Abstract：
Purpose:Retinal vein occlusion (RVO) is the second most common retinal vascular disease and a major cause of visual impairment. In this study, we aimed to observe whether RVO cases have different antibody profiles as a new potential risk factor and whether a conversion of retinal vein occlusion (RVO) to neovascular glaucoma (NVG), one of the major complications, is occurring within a 5-year timeframe. Methods:We performed a nested case-control study (1 : 4) within the Gutenberg Health Study (GHS), a population-based, prospective cohort study in the Rhine-Main Region of Germany including 15,010 participants. RVO subjects (n = 59) were identified by grading of fundus photographs. Optic nerves of RVO subjects and age- and sex-matched controls (n = 229) at baseline and their follow-up examination after 5 years were analyzed for glaucomatous alterations. Of all RVO subjects and controls, serum autoantibody profiles were measured using in-house manufactured antigen-antibody microarrays. Results:Of the 59 RVO patients, 3 patients (5%) showed glaucomatous optic disc alterations at baseline, whereas no new glaucoma case was detected at 5-year follow-up. Four of the autoantibodies measured (against dermcidin, neurotrophin-3, superoxide dismutase 1, and signal recognition particle 14 kDa protein) were significantly increased in the serum of RVO patients (p < 0.001). Multivariable conditional logistic regression analysis showed that 3 of these 4 antibodies were independent of cardiovascular risk factors. Conclusions:We found several autoantibodies associated with RVO, targeting proteins and structures possibly involved in RVO pathogenesis.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Bell K,Beutgen VM,Nickels S,Lorenz K,Scheller Y,Elbaz H,Peto T,Ponto KA,Schulz A,Wild PS,Münzel T,Lackner KJ,Schmidtmann I,Beutel M,Pfeiffer N,Grus FH,Schuster AKdoi
10.1155/2020/8386160subject
Has Abstractpub_date
2020-07-29 00:00:00pages
8386160eissn
2090-004Xissn
2090-0058journal_volume
2020pub_type
杂志文章abstract：:Genome-wide association study (GWAS) analysis identified three new susceptibility loci for PACG. In this study, we aimed to investigate whether these three loci in PLEKHA7, COL11A1, and PCMTD1-ST18 are associated with PAC and ocular biometric characteristics, such as axial length (AL), anterior chamber depth (ACD), an...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2013/641596
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abstract：PURPOSE:To evaluate the static measurement of the accommodative stimulus-response curve with emoji symbols. METHODS:The accommodative stimulus-response curve was measured in 18 subjects using a Hartmann-Shack sensor to obtain the objective accommodative response from the Zernike defocus term. Measurements were acquire...
journal_title：Journal of ophthalmology
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doi：10.1155/2017/4165706
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abstract：:Purpose. To describe the SD-OCT findings in patients with diffuse unilateral subacute neuroretinitis (DUSN) and evaluate CRT and RNFL thickness. Methods. Patients with clinical diagnosis of DUSN who were submitted to SD-OCT were included in the study. Complete ophthalmologic examination and SD-OCT were performed. Cirr...
journal_title：Journal of ophthalmology
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journal_title：Journal of ophthalmology
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journal_title：Journal of ophthalmology
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abstract：:Methylglyoxal (MG) is an intermediate of glucose metabolism and the precursor of advanced glycation end products (AGEs) found in high levels in blood or tissue of diabetic patients. MG and AGEs are thought to play a major role in the pathogenesis of diabetic retinopathy. In order to determine if zebrafish is valuable ...
journal_title：Journal of ophthalmology
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更新日期：2019-04-17 00:00:00
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journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/3983508
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abstract：:Zeaxanthin is a nutritional carotenoid with a considerable amount of safety data based on regulatory studies, which form the basis of its safety evaluation. Subchronic OECD guideline studies with mice and rats receiving beadlet formulations of high purity synthetic zeaxanthin in the diet at dosages up to 1000 mg/kg bo...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
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journal_title：Journal of ophthalmology
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更新日期：2017-01-01 00:00:00
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journal_title：Journal of ophthalmology
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doi：10.1155/2012/430249
更新日期：2012-01-01 00:00:00
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journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
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更新日期：2020-08-24 00:00:00
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journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/3693140
更新日期：2019-05-20 00:00:00
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journal_title：Journal of ophthalmology
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doi：10.1155/2016/8263832
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更新日期：2019-05-02 00:00:00
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journal_title：Journal of ophthalmology
pub_type： 杂志文章
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journal_title：Journal of ophthalmology
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journal_title：Journal of ophthalmology
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journal_title：Journal of ophthalmology
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journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
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journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
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journal_title：Journal of ophthalmology
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更新日期：2018-05-15 00:00:00
