Abstract:
PURPOSE:To investigate neovascular age-related macular degeneration (AMD) in patients aged ≥90 years from several perspectives for a comprehensive overview: prevalence, presenting characteristics, treatment adherence, reasons for discontinuation, and efficacy of antivascular endothelial growth factor (VEGF) treatment comparing Ranibizumab and Aflibercept. METHODS:In this retrospective chart review, we determined the prevalence and presenting characteristics by reviewing all data for patients referred to our department with treatment-naïve neovascular AMD. By looking at historical cohorts, we determined adherence to treatment, reasons for discontinuation, and treatment outcomes after loading dose, 12 months, and 24 months. RESULTS:Patients aged ≥90 years constituted 7% of the patients. Treatment was discontinued in 51%, primarily because of death and treatment burden. Mean change in best-corrected visual acuity was 3.2, 1.5, and -2.2 ETDRS letters at 4, 12, and 24 months, respectively. Aflibercept was superior to Ranibizumab in visual and anatomic outcomes. After two years of treatment, patients losing ≥15 ETDRS letters made up 19% in the Aflibercept group and 26% in the Ranibizumab group. CONCLUSIONS:We propose that the very old patients with neovascular AMD may constitute a distinctive group warranting special attention and possibilities for individualized therapy. Possible differences between anti-VEGF agents need further investigations.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Subhi Y,Sørensen TLdoi
10.1155/2017/7194927subject
Has Abstractpub_date
2017-01-01 00:00:00pages
7194927eissn
2090-004Xissn
2090-0058journal_volume
2017pub_type
杂志文章abstract::Genome-wide association study (GWAS) analysis identified three new susceptibility loci for PACG. In this study, we aimed to investigate whether these three loci in PLEKHA7, COL11A1, and PCMTD1-ST18 are associated with PAC and ocular biometric characteristics, such as axial length (AL), anterior chamber depth (ACD), an...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2013/641596
更新日期:2013-01-01 00:00:00
abstract::Purpose. The aim of this study is to investigate the etiology and the clinical, microbiological, histopathological, and radiological findings of acquired dacryocystoceles. Methods. In this retrospective study, we reviewed the clinical records of 10 eyes of 8 patients with dacryocystoceles who underwent external dacryo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/396782
更新日期:2014-01-01 00:00:00
abstract::Purpose. To evaluate functional and anatomical results of pars plana vitrectomy (PPV) in the retinal detachment (RD) followed by severe eye trauma. Methods. Retrospective analysis of medical records of forty-one consecutive patients treated with 23-gauge PPV due to traumatic RD. Age, gender, timing of PPV, visual acui...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/5084319
更新日期:2017-01-01 00:00:00
abstract:Purpose:The iStent provides a direct pathway for aqueous outflow from the anterior chamber to Schlemm's canal in patients with open-angle glaucoma (OAG). We performed a meta-analysis to evaluate the effectiveness of iStent as a standalone operation in patients with OAG in reducing the intraocular pressure (IOP) and the...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2020/8754730
更新日期:2020-05-24 00:00:00
abstract:Introduction:To assess long-term efficacy of bimedial rectus tendon elongation with Tutopatch in thyroid-associated orbitopathy (TAO). Materials and Methods:Retrospective chart review of 5 patients with TAO undergoing bimedial rectus recession with Tutopatch tendon elongation between 2009 and 2015. We analyzed horizon...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/1294761
更新日期:2018-07-24 00:00:00
abstract:Background:For so long, corneal diseases have been known as one of the leading causes to blindness in the global. This blindness might be due to failure to accept the corneal transplantation. Therefore, this study aimed to determine the prevalence and the root challenges for corneal transplantation acceptance at the Un...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/4560649
更新日期:2019-12-13 00:00:00
abstract::Purpose. To evaluate the corneal higher-order aberrations (HOA), contrast sensitivity function (CSF), and light distortion (LD) in patients undergoing orthokeratology (OK). Methods. Twenty healthy subjects (mean age: 21.40 ± 8 years) with mean spherical equivalent refractive error M = -2.19 ± 0.97 D were evaluated at ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/8453462
更新日期:2016-01-01 00:00:00
abstract::Purpose. To describe the SD-OCT findings in patients with diffuse unilateral subacute neuroretinitis (DUSN) and evaluate CRT and RNFL thickness. Methods. Patients with clinical diagnosis of DUSN who were submitted to SD-OCT were included in the study. Complete ophthalmologic examination and SD-OCT were performed. Cirr...
journal_title:Journal of ophthalmology
pub_type:
doi:10.1155/2011/285296
更新日期:2011-01-01 00:00:00
abstract::Dry eye syndrome is a disease of the ocular surface and tear film that is prevalent in older adults. Even though the degree of visual acuity loss in dry eye patients is commonly mild-to-moderate, in the aging population, this minimal change in visual status can lead to a significant decrease in visual function and qua...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2014/781683
更新日期:2014-01-01 00:00:00
abstract::Background. We aimed to evaluate the association between maternal smoking and the occurrence of childhood refractive error and amblyopia. Methods. Relevant articles were identified from PubMed and EMBASE up to May 2015. Combined odds ratio (OR) corresponding with its 95% confidence interval (CI) was calculated to eval...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/8263832
更新日期:2016-01-01 00:00:00
abstract::Methylglyoxal (MG) is an intermediate of glucose metabolism and the precursor of advanced glycation end products (AGEs) found in high levels in blood or tissue of diabetic patients. MG and AGEs are thought to play a major role in the pathogenesis of diabetic retinopathy. In order to determine if zebrafish is valuable ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/2746735
更新日期:2019-04-17 00:00:00
abstract::Retinitis pigmentosa (RP) represents a clinically and genetically heterogeneous disease characterized by progressive photoreceptor loss. In recent years, research has been rarely made in blood flow affected in RP. The specific mechanism of blood flow affected in RP is not completely clear. A number of studies indicate...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2018/3249064
更新日期:2018-02-25 00:00:00
abstract::Purpose. To evaluate the anterior chamber volume in cataract patients with Swept-Source Optical Coherence Tomography (SS-OCT) and its influencing factors. Methods. Anterior chamber volume of 92 cataract patients was evaluated with SS-OCT in this cross-sectional study. Univariate analyses and multiple linear regression...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/8656301
更新日期:2016-01-01 00:00:00
abstract::Purpose. To assess the morphology of idiopathic choroidal neovascularization (ICNV) by optical coherence tomography angiography (OCTA) and determine the therapeutic effects of intravitreal antivascular endothelial growth factor (anti-VEGF). Method. Patients with naive ICNV were assessed by spectral domain optical cohe...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/5608250
更新日期:2016-01-01 00:00:00
abstract::This paper demonstrates multiple benefits of intravitreal bevacizumab (IVB) on diabetic retinopathy (DR) including diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) at 24 months of followup. This is a retrospective multicenter interventional comparative case series of intravitreal injections of...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/584238
更新日期:2011-01-01 00:00:00
abstract:Purpose:The purpose of this meta-analysis was to assess the percent reduction in the intraocular pressure (IOP) after argon laser peripheral iridoplasty (ALPI) and systemic medical therapy in patients with acute primary angle closure (APAC). Methods:We searched a number of electronic databases, including MEDLINE, EMBA...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2019/7697416
更新日期:2019-05-02 00:00:00
abstract::Background. The vision with diffractive toric multifocal intraocular lenses after cataract surgery in long eyes has not been studied previously. Objectives. To report visual performance after bilateral implantation of a diffractive toric multifocal intraocular lens in high myopes. Methods. Prospective, observational c...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/5320105
更新日期:2016-01-01 00:00:00
abstract:Purpose:The aim of this study was to assess the effects of residual anterior lens epithelial cell (LEC) removal by anterior capsule polishing on the effective lens position (ELP) and axial position stability of the intraocular lens (IOL) after cataract surgery via postoperative measurement of the anterior chamber depth...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/9704892
更新日期:2018-08-19 00:00:00
abstract:Purpose:To evaluate changes in flow density after the implantation of a trabecular microbypass stent (iStent) in combination with cataract surgery. Methods:A total of 48 eyes of 48 patients, who underwent either cataract surgery alone (cataract group) or cataract surgery with implantation of two iStent inject devices ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/2890357
更新日期:2018-01-31 00:00:00
abstract:Introduction:Hepatitis B virus (HBV) and hepatitis C virus (HCV) and their long-term sequelae are considered a major health issue in Egypt. The aim of this study is to determine the prevalence of undiagnosed hepatitis B virus (HBV) and hepatitis C virus (HCV) among patients admitted for elective eye surgery in a specia...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/3985865
更新日期:2019-07-01 00:00:00
abstract:Purpose:To report a novel technique of cross-knotted suture basket and to test its effectiveness in large nonmagnetic intraocular foreign body (IOFB) removal. Methods:A 7/0 Vicryl suture was cut in half and cross-knotted, and four ends were introduced into a 23G needle to form a basket. Pig eyes were used to set up th...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/1061462
更新日期:2020-04-25 00:00:00
abstract:Purpose:To compare ocular biometry between children with type 1 diabetes mellitus (T1DM) and healthy children in China and to determine the correlation of ocular biometry with the glycosylated hemoglobin (HbA1c) level and diabetes duration. Methods:A case-control study was conducted at Children's Hospital of Fudan Uni...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/7216490
更新日期:2019-02-14 00:00:00
abstract:Objective:To calculate the Q values from the human anterior corneal surface with the tangential radius of curvature and analyze its distribution characteristics in different age and refractive status groups. Methods:Tangential power maps of the anterior cornea from Orbscan II were acquired for 201 subjects' right eyes...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/7263564
更新日期:2018-04-17 00:00:00
abstract::Purpose. To report the 12-month follow-up after big-bubble deep anterior lamellar keratoplasty (DALK) assisted by femtosecond laser that we have called IntraBubble. Methods. A 60 kHz IntraLase femtosecond laser (Abbott Medical Optics) firstly created a 30° angled intrastromal channel to insert the air injection cannul...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2012/264590
更新日期:2012-01-01 00:00:00
abstract::Here we review evidence that loss of photoreceptors due to degenerative retinal disease causes an increase in the rate of spontaneous ganglion spike discharge. Information about persistent spike activity is important since it is expected to add noise to the communication between the eye and the brain and thus impact t...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/507037
更新日期:2011-01-01 00:00:00
abstract::Purpose. To examine causes as well as extent of delay in diagnosis and treatment of primary open angle glaucoma patients in a sample of Egyptians. Patients and Methods. 440 patients with primary open angle glaucoma were interviewed to evaluate delay in their diagnosis and treatment. The extent and cause of delay were ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/7012826
更新日期:2016-01-01 00:00:00
abstract::Purpose. To evaluate interobserver, intervisit, and interinstrument agreements for gonioscopy and Fourier domain anterior segment optical coherence tomography (FD ASOCT) for classifying open and narrow angle eyes. Methods. Eighty-six eyes with open or narrow anterior chamber angles were included. The superior angle wa...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1727039
更新日期:2016-01-01 00:00:00
abstract:Objective:To evaluate optical coherence tomography (OCT) findings of pediatric Alport syndrome (AS) patients with no retinal pathology on fundus examination. Materials and Methods:Twenty-one patients being followed up with the diagnosis of AS (Group 1) and 24 age- and sex-matched healthy volunteers (Group 2) were pros...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/6741930
更新日期:2019-01-21 00:00:00
abstract:Purpose:To analyze the results of three-year outcomes of combined epithelium-on cross-linking with femtosecond laser ICRS (cross-linking PLUS) for keratoconus management. Design:A retrospective multicenter clinical study. Methods:43 eyes of 38 patients were subjected to preoperative and postoperative UCVA, BCVA, refr...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/6907573
更新日期:2018-01-17 00:00:00
abstract:Purpose:Although optical coherence tomography (OCT) is essential for ophthalmologists, reading of findings requires expertise. The purpose of this study is to test deep learning with image augmentation for automated detection of chorioretinal diseases. Methods:A retina specialist diagnosed 1,200 OCT images. The diagno...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/6319581
更新日期:2019-04-09 00:00:00