaluate the effect of corneal cap thickness on visual acuity and corneal biomechanics in small incision lenticule extraction (SMILE) for the treatment of myopia. Methods:Forty eyes of 20 patients undergoing SMILE for the treatment of myopia were enrolled in this prospective controlled study. The patients w...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/6040873
更新日期:2018-06-28 00:00:00
abstract:Background:Uveal melanoma (UM) is the most common primary intraocular tumor in adults and arises from the uvea. Marital status was a vital factor among physical conditions and social networks of cancer patients. Our study aimed to evaluate the impact of marital status on the outcomes among patients with UM. Methods:Pa...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/7012940
更新日期:2020-12-04 00:00:00
abstract::Purpose. To investigate the thickness of the retinal nerve fiber layer (RNFL) and choroid in patients who have migraines in comparison to healthy controls. Methods. This study included 76 eyes and patients in the migraine group, 36 with aura (MWA group) and 40 without (MWoA group), and 38 eyes as control subjects. The...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/868967
更新日期:2015-01-01 00:00:00
abstract::Purpose. This study investigated the effects of oral propolis on the progression of galactose-induced sugar cataracts in rats and the in vitro effects of propolis on high-glucose-induced reactive oxygen species (ROS) and cell death in cultured rat lens cells (RLECs). Methods. Galactose-fed rats and RLECs cultured in h...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1917093
更新日期:2016-01-01 00:00:00
abstract::The ocular surface-a continuous epithelial surface with regional specializations including the surface and glandular epithelia of the cornea, conjunctiva, and lacrimal and meibomian glands connected by the overlying tear film-plays a central role in vision. Molecular and cellular events involved in embryonic developme...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2013/103947
更新日期:2013-01-01 00:00:00
abstract:Background:The aim of this meta-analysis was to compare morphological and functional outcomes between vitrectomy with the inverted internal limiting membrane (ILM) flap technique and vitrectomy with internal limiting membrane peeling in highly myopic eyes with macular hole- (MH-) induced retinal detachment (MHRD). Met...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2020/2374650
更新日期:2020-08-24 00:00:00
abstract::Purpose. To evaluate the relationship between the macular ganglion cell complex (mGCC) thickness, which is the sum of the retinal nerve fiber, ganglion cell, and inner plexiform layers, measured with a spectral-domain optical coherence tomograph and the optic nerve head topography measured with a confocal scanning las...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/914250
更新日期:2011-01-01 00:00:00
abstract::Purpose. To examine causes as well as extent of delay in diagnosis and treatment of primary open angle glaucoma patients in a sample of Egyptians. Patients and Methods. 440 patients with primary open angle glaucoma were interviewed to evaluate delay in their diagnosis and treatment. The extent and cause of delay were ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/7012826
更新日期:2016-01-01 00:00:00
abstract::Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. The objective of this study is to investigate the effects of vascular endothelial growth factor receptor 1 (VEGFR1) blockade on the complications of DR. Experimental models of diabetes were induced with streptozotocin (STZ) treatment or I...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/605946
更新日期:2015-01-01 00:00:00
abstract::SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness m...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/692574
更新日期:2011-01-01 00:00:00
abstract:Purpose:Lanosterol synthase (LSS) abnormity contributes to lens opacity in rats, mice, dogs, and human congenital cataract development. This study examined whether LSS pathway has a role in different subtypes of age-related cataract (ARC). Methods:A total of 390 patients with ARC and 88 age-matched non-ARC patients we...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/4125893
更新日期:2018-07-11 00:00:00
abstract::Quantitative measurement of the orbital soft tissue volume plays a very important role in the study of orbital diseases. The purpose of this study is to establish a computed tomography- (CT-) based three-dimensional (3D) reconstruction model and measure the orbital soft tissue volume in Chinese adults. We collected da...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/9721085
更新日期:2019-07-02 00:00:00
abstract:Background:Endoplasmic reticulum stress (ERS) in the retinal Müller cells is a key factor contributing to the retinal inflammation and vascular leakage in diabetic retinopathy (DR). This study was to investigate the underlying mechanisms through which the 3 main unfolded protein response (UPR) pathways regulate ERS and...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/9028483
更新日期:2019-02-24 00:00:00
abstract:Purpose:To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes. Methods:Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy co...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/1825819
更新日期:2019-08-07 00:00:00
abstract:Purpose:Healthcare access is one of the determinants of visual impairment (VI), as a public health problem. The objective of this study was to estimate VI prevalence, related causes, and its correlation with access to physicians in Iran. Methods:: This systematic review and meta-analysis include observational studies ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2020/4710328
更新日期:2020-11-23 00:00:00
abstract::Purpose. To compare the corneal endothelial cell loss after phacoemulsification, alone or combined with microinvasive glaucoma surgery (MIGS), in nonglaucomatous versus primary open angle glaucoma (POAG) eyes affected by age-related cataract. Methods. 62 eyes of 62 patients were divided into group 1 (n = 25, affected ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/769289
更新日期:2015-01-01 00:00:00
abstract:Background:Chromatic contrast may affect stereopsis. Daltonism is a common color deficiency in which the colors red and green are incorrectly detected. The aim of this study was to evaluate the stereoacuity of color-defective individuals presented with color symbols that they see defectively. Methods:Ten students diag...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/1926736
更新日期:2018-08-01 00:00:00
abstract::Purpose. To assess the morphology of idiopathic choroidal neovascularization (ICNV) by optical coherence tomography angiography (OCTA) and determine the therapeutic effects of intravitreal antivascular endothelial growth factor (anti-VEGF). Method. Patients with naive ICNV were assessed by spectral domain optical cohe...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/5608250
更新日期:2016-01-01 00:00:00
abstract::Purpose. To determine the efficacy of povidone-iodine (P-I) prophylaxis for ophthalmia neonatorum (ON) in Angola and to document maternal prevalence and mother-to-child transmission rates. Methods. Endocervical samples from mothers (n = 317) and newborn conjunctival smears (n = 245) were analysed by multiplex polymera...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/326526
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To evaluate the static measurement of the accommodative stimulus-response curve with emoji symbols. METHODS:The accommodative stimulus-response curve was measured in 18 subjects using a Hartmann-Shack sensor to obtain the objective accommodative response from the Zernike defocus term. Measurements were acquire...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/4165706
更新日期:2017-01-01 00:00:00
abstract::Purpose. Ischemic central retinal vein occlusion (CRVO) eyes are at high risk of developing neovascular glaucoma (NVG). Our purpose is to investigate the effect of anti-VEGF therapy for macular edema after CRVO on the development of neovascular glaucoma (NVG) in ischemic CRVO eyes. Methods. This is a retrospective cas...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/317694
更新日期:2014-01-01 00:00:00